IL207217A - Purified and/or recombinant humanized antibody which binds human c5ar and various aspects related thereto - Google Patents
Purified and/or recombinant humanized antibody which binds human c5ar and various aspects related theretoInfo
- Publication number
- IL207217A IL207217A IL207217A IL20721710A IL207217A IL 207217 A IL207217 A IL 207217A IL 207217 A IL207217 A IL 207217A IL 20721710 A IL20721710 A IL 20721710A IL 207217 A IL207217 A IL 207217A
- Authority
- IL
- Israel
- Prior art keywords
- purified
- various aspects
- humanized antibody
- binds human
- aspects related
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6653908P | 2008-02-20 | 2008-02-20 | |
PCT/AU2009/000184 WO2009103113A1 (en) | 2008-02-20 | 2009-02-19 | HUMANIZED ANTI-C5aR ANTIBODIES |
Publications (2)
Publication Number | Publication Date |
---|---|
IL207217A0 IL207217A0 (en) | 2010-12-30 |
IL207217A true IL207217A (en) | 2015-03-31 |
Family
ID=40984994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL207217A IL207217A (en) | 2008-02-20 | 2010-07-26 | Purified and/or recombinant humanized antibody which binds human c5ar and various aspects related thereto |
Country Status (14)
Country | Link |
---|---|
US (3) | US8268972B2 (en) |
EP (2) | EP2826791A3 (en) |
JP (2) | JP2011515073A (en) |
KR (1) | KR20100117120A (en) |
CN (2) | CN101970494B (en) |
AU (1) | AU2009217224B2 (en) |
BR (1) | BRPI0907532A2 (en) |
CA (1) | CA2714296A1 (en) |
ES (1) | ES2562627T3 (en) |
IL (1) | IL207217A (en) |
MX (1) | MX2010009190A (en) |
RU (1) | RU2010138612A (en) |
WO (1) | WO2009103113A1 (en) |
ZA (1) | ZA201005348B (en) |
Families Citing this family (36)
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ES2561828T3 (en) | 2002-01-25 | 2016-03-01 | Novo Nordisk A/S | Monoclonal antibodies against C5aR extracellular loops |
ZA200900954B (en) * | 2006-08-22 | 2010-05-26 | G2 Inflammation Pty Ltd | Ant-C5aR antibodies with improved properties |
BRPI0907532A2 (en) | 2008-02-20 | 2015-07-28 | G2 Inflammation Pty Ltd | Humanized anti-c5ar antibodies |
EP2297203A1 (en) | 2008-06-30 | 2011-03-23 | Novo Nordisk A/S | Anti-human interleukin-20 antibodies |
BRPI0918947A2 (en) * | 2008-09-26 | 2015-12-01 | Ucb Pharma Sa | antibody fusion protein |
US8454956B2 (en) | 2009-08-31 | 2013-06-04 | National Cheng Kung University | Methods for treating rheumatoid arthritis and osteoporosis with anti-IL-20 antibodies |
JP2013520476A (en) | 2010-02-26 | 2013-06-06 | ノヴォ ノルディスク アー/エス | Stable antibody-containing composition |
PT2542257T (en) | 2010-03-01 | 2017-10-09 | Bayer Healthcare Llc | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
CN102905692B (en) | 2010-05-28 | 2015-09-16 | 诺沃—诺迪斯克有限公司 | Comprise the stable multi-dose compositions of antibody and antiseptic |
EP2468295A1 (en) | 2010-12-21 | 2012-06-27 | Affiris AG | Vaccines based on peptides of the complement protein C5a |
BR112013031198B1 (en) | 2011-06-06 | 2020-10-20 | Novo Nordisk A/S | c5ar binding antibody and its use |
WO2014015133A1 (en) | 2012-07-19 | 2014-01-23 | National Cheng Kung University | Treatment of osteoarthritis using il-20 antagonists |
US8852588B2 (en) | 2012-08-07 | 2014-10-07 | National Cheng Kung University | Treating allergic airway disorders using anti-IL-20 receptor antibodies |
US8603470B1 (en) | 2012-08-07 | 2013-12-10 | National Cheng Kung University | Use of IL-20 antagonists for treating liver diseases |
US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
US8613919B1 (en) | 2012-08-31 | 2013-12-24 | Bayer Healthcare, Llc | High concentration antibody and protein formulations |
GB201220242D0 (en) * | 2012-11-09 | 2012-12-26 | Fusion Antibodies Ltd | Antibody |
TWI682941B (en) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | Antibodies comprising chimeric constant domains |
CN105392803B (en) * | 2013-05-08 | 2019-12-06 | 诺和诺德股份有限公司 | Use of C5aR antagonists |
TWI701042B (en) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | Methods and antibody compositions for tumor treatment |
EP3636073B1 (en) * | 2014-05-05 | 2023-11-15 | Regeneron Pharmaceuticals, Inc. | Humanized c5 and c3 animals |
PL3221359T3 (en) | 2014-11-17 | 2020-11-16 | Regeneron Pharmaceuticals, Inc. | Methods for tumor treatment using cd3xcd20 bispecific antibody |
KR20170094787A (en) * | 2014-12-18 | 2017-08-21 | 에프. 호프만-라 로슈 아게 | Assay and method for determining cdc eliciting antibodies |
US10556952B2 (en) | 2015-03-30 | 2020-02-11 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to Fc gamma receptors |
IL292798A (en) | 2015-05-04 | 2022-07-01 | Cytomx Therapeutics Inc | Anti-cd166 antibodies, activatable anti-cd166 antibodies, preparations containing them and their uses |
CN106957366B (en) * | 2016-01-12 | 2022-02-01 | 上海昀怡健康科技发展有限公司 | C5aR antibody and preparation method and application thereof |
CA3057146A1 (en) * | 2017-03-23 | 2018-09-27 | The Trustees Of The University Of Pennsylvania | Anti-c5a antibodies and uses thereof |
US11220544B2 (en) | 2017-07-14 | 2022-01-11 | Cytomx Therapeutics, Inc. | Anti-CD166 antibodies and uses thereof |
JP6511200B1 (en) * | 2017-12-14 | 2019-05-15 | 硬化クローム工業株式会社 | Cooling roll and method of manufacturing thermoplastic resin sheet using the same |
KR20210018906A (en) * | 2018-06-07 | 2021-02-18 | 케모센트릭스, 인크. | Administration and effects of C5A antagonists on ANCA-associated vasculitis |
KR20210054528A (en) | 2018-08-31 | 2021-05-13 | 리제너론 파아마슈티컬스, 인크. | Dosing strategies to alleviate cytokine release syndrome against CD3/C20 bispecific antibodies |
CN109439662B (en) * | 2018-11-15 | 2020-09-01 | 北京大学第三医院 | sgRNA for C5aR1 gene knockout, vector, construction method and detection method |
BR112021017860A2 (en) | 2019-03-14 | 2021-12-07 | Morphosys Ag | Isolated antibody or antibody fragment specific to human c5ar, nucleic acid composition, vector composition, host cell and pharmaceutical composition |
US11773179B2 (en) * | 2020-01-13 | 2023-10-03 | Visterra, Inc. | Antibody molecules to C5aR1 and uses thereof |
MX2023008302A (en) | 2021-01-13 | 2023-09-25 | Visterra Inc | Humanized complement 5a receptor 1 antibodies and methods of use thereof. |
WO2024193714A1 (en) * | 2023-03-23 | 2024-09-26 | 科济生物医药(上海)有限公司 | Cell immunotherapy composition and method |
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BRPI0907532A2 (en) | 2008-02-20 | 2015-07-28 | G2 Inflammation Pty Ltd | Humanized anti-c5ar antibodies |
WO2010000864A1 (en) | 2008-07-04 | 2010-01-07 | Novo Nordisk A/S | Method for producing monoclonal antibodies |
JP2013520476A (en) | 2010-02-26 | 2013-06-06 | ノヴォ ノルディスク アー/エス | Stable antibody-containing composition |
CN102905692B (en) | 2010-05-28 | 2015-09-16 | 诺沃—诺迪斯克有限公司 | Comprise the stable multi-dose compositions of antibody and antiseptic |
-
2009
- 2009-02-19 BR BRPI0907532-1A patent/BRPI0907532A2/en not_active Application Discontinuation
- 2009-02-19 CA CA2714296A patent/CA2714296A1/en not_active Abandoned
- 2009-02-19 US US12/866,009 patent/US8268972B2/en not_active Expired - Fee Related
- 2009-02-19 EP EP14177321.8A patent/EP2826791A3/en not_active Withdrawn
- 2009-02-19 KR KR1020107020742A patent/KR20100117120A/en not_active Application Discontinuation
- 2009-02-19 CN CN200980105691.9A patent/CN101970494B/en not_active Expired - Fee Related
- 2009-02-19 ES ES09713373.0T patent/ES2562627T3/en active Active
- 2009-02-19 CN CN201410315627.6A patent/CN104193824A/en not_active Withdrawn
- 2009-02-19 RU RU2010138612/10A patent/RU2010138612A/en not_active Application Discontinuation
- 2009-02-19 JP JP2010547002A patent/JP2011515073A/en active Pending
- 2009-02-19 EP EP09713373.0A patent/EP2254911B1/en active Active
- 2009-02-19 WO PCT/AU2009/000184 patent/WO2009103113A1/en active Application Filing
- 2009-02-19 AU AU2009217224A patent/AU2009217224B2/en not_active Ceased
- 2009-02-19 MX MX2010009190A patent/MX2010009190A/en active IP Right Grant
-
2010
- 2010-07-26 IL IL207217A patent/IL207217A/en not_active IP Right Cessation
- 2010-07-27 ZA ZA2010/05348A patent/ZA201005348B/en unknown
-
2012
- 2012-08-20 US US13/590,016 patent/US8361468B2/en not_active Expired - Fee Related
- 2012-12-19 US US13/720,685 patent/US8808701B2/en not_active Expired - Fee Related
-
2014
- 2014-04-28 JP JP2014092573A patent/JP6034826B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
RU2010138612A (en) | 2012-03-27 |
CN104193824A (en) | 2014-12-10 |
ZA201005348B (en) | 2011-10-26 |
EP2254911A4 (en) | 2011-10-19 |
US20130129721A1 (en) | 2013-05-23 |
KR20100117120A (en) | 2010-11-02 |
CA2714296A1 (en) | 2009-08-27 |
BRPI0907532A2 (en) | 2015-07-28 |
JP2014193164A (en) | 2014-10-09 |
US8361468B2 (en) | 2013-01-29 |
CN101970494B (en) | 2015-01-21 |
EP2826791A3 (en) | 2015-07-29 |
MX2010009190A (en) | 2010-09-10 |
US8808701B2 (en) | 2014-08-19 |
EP2826791A2 (en) | 2015-01-21 |
AU2009217224B2 (en) | 2014-09-11 |
US20120315275A1 (en) | 2012-12-13 |
WO2009103113A1 (en) | 2009-08-27 |
ES2562627T3 (en) | 2016-03-07 |
IL207217A0 (en) | 2010-12-30 |
JP6034826B2 (en) | 2016-11-30 |
JP2011515073A (en) | 2011-05-19 |
EP2254911B1 (en) | 2015-11-25 |
US20110190477A1 (en) | 2011-08-04 |
AU2009217224A1 (en) | 2009-08-27 |
EP2254911A1 (en) | 2010-12-01 |
US8268972B2 (en) | 2012-09-18 |
CN101970494A (en) | 2011-02-09 |
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