IL170468A - Substituted 2-(diaza-bicyclo-alkyl)-pyrimidone derivatives - Google Patents
Substituted 2-(diaza-bicyclo-alkyl)-pyrimidone derivativesInfo
- Publication number
- IL170468A IL170468A IL170468A IL17046805A IL170468A IL 170468 A IL170468 A IL 170468A IL 170468 A IL170468 A IL 170468A IL 17046805 A IL17046805 A IL 17046805A IL 170468 A IL170468 A IL 170468A
- Authority
- IL
- Israel
- Prior art keywords
- diaza
- bicyclo
- substituted
- alkyl
- pyrimidone derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20030290571 EP1454908B1 (de) | 2003-03-07 | 2003-03-07 | Substituierte Pyridinyl-2-(diaza-bicyclo-alkyl)-pyrimidinonderivate |
EP03290570A EP1454910A1 (de) | 2003-03-07 | 2003-03-07 | Substitutierte Pyrimidinyl-2-(diaza-bicyclo-alkyl)-pyrimidonederivate |
PCT/EP2004/003050 WO2004078759A1 (en) | 2003-03-07 | 2004-03-05 | Substituted 2-(diaza-bicyclo-alkyl)-pyrimidone derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
IL170468A true IL170468A (en) | 2010-12-30 |
Family
ID=32963795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL170468A IL170468A (en) | 2003-03-07 | 2005-08-23 | Substituted 2-(diaza-bicyclo-alkyl)-pyrimidone derivatives |
Country Status (23)
Country | Link |
---|---|
US (2) | US7211581B2 (de) |
EP (1) | EP1603910B1 (de) |
JP (1) | JP4778890B2 (de) |
KR (1) | KR101072159B1 (de) |
AR (1) | AR043486A1 (de) |
AT (1) | ATE440844T1 (de) |
AU (1) | AU2004218249B2 (de) |
BR (1) | BRPI0408186A (de) |
CA (1) | CA2516934C (de) |
CY (1) | CY1111132T1 (de) |
DE (1) | DE602004022784D1 (de) |
DK (1) | DK1603910T3 (de) |
EA (1) | EA008595B1 (de) |
ES (1) | ES2332132T3 (de) |
HK (1) | HK1085742A1 (de) |
IL (1) | IL170468A (de) |
MX (1) | MXPA05009575A (de) |
NO (1) | NO20054141L (de) |
NZ (1) | NZ542136A (de) |
PL (1) | PL1603910T3 (de) |
PT (1) | PT1603910E (de) |
SI (1) | SI1603910T1 (de) |
WO (1) | WO2004078759A1 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200813015A (en) * | 2006-03-15 | 2008-03-16 | Mitsubishi Pharma Corp | 2-(cyclic amino)-pyrimidone derivatives |
EP1992620A1 (de) | 2007-05-16 | 2008-11-19 | Sanofi-Aventis | Arylamid-Pyrimidon-Derivate zur Behandlung von neurodegenerativen Krankheiten |
EP1992621A1 (de) * | 2007-05-16 | 2008-11-19 | Sanofi-Aventis | Heteroarylamid-substituierte Pyrimidon-Derivate zur Behandlung von neurodegenerativen Krankheiten |
EP1992625A1 (de) | 2007-05-16 | 2008-11-19 | Sanofi-Aventis | Arylamid-Pyrimidon-Verbindungen |
EP1992624A1 (de) | 2007-05-16 | 2008-11-19 | Sanofi-Aventis | Heteroarylamid-Pyrimidon-Verbindungen |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4994460A (en) * | 1989-06-01 | 1991-02-19 | Bristol-Myers Squibb Co. | Agents for treatment of brain ischemia |
US5883254A (en) * | 1996-11-08 | 1999-03-16 | Hoffmann-La Roche Inc. | Process for making pyrimidine derivatives |
WO2001070728A1 (en) * | 2000-03-23 | 2001-09-27 | Sanofi-Synthelabo | 2-[nitrogen-heterocyclic]pyrimidone derivatives |
EP1136483A1 (de) * | 2000-03-23 | 2001-09-26 | Sanofi-Synthelabo | 2-[Piperazinyl]pyrimidonderivate |
WO2003072579A1 (en) * | 2002-02-28 | 2003-09-04 | Sanofi-Aventis | HETEROARYL SUBSTITUTED 2-PYRIDINYL AND 2-PYRIMIDINYL -6,7,8,9- TETRAHYDROPYRIMIDO[1,2-a] PYRIMIDIN-4-ONE DERIVATIVES |
-
2004
- 2004-03-05 JP JP2006504812A patent/JP4778890B2/ja not_active Expired - Fee Related
- 2004-03-05 ES ES04717644T patent/ES2332132T3/es not_active Expired - Lifetime
- 2004-03-05 PT PT04717644T patent/PT1603910E/pt unknown
- 2004-03-05 DE DE602004022784T patent/DE602004022784D1/de not_active Expired - Lifetime
- 2004-03-05 AR ARP040100695A patent/AR043486A1/es not_active Application Discontinuation
- 2004-03-05 MX MXPA05009575A patent/MXPA05009575A/es active IP Right Grant
- 2004-03-05 BR BRPI0408186-2A patent/BRPI0408186A/pt not_active IP Right Cessation
- 2004-03-05 NZ NZ542136A patent/NZ542136A/en not_active IP Right Cessation
- 2004-03-05 EP EP04717644A patent/EP1603910B1/de not_active Expired - Lifetime
- 2004-03-05 EA EA200501243A patent/EA008595B1/ru not_active IP Right Cessation
- 2004-03-05 WO PCT/EP2004/003050 patent/WO2004078759A1/en active Application Filing
- 2004-03-05 DK DK04717644T patent/DK1603910T3/da active
- 2004-03-05 SI SI200431263T patent/SI1603910T1/sl unknown
- 2004-03-05 CA CA2516934A patent/CA2516934C/en not_active Expired - Fee Related
- 2004-03-05 PL PL04717644T patent/PL1603910T3/pl unknown
- 2004-03-05 AU AU2004218249A patent/AU2004218249B2/en not_active Ceased
- 2004-03-05 AT AT04717644T patent/ATE440844T1/de active
-
2005
- 2005-08-23 IL IL170468A patent/IL170468A/en not_active IP Right Cessation
- 2005-09-06 KR KR1020057016636A patent/KR101072159B1/ko not_active IP Right Cessation
- 2005-09-06 NO NO20054141A patent/NO20054141L/no not_active Application Discontinuation
- 2005-09-06 US US11/219,923 patent/US7211581B2/en not_active Expired - Fee Related
-
2006
- 2006-07-19 HK HK06108099A patent/HK1085742A1/xx not_active IP Right Cessation
-
2007
- 2007-03-29 US US11/693,345 patent/US7452897B2/en not_active Expired - Fee Related
-
2009
- 2009-10-26 CY CY20091101113T patent/CY1111132T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU2004218249A1 (en) | 2004-09-16 |
NO20054141L (no) | 2005-12-07 |
EP1603910A1 (de) | 2005-12-14 |
MXPA05009575A (es) | 2006-05-19 |
CA2516934C (en) | 2011-09-20 |
NZ542136A (en) | 2008-07-31 |
CY1111132T1 (el) | 2015-06-11 |
ES2332132T3 (es) | 2010-01-27 |
US7452897B2 (en) | 2008-11-18 |
AR043486A1 (es) | 2005-08-03 |
CA2516934A1 (en) | 2004-09-16 |
US20070167455A1 (en) | 2007-07-19 |
WO2004078759A1 (en) | 2004-09-16 |
US20060025417A1 (en) | 2006-02-02 |
PT1603910E (pt) | 2009-10-30 |
HK1085742A1 (en) | 2006-09-01 |
JP2006519813A (ja) | 2006-08-31 |
NO20054141D0 (no) | 2005-09-06 |
BRPI0408186A (pt) | 2006-04-04 |
AU2004218249B2 (en) | 2009-04-30 |
DE602004022784D1 (de) | 2009-10-08 |
PL1603910T3 (pl) | 2010-02-26 |
EA200501243A1 (ru) | 2006-04-28 |
KR20050113218A (ko) | 2005-12-01 |
ATE440844T1 (de) | 2009-09-15 |
US7211581B2 (en) | 2007-05-01 |
SI1603910T1 (sl) | 2009-12-31 |
EA008595B1 (ru) | 2007-06-29 |
KR101072159B1 (ko) | 2011-10-10 |
EP1603910B1 (de) | 2009-08-26 |
DK1603910T3 (da) | 2009-11-23 |
JP4778890B2 (ja) | 2011-09-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
MM9K | Patent not in force due to non-payment of renewal fees |