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IL152580A0 - Process for the preparation of indole derivatives and intermediates of the process - Google Patents

Process for the preparation of indole derivatives and intermediates of the process

Info

Publication number
IL152580A0
IL152580A0 IL15258001A IL15258001A IL152580A0 IL 152580 A0 IL152580 A0 IL 152580A0 IL 15258001 A IL15258001 A IL 15258001A IL 15258001 A IL15258001 A IL 15258001A IL 152580 A0 IL152580 A0 IL 152580A0
Authority
IL
Israel
Prior art keywords
intermediates
preparation
indole derivatives
indole
derivatives
Prior art date
Application number
IL15258001A
Other languages
English (en)
Original Assignee
Ciba Sc Holding Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Sc Holding Ag filed Critical Ciba Sc Holding Ag
Publication of IL152580A0 publication Critical patent/IL152580A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL15258001A 2000-05-26 2001-05-17 Process for the preparation of indole derivatives and intermediates of the process IL152580A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00810460 2000-05-26
PCT/EP2001/005667 WO2001092223A1 (en) 2000-05-26 2001-05-17 Process for the preparation of indole derivatives and intermediates of the process

Publications (1)

Publication Number Publication Date
IL152580A0 true IL152580A0 (en) 2003-05-29

Family

ID=8174725

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15258001A IL152580A0 (en) 2000-05-26 2001-05-17 Process for the preparation of indole derivatives and intermediates of the process

Country Status (9)

Country Link
US (2) US6743926B2 (zh)
EP (1) EP1284964A1 (zh)
JP (1) JP2003535077A (zh)
CN (1) CN1217930C (zh)
AR (1) AR036000A1 (zh)
AU (1) AU2001274049A1 (zh)
CA (1) CA2407862A1 (zh)
IL (1) IL152580A0 (zh)
WO (1) WO2001092223A1 (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003535077A (ja) * 2000-05-26 2003-11-25 チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド インドール誘導体を製造する方法、および該方法の中間体
US7420078B2 (en) * 2001-07-06 2008-09-02 Ciba Specialty Chemicals Corp. Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof
CA2455842A1 (en) * 2001-08-22 2003-03-06 Ciba Specialty Chemicals Holding Inc. Process for the preparation of indole derivatives
GB0204129D0 (en) * 2002-02-21 2002-04-10 Novartis Ag Process for the manufacture of organic compounds
AU2003276960A1 (en) * 2002-06-13 2003-12-31 Novartis Ag Calcium salts of indole derived statins
WO2004009527A1 (en) * 2002-07-19 2004-01-29 Aryx Therapeutics Materials and methods for treating hypercholesterolemia
WO2004080963A1 (en) * 2003-03-13 2004-09-23 Ciba Specialty Chemicals Holding Inc. Process for the preparation of indole derivatives by enzymatic acylation
JP4269902B2 (ja) 2003-08-27 2009-05-27 住友化学株式会社 芳香族不飽和化合物の製造方法
US7432380B2 (en) * 2003-10-16 2008-10-07 Ciba Specialty Chemicals Corp. Crystalline form of Fluvastatin sodium
WO2006030304A2 (en) * 2004-09-17 2006-03-23 Ranbaxy Laboratories Limited Novel forms of fluvastatin sodium, processes for preparation and pharmaceutical compositions thereof
WO2006085338A2 (en) * 2005-02-11 2006-08-17 Jubilant Organosys Limited Novel polymorphic forms of fluvastatin sodium and process for preparing the same
CN1978428B (zh) * 2005-12-05 2012-07-04 四川抗菌素工业研究所有限公司 一种(3r，5s）-氟伐他汀的制备方法
EP1847529B1 (en) * 2006-04-20 2009-05-20 F.I.S. Fabbrica Italiana Sintetici S.P.A. Process for the preparation of Fluvastatin Sodium salt
CN104250222A (zh) * 2013-06-27 2014-12-31 上海朴颐化学科技有限公司 一种氟伐醇酮制备工艺改进方法
CN103342721B (zh) * 2013-07-15 2016-04-13 凯莱英医药集团（天津）股份有限公司 一种制备氟伐他汀关键中间体的方法
WO2016056658A1 (ja) * 2014-10-10 2016-04-14 株式会社エーピーアイ コーポレーション スタチン系化合物の精製方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4739073A (en) 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
HU204253B (en) 1982-11-22 1991-12-30 Sandoz Ag Process for producing mevalonolactone analogues and derivatives and pharmaceutical compositions containing them
US4571428A (en) * 1983-07-08 1986-02-18 Sandoz, Inc. 6-Substituted-4-hydroxy-tetrahydropyran-2-ones
US4650890A (en) 1984-04-03 1987-03-17 Sandoz Corp. Preparation of olefinic compounds and intermediates thereof
US4677211A (en) * 1984-06-29 1987-06-30 Sandoz Pharmaceuticals Corp. Preparation of lactones
JPS6322056A (ja) 1986-04-30 1988-01-29 サンド・アクチエンゲゼルシヤフト オレフイン性化合物の製造法
US4870199A (en) * 1986-04-30 1989-09-26 Sandoz Pharm. Corp. Processes for the synthesis of diprotected R[R*,S*]-3,5-dihydroxy-6-oxohexanoate esters
SG139553A1 (en) * 1988-10-13 2008-02-29 Novartis Ag 7-substituted-hept-6-enoic and -heptanoic acids and derivatives thereof
DK181190D0 (da) * 1990-07-30 1990-07-30 Lundbeck & Co As H 3-aryl-indol- eller 3-aryl-indazolderivater
HU217629B (hu) 1991-12-12 2000-03-28 Novartis Ag. Eljárás fluvasztatint tartalmazó stabilizált gyógyszerkészítmények előállítására
EP1064243B1 (en) * 1998-03-18 2002-10-23 Ciba SC Holding AG Coupling reactions with palladium catalysts
JP2003535077A (ja) * 2000-05-26 2003-11-25 チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド インドール誘導体を製造する方法、および該方法の中間体

Also Published As

Publication number Publication date
US20040176614A1 (en) 2004-09-09
US6743926B2 (en) 2004-06-01
CN1430604A (zh) 2003-07-16
EP1284964A1 (en) 2003-02-26
WO2001092223A1 (en) 2001-12-06
JP2003535077A (ja) 2003-11-25
CN1217930C (zh) 2005-09-07
CA2407862A1 (en) 2001-12-06
AU2001274049A1 (en) 2001-12-11
US20030166946A1 (en) 2003-09-04
AR036000A1 (es) 2004-08-04

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