IL148670A0 - Indolyl-3-glyoxylic acid derivatives comprising therapeutically valuable properties - Google Patents

Indolyl-3-glyoxylic acid derivatives comprising therapeutically valuable properties

Info

Publication number: IL148670A0
Authority: IL; Israel
Prior art keywords: indolyl; acid derivatives; glyoxylic acid; therapeutically valuable; valuable properties
Prior art date: 1999-09-28

Application number

IL14867000A

Original Assignee

Baxter Healthcare Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-28

Filing date

2000-09-26

Publication date

2002-09-12

1999-09-28 Priority claimed from DE19946301A external-priority patent/DE19946301A1/en

2000-09-26 Application filed by Baxter Healthcare Sa filed Critical Baxter Healthcare Sa

2002-09-12 Publication of IL148670A0 publication Critical patent/IL148670A0/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

IL14867000A 1999-09-28 2000-09-26 Indolyl-3-glyoxylic acid derivatives comprising therapeutically valuable properties IL148670A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19946301A DE19946301A1 (en)	1998-04-02	1999-09-28	Antitumor agents and angiogenesis inhibitors having low neurotoxicity, comprise indole-3-glyoxylamide derivatives, are effective against resistant and metastasis-forming carcinomas
PCT/EP2000/009390 WO2001022954A2 (en)	1999-09-28	2000-09-26	Indolyl-3-glyoxylic acid derivatives serving as antitumor agents

Publications (1)

Publication Number	Publication Date
IL148670A0 true IL148670A0 (en)	2002-09-12

Family

ID=7923485

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL14867000A IL148670A0 (en)	1999-09-28	2000-09-26	Indolyl-3-glyoxylic acid derivatives comprising therapeutically valuable properties
IL148670A IL148670A (en)	1999-09-28	2002-03-13	Indolyl-3-glyoxylic acid derivatives comprising therapeutically valuable properties

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL148670A IL148670A (en)	1999-09-28	2002-03-13	Indolyl-3-glyoxylic acid derivatives comprising therapeutically valuable properties

Country Status (32)

Country	Link
EP (1)	EP1218006B1 (en)
JP (1)	JP2003510274A (en)
KR (1)	KR100759242B1 (en)
CN (1)	CN1301712C (en)
AR (1)	AR025885A1 (en)
AT (1)	ATE459356T1 (en)
AU (1)	AU783436B2 (en)
BG (1)	BG106639A (en)
BR (1)	BR0014378A (en)
CA (1)	CA2386069C (en)
CZ (1)	CZ303246B6 (en)
DE (1)	DE50015879D1 (en)
DZ (1)	DZ3196A1 (en)
EE (1)	EE200200169A (en)
ES (1)	ES2342042T3 (en)
GE (1)	GEP20043250B (en)
HK (1)	HK1048941B (en)
HR (1)	HRP20020369A2 (en)
HU (1)	HUP0202788A3 (en)
IL (2)	IL148670A0 (en)
IS (1)	IS6319A (en)
MX (1)	MXPA02002824A (en)
NO (1)	NO322614B1 (en)
NZ (1)	NZ517988A (en)
PL (1)	PL199576B1 (en)
RS (1)	RS51302B (en)
RU (1)	RU2282444C2 (en)
SK (1)	SK287533B6 (en)
TW (1)	TWI269654B (en)
UA (1)	UA75872C2 (en)
WO (1)	WO2001022954A2 (en)
ZA (1)	ZA200202556B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19962300A1 (en) *	1999-12-23	2001-06-28	Asta Medica Ag	New N-benzylindolyl glyoxylic acid derivatives are useful as antitumor agents
AU2001258628A1 (en)	2000-05-31	2001-12-11	Astrazeneca Ab	Indole derivatives with vascular damaging activity
DE10037310A1 (en) *	2000-07-28	2002-02-07	Asta Medica Ag	New indole derivatives and their use as medicines
EP1484329A1 (en) *	2003-06-06	2004-12-08	Zentaris GmbH	Indole derivatives with apoptosis inducing activity
EP1595878A1 (en) *	2004-05-15	2005-11-16	Zentaris GmbH	Indole derivatives with apoptosis inducing activity
EP1641777A1 (en) *	2003-06-05	2006-04-05	Zentaris GmbH	Indole derivatives with apoptosis-inducing effect
US20050124623A1 (en)	2003-11-26	2005-06-09	Bender John A.	Diazaindole-dicarbonyl-piperazinyl antiviral agents
DK2447252T3 (en) *	2004-05-23	2020-03-16	Hmi Medical Innovations Llc	Theramutein modulators
CA2587276A1 (en) *	2004-11-08	2006-05-18	Baxter International Inc.	Nanoparticulate compositions of tubulin inhibitor compounds
US20060100432A1 (en)	2004-11-09	2006-05-11	Matiskella John D	Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US8604055B2 (en)	2004-12-31	2013-12-10	Dr. Reddy's Laboratories Ltd.	Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
CA2605214C (en)	2004-12-31	2016-07-12	Reddy Us Therapeutics, Inc.	Benzylamine derivatives as cetp inhibitors
US7851476B2 (en)	2005-12-14	2010-12-14	Bristol-Myers Squibb Company	Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en)	2006-04-25	2010-10-05	Bristol-Myers Squibb Company	Diketo-piperazine and piperidine derivatives as antiviral agents
AU2007325797B2 (en) *	2006-11-28	2014-03-13	Ziopharm Oncology, Inc.	Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
CN103827105B (en)	2011-08-18	2016-08-17	雷迪博士实验室有限公司	Substituted heterocyclic amine compound as cholesterol ester transfer protein (CETP) inhibitor
KR101803866B1 (en)	2011-09-27	2017-12-04	닥터 레디스 레보러터리즈 리미티드	5-benzylaminomethyl-6-aminopyrazolo[3,4-b]pyridine derivatives as cholesteryl ester-transfer protein(cetp) inhibitors useful for the treatment of atherosclerosis
US9353150B2 (en)	2012-12-04	2016-05-31	Massachusetts Institute Of Technology	Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
WO2014144715A1 (en)	2013-03-15	2014-09-18	Memorial Sloan-Kettering Cancer Center	Hsp90-targeted cardiac imaging and therapy
WO2017197045A1 (en)	2016-05-11	2017-11-16	Movassaghi Mohammad	Convergent and enantioselective total synthesis of communesin analogs
WO2018209239A1 (en)	2017-05-11	2018-11-15	Massachusetts Institute Of Technology	Potent agelastatin derivatives as modulators for cancer invasion and metastasis
CN109111501B (en) *	2017-06-23	2022-04-22	首都医科大学	Fatty amino acid-modified indoleethanol derivatives, their synthesis, activities and applications
US10640508B2 (en)	2017-10-13	2020-05-05	Massachusetts Institute Of Technology	Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en)	2019-06-05	2022-12-27	Massachusetts Institute Of Technology	Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
US12030888B2 (en)	2021-02-24	2024-07-09	Massachusetts Institute Of Technology	Himastatin derivatives, and processes of preparation thereof, and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU4128089A (en)	1988-09-15	1990-03-22	Rorer International (Overseas) Inc.	Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
EP0617961A4 (en) *	1992-10-20	1995-03-29	Toray Industries	Eosinophil infiltration inhibitor.
DE19636150A1 (en) *	1996-09-06	1998-03-12	Asta Medica Ag	N-substituted indole-3-glyoxylamides with antiasthmatic, antiallergic and immunosuppressive / immunomodulating effects
EP0974652A4 (en)	1997-04-08	2000-08-30	Banyu Pharma Co Ltd	GENE ASSOCIATED WITH CANCER METASTASE
GEP20032920B (en) *	1998-02-25	2003-03-25	Genetics Inst	Inhibitors of Phospholipase Enzymes
JP2004500308A (en) *	1998-03-12	2004-01-08	ノボ　ノルディスク　アクティーゼルスカブ	Modulator of protein tyrosine phosphatase
DE19814838C2 (en) *	1998-04-02	2001-01-18	Asta Medica Ag	Indolyl-3-glyoxylic acid derivatives with anti-tumor effects
DK1076657T3 (en) *	1998-04-28	2004-11-08	Elbion Ag	New hydroxy indoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation
JP2000239252A (en) *	1999-02-16	2000-09-05	Mitsubishi Chemicals Corp	Indole derivative
AU4834200A (en) *	1999-05-10	2000-11-21	Protarga, Inc.	Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof

2000
- 2000-09-22 TW TW089119680A patent/TWI269654B/en not_active IP Right Cessation
- 2000-09-26 PL PL364811A patent/PL199576B1/en not_active IP Right Cessation
- 2000-09-26 NZ NZ517988A patent/NZ517988A/en not_active IP Right Cessation
- 2000-09-26 SK SK407-2002A patent/SK287533B6/en not_active IP Right Cessation
- 2000-09-26 DZ DZ003196A patent/DZ3196A1/en active
- 2000-09-26 EE EEP200200169A patent/EE200200169A/en unknown
- 2000-09-26 ES ES00967789T patent/ES2342042T3/en not_active Expired - Lifetime
- 2000-09-26 RS YUP-227/02A patent/RS51302B/en unknown
- 2000-09-26 RU RU2002111866/15A patent/RU2282444C2/en not_active IP Right Cessation
- 2000-09-26 CA CA2386069A patent/CA2386069C/en not_active Expired - Fee Related
- 2000-09-26 EP EP00967789A patent/EP1218006B1/en not_active Expired - Lifetime
- 2000-09-26 UA UA2002043433A patent/UA75872C2/en unknown
- 2000-09-26 CZ CZ20021005A patent/CZ303246B6/en not_active IP Right Cessation
- 2000-09-26 KR KR1020027003937A patent/KR100759242B1/en not_active IP Right Cessation
- 2000-09-26 MX MXPA02002824A patent/MXPA02002824A/en active IP Right Grant
- 2000-09-26 GE GEAP20006425A patent/GEP20043250B/en unknown
- 2000-09-26 WO PCT/EP2000/009390 patent/WO2001022954A2/en active IP Right Grant
- 2000-09-26 CN CNB008134499A patent/CN1301712C/en not_active Expired - Fee Related
- 2000-09-26 BR BR0014378-2A patent/BR0014378A/en not_active Application Discontinuation
- 2000-09-26 AT AT00967789T patent/ATE459356T1/en not_active IP Right Cessation
- 2000-09-26 AU AU77829/00A patent/AU783436B2/en not_active Ceased
- 2000-09-26 DE DE50015879T patent/DE50015879D1/en not_active Expired - Lifetime
- 2000-09-26 JP JP2001526166A patent/JP2003510274A/en active Pending
- 2000-09-26 HU HU0202788A patent/HUP0202788A3/en unknown
- 2000-09-26 IL IL14867000A patent/IL148670A0/en unknown
- 2000-09-28 AR ARP000105105A patent/AR025885A1/en unknown
2002
- 2002-03-13 IL IL148670A patent/IL148670A/en not_active IP Right Cessation
- 2002-03-19 NO NO20021367A patent/NO322614B1/en not_active IP Right Cessation
- 2002-03-21 IS IS6319A patent/IS6319A/en unknown
- 2002-04-02 ZA ZA200202556A patent/ZA200202556B/en unknown
- 2002-04-23 BG BG106639A patent/BG106639A/en unknown
- 2002-04-26 HR HR20020369A patent/HRP20020369A2/en not_active Application Discontinuation
2003
- 2003-02-18 HK HK03101178.9A patent/HK1048941B/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO2001022954A3 (en)	2002-03-28
CN1376064A (en)	2002-10-23
RU2282444C2 (en)	2006-08-27
JP2003510274A (en)	2003-03-18
KR100759242B1 (en)	2007-09-18
ES2342042T3 (en)	2010-07-01
KR20030019295A (en)	2003-03-06
AU7782900A (en)	2001-04-30
PL364811A1 (en)	2004-12-13
DE50015879D1 (en)	2010-04-15
IS6319A (en)	2002-03-21
HUP0202788A2 (en)	2003-01-28
AR025885A1 (en)	2002-12-18
BR0014378A (en)	2003-07-29
EP1218006B1 (en)	2010-03-03
AU783436B2 (en)	2005-10-27
NO20021367L (en)	2002-05-22
TWI269654B (en)	2007-01-01
IL148670A (en)	2009-09-01
DZ3196A1 (en)	2001-04-05
HUP0202788A3 (en)	2003-02-28
HK1048941B (en)	2007-09-21
SK287533B6 (en)	2011-01-04
NO322614B1 (en)	2006-11-06
HRP20020369A2 (en)	2004-12-31
UA75872C2 (en)	2006-06-15
NO20021367D0 (en)	2002-03-19
CN1301712C (en)	2007-02-28
ATE459356T1 (en)	2010-03-15
CA2386069C (en)	2012-08-14
EP1218006A2 (en)	2002-07-03
CZ20021005A3 (en)	2004-01-14
WO2001022954A2 (en)	2001-04-05
EE200200169A (en)	2003-04-15
CZ303246B6 (en)	2012-06-20
CA2386069A1 (en)	2001-04-05
BG106639A (en)	2002-12-29
RS51302B (en)	2010-12-31
GEP20043250B (en)	2004-06-25
SK4072002A3 (en)	2003-11-04
ZA200202556B (en)	2003-08-27
HK1048941A1 (en)	2003-04-25
YU22702A (en)	2004-12-31
MXPA02002824A (en)	2003-07-21
PL199576B1 (en)	2008-10-31
NZ517988A (en)	2004-10-29

Publication	Publication Date	Title
IL148670A0 (en)	2002-09-12	Indolyl-3-glyoxylic acid derivatives comprising therapeutically valuable properties
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AUPP812699A0 (en)	1999-02-04	Direct smelting process
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