IL145953A0 - A new inhibitor of carboxypeptidase u - Google Patents
A new inhibitor of carboxypeptidase uInfo
- Publication number
- IL145953A0 IL145953A0 IL14595300A IL14595300A IL145953A0 IL 145953 A0 IL145953 A0 IL 145953A0 IL 14595300 A IL14595300 A IL 14595300A IL 14595300 A IL14595300 A IL 14595300A IL 145953 A0 IL145953 A0 IL 145953A0
- Authority
- IL
- Israel
- Prior art keywords
- carboxypeptidase
- new inhibitor
- inhibitor
- new
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/09—Diamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9901572A SE9901572D0 (sv) | 1999-05-03 | 1999-05-03 | New compounds |
| PCT/SE2000/000846 WO2000066550A1 (en) | 1999-05-03 | 2000-05-03 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL145953A0 true IL145953A0 (en) | 2002-11-10 |
Family
ID=20415425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14595300A IL145953A0 (en) | 1999-05-03 | 2000-05-03 | A new inhibitor of carboxypeptidase u |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7354895B1 (xx) |
| EP (1) | EP1180099A1 (xx) |
| JP (1) | JP4270759B2 (xx) |
| KR (1) | KR20020010631A (xx) |
| CN (1) | CN1358187A (xx) |
| AR (1) | AR028826A1 (xx) |
| AU (1) | AU4447100A (xx) |
| BR (1) | BR0010256A (xx) |
| CA (1) | CA2371215A1 (xx) |
| CZ (1) | CZ20013931A3 (xx) |
| EE (1) | EE200100573A (xx) |
| HK (1) | HK1042493A1 (xx) |
| HU (1) | HUP0202379A3 (xx) |
| IL (1) | IL145953A0 (xx) |
| IS (1) | IS6141A (xx) |
| MX (1) | MXPA01011043A (xx) |
| NO (1) | NO20015374L (xx) |
| PL (1) | PL356140A1 (xx) |
| SE (1) | SE9901572D0 (xx) |
| SK (1) | SK15662001A3 (xx) |
| TR (1) | TR200103144T2 (xx) |
| WO (1) | WO2000066550A1 (xx) |
| ZA (2) | ZA200108966B (xx) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100681632B1 (ko) * | 1999-09-14 | 2007-02-09 | 메이지 세이카 가이샤 리미티드 | 카르복시펩티다아제 ｂ 저해활성을 갖는 포스폰산 유도체 |
| AU2001276605A1 (en) * | 2000-08-17 | 2002-02-25 | Pfizer Inc. | Substituted imidazoles as tafia inhibitors |
| SE0103272D0 (sv) * | 2001-09-28 | 2001-09-28 | Astrazeneca Ab | Chemical compounds |
| US6713496B2 (en) | 2002-01-22 | 2004-03-30 | Pfizer Inc | 3-(imidazolyl)-2-alkoxypropanoic acids |
| IL162677A0 (en) * | 2002-01-22 | 2005-11-20 | Pfizer | 3-(Imidazolyl)-2-alkoxypropanoic acids as tafia inhibitors |
| JP2005516972A (ja) | 2002-01-22 | 2005-06-09 | ファイザー・インク | 血栓疾患の治療のためのｔａｆｉ−ａ阻害剤として使用される３−（イミダゾリル）−２−アミノプロピオン酸 |
| CA2479892C (en) * | 2002-03-21 | 2011-12-20 | Brad O. Buckman | Plasma carboxypeptidase b inhibitors |
| CA2741783A1 (en) | 2008-10-29 | 2010-05-06 | Taisho Pharmaceutical Co., Ltd. | Compounds having tafia inhibitory activity |
| EA202192114A1 (ru) * | 2019-02-08 | 2021-12-01 | Астразенека Аб | Ингибиторы аргиназы и способы их применения |
| CN111110837B (zh) * | 2020-01-06 | 2022-11-25 | 中国人民解放军陆军军医大学 | 一种羧肽酶抑制剂在制备预防重症致死性轮状病毒感染药物中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2516307A (en) * | 1949-01-06 | 1950-07-25 | Gen Mills Inc | Vinyl resins plasticized with cyano esters |
| US4560680A (en) * | 1982-03-15 | 1985-12-24 | E. R. Squibb & Sons, Inc. | Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors |
| US4849414A (en) * | 1986-06-11 | 1989-07-18 | E. R. Squibb & Sons, Inc. | Substituted aminoalkanoylaminoalkyl phosphonate angiotensin converting enzyme inhibitors |
| FR2610951B1 (fr) * | 1987-02-17 | 1989-05-05 | Aerospatiale | Armature tissee pour materiau composite |
| IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| EP0618805A1 (en) * | 1991-12-17 | 1994-10-12 | PROCTER & GAMBLE PHARMACEUTICALS, INC. | Methods for the treatment of osteoporosis using bisphosphonates and parathyroid hormone |
| US5550119A (en) * | 1995-03-02 | 1996-08-27 | Ciba-Geigy Corporation | Phosphono substituted tetrazole derivatives as ECE inhibitors |
| US5672592A (en) * | 1996-06-17 | 1997-09-30 | Guilford Pharmaceuticals Inc. | Certain phosphonomethyl-pentanedioic acid derivatives thereof |
| JP3440305B2 (ja) * | 1997-04-02 | 2003-08-25 | 高砂香料工業株式会社 | ７−（ｎ−置換アミノ）−２−フェニルヘプタン酸 エステル誘導体及び該誘導体の製造方法 |
| HUP0002092A3 (en) | 1997-02-27 | 2002-06-28 | Wyeth Holdings Corp Madison | N-hydroxy-2-(alkyl, aryl or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
| AR023819A1 (es) * | 1999-05-03 | 2002-09-04 | Astrazeneca Ab | FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION |
| SE9901573D0 (sv) * | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
| KR100681632B1 (ko) * | 1999-09-14 | 2007-02-09 | 메이지 세이카 가이샤 리미티드 | 카르복시펩티다아제 ｂ 저해활성을 갖는 포스폰산 유도체 |
-
1999
- 1999-05-03 SE SE9901572A patent/SE9901572D0/xx unknown
-
2000
- 2000-04-28 AR ARP000102082A patent/AR028826A1/es not_active Application Discontinuation
- 2000-05-03 KR KR1020017014014A patent/KR20020010631A/ko not_active Application Discontinuation
- 2000-05-03 JP JP2000615381A patent/JP4270759B2/ja not_active Expired - Fee Related
- 2000-05-03 US US09/600,660 patent/US7354895B1/en not_active Expired - Fee Related
- 2000-05-03 IL IL14595300A patent/IL145953A0/xx unknown
- 2000-05-03 CA CA002371215A patent/CA2371215A1/en not_active Abandoned
- 2000-05-03 EP EP00925844A patent/EP1180099A1/en not_active Ceased
- 2000-05-03 AU AU44471/00A patent/AU4447100A/en not_active Abandoned
- 2000-05-03 CZ CZ20013931A patent/CZ20013931A3/cs unknown
- 2000-05-03 TR TR2001/03144T patent/TR200103144T2/xx unknown
- 2000-05-03 HU HU0202379A patent/HUP0202379A3/hu unknown
- 2000-05-03 WO PCT/SE2000/000846 patent/WO2000066550A1/en not_active Application Discontinuation
- 2000-05-03 BR BR0010256-3A patent/BR0010256A/pt not_active Application Discontinuation
- 2000-05-03 SK SK1566-2001A patent/SK15662001A3/sk unknown
- 2000-05-03 EE EEP200100573A patent/EE200100573A/xx unknown
- 2000-05-03 PL PL00356140A patent/PL356140A1/xx not_active Application Discontinuation
- 2000-05-03 MX MXPA01011043A patent/MXPA01011043A/es unknown
- 2000-05-03 CN CN00809484A patent/CN1358187A/zh active Pending
-
2001
- 2001-10-30 ZA ZA200108966A patent/ZA200108966B/en unknown
- 2001-10-30 ZA ZA200108967A patent/ZA200108967B/en unknown
- 2001-11-01 IS IS6141A patent/IS6141A/is unknown
- 2001-11-02 NO NO20015374A patent/NO20015374L/no not_active Application Discontinuation
-
2002
- 2002-06-06 HK HK02104304.1A patent/HK1042493A1/zh unknown
-
2005
- 2005-12-02 US US11/293,060 patent/US7423012B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU4447100A (en) | 2000-11-17 |
| AR028826A1 (es) | 2003-05-28 |
| SK15662001A3 (sk) | 2002-09-10 |
| CN1358187A (zh) | 2002-07-10 |
| WO2000066550A1 (en) | 2000-11-09 |
| JP4270759B2 (ja) | 2009-06-03 |
| KR20020010631A (ko) | 2002-02-04 |
| SE9901572D0 (sv) | 1999-05-03 |
| IS6141A (is) | 2001-11-01 |
| NO20015374D0 (no) | 2001-11-02 |
| US20060079484A1 (en) | 2006-04-13 |
| NO20015374L (no) | 2001-11-02 |
| WO2000066550A8 (en) | 2001-01-25 |
| BR0010256A (pt) | 2002-02-13 |
| PL356140A1 (en) | 2004-06-14 |
| ZA200108967B (en) | 2003-01-30 |
| ZA200108966B (en) | 2003-01-30 |
| TR200103144T2 (tr) | 2004-11-22 |
| JP2002543179A (ja) | 2002-12-17 |
| EE200100573A (et) | 2003-02-17 |
| CZ20013931A3 (cs) | 2002-04-17 |
| CA2371215A1 (en) | 2000-11-09 |
| MXPA01011043A (es) | 2002-06-04 |
| EP1180099A1 (en) | 2002-02-20 |
| HUP0202379A2 (hu) | 2002-12-28 |
| HK1042493A1 (zh) | 2002-08-16 |
| US7423012B2 (en) | 2008-09-09 |
| HUP0202379A3 (en) | 2003-04-28 |
| US7354895B1 (en) | 2008-04-08 |
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