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IL136800A - Neuroprotective compounds - Google Patents

Neuroprotective compounds

Info

Publication number
IL136800A
IL136800A IL13680098A IL13680098A IL136800A IL 136800 A IL136800 A IL 136800A IL 13680098 A IL13680098 A IL 13680098A IL 13680098 A IL13680098 A IL 13680098A IL 136800 A IL136800 A IL 136800A
Authority
IL
Israel
Prior art keywords
sup
group
aryl
alkyl
formula
Prior art date
Application number
IL13680098A
Other languages
English (en)
Other versions
IL136800A0 (en
Original Assignee
Univ Southampton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Southampton filed Critical Univ Southampton
Publication of IL136800A0 publication Critical patent/IL136800A0/xx
Publication of IL136800A publication Critical patent/IL136800A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
IL13680098A 1997-12-16 1998-12-16 Neuroprotective compounds IL136800A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9726569.8A GB9726569D0 (en) 1997-12-16 1997-12-16 Neuroprotective agents
PCT/GB1998/003775 WO1999031049A1 (en) 1997-12-16 1998-12-16 Neuroprotective agents

Publications (2)

Publication Number Publication Date
IL136800A0 IL136800A0 (en) 2001-06-14
IL136800A true IL136800A (en) 2005-07-25

Family

ID=10823695

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13680098A IL136800A (en) 1997-12-16 1998-12-16 Neuroprotective compounds

Country Status (20)

Country Link
US (2) US6797699B1 (zh)
EP (1) EP1040096B1 (zh)
JP (1) JP2002508349A (zh)
KR (1) KR20010033249A (zh)
CN (1) CN1284058A (zh)
AT (1) ATE244698T1 (zh)
AU (1) AU739296B2 (zh)
CA (1) CA2315258C (zh)
DE (1) DE69816337T2 (zh)
DK (1) DK1040096T3 (zh)
ES (1) ES2201563T3 (zh)
GB (1) GB9726569D0 (zh)
HK (1) HK1029331A1 (zh)
HU (1) HUP0004486A3 (zh)
IL (1) IL136800A (zh)
NO (1) NO20003075L (zh)
NZ (1) NZ505110A (zh)
PT (1) PT1040096E (zh)
RU (1) RU2205177C2 (zh)
WO (1) WO1999031049A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2363983A (en) 2000-06-29 2002-01-16 Hunter Fleming Ltd Protection against neuronal damage using 7-hydroxyepiandrosterone
JP2004513136A (ja) 2000-11-08 2004-04-30 スリル　バイオメディカル　コーポレーション 抗癌剤として有用な新規ポリアミンアナログ−アミノ酸結合体
WO2003063891A1 (en) * 2002-01-29 2003-08-07 Wyeth Compositions and methods for modulating connexin hemichannels
GB0202645D0 (en) * 2002-02-05 2002-03-20 Univ Southampton Treatment of chronic neurodegenerative diseases
WO2008105441A1 (ja) * 2007-02-27 2008-09-04 Ajinomoto Co., Inc. リン吸収抑制活性を有するポリアミノ酸化合物及びリン吸収抑制剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2465303A (en) * 1939-04-03 1949-03-22 Research Corp Lactones
ES2039213T3 (es) * 1986-04-04 1993-09-16 Microbial Chemistry Research Foundation Procedimiento para producir nuevos compuestos relacionados con espergualina.
US6262125B1 (en) * 1986-12-02 2001-07-17 University Of Florida Research Foundation, Inc. Sterically hindered tetraamines and method for their production
US5242947A (en) 1988-02-10 1993-09-07 New York University Use of polyamines as ionic-channel regulating agents
WO1991000853A1 (en) 1989-07-03 1991-01-24 New York University Use of polyamines as ionic-channel regulating agents
FR2773798B1 (fr) * 1998-01-16 2001-02-02 Adir Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
IL136800A0 (en) 2001-06-14
DK1040096T3 (da) 2003-10-20
NO20003075D0 (no) 2000-06-15
CA2315258C (en) 2008-07-15
EP1040096A1 (en) 2000-10-04
US20040106560A1 (en) 2004-06-03
RU2205177C2 (ru) 2003-05-27
NO20003075L (no) 2000-08-15
DE69816337D1 (de) 2003-08-14
ES2201563T3 (es) 2004-03-16
DE69816337T2 (de) 2004-04-15
US7026297B2 (en) 2006-04-11
CN1284058A (zh) 2001-02-14
AU739296B2 (en) 2001-10-11
EP1040096B1 (en) 2003-07-09
AU1571799A (en) 1999-07-05
ATE244698T1 (de) 2003-07-15
WO1999031049A1 (en) 1999-06-24
HUP0004486A2 (hu) 2001-05-28
CA2315258A1 (en) 1999-06-24
PT1040096E (pt) 2003-09-30
HUP0004486A3 (en) 2002-11-28
NZ505110A (en) 2003-01-31
US6797699B1 (en) 2004-09-28
KR20010033249A (ko) 2001-04-25
GB9726569D0 (en) 1998-02-11
JP2002508349A (ja) 2002-03-19
HK1029331A1 (en) 2001-03-30

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Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees