IL136421A0 - Intermediates for preparing 1-benzyl -4-((5,6- dimethoxy -1-indanon)-2-yl) methylpiperidine - Google Patents

Intermediates for preparing 1-benzyl -4-((5,6- dimethoxy -1-indanon)-2-yl) methylpiperidine

Info

Publication number: IL136421A0
Authority: IL; Israel
Prior art keywords: indanon; methylpiperidine; dimethoxy; intermediates; benzyl
Prior art date: 1995-12-15

Application number

IL13642196A

Other languages

English (en)

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-15

Filing date

1996-10-11

Publication date

2001-06-14

1996-10-11 Application filed by Pfizer filed Critical Pfizer

2001-06-14 Publication of IL136421A0 publication Critical patent/IL136421A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

IL13642196A 1995-12-15 1996-10-11 Intermediates for preparing 1-benzyl -4-((5,6- dimethoxy -1-indanon)-2-yl) methylpiperidine IL136421A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US875395P	1995-12-15	1995-12-15
IL12445296A IL124452A0 (en)	1995-12-15	1996-10-11	Processes and intermediates for preparing 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-YL)methylpiperidine
PCT/IB1996/001076 WO1997022584A1 (en)	1995-12-15	1996-10-11	Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine

Publications (1)

Publication Number	Publication Date
IL136421A0 true IL136421A0 (en)	2001-06-14

Family

ID=21733469

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL13642196A IL136421A0 (en)	1995-12-15	1996-10-11	Intermediates for preparing 1-benzyl -4-((5,6- dimethoxy -1-indanon)-2-yl) methylpiperidine
IL13642096A IL136420A0 (en)	1995-12-15	1996-10-11	Process for preparing 1- benzyl -4-((5,6 dimethoxy -1- indanon) -2-yl) methylpiperidine
IL12445296A IL124452A0 (en)	1995-12-15	1996-10-11	Processes and intermediates for preparing 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-YL)methylpiperidine

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
IL13642096A IL136420A0 (en)	1995-12-15	1996-10-11	Process for preparing 1- benzyl -4-((5,6 dimethoxy -1- indanon) -2-yl) methylpiperidine
IL12445296A IL124452A0 (en)	1995-12-15	1996-10-11	Processes and intermediates for preparing 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-YL)methylpiperidine

Country Status (33)

Country	Link
EP (1)	EP0883607A1 (xx)
JP (1)	JP3066083B2 (xx)
KR (1)	KR20000064387A (xx)
AP (1)	AP708A (xx)
AR (1)	AR004368A1 (xx)
AU (1)	AU716462B2 (xx)
BG (1)	BG102525A (xx)
BR (1)	BR9612018A (xx)
CA (1)	CA2237647A1 (xx)
CO (1)	CO4750831A1 (xx)
CZ (1)	CZ180898A3 (xx)
DZ (1)	DZ2141A1 (xx)
GT (1)	GT199600092A (xx)
HN (1)	HN1996000065A (xx)
HR (1)	HRP960592A2 (xx)
HU (1)	HUP9904275A3 (xx)
IL (3)	IL136421A0 (xx)
IS (1)	IS4752A (xx)
MA (1)	MA24032A1 (xx)
NO (1)	NO982712L (xx)
NZ (1)	NZ318843A (xx)
OA (1)	OA10694A (xx)
PE (1)	PE25698A1 (xx)
PL (1)	PL197306B1 (xx)
RO (1)	RO121382B1 (xx)
RU (1)	RU2160731C2 (xx)
SK (1)	SK75498A3 (xx)
TN (1)	TNSN96153A1 (xx)
TW (1)	TW414787B (xx)
UY (1)	UY24401A1 (xx)
WO (1)	WO1997022584A1 (xx)
YU (1)	YU49486B (xx)
ZA (1)	ZA9610533B (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999036405A1 (en)	1998-01-16	1999-07-22	Eisai Co., Ltd.	Process for production of donepezil derivative
IL125809A (en) *	1998-08-17	2005-08-31	Finetech Lab Ltd	Process and intermediates for production of donepezil and related compounds
US7148354B2 (en) *	2002-07-24	2006-12-12	Dr. Reddy's Laboratories Limited	Process for preparation of donepezil
IL150982A (en)	2002-07-30	2007-02-11	Ori Lerman	Process for making Donafzil
IL151253A0 (en) *	2002-08-14	2003-04-10	Finetech Lab Ltd	Process for production of highly pure donepezil hydrochloride
US6649765B1 (en)	2003-02-12	2003-11-18	Usv Limited, Bsd Marg.	Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL)
US6953856B2 (en)	2003-02-12	2005-10-11	Usv, Limited	Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI)
WO2004082685A1 (en) *	2003-03-21	2004-09-30	Ranbaxy Laboratories Limited	Process for the preparation of donepezil and derivatives thereof
WO2004099142A1 (en) *	2003-05-05	2004-11-18	Ranbaxy Laboratories Limited	Hydrobromide salt of benzyl-piperidylmethyl-indanone and its polymorphs
WO2005003092A1 (en)	2003-07-01	2005-01-13	Hetero Drugs Limited	Preparation of intermediates for acetyl cholinesterase inhibitors
CN1280273C (zh) *	2003-11-05	2006-10-18	天津和美生物技术有限公司	合成多奈哌齐及其衍生物的方法
IL171137A (en)	2004-09-29	2012-01-31	Chemagis Ltd	Use of purified malt donfazil for the preparation of pure pharmaceutical amorphous donfazil hydrochloride
CN100436416C (zh) *	2005-07-29	2008-11-26	西南合成制药股份有限公司	盐酸多奈哌齐合成工艺
GB0515803D0 (en) *	2005-07-30	2005-09-07	Pliva Hrvatska D O O	Intermediate compounds
AR057910A1 (es)	2005-11-18	2007-12-26	Synthon Bv	Proceso para preparar donepezilo
DE602007010725D1 (de)	2006-01-04	2011-01-05	Cipla Ltd	Verfahren und zwischenprodukt zur herstellung von donezepil
CA2672212A1 (en) *	2006-12-11	2008-06-19	Reviva Pharmaceuticals, Inc.	Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
WO2013078608A1 (en) *	2011-11-29	2013-06-06	Ziqiang Gu	Donepezil pamoate and methods of making and using the same
CA2921308A1 (en)	2013-08-16	2015-02-19	Universiteit Maastricht	Treatment of cognitive impairment with pde4 inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI95572C (fi) *	1987-06-22	1996-02-26	Eisai Co Ltd	Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
FR2642069B1 (fr) *	1989-01-20	1991-04-12	Rhone Poulenc Sante	Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent
DE4439822A1 (de) *	1994-11-08	1996-08-29	Bayer Ag	Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen

1996
- 1996-10-11 RO RO98-01070A patent/RO121382B1/ro unknown
- 1996-10-11 CZ CZ981808A patent/CZ180898A3/cs unknown
- 1996-10-11 CA CA002237647A patent/CA2237647A1/en not_active Abandoned
- 1996-10-11 IL IL13642196A patent/IL136421A0/xx unknown
- 1996-10-11 SK SK754-98A patent/SK75498A3/sk unknown
- 1996-10-11 JP JP9522607A patent/JP3066083B2/ja not_active Expired - Lifetime
- 1996-10-11 KR KR1019980704423A patent/KR20000064387A/ko not_active Application Discontinuation
- 1996-10-11 RU RU98111204/04A patent/RU2160731C2/ru not_active IP Right Cessation
- 1996-10-11 EP EP96931937A patent/EP0883607A1/en not_active Withdrawn
- 1996-10-11 PL PL327512A patent/PL197306B1/pl not_active IP Right Cessation
- 1996-10-11 NZ NZ318843A patent/NZ318843A/xx unknown
- 1996-10-11 IL IL13642096A patent/IL136420A0/xx unknown
- 1996-10-11 BR BR9612018A patent/BR9612018A/pt not_active Application Discontinuation
- 1996-10-11 WO PCT/IB1996/001076 patent/WO1997022584A1/en not_active Application Discontinuation
- 1996-10-11 AU AU70925/96A patent/AU716462B2/en not_active Ceased
- 1996-10-11 IL IL12445296A patent/IL124452A0/xx unknown
- 1996-10-11 HU HU9904275A patent/HUP9904275A3/hu unknown
- 1996-10-14 TW TW085112515A patent/TW414787B/zh not_active IP Right Cessation
- 1996-10-15 HN HN1996000065A patent/HN1996000065A/es unknown
- 1996-11-18 GT GT199600092A patent/GT199600092A/es unknown
- 1996-12-09 PE PE1996000883A patent/PE25698A1/es not_active Application Discontinuation
- 1996-12-10 AR ARP960105577A patent/AR004368A1/es unknown
- 1996-12-11 MA MA24424A patent/MA24032A1/fr unknown
- 1996-12-11 DZ DZ960186A patent/DZ2141A1/fr active
- 1996-12-11 YU YU66096A patent/YU49486B/sh unknown
- 1996-12-11 TN TNTNSN96153A patent/TNSN96153A1/fr unknown
- 1996-12-12 AP APAP/P/1996/000892A patent/AP708A/en active
- 1996-12-12 CO CO96065334A patent/CO4750831A1/es unknown
- 1996-12-12 UY UY24401A patent/UY24401A1/es not_active IP Right Cessation
- 1996-12-13 ZA ZA9610533A patent/ZA9610533B/xx unknown
- 1996-12-13 HR HR60/008,753A patent/HRP960592A2/xx not_active Application Discontinuation
1998
- 1998-05-22 IS IS4752A patent/IS4752A/is unknown
- 1998-06-05 OA OA9800076A patent/OA10694A/en unknown
- 1998-06-09 BG BG102525A patent/BG102525A/xx unknown
- 1998-06-12 NO NO982712A patent/NO982712L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP3066083B2 (ja)	2000-07-17
YU66096A (en)	1999-11-22
TNSN96153A1 (fr)	2005-03-15
BR9612018A (pt)	1999-02-17
NO982712D0 (no)	1998-06-12
IL136420A0 (en)	2001-06-14
KR20000064387A (ko)	2000-11-06
BG102525A (en)	1999-05-31
HN1996000065A (es)	1997-06-26
TW414787B (en)	2000-12-11
JPH11500756A (ja)	1999-01-19
NZ318843A (en)	2000-01-28
PL197306B1 (pl)	2008-03-31
CZ180898A3 (cs)	1999-05-12
AU7092596A (en)	1997-07-14
IL124452A0 (en)	1998-12-06
UY24401A1 (es)	1997-06-09
RU2160731C2 (ru)	2000-12-20
HRP960592A2 (en)	1998-06-30
IS4752A (is)	1998-05-22
AP708A (en)	1998-12-04
GT199600092A (es)	1998-05-12
AU716462B2 (en)	2000-02-24
PL327512A1 (en)	1998-12-21
AP9600892A0 (en)	1997-01-31
SK75498A3 (en)	1999-08-06
HUP9904275A2 (hu)	2000-05-28
CA2237647A1 (en)	1997-06-26
OA10694A (en)	2001-05-04
YU49486B (sh)	2006-08-17
DZ2141A1 (fr)	2002-07-23
MX9804820A (es)	1998-10-31
ZA9610533B (en)	1998-06-15
WO1997022584A1 (en)	1997-06-26
PE25698A1 (es)	1998-05-21
EP0883607A1 (en)	1998-12-16
NO982712L (no)	1998-06-12
CO4750831A1 (es)	1999-03-31
MA24032A1 (fr)	1997-07-01
HUP9904275A3 (en)	2001-05-28
AR004368A1 (es)	1998-11-04
RO121382B1 (ro)	2007-04-30

Publication	Publication Date	Title
IL136421A0 (en)	2001-06-14	Intermediates for preparing 1-benzyl -4-((5,6- dimethoxy -1-indanon)-2-yl) methylpiperidine
CZ186498A3 (cs)	1998-12-16	1-(1,2-Disubstituovaný piperidinyl)-4-substituované deriváty piperidinu
HUP9902381A3 (en)	2000-06-28	Fluorinated 1,4-disubstituted piperidine derivatives
ZA962200B (en)	1996-10-30	Piperidine derivatives
AU4343796A (en)	1996-07-03	Tachykinin antagonists
NZ238884A (en)	1993-12-23	Piperidine, tetrahydropyridine and pyrrolidine derivatives and
IL124642A0 (en)	1998-12-06	N-acyl-2- substituted-4- (benzimidazolyl- or imidazopyridinyl-substituted residues)- piperidines as tachykinin antagonists
ZA929011B (en)	1993-05-17	Novel N-hydroxyalkyl-substituted 1,2,3,6-tetrahydropyridine and piperidine derivatives.
AU3567195A (en)	1996-03-29	Neurokinin antagonists
HUP9903987A3 (en)	2002-01-28	N-acyl-2-substituted -4-(benzimidazolyl- or imidazopyridinyl-substituted residues)-piperidines as tachykinin antagonosts
CA2291170A1 (en)	1998-11-26	Processes and intermediates for resolving piperidyl acetamide stereoisomers
AU2793197A (en)	1998-01-05	1,4-disubstituted piperidine derivatives
DE69629454D1 (en)	2003-09-18	Antipsychotische 4-(1h-indolyl-1-yl)-1-substituierte piperidine derivate
EP0714890A3 (de)	1997-01-22	Verfahren zur Herstellung von 4-Amino-2,2,6,6-tetramethyl-piperidin
AU7578496A (en)	1997-06-05	Azetidine, pyrrolidine and piperidine derivatives
EP1316549A4 (en)	2005-01-12	1-BENZYL-4 - [(5,6-DIMETHOXY-2-FLUORO-1-INDANONE) -2-YL] METHYLPIPERIDIN
ZA97329B (en)	1998-07-15	Piperidine or tetrahydropyridine derivatives
AU6086998A (en)	1998-09-29	Process for preparing 1,4-disubstituted piperidine compounds
HUP0001185A3 (en)	2002-10-28	1-phenylalkyl-1,2,3,6-tetrahydropyridines, process for producing them and pharmaceutical compositions containing them
GR3031513T3 (en)	2000-01-31	4-(cycloalkyl)piperidines and 4-(cycloalkylalkyl)-piperidines derivatives, preparation thereof and therapeutical applications thereof
AU7319196A (en)	1997-05-22	Azetidine, pyrrolidine and piperidine derivatives
ZA967424B (en)	1997-03-07	Novel piperidines
ZA943036B (en)	1995-05-02	1,4-disubstituted piperidine derivative compounds
SI0765311T1 (en)	2001-02-28	4-aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidines, tetrahydropyridines or piperazines
AU3093792A (en)	1993-06-28	Novel n-hydroxyalkyl-substituted 1,2,3,6-tetrahydropyridine and piperidine derivatives