IL135400A0 - Aggregates of human insulin derivatives - Google Patents

Aggregates of human insulin derivatives

Info

Publication number: IL135400A0
Authority: IL; Israel
Prior art keywords: aggregates; derivatives; human insulin; soluble; insulin derivatives
Prior art date: 1997-10-24

Application number

IL13540098A

Other languages

English (en)

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-24

Filing date

1998-10-23

Publication date

2001-05-20

1998-10-23 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2001-05-20 Publication of IL135400A0 publication Critical patent/IL135400A0/xx

Links

PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title abstract 2
102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 abstract 1
108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000002523 gelfiltration Methods 0.000 abstract 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Emergency Medicine (AREA)
Immunology (AREA)
Hematology (AREA)
Epidemiology (AREA)
Toxicology (AREA)
Obesity (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IL13540098A 1997-10-24 1998-10-23 Aggregates of human insulin derivatives IL135400A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK121897		1997-10-24
US6417097P	1997-11-04	1997-11-04
PCT/DK1998/000461 WO1999021888A1 (en)	1997-10-24	1998-10-23	Aggregates of human insulin derivatives

Publications (1)

Publication Number	Publication Date
IL135400A0 true IL135400A0 (en)	2001-05-20

Family

ID=26065414

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL13540098A IL135400A0 (en)	1997-10-24	1998-10-23	Aggregates of human insulin derivatives
IL135400A IL135400A (en)	1997-10-24	2000-03-31	Accumulate humane insulin derivatives

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL135400A IL135400A (en)	1997-10-24	2000-03-31	Accumulate humane insulin derivatives

Country Status (20)

Country	Link
EP (1)	EP1025125B1 (da)
JP (1)	JP2003525846A (da)
KR (1)	KR100539193B1 (da)
CN (1)	CN1240718C (da)
AT (1)	ATE243711T1 (da)
AU (1)	AU757933B2 (da)
BR (1)	BR9813128A (da)
CA (1)	CA2308705A1 (da)
DE (1)	DE69815877T2 (da)
DK (1)	DK1025125T3 (da)
ES (1)	ES2202899T3 (da)
HU (1)	HUP0004096A3 (da)
IL (2)	IL135400A0 (da)
NO (1)	NO20002050L (da)
PL (1)	PL195845B1 (da)
PT (1)	PT1025125E (da)
RU (1)	RU2218349C2 (da)
UA (1)	UA69393C2 (da)
WO (1)	WO1999021888A1 (da)
ZA (1)	ZA989722B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7316999B2 (en)	2000-06-02	2008-01-08	Novo Nordisk A/S	Glucose dependent release of insulin from glucose sensing insulin derivatives
JP2004535401A (ja)	2001-05-21	2004-11-25	ネクターセラピューティックス	化学的に改変されたインスリンの肺投与
US7317000B2 (en)	2001-12-02	2008-01-08	Novo Nordisk A/S	Glucose-dependent insulins
KR101186851B1 (ko) *	2003-08-05	2012-10-02	노보 노르디스크 에이/에스	신규의 인슐린 유도체
BRPI0413276B8 (pt) *	2003-08-05	2021-05-25	Novo Nordisk As	derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica
WO2006014673A2 (en) *	2004-07-19	2006-02-09	Nobex Corporation	Insulin-oligomer conjugates, formulations and uses thereof
WO2006125765A2 (en) *	2005-05-26	2006-11-30	Novo Nordisk A/S	Acylated insulin with high purity
EP2505593A1 (en)	2005-12-28	2012-10-03	Novo Nordisk A/S	Compositions comprising an acylated insulin and zinc and method of making the said compositions
US8722620B2 (en)	2006-02-27	2014-05-13	Novo Nordisk A/S	Insulin derivatives
US20090099064A1 (en) *	2006-06-08	2009-04-16	Diabecore Medical Inc.,	Derivatized insulin oligomers
EP2049149B1 (en)	2006-07-31	2015-04-15	Novo Nordisk A/S	Pegylated extended insulins
DK2074141T3 (da)	2006-09-22	2016-11-28	Novo Nordisk As	Proteaseresistente insulinanaloger.
ES2563038T3 (es)	2007-04-30	2016-03-10	Novo Nordisk A/S	Método para secar una composición proteica, una composición proteica seca y una composición farmacéutica que comprende la proteína seca
EP2167032B1 (en)	2007-06-13	2019-08-07	Novo Nordisk A/S	Pharmaceutical formulation comprising an insulin derivative
JP5762001B2 (ja)	2008-03-14	2015-08-12	ノボ・ノルデイスク・エー／エス	プロテアーゼ安定化インスリンアナログ
RU2571857C2 (ru)	2008-03-18	2015-12-20	Ново Нордиск А/С	Стабилизированные по отношению к протеазам ацилированные аналоги инсулина
BRPI0919946A2 (pt)	2008-10-30	2016-02-16	Novo Nordisk As	tratamento de diabetes melito usando injeções de insulina com frequência de injeção menor que diariamente
RU2013123515A (ru)	2010-10-27	2014-12-10	Ново Нордиск А/С	Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами
CN103191416A (zh) *	2012-01-05	2013-07-10	四川大学	一种猪胰岛素超分子聚集体及其制备方法
EP2836508B1 (en)	2012-04-11	2016-06-29	Novo Nordisk A/S	Insulin formulations
EP2991672A1 (en)	2013-04-30	2016-03-09	Novo Nordisk A/S	Novel administration regime
MX366636B (es)	2013-10-07	2019-07-17	Novo Nordisk As	Nuevo derivado de un análogo de insulina.
AR099569A1 (es)	2014-02-28	2016-08-03	Novo Nordisk As	Derivados de insulina y los usos médicos de estos
DK3554534T3 (da)	2016-12-16	2021-08-23	Novo Nordisk As	Farmaceutisk sammensætning omfattende insulin
EP4360651A3 (en)	2017-08-24	2024-07-17	Novo Nordisk A/S	Glp-1 compositions and uses thereof
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
US12343383B2 (en)	2019-07-12	2025-07-01	Novo Nordisk A/S	High concentration insulin formulation
TWI878456B (zh)	2020-02-18	2025-04-01	丹麥商諾佛儂迪克股份有限公司	Glp-1組成物及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT792290E (pt) *	1993-09-17	2002-01-30	Novo Nordisk As	Insulina acilada
US5559094A (en) *	1994-08-02	1996-09-24	Eli Lilly And Company	AspB1 insulin analogs
US6451970B1 (en) *	1996-02-21	2002-09-17	Novo Nordisk A/S	Peptide derivatives

1998
- 1998-10-23 CN CNB988104458A patent/CN1240718C/zh not_active Expired - Fee Related
- 1998-10-23 UA UA2000042275A patent/UA69393C2/uk unknown
- 1998-10-23 PL PL98340032A patent/PL195845B1/pl unknown
- 1998-10-23 ES ES98949960T patent/ES2202899T3/es not_active Expired - Lifetime
- 1998-10-23 PT PT98949960T patent/PT1025125E/pt unknown
- 1998-10-23 AT AT98949960T patent/ATE243711T1/de not_active IP Right Cessation
- 1998-10-23 BR BR9813128-1A patent/BR9813128A/pt not_active IP Right Cessation
- 1998-10-23 EP EP98949960A patent/EP1025125B1/en not_active Expired - Lifetime
- 1998-10-23 IL IL13540098A patent/IL135400A0/xx not_active IP Right Cessation
- 1998-10-23 KR KR10-2000-7004229A patent/KR100539193B1/ko not_active Expired - Fee Related
- 1998-10-23 DK DK98949960T patent/DK1025125T3/da active
- 1998-10-23 DE DE69815877T patent/DE69815877T2/de not_active Expired - Fee Related
- 1998-10-23 RU RU2000112882/04A patent/RU2218349C2/ru not_active IP Right Cessation
- 1998-10-23 JP JP2000517995A patent/JP2003525846A/ja not_active Withdrawn
- 1998-10-23 AU AU96221/98A patent/AU757933B2/en not_active Ceased
- 1998-10-23 CA CA002308705A patent/CA2308705A1/en not_active Abandoned
- 1998-10-23 HU HU0004096A patent/HUP0004096A3/hu unknown
- 1998-10-23 WO PCT/DK1998/000461 patent/WO1999021888A1/en active IP Right Grant
- 1998-10-26 ZA ZA989722A patent/ZA989722B/xx unknown
2000
- 2000-03-31 IL IL135400A patent/IL135400A/en unknown
- 2000-04-18 NO NO20002050A patent/NO20002050L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU757933B2 (en)	2003-03-13
PL195845B1 (pl)	2007-10-31
ZA989722B (en)	1999-04-26
CN1240718C (zh)	2006-02-08
DE69815877T2 (de)	2004-05-19
PT1025125E (pt)	2003-11-28
CA2308705A1 (en)	1999-05-06
EP1025125B1 (en)	2003-06-25
NO20002050D0 (no)	2000-04-18
IL135400A (en)	2007-08-19
HUP0004096A2 (hu)	2001-05-28
HUP0004096A3 (en)	2001-12-28
DE69815877D1 (de)	2003-07-31
RU2218349C2 (ru)	2003-12-10
BR9813128A (pt)	2000-08-15
JP2003525846A (ja)	2003-09-02
DK1025125T3 (da)	2003-10-06
PL340032A1 (en)	2001-01-15
ES2202899T3 (es)	2004-04-01
EP1025125A1 (en)	2000-08-09
KR100539193B1 (ko)	2005-12-27
NO20002050L (no)	2000-06-23
UA69393C2 (uk)	2004-09-15
ATE243711T1 (de)	2003-07-15
CN1281466A (zh)	2001-01-24
KR20010031247A (ko)	2001-04-16
WO1999021888A1 (en)	1999-05-06
AU9622198A (en)	1999-05-17

Publication	Publication Date	Title
ZA989722B (en)	1999-04-26	Aggregates of human insulin derivatives
CA2209060A1 (en)	1997-12-28	Water-soluble or water-swellable polymers
ZA9710290B (en)	1998-06-10	Aqueous dispersion polymers.
EP0537292A4 (en)	1993-07-28	Water insoluble derivatives of hyaluronic acid
EP0886408A3 (en)	2002-01-16	Multicarrier modulation using guard intervals to reduce the effects of discontinuities
PL331988A1 (en)	1999-08-16	Substitution 6,6-heterobicyclic derivatives
ZA972056B (en)	1997-09-22	Substituted 1,2,3,4-tetrahydronaphthalene derivatives.
AU4270596A (en)	1996-07-19	Human phosphodiesterase type ivc, and its production and use
HK1006974B (en)	1999-03-26	Aqueous wax and silicone dispersions, their production and use
GB2270919B (en)	1996-04-24	Aqueous wax and silicone dispersions,their production and use
MX9803728A (es)	1998-09-30	Agentes floculantes de polimero de alto rendimiento.
CY2425B1 (en)	2004-11-12	2,4-Diaminopyrimidine derivatives.
AU3657100A (en)	2000-10-04	Use of water-soluble beta-(1,3) glucans as agents for producing therapeutic skintreatment agents
ZA200309114B (en)	2005-02-23	Disodium salts, monohydrates and ethanol solvates.
AU5886500A (en)	2001-01-09	Indolyl-benzimidazole antibacterials, and methods of use thereof
EP0882447B8 (en)	2006-07-05	Soluble cosmetics
WO1997030092A3 (en)	1997-11-20	Hydrogels
AU7624598A (en)	1998-06-29	1,4-diazabicyclo (2.2.2) Oct-2-ylmethyl derivatives, their preparation and the rapeutic application
HUP9901315A3 (en)	2000-03-28	New carboxzlic acid derivatives, their production and use
TR200001102T2 (tr)	2000-08-21	İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
ZA971883B (en)	1997-11-10	1,3,5-trisubstituted indazole derivatives.
AU3693797A (en)	1998-02-10	1,3-dimethyl-5-fluoro-pyrazole-4-carboxamide derivatives, their preparation and their use as microbicides
AU4571997A (en)	1998-05-11	Resin-coated segment, and manufacture thereof
CA2314716A1 (en)	1999-06-17	Modified polysaccharides exhibiting altered biological recognition
ATE230592T1 (de)	2003-01-15	Dekorative kosmetische zubereitungen

Legal Events

Date	Code	Title
2008-01-22	FF	Patent granted
2008-01-22	KB	Patent renewed
2009-12-24	MM9K	Patent not in force due to non-payment of renewal fees