DK1025125T3 - Aggregater for humane insulinderivater - Google Patents

Aggregater for humane insulinderivater

Info

Publication number: DK1025125T3
Authority: DK; Denmark
Prior art keywords: aggregates; derivatives; human insulin; soluble; insulin derivatives
Prior art date: 1997-10-24

Application number

DK98949960T

Other languages

English (en)

Inventor

Ib Jonassen

Svend Havelund

Per Balschmidt

Thomas Hoeg-Jensen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-24

Filing date

1998-10-23

Publication date

2003-10-06

1998-10-23 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2003-10-06 Application granted granted Critical

2003-10-06 Publication of DK1025125T3 publication Critical patent/DK1025125T3/da

Links

PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title abstract 2
102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 abstract 1
108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000002523 gelfiltration Methods 0.000 abstract 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Immunology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK98949960T 1997-10-24 1998-10-23 Aggregater for humane insulinderivater DK1025125T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK121897		1997-10-24
US6417097P	1997-11-04	1997-11-04
PCT/DK1998/000461 WO1999021888A1 (en)	1997-10-24	1998-10-23	Aggregates of human insulin derivatives

Publications (1)

Publication Number	Publication Date
DK1025125T3 true DK1025125T3 (da)	2003-10-06

Family

ID=26065414

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98949960T DK1025125T3 (da)	1997-10-24	1998-10-23	Aggregater for humane insulinderivater

Country Status (20)

Country	Link
EP (1)	EP1025125B1 (da)
JP (1)	JP2003525846A (da)
KR (1)	KR100539193B1 (da)
CN (1)	CN1240718C (da)
AT (1)	ATE243711T1 (da)
AU (1)	AU757933B2 (da)
BR (1)	BR9813128A (da)
CA (1)	CA2308705A1 (da)
DE (1)	DE69815877T2 (da)
DK (1)	DK1025125T3 (da)
ES (1)	ES2202899T3 (da)
HU (1)	HUP0004096A3 (da)
IL (2)	IL135400A0 (da)
NO (1)	NO20002050L (da)
PL (1)	PL195845B1 (da)
PT (1)	PT1025125E (da)
RU (1)	RU2218349C2 (da)
UA (1)	UA69393C2 (da)
WO (1)	WO1999021888A1 (da)
ZA (1)	ZA989722B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7316999B2 (en)	2000-06-02	2008-01-08	Novo Nordisk A/S	Glucose dependent release of insulin from glucose sensing insulin derivatives
CA2447236A1 (en)	2001-05-21	2002-11-28	Nektar Therapeutics	Pulmonary administration of chemically modified insulin
US7317000B2 (en)	2001-12-02	2008-01-08	Novo Nordisk A/S	Glucose-dependent insulins
DK2275439T3 (da) *	2003-08-05	2014-05-12	Novo Nordisk As	Hidtil ukendte insulinderivater
MXPA06001283A (es) *	2003-08-05	2006-04-11	Novo Nordisk As	Derivados de insulina novedosos.
AU2005269753B2 (en) *	2004-07-19	2011-08-18	Biocon Limited	Insulin-oligomer conjugates, formulations and uses thereof
EP1888104A2 (en) *	2005-05-26	2008-02-20	Novo Nordisk A/S	Acylated insulin with high purity
WO2007074133A2 (en)	2005-12-28	2007-07-05	Novo Nordisk A/S	Compositions comprising an acylated insulin and zinc and method of making the said compositions
EP1991576B1 (en) *	2006-02-27	2010-09-29	Novo Nordisk A/S	Insulin derivatives
US20090099064A1 (en) *	2006-06-08	2009-04-16	Diabecore Medical Inc.,	Derivatized insulin oligomers
US20090306337A1 (en)	2006-07-31	2009-12-10	Novo Nordisk A/S	Pegylated, Extended Insulins
BRPI0717098B8 (pt)	2006-09-22	2021-05-25	Novo Nordisk As	análogos de insulina humana resistentes à protease, composição farmacêutica e processo para sua preparação
JP5496082B2 (ja)	2007-04-30	2014-05-21	ノボ・ノルデイスク・エー／エス	タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物
JP5552046B2 (ja)	2007-06-13	2014-07-16	ノボ・ノルデイスク・エー／エス	インスリン誘導体を含有する薬学的製剤
WO2009112583A2 (en)	2008-03-14	2009-09-17	Novo Nordisk A/S	Protease-stabilized insulin analogues
PT2910570T (pt)	2008-03-18	2017-01-24	Novo Nordisk As	Análogos de insulina acilados, estabilizados contra proteases
MX2011004357A (es)	2008-10-30	2011-05-23	Novo Nordisk As	Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyeccion menor que a diario.
JP6049625B2 (ja)	2010-10-27	2016-12-21	ノヴォノルディスクアー／エス	様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
CN103191416A (zh) *	2012-01-05	2013-07-10	四川大学	一种猪胰岛素超分子聚集体及其制备方法
KR20150002777A (ko)	2012-04-11	2015-01-07	노보 노르디스크 에이/에스	인슐린 제제
US10137172B2 (en)	2013-04-30	2018-11-27	Novo Nordisk A/S	Administration regime
US9896496B2 (en)	2013-10-07	2018-02-20	Novo Nordisk A/S	Derivative of an insulin analogue
AR099569A1 (es)	2014-02-28	2016-08-03	Novo Nordisk As	Derivados de insulina y los usos médicos de estos
HUE060149T2 (hu)	2016-12-16	2023-02-28	Novo Nordisk As	Inzulint tartalmazó gyógyászati készítmények
ES2976496T3 (es)	2017-08-24	2024-08-02	Novo Nordisk As	Composiciones de GLP-1 y usos de las mismas
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
US20230082544A1 (en)	2020-02-18	2023-03-16	Novo Nordisk A/S	Pharmaceutical formulations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5559094A (en) *	1994-08-02	1996-09-24	Eli Lilly And Company	AspB1 insulin analogs
US6451970B1 (en) *	1996-02-21	2002-09-17	Novo Nordisk A/S	Peptide derivatives

1998
- 1998-10-23 ES ES98949960T patent/ES2202899T3/es not_active Expired - Lifetime
- 1998-10-23 CN CNB988104458A patent/CN1240718C/zh not_active Expired - Fee Related
- 1998-10-23 DK DK98949960T patent/DK1025125T3/da active
- 1998-10-23 IL IL13540098A patent/IL135400A0/xx not_active IP Right Cessation
- 1998-10-23 PT PT98949960T patent/PT1025125E/pt unknown
- 1998-10-23 UA UA2000042275A patent/UA69393C2/uk unknown
- 1998-10-23 JP JP2000517995A patent/JP2003525846A/ja not_active Withdrawn
- 1998-10-23 HU HU0004096A patent/HUP0004096A3/hu unknown
- 1998-10-23 AT AT98949960T patent/ATE243711T1/de not_active IP Right Cessation
- 1998-10-23 CA CA002308705A patent/CA2308705A1/en not_active Abandoned
- 1998-10-23 KR KR10-2000-7004229A patent/KR100539193B1/ko not_active IP Right Cessation
- 1998-10-23 WO PCT/DK1998/000461 patent/WO1999021888A1/en active IP Right Grant
- 1998-10-23 AU AU96221/98A patent/AU757933B2/en not_active Ceased
- 1998-10-23 RU RU2000112882/04A patent/RU2218349C2/ru not_active IP Right Cessation
- 1998-10-23 EP EP98949960A patent/EP1025125B1/en not_active Expired - Lifetime
- 1998-10-23 DE DE69815877T patent/DE69815877T2/de not_active Expired - Fee Related
- 1998-10-23 BR BR9813128-1A patent/BR9813128A/pt not_active IP Right Cessation
- 1998-10-23 PL PL98340032A patent/PL195845B1/pl unknown
- 1998-10-26 ZA ZA989722A patent/ZA989722B/xx unknown
2000
- 2000-03-31 IL IL135400A patent/IL135400A/en unknown
- 2000-04-18 NO NO20002050A patent/NO20002050L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR100539193B1 (ko)	2005-12-27
CN1240718C (zh)	2006-02-08
CN1281466A (zh)	2001-01-24
DE69815877D1 (de)	2003-07-31
HUP0004096A3 (en)	2001-12-28
EP1025125A1 (en)	2000-08-09
DE69815877T2 (de)	2004-05-19
NO20002050L (no)	2000-06-23
PL195845B1 (pl)	2007-10-31
AU9622198A (en)	1999-05-17
BR9813128A (pt)	2000-08-15
ATE243711T1 (de)	2003-07-15
KR20010031247A (ko)	2001-04-16
UA69393C2 (uk)	2004-09-15
PT1025125E (pt)	2003-11-28
NO20002050D0 (no)	2000-04-18
AU757933B2 (en)	2003-03-13
IL135400A0 (en)	2001-05-20
RU2218349C2 (ru)	2003-12-10
ZA989722B (en)	1999-04-26
CA2308705A1 (en)	1999-05-06
IL135400A (en)	2007-08-19
PL340032A1 (en)	2001-01-15
ES2202899T3 (es)	2004-04-01
JP2003525846A (ja)	2003-09-02
EP1025125B1 (en)	2003-06-25
HUP0004096A2 (hu)	2001-05-28
WO1999021888A1 (en)	1999-05-06

Publication	Publication Date	Title
DK1025125T3 (da)	2003-10-06	Aggregater for humane insulinderivater
TR199600322A2 (tr)	1996-11-21	Arilsülfonil hidroksamik asit türevleri.
BR9809025B1 (pt)	2010-05-18	polìmero anfótero, e, veìculo cosmeticamente aceitável.
CA2119154A1 (en)	1994-02-03	Derivatives of Cyclodextrins Exhibiting Enhanced Aqueous Solubility and the Use Thereof
AU2002343557A1 (en)	2003-06-10	Substituted aryl 1,4-pyrazine derivatives
DE3880465D1 (de)	1993-05-27	Wasserloesliche polymerdispersion.
DK0920429T3 (da)	2003-05-12	Substituerede pyrido- eller pyrimidoholdige, 6,6- eller 6,7-bicykliske derivater
PT925298E (pt)	2004-07-30	Derivados 6,6-hetero-biciclicos substituidos
AP2000001923A0 (en)	2000-09-30	6,9.Disubstituted 2-[trans-(4-aminocyclohexyl)amino]purines
RS49723B (sr)	2007-12-31	Farmaceutska kompozicija koja sadrži entakapon ili nitekapon kao i umreženi derivat celuloze
DE69631774D1 (de)	2004-04-08	2,3-dioxo-1,2,3,4-tetrahydro-chinoxalin derivate
MX9803728A (es)	1998-09-30	Agentes floculantes de polimero de alto rendimiento.
AU3657100A (en)	2000-10-04	Use of water-soluble beta-(1,3) glucans as agents for producing therapeutic skintreatment agents
DE69931260D1 (de)	2006-06-14	Wässriges künstliches medium
TR199701576T1 (xx)	1998-05-21	N-aril-1,2,4,-triazolin-5-onlar.
FR2684543B1 (fr)	1999-04-09	Ligament artificiel, notamment pour la cheville.
TR200001102T2 (tr)	2000-08-21	İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
DE69628458D1 (de)	2003-07-03	25-hydroxy-16-ene-26,27-bishome-cholecalceriferol derivate
NO981484D0 (no)	1998-04-01	Olje-fri, vann-opplöselig, hydroksyetylcellulose, flytende polymerdispersjon
DE50001049D1 (de)	2003-02-13	Dekorative kosmetische zubereitungen
IS5731A (is)	2000-11-24	4, 5, 6 og 7-indól og indólín afleiður, framleiðsla þeirra og notkun
ATE202922T1 (de)	2001-07-15	Ophthalmische cromolyn-gelzubereitung
TR199700219A3 (tr)	1997-10-21	1,25-Dihidroksi-16, 22, 23-Trisdihidro-kolkalsiferol türevleri.
AU4506499A (en)	2000-01-05	Novel 2,4-diaminophenol derivatives and the use thereof
WO2001085683A3 (de)	2002-04-25	Pyrrolyl-, furanyl- und thienyl-substituierte p-aminophenole und diese verbindungen enthaltende färbemittel