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IL134074A0 - Method to produce novel polyketides - Google Patents

Method to produce novel polyketides

Info

Publication number
IL134074A0
IL134074A0 IL13407498A IL13407498A IL134074A0 IL 134074 A0 IL134074 A0 IL 134074A0 IL 13407498 A IL13407498 A IL 13407498A IL 13407498 A IL13407498 A IL 13407498A IL 134074 A0 IL134074 A0 IL 134074A0
Authority
IL
Israel
Prior art keywords
produce novel
novel polyketides
polyketides
produce
novel
Prior art date
Application number
IL13407498A
Other languages
English (en)
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Publication of IL134074A0 publication Critical patent/IL134074A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL13407498A 1997-07-17 1998-07-17 Method to produce novel polyketides IL134074A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/896,323 US6066721A (en) 1995-07-06 1997-07-17 Method to produce novel polyketides
PCT/US1998/014911 WO1999003986A2 (en) 1997-07-17 1998-07-17 Method to produce polyketides and polyketides

Publications (1)

Publication Number Publication Date
IL134074A0 true IL134074A0 (en) 2001-04-30

Family

ID=25406015

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13407498A IL134074A0 (en) 1997-07-17 1998-07-17 Method to produce novel polyketides

Country Status (13)

Country Link
US (3) US6066721A (hu)
EP (1) EP0996714A2 (hu)
JP (1) JP2001510038A (hu)
KR (1) KR20010021933A (hu)
CN (1) CN1267332A (hu)
AU (1) AU736972B2 (hu)
BR (1) BR9813004A (hu)
CA (1) CA2296728A1 (hu)
HU (1) HUP0003728A2 (hu)
IL (1) IL134074A0 (hu)
MX (1) MXPA00000623A (hu)
NZ (1) NZ502360A (hu)
WO (1) WO1999003986A2 (hu)

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US6500960B1 (en) 1995-07-06 2002-12-31 Stanford University (Board Of Trustees Of The Leland Stanford Junior University) Method to produce novel polyketides
US6927057B2 (en) 1993-09-20 2005-08-09 Kosan Biosciences Macrolide analogs
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US6066721A (en) * 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
US6558942B1 (en) * 1994-05-06 2003-05-06 The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US20030170725A1 (en) * 1993-09-20 2003-09-11 Chaitan Khosla Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
US6187757B1 (en) * 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
WO1997002358A1 (en) * 1995-07-06 1997-01-23 The Leland Stanford Junior University Cell-free synthesis of polyketides
US6960453B1 (en) 1996-07-05 2005-11-01 Biotica Technology Limited Hybrid polyketide synthases combining heterologous loading and extender modules
US6271255B1 (en) 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
US6399789B1 (en) * 1996-12-18 2002-06-04 Kosan Biosciences, Inc. Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
US20040209322A1 (en) * 1997-04-30 2004-10-21 Chaitan Khosla Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US20080003648A1 (en) * 1997-04-30 2008-01-03 Chaitan Khosla Method to prepare macrolide analogs
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
JP2002525026A (ja) 1998-07-02 2002-08-13 ザ ボード オブ リージェンツ オブ ザ レランド スタンフォード ジュニア ユニバーシティ ポリケチドを作製するための方法
US6177262B1 (en) 1998-09-22 2001-01-23 Kosan Biosciences, Inc. Recombinant host cells for the production of polyketides
US6388099B2 (en) 1998-10-29 2002-05-14 Kosan Biosciences, Inc. Production of 8,8a-dihydroxy-6-deoxyerythronolide B
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
KR20070087132A (ko) 1998-11-20 2007-08-27 코산 바이오사이언시즈, 인코포레이티드 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법및 물질
WO2000044717A2 (en) * 1999-01-27 2000-08-03 Kosan Biosciences, Inc. Synthesis of oligoketides
EP1754700A3 (en) 1999-01-27 2007-05-09 Kosan Biosciences, Inc. Synthesis of oligoketides
US7001748B2 (en) * 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
WO2000047724A2 (en) 1999-02-09 2000-08-17 Board Of Trustees Of The Leland Stanford Junior University Methods to mediate polyketide synthase module effectiveness
NZ514917A (en) * 1999-04-16 2004-02-27 Ortho Mcneil Pharm Inc Ketolide antibacterials
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
KR100710605B1 (ko) 1999-04-16 2007-04-24 코산 바이오사이언시즈, 인코포레이티드 매크롤라이드 항감염제
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
ATE264863T1 (de) * 1999-08-24 2004-05-15 Ariad Gene Therapeutics Inc 28-epirapaloge
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
US6524841B1 (en) 1999-10-08 2003-02-25 Kosan Biosciences, Inc. Recombinant megalomicin biosynthetic genes and uses thereof
US7033818B2 (en) * 1999-10-08 2006-04-25 Kosan Biosciences, Inc. Recombinant polyketide synthase genes
US6939691B1 (en) 1999-10-13 2005-09-06 Board Of Trustees Of The Leland Stanford Junior University E. coli and Streptomyces host cells that contain MatBC genes or E. coli host cells that contain pcc genes useful for enhanced polyketide production
WO2001027306A2 (en) * 1999-10-13 2001-04-19 The Board Of Trustees Of The Leland Stanford Junior University Biosynthesis of polyketide synthase substrates
WO2001031049A2 (en) * 1999-10-25 2001-05-03 Kosan Biosciences, Inc. Production of polyketides
US6670168B1 (en) 1999-10-29 2003-12-30 Kosan Bioscience, Inc. Recombinant Streptomyces hygroscopicus host cells that produce 17-desmethylrapamycin
EP1255763A2 (en) 2000-02-18 2002-11-13 Kosan Biosciences, Inc. Motilide compounds
DE60127948T2 (de) * 2000-02-24 2008-01-17 Kyowa Hakko Kogyo Co., Ltd. Verfahren zur herstellung von avermectinderivaten
WO2001092991A2 (en) 2000-05-30 2001-12-06 Kosan Biosciences, Inc. Design of polyketide synthase genes
CA2348145C (en) * 2001-05-22 2005-04-12 Surface Engineered Products Corporation Protective system for high temperature metal alloys
JP2004520008A (ja) * 2000-08-09 2004-07-08 コーサン バイオサイエンシーズ， インコーポレイテッド ポリケチドの化学合成において使用するための生物中間体
US20030077759A1 (en) * 2000-12-28 2003-04-24 Zhihao Hu Plasmids for polyketide production
AU2003213757A1 (en) * 2002-03-04 2003-09-22 Brown University Research Foundation Methods to mediate polyketide synthase module effectiveness
WO2003106638A2 (en) * 2002-06-13 2003-12-24 Kosan Biosciences, Inc. Methods and cells for improved production of polyketides
AU2003258978A1 (en) 2002-06-28 2004-01-19 Kosan Biosciences, Inc. Recombinant genes for polyketide modifying enzymes
US7413878B2 (en) 2002-07-15 2008-08-19 Kosan Biosciences, Inc. Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit
WO2004024744A2 (en) * 2002-07-31 2004-03-25 The Board Of Trustees Of The Leland Stanford Junior University Production of glycosylated macrolides in e. coli
AU2003273254B2 (en) * 2002-08-29 2008-10-30 Bristol-Myers Squibb Company Motilide compounds
WO2004029220A2 (en) * 2002-09-26 2004-04-08 Kosan Biosciences, Inc. Synthetic genes
AU2003275372A1 (en) * 2002-09-30 2004-04-19 Compound Therapeutics, Inc. Methods of engineering spatially conserved motifs in polypeptides
US7067290B2 (en) * 2002-11-12 2006-06-27 Kosan Biosciences Incorporated Method for production of polyketides
US7799904B2 (en) * 2003-06-13 2010-09-21 University Of Kentucky Research Foundation Gilvocarcin gene cluster, recombinant production and use thereof
US7459294B2 (en) * 2003-08-08 2008-12-02 Kosan Biosciences Incorporated Method of producing a compound by fermentation
EP2658855A2 (en) * 2010-12-31 2013-11-06 Acies Bio d.o.o. Novel polyketide compounds and methods of making same
EP3823990A1 (en) 2018-07-20 2021-05-26 TeneoBio, Inc. Heavy chain antibodies binding to cd19
US20230203161A1 (en) 2020-04-29 2023-06-29 Teneobio, Inc Multispecific heavy chain antibodies with modified heavy chain constant regions

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Also Published As

Publication number Publication date
AU736972B2 (en) 2001-08-09
CA2296728A1 (en) 1999-01-28
NZ502360A (en) 2001-11-30
US6261816B1 (en) 2001-07-17
WO1999003986A3 (en) 1999-04-08
HUP0003728A2 (hu) 2001-02-28
WO1999003986A2 (en) 1999-01-28
BR9813004A (pt) 2002-02-05
MXPA00000623A (es) 2002-04-24
US6066721A (en) 2000-05-23
EP0996714A2 (en) 2000-05-03
US20010024811A1 (en) 2001-09-27
CN1267332A (zh) 2000-09-20
KR20010021933A (ko) 2001-03-15
JP2001510038A (ja) 2001-07-31
AU8412398A (en) 1999-02-10

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