IL120984A - Salts of ethyl 3-(2-(4-(4-(amino-imino-methyl) phenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate, their preparation and pharmaceutical compositions containing them - Google Patents

Salts of ethyl 3-(2-(4-(4-(amino-imino-methyl) phenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate, their preparation and pharmaceutical compositions containing them

Info

Publication number: IL120984A
Authority: IL; Israel
Prior art keywords: methyl; dioxoimidazolidin; phenylpropionate; acetylamino; imino
Prior art date: 1996-06-05

Application number

IL12098497A

Other languages

English (en)

Other versions

IL120984A0 (en

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-05

Filing date

1997-06-03

Publication date

2001-08-26

1997-06-03 Application filed by Hoechst Ag filed Critical Hoechst Ag

1997-11-20 Publication of IL120984A0 publication Critical patent/IL120984A0/xx

2001-08-26 Publication of IL120984A publication Critical patent/IL120984A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)

IL12098497A 1996-06-05 1997-06-03 Salts of ethyl 3-(2-(4-(4-(amino-imino-methyl) phenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate, their preparation and pharmaceutical compositions containing them IL120984A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19622489A DE19622489A1 (de)	1996-06-05	1996-06-05	Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters

Publications (2)

Publication Number	Publication Date
IL120984A0 IL120984A0 (en)	1997-11-20
IL120984A true IL120984A (en)	2001-08-26

Family

ID=7796165

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12098497A IL120984A (en)	1996-06-05	1997-06-03	Salts of ethyl 3-(2-(4-(4-(amino-imino-methyl) phenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate, their preparation and pharmaceutical compositions containing them

Country Status (24)

Country	Link
US (1)	US6294562B1 (es)
EP (1)	EP0811616B1 (es)
JP (1)	JP4249277B2 (es)
KR (1)	KR980002029A (es)
CN (1)	CN1104420C (es)
AR (1)	AR008993A1 (es)
AT (1)	ATE294783T1 (es)
AU (1)	AU717106B2 (es)
BR (1)	BR9703459A (es)
CA (1)	CA2206748C (es)
CZ (1)	CZ292672B6 (es)
DE (2)	DE19622489A1 (es)
ES (1)	ES2241016T3 (es)
HK (1)	HK1006359A1 (es)
HR (1)	HRP970309B1 (es)
HU (1)	HUP9700998A3 (es)
IL (1)	IL120984A (es)
MX (1)	MX9704128A (es)
NO (1)	NO307999B1 (es)
PL (1)	PL320355A1 (es)
RU (1)	RU2174119C2 (es)
SK (1)	SK70897A3 (es)
TR (1)	TR199700457A2 (es)
ZA (1)	ZA974912B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19647380A1 (de) *	1996-11-15	1998-05-20	Hoechst Ag	5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
US7544681B2 (en)	2001-09-27	2009-06-09	Ramot At Tel Aviv University Ltd.	Conjugated psychotropic drugs and uses thereof
JP4933259B2 (ja) *	2003-10-02	2012-05-16	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	ピロール置換インドリノン化合物の塩および多形
AU2006256369B2 (en) *	2005-06-07	2012-08-02	Bar-Ilan University	Novel salts of conjugated psychotropic drugs and processes of preparing same
US8222296B2 (en)	2006-07-17	2012-07-17	Ramot At Tel-Aviv University Ltd.	Conjugates comprising a GABA- or glycine compound, pharmaceutical compositions and combinations thereof and their use in treating CNS disorders
EP2252578B1 (en)	2008-02-11	2012-08-01	Ramot at Tel Aviv University Ltd.	Conjugates for treating neurodegenerative diseases and disorders
MX2012006566A (es)	2009-12-09	2012-11-29	Univ Ramot	Metodo para mejorar las funciones cognoscitivas.
CA2789654A1 (en)	2010-02-24	2011-09-01	Ramot At Tel-Aviv University Ltd.	Crystalline forms of the tri-mesylate salt of perphenazine-gaba and process of producing the same
US8916610B2 (en)	2010-09-22	2014-12-23	Ramot At Tel-Aviv University Ltd.	Acid addition salt of a nortriptyline-GABA conjugate and a process of preparing same
CN112312910A (zh)	2018-04-12	2021-02-02	莫菲克医疗股份有限公司	人整合素α4β7拮抗剂
UY38926A (es)	2019-10-16	2021-05-31	Morphic Therapeutic Inc	INHIBICIÓN DE INTEGRINA alfa4beta7 HUMANA

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4126277A1 (de) *	1991-08-08	1993-02-11	Cassella Ag	Hydantoinderivate
DE4213634A1 (de) *	1992-04-24	1993-10-28	Cassella Ag	2,4-Dioxo-imidazolidin-Derivate
DE4224414A1 (de)	1992-07-24	1994-01-27	Cassella Ag	Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung
DE4308034A1 (de)	1993-03-13	1994-09-15	Cassella Ag	Neue Heterocyclen, ihre Herstellung und ihre Verwendung
DE4309867A1 (de)	1993-03-26	1994-09-29	Cassella Ag	Neue Harnstoffderivate, ihre Herstellung und Verwendung
DE4427979A1 (de) *	1993-11-15	1996-02-15	Cassella Ag	Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung
DE19515177A1 (de)	1995-04-28	1996-10-31	Cassella Ag	Hydantoinderivate als Zwischenprodukte für pharmazeutische Wirkstoffe

1996
- 1996-06-05 DE DE19622489A patent/DE19622489A1/de not_active Withdrawn
1997
- 1997-05-28 ES ES97108569T patent/ES2241016T3/es not_active Expired - Lifetime
- 1997-05-28 DE DE59712294T patent/DE59712294D1/de not_active Expired - Lifetime
- 1997-05-28 EP EP97108569A patent/EP0811616B1/de not_active Expired - Lifetime
- 1997-05-28 AT AT97108569T patent/ATE294783T1/de not_active IP Right Cessation
- 1997-06-02 NO NO972506A patent/NO307999B1/no not_active IP Right Cessation
- 1997-06-03 TR TR97/00457A patent/TR199700457A2/xx unknown
- 1997-06-03 CN CN97105465A patent/CN1104420C/zh not_active Expired - Fee Related
- 1997-06-03 AU AU24674/97A patent/AU717106B2/en not_active Ceased
- 1997-06-03 IL IL12098497A patent/IL120984A/xx not_active IP Right Cessation
- 1997-06-03 JP JP14561797A patent/JP4249277B2/ja not_active Expired - Fee Related
- 1997-06-03 AR ARP970102405A patent/AR008993A1/es unknown
- 1997-06-04 ZA ZA9704912A patent/ZA974912B/xx unknown
- 1997-06-04 MX MX9704128A patent/MX9704128A/es not_active IP Right Cessation
- 1997-06-04 HU HU9700998A patent/HUP9700998A3/hu unknown
- 1997-06-04 CA CA002206748A patent/CA2206748C/en not_active Expired - Fee Related
- 1997-06-04 CZ CZ19971729A patent/CZ292672B6/cs unknown
- 1997-06-04 PL PL97320355A patent/PL320355A1/xx unknown
- 1997-06-04 SK SK708-97A patent/SK70897A3/sk unknown
- 1997-06-04 HR HR970309A patent/HRP970309B1/xx not_active IP Right Cessation
- 1997-06-04 KR KR1019970022995A patent/KR980002029A/ko not_active Application Discontinuation
- 1997-06-05 BR BR9703459A patent/BR9703459A/pt not_active IP Right Cessation
- 1997-06-05 RU RU97109041/04A patent/RU2174119C2/ru not_active IP Right Cessation
1998
- 1998-06-18 HK HK98105621A patent/HK1006359A1/xx not_active IP Right Cessation
1999
- 1999-04-29 US US09/301,907 patent/US6294562B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HRP970309A2 (en)	1998-04-30
IL120984A0 (en)	1997-11-20
BR9703459A (pt)	1998-10-06
CA2206748A1 (en)	1997-12-05
DE19622489A1 (de)	1997-12-11
SK70897A3 (en)	1999-05-07
TR199700457A2 (xx)	1997-12-21
HUP9700998A1 (hu)	1998-03-30
EP0811616B1 (de)	2005-05-04
KR980002029A (ko)	1998-03-30
HUP9700998A3 (en)	1999-03-01
US6294562B1 (en)	2001-09-25
CN1104420C (zh)	2003-04-02
AU717106B2 (en)	2000-03-16
HK1006359A1 (en)	1999-02-26
ZA974912B (en)	1997-12-05
CA2206748C (en)	2007-05-01
PL320355A1 (en)	1997-12-08
AU2467497A (en)	1997-12-11
RU2174119C2 (ru)	2001-09-27
NO307999B1 (no)	2000-07-03
JP4249277B2 (ja)	2009-04-02
CZ172997A3 (en)	1997-12-17
CZ292672B6 (cs)	2003-11-12
HRP970309B1 (en)	2002-06-30
HU9700998D0 (en)	1997-07-28
ES2241016T3 (es)	2005-10-16
MX9704128A (es)	1997-12-31
NO972506D0 (no)	1997-06-02
NO972506L (no)	1997-12-08
EP0811616A1 (de)	1997-12-10
JPH1059948A (ja)	1998-03-03
AR008993A1 (es)	2000-03-08
DE59712294D1 (de)	2005-06-09
CN1174835A (zh)	1998-03-04
ATE294783T1 (de)	2005-05-15

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Legal Events

Date	Code	Title
2002-02-10	KB	Patent renewed
2003-07-31	KB	Patent renewed
2008-02-10	MM9K	Patent not in force due to non-payment of renewal fees