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AR008993A1 - Sales de esteres etilicos de acidos 3-(2-(4-(4-(amino-imino-metil)-fenil)-4 -metil-2,5-dioxo-imidazolidin-1-il)-acetilamino)-3-fenil-propionicos - Google Patents

Sales de esteres etilicos de acidos 3-(2-(4-(4-(amino-imino-metil)-fenil)-4 -metil-2,5-dioxo-imidazolidin-1-il)-acetilamino)-3-fenil-propionicos

Info

Publication number
AR008993A1
AR008993A1 ARP970102405A ARP970102405A AR008993A1 AR 008993 A1 AR008993 A1 AR 008993A1 AR P970102405 A ARP970102405 A AR P970102405A AR P970102405 A ARP970102405 A AR P970102405A AR 008993 A1 AR008993 A1 AR 008993A1
Authority
AR
Argentina
Prior art keywords
phenyl
methyl
salts
propionics
imidazolidin
Prior art date
Application number
ARP970102405A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of AR008993A1 publication Critical patent/AR008993A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Concierne a sales de ésteres etílicos de ácidos 3-(2-(4-(4-(amino-imino- metil)-fenil)-4-metil-2,5-dioxo-imidazolidin-1-il)-acetilamino)-3-fenil-propionicos de la formula general (I), en la que HB significa ácido maleico, así como sus salesfis iologicamente compatibles, a procedimientos para supreparacion y a su utilizacion en medicamentos.
ARP970102405A 1996-06-05 1997-06-03 Sales de esteres etilicos de acidos 3-(2-(4-(4-(amino-imino-metil)-fenil)-4 -metil-2,5-dioxo-imidazolidin-1-il)-acetilamino)-3-fenil-propionicos AR008993A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19622489A DE19622489A1 (de) 1996-06-05 1996-06-05 Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters

Publications (1)

Publication Number Publication Date
AR008993A1 true AR008993A1 (es) 2000-03-08

Family

ID=7796165

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970102405A AR008993A1 (es) 1996-06-05 1997-06-03 Sales de esteres etilicos de acidos 3-(2-(4-(4-(amino-imino-metil)-fenil)-4 -metil-2,5-dioxo-imidazolidin-1-il)-acetilamino)-3-fenil-propionicos

Country Status (24)

Country Link
US (1) US6294562B1 (es)
EP (1) EP0811616B1 (es)
JP (1) JP4249277B2 (es)
KR (1) KR980002029A (es)
CN (1) CN1104420C (es)
AR (1) AR008993A1 (es)
AT (1) ATE294783T1 (es)
AU (1) AU717106B2 (es)
BR (1) BR9703459A (es)
CA (1) CA2206748C (es)
CZ (1) CZ292672B6 (es)
DE (2) DE19622489A1 (es)
ES (1) ES2241016T3 (es)
HK (1) HK1006359A1 (es)
HR (1) HRP970309B1 (es)
HU (1) HUP9700998A3 (es)
IL (1) IL120984A (es)
MX (1) MX9704128A (es)
NO (1) NO307999B1 (es)
PL (1) PL320355A1 (es)
RU (1) RU2174119C2 (es)
SK (1) SK70897A3 (es)
TR (1) TR199700457A2 (es)
ZA (1) ZA974912B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19647380A1 (de) * 1996-11-15 1998-05-20 Hoechst Ag 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
US7544681B2 (en) 2001-09-27 2009-06-09 Ramot At Tel Aviv University Ltd. Conjugated psychotropic drugs and uses thereof
DK1670785T3 (da) * 2003-10-02 2010-10-18 Pharmacia & Upjohn Co Llc Salte og polymorphe former af en pyrrolsubstitueret indolinonforbindelse
ES2400772T3 (es) * 2005-06-07 2013-04-12 Ramot At Tel Aviv University Ltd. Sales novedosas de fármacos psicotrópicos conjugados y procedimientos para la preparación de las mismas
US8377990B2 (en) 2006-07-17 2013-02-19 Ramot At Tel-Aviv University Ltd. Conjugates comprising a psychotropic drug or a GABA agonist and an organic acid and their use in treating pain and other CNS disorders
EP2252578B1 (en) 2008-02-11 2012-08-01 Ramot at Tel Aviv University Ltd. Conjugates for treating neurodegenerative diseases and disorders
JP2013513600A (ja) 2009-12-09 2013-04-22 バイオラインアールエックス リミテッド 認知機能改善方法
WO2011104637A2 (en) 2010-02-24 2011-09-01 Ramot At Tel-Aviv University Ltd. Crystalline forms of the tri-mesylate salt of perphenazine-gaba and process of producing the same
WO2012038963A1 (en) 2010-09-22 2012-03-29 Ramot At Tel-Aviv University Ltd. An acid addition salt of a nortriptyline-gaba conjugate and a process of preparing same
TWI856956B (zh) * 2018-04-12 2024-10-01 美商莫菲克醫療股份有限公司 人類整合素α４β７拮抗劑
WO2021076902A1 (en) 2019-10-16 2021-04-22 Morphic Therapeutic, Inc. INHIBITING HUMAN INTEGRIN α 4 β 7

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4126277A1 (de) * 1991-08-08 1993-02-11 Cassella Ag Hydantoinderivate
DE4213634A1 (de) * 1992-04-24 1993-10-28 Cassella Ag 2,4-Dioxo-imidazolidin-Derivate
DE4224414A1 (de) 1992-07-24 1994-01-27 Cassella Ag Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung
DE4308034A1 (de) 1993-03-13 1994-09-15 Cassella Ag Neue Heterocyclen, ihre Herstellung und ihre Verwendung
DE4309867A1 (de) 1993-03-26 1994-09-29 Cassella Ag Neue Harnstoffderivate, ihre Herstellung und Verwendung
DE4427979A1 (de) 1993-11-15 1996-02-15 Cassella Ag Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung
DE19515177A1 (de) * 1995-04-28 1996-10-31 Cassella Ag Hydantoinderivate als Zwischenprodukte für pharmazeutische Wirkstoffe

Also Published As

Publication number Publication date
DE19622489A1 (de) 1997-12-11
US6294562B1 (en) 2001-09-25
MX9704128A (es) 1997-12-31
NO307999B1 (no) 2000-07-03
CA2206748A1 (en) 1997-12-05
NO972506D0 (no) 1997-06-02
AU2467497A (en) 1997-12-11
JP4249277B2 (ja) 2009-04-02
AU717106B2 (en) 2000-03-16
TR199700457A2 (xx) 1997-12-21
CN1174835A (zh) 1998-03-04
JPH1059948A (ja) 1998-03-03
ATE294783T1 (de) 2005-05-15
BR9703459A (pt) 1998-10-06
HUP9700998A3 (en) 1999-03-01
HUP9700998A1 (hu) 1998-03-30
HRP970309B1 (en) 2002-06-30
HK1006359A1 (en) 1999-02-26
KR980002029A (ko) 1998-03-30
DE59712294D1 (de) 2005-06-09
HU9700998D0 (en) 1997-07-28
HRP970309A2 (en) 1998-04-30
CZ292672B6 (cs) 2003-11-12
CN1104420C (zh) 2003-04-02
EP0811616A1 (de) 1997-12-10
ES2241016T3 (es) 2005-10-16
ZA974912B (en) 1997-12-05
CZ172997A3 (en) 1997-12-17
PL320355A1 (en) 1997-12-08
SK70897A3 (en) 1999-05-07
NO972506L (no) 1997-12-08
RU2174119C2 (ru) 2001-09-27
EP0811616B1 (de) 2005-05-04
IL120984A0 (en) 1997-11-20
IL120984A (en) 2001-08-26
CA2206748C (en) 2007-05-01

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