IL119273A - Enantiomerically enriched or enantiomerically pure cis-3-methoxy-4-aminopiperidines and their preparation - Google Patents

Enantiomerically enriched or enantiomerically pure cis-3-methoxy-4-aminopiperidines and their preparation

Info

Publication number: IL119273A
Authority: IL; Israel
Prior art keywords: pct; methoxy; enantiomerically; aminopiperidines; date jun
Prior art date: 1992-11-20

Application number

IL11927393A

Other languages

English (en)

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-20

Filing date

1993-11-18

Publication date

2000-07-16

1993-11-18 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2000-07-16 Publication of IL119273A publication Critical patent/IL119273A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Addiction (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrane Compounds (AREA)
Dental Preparations (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

IL11927393A 1992-11-20 1993-11-18 Enantiomerically enriched or enantiomerically pure cis-3-methoxy-4-aminopiperidines and their preparation IL119273A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US97901392A	1992-11-20	1992-11-20
IL107654A IL107654A (en)	1992-11-20	1993-11-18	Use of N -]]]) 3,4-Dihydro-4-oxo-2-pyrimidyl (amino [alkyl] -4-piperidinyl [2,2-dimethyl-7-benzopuran-and-benzopyran

Publications (1)

Publication Number	Publication Date
IL119273A true IL119273A (en)	2000-07-16

Family

ID=25526607

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL11927393A IL119273A (en)	1992-11-20	1993-11-18	Enantiomerically enriched or enantiomerically pure cis-3-methoxy-4-aminopiperidines and their preparation
IL107654A IL107654A (en)	1992-11-20	1993-11-18	Use of N -]]]) 3,4-Dihydro-4-oxo-2-pyrimidyl (amino [alkyl] -4-piperidinyl [2,2-dimethyl-7-benzopuran-and-benzopyran
IL11927396A IL119273A0 (en)	1992-11-20	1993-11-18	3-Methoxy-4-amino-piperidines and their preparation

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
IL107654A IL107654A (en)	1992-11-20	1993-11-18	Use of N -]]]) 3,4-Dihydro-4-oxo-2-pyrimidyl (amino [alkyl] -4-piperidinyl [2,2-dimethyl-7-benzopuran-and-benzopyran
IL11927396A IL119273A0 (en)	1992-11-20	1993-11-18	3-Methoxy-4-amino-piperidines and their preparation

Country Status (31)

Country	Link
US (2)	US5674868A (sv)
EP (1)	EP0669919B1 (sv)
JP (1)	JP2830952B2 (sv)
KR (1)	KR0166661B1 (sv)
AT (1)	ATE176232T1 (sv)
AU (1)	AU680640B2 (sv)
BG (1)	BG62489B1 (sv)
BR (1)	BR9307477A (sv)
CA (1)	CA2149044C (sv)
CZ (1)	CZ287262B6 (sv)
DE (1)	DE69323322T2 (sv)
DK (1)	DK0669919T3 (sv)
ES (1)	ES2129615T3 (sv)
FI (1)	FI952458A (sv)
GR (1)	GR3029831T3 (sv)
HU (2)	HUT72740A (sv)
IL (3)	IL119273A (sv)
LV (1)	LV10956B (sv)
MX (1)	MX9307257A (sv)
NO (2)	NO307690B1 (sv)
NZ (1)	NZ257854A (sv)
OA (1)	OA10158A (sv)
PL (1)	PL176051B1 (sv)
RO (1)	RO115160B1 (sv)
RU (1)	RU2116072C1 (sv)
SG (1)	SG47488A1 (sv)
SK (1)	SK282378B6 (sv)
TW (1)	TW294595B (sv)
UA (1)	UA49792C2 (sv)
WO (1)	WO1994012494A1 (sv)
ZA (1)	ZA938676B (sv)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5374637A (en) *	1989-03-22	1994-12-20	Janssen Pharmaceutica N.V.	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
CA2286076C (en)	1997-04-18	2006-12-12	Janssen Pharmaceutica N.V.	Use of 5ht3 antagonists for promoting intestinal lavage
JP3529102B2 (ja) *	1997-07-11	2004-05-24	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	５−ｈｔ３および５−ｈｔ４介在性障害に有用な（＋）−ノルシサプリド
US6239122B1 (en) *	2000-01-05	2001-05-29	Joy Ann Steele	Method of treatment of nausea, vomiting, and other disorders using estrogens
EP1646615B1 (en) *	2003-06-06	2009-08-26	Vertex Pharmaceuticals Incorporated	Pyrimidine derivatives as modulators of atp-binding cassette transporters
SG150533A1 (en)	2003-11-20	2009-03-30	Janssen Pharmaceutica Nv	6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2- quinoxalinones as poly(adp-ribose) polymerase inhibitors
CN1882549B (zh)	2003-11-20	2011-02-23	詹森药业有限公司	用作聚(adp-核糖)聚合酶抑制剂的7-苯基烷基取代的2-喹啉酮和2-喹喔啉酮
US7803795B2 (en)	2004-06-30	2010-09-28	Janssen Pharmaceutica N.V.	Phthalazine derivatives as parp inhibitors
AU2005259190B2 (en)	2004-06-30	2011-05-12	Janssen Pharmaceutica N.V.	Quinazolinedione derivatives as PARP inhibitors
KR101286969B1 (ko)	2004-06-30	2013-07-23	얀센 파마슈티카 엔.브이.	Ｐａｒｐ 저해제로서의 퀴나졸리논 유도체
ES2381446T3 (es)	2007-03-08	2012-05-28	Janssen Pharmaceutica, N.V.	Derivado de quinolinona como inhibidores de PARP y TANK
ES2448870T3 (es)	2007-10-26	2014-03-17	Janssen Pharmaceutica, N.V.	Derivados de quinolina como inhibidores de PARP
CA2716088C (en)	2008-03-27	2017-03-07	Eddy Jean Edgard Freyne	Quinazolinone derivatives as tubulin polymerization inhibitors
MX2010010406A (es)	2008-03-27	2010-10-25	Janssen Pharmaceutica Nv	Tetrahidrofenantridinonas y tetrahidrociclopentaquinolinonas como inhibidores de la polimerizacion de poli(adp-ribosa)polimerasa-1 y tubulina.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1183847A (en) *	1981-10-01	1985-03-12	Georges Van Daele	N-(3-hydroxy-4-piperidinyl)benzamide derivatives
ZW12187A1 (en) *	1986-07-03	1989-02-01	Janssen Pharmaceutica Nv	4-(aroylamino)piperidinebutanamide derivatives
CA1317940C (en) *	1987-09-25	1993-05-18	Georges H. P. Van Daele	Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5374637A (en) *	1989-03-22	1994-12-20	Janssen Pharmaceutica N.V.	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) *	1990-03-06	1990-05-02	Janssen Pharmaceutica Nv	N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives

1993
- 1993-11-03 TW TW082109153A patent/TW294595B/zh active
- 1993-11-15 RO RO95-00941A patent/RO115160B1/ro unknown
- 1993-11-15 PL PL93309045A patent/PL176051B1/pl not_active IP Right Cessation
- 1993-11-15 SG SG1996002238A patent/SG47488A1/en unknown
- 1993-11-15 AT AT94900151T patent/ATE176232T1/de not_active IP Right Cessation
- 1993-11-15 NZ NZ257854A patent/NZ257854A/en unknown
- 1993-11-15 AU AU54659/94A patent/AU680640B2/en not_active Ceased
- 1993-11-15 BR BR9307477A patent/BR9307477A/pt not_active Application Discontinuation
- 1993-11-15 WO PCT/EP1993/003206 patent/WO1994012494A1/en active IP Right Grant
- 1993-11-15 CA CA002149044A patent/CA2149044C/en not_active Expired - Fee Related
- 1993-11-15 DE DE69323322T patent/DE69323322T2/de not_active Expired - Fee Related
- 1993-11-15 SK SK675-95A patent/SK282378B6/sk unknown
- 1993-11-15 JP JP6512708A patent/JP2830952B2/ja not_active Expired - Fee Related
- 1993-11-15 KR KR1019950701615A patent/KR0166661B1/ko not_active IP Right Cessation
- 1993-11-15 DK DK94900151T patent/DK0669919T3/da active
- 1993-11-15 US US08/416,914 patent/US5674868A/en not_active Expired - Fee Related
- 1993-11-15 HU HU9501476A patent/HUT72740A/hu unknown
- 1993-11-15 RU RU95113434A patent/RU2116072C1/ru not_active IP Right Cessation
- 1993-11-15 UA UA95048357A patent/UA49792C2/uk unknown
- 1993-11-15 CZ CZ19951258A patent/CZ287262B6/cs not_active IP Right Cessation
- 1993-11-15 ES ES94900151T patent/ES2129615T3/es not_active Expired - Lifetime
- 1993-11-15 EP EP94900151A patent/EP0669919B1/en not_active Expired - Lifetime
- 1993-11-18 IL IL11927393A patent/IL119273A/xx not_active IP Right Cessation
- 1993-11-18 IL IL107654A patent/IL107654A/en not_active IP Right Cessation
- 1993-11-18 IL IL11927396A patent/IL119273A0/xx unknown
- 1993-11-19 ZA ZA938676A patent/ZA938676B/xx unknown
- 1993-11-19 MX MX9307257A patent/MX9307257A/es unknown
1995
- 1995-04-20 BG BG99593A patent/BG62489B1/bg unknown
- 1995-05-19 OA OA60663A patent/OA10158A/en unknown
- 1995-05-19 NO NO951980A patent/NO307690B1/no unknown
- 1995-05-19 FI FI952458A patent/FI952458A/sv unknown
- 1995-06-20 LV LVP-95-184A patent/LV10956B/en unknown
- 1995-06-30 HU HU95P/P00699P patent/HU211546A9/hu unknown
1997
- 1997-05-01 US US08/848,777 patent/US5863923A/en not_active Expired - Fee Related
1999
- 1999-03-31 GR GR990400922T patent/GR3029831T3/el unknown
- 1999-11-24 NO NO995762A patent/NO308530B1/no unknown

Also Published As

Publication number	Publication date
ATE176232T1 (de)	1999-02-15
BR9307477A (pt)	1999-06-29
IL119273A0 (en)	1996-12-05
RU95113434A (ru)	1997-03-10
WO1994012494A1 (en)	1994-06-09
US5674868A (en)	1997-10-07
HUT72740A (en)	1996-05-28
PL176051B1 (pl)	1999-03-31
PL309045A1 (en)	1995-09-18
DE69323322T2 (de)	1999-09-09
UA49792C2 (uk)	2002-10-15
FI952458A0 (sv)	1995-05-19
KR0166661B1 (ko)	1999-01-15
EP0669919A1 (en)	1995-09-06
SK282378B6 (sk)	2002-01-07
CA2149044A1 (en)	1994-06-09
HU9501476D0 (en)	1995-07-28
NO308530B1 (no)	2000-09-25
MX9307257A (es)	1994-05-31
OA10158A (en)	1996-12-18
DE69323322D1 (de)	1999-03-11
NO951980D0 (no)	1995-05-19
IL107654A (en)	1998-01-04
ZA938676B (en)	1995-05-19
SK67595A3 (en)	1995-11-08
NO951980L (no)	1995-05-19
JPH08505840A (ja)	1996-06-25
GR3029831T3 (en)	1999-06-30
CA2149044C (en)	2007-04-03
NO307690B1 (no)	2000-05-15
BG99593A (en)	1995-12-29
CZ125895A3 (en)	1995-10-18
FI952458A (sv)	1995-05-19
LV10956B (en)	1996-10-20
AU5465994A (en)	1994-06-22
RU2116072C1 (ru)	1998-07-27
TW294595B (sv)	1997-01-01
RO115160B1 (ro)	1999-11-30
CZ287262B6 (en)	2000-10-11
BG62489B1 (bg)	1999-12-30
IL107654A0 (en)	1994-02-27
US5863923A (en)	1999-01-26
NO995762D0 (no)	1999-11-24
DK0669919T3 (da)	1999-09-13
SG47488A1 (en)	1998-04-17
JP2830952B2 (ja)	1998-12-02
AU680640B2 (en)	1997-08-07
HU211546A9 (en)	1995-12-28
EP0669919B1 (en)	1999-01-27
NZ257854A (en)	1997-04-24
LV10956A (lv)	1995-12-20
NO995762L (no)	1995-05-19
ES2129615T3 (es)	1999-06-16

Publication	Publication Date	Title
IL119273A (en)	2000-07-16	Enantiomerically enriched or enantiomerically pure cis-3-methoxy-4-aminopiperidines and their preparation
AU6073596A (en)	1996-10-03	Intermediates useful in the preparation of 5-HT4 receptor antagonists
GB9204365D0 (en)	1992-04-08	Indoles
TW261614B (sv)	1995-11-01
IL113254A (en)	1999-03-12	Substituted azolone derivatives their preparation and pharmaceutical compositions containing them
PH31308A (en)	1998-07-06	Positive inotropic and lusitropic pyrroloquinolinone derivatives.
SE9202218D0 (sv)	1992-07-22	Pharmacologically active alfa-(tertiary-aminomethyl)-benzenemethanol derivatives, pharmaceutical composition containing them, therapeutical use thereof and processes for their preparation
ES8307778A1 (es)	1983-08-16	Procedimiento para preparar difenilbutil-1-piperazinocarboxilatos.
LTIP1450A (en)	1994-10-25	Azaspiroalkane derivatives,processes for their preparation and pharmaceutical compositions containing them

Legal Events

Date	Code	Title
2000-11-21	FF	Patent granted
2004-01-04	KB	Patent renewed
2008-11-03	MM9K	Patent not in force due to non-payment of renewal fees