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IL116385A - Sulphonamides their manufacture and pharmaceutical compositions containing them - Google Patents

Sulphonamides their manufacture and pharmaceutical compositions containing them

Info

Publication number
IL116385A
IL116385A IL11638595A IL11638595A IL116385A IL 116385 A IL116385 A IL 116385A IL 11638595 A IL11638595 A IL 11638595A IL 11638595 A IL11638595 A IL 11638595A IL 116385 A IL116385 A IL 116385A
Authority
IL
Israel
Prior art keywords
pct
pharmaceutical compositions
compositions containing
sulphonamides
manufacture
Prior art date
Application number
IL11638595A
Other languages
English (en)
Other versions
IL116385A0 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL116385A0 publication Critical patent/IL116385A0/xx
Publication of IL116385A publication Critical patent/IL116385A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Bipolar Transistors (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Lubricants (AREA)
  • Surgical Instruments (AREA)
IL11638595A 1994-12-20 1995-12-14 Sulphonamides their manufacture and pharmaceutical compositions containing them IL116385A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH383794 1994-12-20
CH241995 1995-08-24

Publications (2)

Publication Number Publication Date
IL116385A0 IL116385A0 (en) 1996-03-31
IL116385A true IL116385A (en) 2000-07-16

Family

ID=25690401

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11638595A IL116385A (en) 1994-12-20 1995-12-14 Sulphonamides their manufacture and pharmaceutical compositions containing them

Country Status (26)

Country Link
US (1) US6004965A (de)
EP (1) EP0799209B1 (de)
JP (1) JP2989014B2 (de)
KR (1) KR100445085B1 (de)
CN (1) CN1098254C (de)
AT (1) ATE246681T1 (de)
AU (1) AU701767B2 (de)
BR (1) BR9510104A (de)
CA (1) CA2208018C (de)
CY (1) CY2495B1 (de)
CZ (1) CZ287916B6 (de)
DE (1) DE69531457T2 (de)
DK (1) DK0799209T3 (de)
ES (1) ES2203649T3 (de)
FI (1) FI120397B (de)
HK (1) HK1001973A1 (de)
HU (1) HU228619B1 (de)
IL (1) IL116385A (de)
MA (1) MA23744A1 (de)
MY (1) MY131126A (de)
NO (1) NO316645B1 (de)
NZ (1) NZ297797A (de)
PT (1) PT799209E (de)
SA (1) SA95160421B1 (de)
TW (1) TW313568B (de)
WO (1) WO1996019459A1 (de)

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ES2312179T3 (es) 1996-12-06 2009-02-16 Amgen Inc. Terapia combinada que utiliza un inhibidor del il-1 para el tratamiento de enfermedades mediadas por el il-1.
ES2221696T3 (es) * 1997-08-19 2005-01-01 F. Hoffmann-La Roche Ag Procedimiento para la preparacion de piridinas 2,5.disustituidas.
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
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AU2725000A (en) * 1999-01-13 2000-08-01 Bayer Corporation Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
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US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
US7351834B1 (en) 1999-01-13 2008-04-01 Bayer Pharmaceuticals Corporation ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
TWI284642B (en) 1999-01-18 2007-08-01 Hoffmann La Roche Novel heterocyclic sulfonamides
US6417360B1 (en) 1999-03-03 2002-07-09 Hoffmann-La Roche Inc. Heterocyclic sulfonamides
AU747596B2 (en) * 1999-05-22 2002-05-16 Actelion Pharmaceuticals Ltd Aqueous pharmaceutical composition
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CA2315614C (en) 1999-07-29 2004-11-02 Pfizer Inc. Pyrazoles
CN100424079C (zh) 1999-09-03 2008-10-08 埃科特莱茵药品有限公司 双磺胺
KR20020068373A (ko) * 1999-12-22 2002-08-27 액테리온 파마슈티칼 리미티드 부틴 디올 유도체
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US6387915B2 (en) 2000-05-31 2002-05-14 Pfizer Inc. Isoxazole-sulfonamide endothelin antagonists
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US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
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US7371763B2 (en) 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
EP1474393A1 (de) 2002-02-11 2004-11-10 Bayer Pharmaceuticals Corporation Aryl-harnstoffe als kinase inhibitoren
DK1478358T3 (da) 2002-02-11 2013-10-07 Bayer Healthcare Llc Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese
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KR101139557B1 (ko) 2003-07-23 2012-04-30 바이엘 파마슈티칼스 코포레이션 질환 및 상태의 치료 및 예방을 위한 플루오로 치환오메가-카르복시아릴 디페닐 우레아
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US7402730B1 (en) 2005-02-03 2008-07-22 Lexicon Pharmaceuticals, Inc. Knockout animals manifesting hyperlipidemia
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AR062501A1 (es) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd Composiciones terapeuticas
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MX2017009534A (es) 2015-01-23 2018-04-10 Novartis Ag Conjugados de acidos grasos y apelina sintetica con mayor vida media.
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
TWI835843B (zh) 2018-10-03 2024-03-21 瑞士商亨斯邁紡織染化（瑞士）有限公司 新的經吡啶及經嘧啶取代之三ｕｖ吸收劑
KR20230104232A (ko) 2020-11-05 2023-07-07 이도르시아 파마슈티컬스 리미티드 클라조센탄 디소듐 염의 안정한 결정성 수화물
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Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW270116B (de) * 1991-04-25 1996-02-11 Hoffmann La Roche
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
TW287160B (de) * 1992-12-10 1996-10-01 Hoffmann La Roche
TW394761B (en) * 1993-06-28 2000-06-21 Hoffmann La Roche Novel Sulfonylamino Pyrimidines
IL111959A (en) * 1993-12-17 2000-07-16 Tanabe Seiyaku Co N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AU701767B2 (en) 1999-02-04
MY131126A (en) 2007-07-31
FI972628A (fi) 1997-06-18
SA95160421B1 (ar) 2006-05-01
EP0799209A1 (de) 1997-10-08
ES2203649T3 (es) 2004-04-16
CN1098254C (zh) 2003-01-08
FI120397B (fi) 2009-10-15
HUT77884A (hu) 1998-09-28
BR9510104A (pt) 1997-11-25
HU228619B1 (en) 2013-04-29
DE69531457T2 (de) 2004-06-24
NZ297797A (en) 1999-10-28
CZ287916B6 (cs) 2001-03-14
FI972628A0 (fi) 1997-06-18
EP0799209B1 (de) 2003-08-06
DK0799209T3 (da) 2003-11-24
CZ187497A3 (en) 1997-10-15
AU4304196A (en) 1996-07-10
PT799209E (pt) 2003-12-31
JPH10509182A (ja) 1998-09-08
IL116385A0 (en) 1996-03-31
TW313568B (de) 1997-08-21
NO972538L (no) 1997-06-04
CA2208018A1 (en) 1996-06-27
ATE246681T1 (de) 2003-08-15
MA23744A1 (fr) 1996-07-01
DE69531457D1 (en) 2003-09-11
CY2495B1 (en) 2005-09-02
KR100445085B1 (ko) 2004-10-14
MX9704587A (es) 1998-07-31
CN1170407A (zh) 1998-01-14
NO316645B1 (no) 2004-03-22
US6004965A (en) 1999-12-21
HK1001973A1 (en) 1998-07-24
CA2208018C (en) 2007-03-27
WO1996019459A1 (en) 1996-06-27
NO972538D0 (no) 1997-06-04
JP2989014B2 (ja) 1999-12-13

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