IL116385A0 - Sulphonamides their manufacture and pharmaceutical compositions containing them - Google Patents
Sulphonamides their manufacture and pharmaceutical compositions containing themInfo
- Publication number
- IL116385A0 IL116385A0 IL11638595A IL11638595A IL116385A0 IL 116385 A0 IL116385 A0 IL 116385A0 IL 11638595 A IL11638595 A IL 11638595A IL 11638595 A IL11638595 A IL 11638595A IL 116385 A0 IL116385 A0 IL 116385A0
- Authority
- IL
- Israel
- Prior art keywords
- pct
- pharmaceutical compositions
- compositions containing
- sulphonamides
- manufacture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Bipolar Transistors (AREA)
- Lubricants (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Surgical Instruments (AREA)
- Steroid Compounds (AREA)
Abstract
PCT No. PCT/EP95/04843 Sec. 371 Date Aug. 15, 1997 Sec. 102(e) Date Aug. 15, 1997 PCT Filed Dec. 8, 1995 PCT Pub. No. WO96/19459 PCT Pub. Date Jun. 27, 1996Compounds of the formula: where A, B, R1-R8 are as described herein are endothelin inhibitors that can be used in treating diseases associated with endothelin, such as high blood pressure. Chemical synthesis of these compounds and pharmaceutical compositions containing these compounds are also useful.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH383794 | 1994-12-20 | ||
| CH241995 | 1995-08-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL116385A0 true IL116385A0 (en) | 1996-03-31 |
| IL116385A IL116385A (en) | 2000-07-16 |
Family
ID=25690401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11638595A IL116385A (en) | 1994-12-20 | 1995-12-14 | Sulphonamides their manufacture and pharmaceutical compositions containing them |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6004965A (en) |
| EP (1) | EP0799209B1 (en) |
| JP (1) | JP2989014B2 (en) |
| KR (1) | KR100445085B1 (en) |
| CN (1) | CN1098254C (en) |
| AT (1) | ATE246681T1 (en) |
| AU (1) | AU701767B2 (en) |
| BR (1) | BR9510104A (en) |
| CA (1) | CA2208018C (en) |
| CY (1) | CY2495B1 (en) |
| CZ (1) | CZ287916B6 (en) |
| DE (1) | DE69531457T2 (en) |
| DK (1) | DK0799209T3 (en) |
| ES (1) | ES2203649T3 (en) |
| FI (1) | FI120397B (en) |
| HK (1) | HK1001973A1 (en) |
| HU (1) | HU228619B1 (en) |
| IL (1) | IL116385A (en) |
| MA (1) | MA23744A1 (en) |
| MY (1) | MY131126A (en) |
| NO (1) | NO316645B1 (en) |
| NZ (1) | NZ297797A (en) |
| PT (1) | PT799209E (en) |
| SA (1) | SA95160421B1 (en) |
| TW (1) | TW313568B (en) |
| WO (1) | WO1996019459A1 (en) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6063911A (en) * | 1993-12-01 | 2000-05-16 | Marine Polymer Technologies, Inc. | Methods and compositions for treatment of cell proliferative disorders |
| TW555765B (en) | 1996-07-09 | 2003-10-01 | Amgen Inc | Low molecular weight soluble tumor necrosis factor type-I and type-II proteins |
| ATE406176T1 (en) | 1996-12-06 | 2008-09-15 | Amgen Inc | IL-1 INHIBITOR IN COMBINATION THERAPY FOR THE TREATMENT OF IL-1-MEDIATED DISEASES |
| EP0897914B1 (en) * | 1997-08-19 | 2004-05-26 | F. Hoffmann-La Roche Ag | Process for the preparation of 2,5-disubstitued pyridines |
| US7329670B1 (en) | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
| US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| ATE311382T1 (en) * | 1998-08-10 | 2005-12-15 | METHOD FOR PRODUCING 2-CARBAMOYL-PYRIDINES | |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| WO2000042012A1 (en) | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
| RU2319693C9 (en) | 1999-01-13 | 2008-08-20 | Байер Копэрейшн | Derivatives of urea (variants), pharmaceutical composition (variants) and method for treatment of diseases associated with cancer cells growth (variants) |
| US7928239B2 (en) | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
| JP2002534468A (en) * | 1999-01-13 | 2002-10-15 | バイエル コーポレイション | ω-Carboxyaryl-substituted diphenylureas as p38 kinase inhibitors |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| TWI284642B (en) * | 1999-01-18 | 2007-08-01 | Hoffmann La Roche | Novel heterocyclic sulfonamides |
| US6417360B1 (en) * | 1999-03-03 | 2002-07-09 | Hoffmann-La Roche Inc. | Heterocyclic sulfonamides |
| AU747596B2 (en) * | 1999-05-22 | 2002-05-16 | Actelion Pharmaceuticals Ltd | Aqueous pharmaceutical composition |
| ZA200002318B (en) * | 1999-05-22 | 2000-11-16 | Actelion Pharmaceuticals Ltd | Aqueous pharmaceutical composition. |
| CA2315614C (en) | 1999-07-29 | 2004-11-02 | Pfizer Inc. | Pyrazoles |
| CN100424079C (en) | 1999-09-03 | 2008-10-08 | 埃科特莱茵药品有限公司 | Bis-sulfonamides |
| AU3536701A (en) * | 1999-12-22 | 2001-07-03 | Actelion Pharmaceuticals Ltd | Butyne diol derivatives |
| WO2001081338A1 (en) * | 2000-04-25 | 2001-11-01 | Actelion Pharmaceuticals Ltd | Substituted sulfonylaminopyrimidines |
| US6387915B2 (en) | 2000-05-31 | 2002-05-14 | Pfizer Inc. | Isoxazole-sulfonamide endothelin antagonists |
| US6670362B2 (en) | 2000-09-20 | 2003-12-30 | Pfizer Inc. | Pyridazine endothelin antagonists |
| US8168616B1 (en) | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
| JP4245130B2 (en) * | 2000-12-18 | 2009-03-25 | アクテリオン ファーマシューティカルズ リミテッド | New sulfamides |
| US7235576B1 (en) | 2001-01-12 | 2007-06-26 | Bayer Pharmaceuticals Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| WO2002083650A1 (en) * | 2001-04-11 | 2002-10-24 | Actelion Pharmaceuticals Ltd | Novel sulfonylamino-pyrimidines |
| US7371763B2 (en) | 2001-04-20 | 2008-05-13 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
| US20030216396A1 (en) | 2002-02-11 | 2003-11-20 | Bayer Corporation | Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors |
| CN1318404C (en) | 2002-02-11 | 2007-05-30 | 拜耳制药公司 | Aryl ureas as kinase inhibitors |
| CA2475703C (en) | 2002-02-11 | 2016-12-20 | Bayer Pharmaceuticals Corporation | Aryl ureas with angiogenesis inhibiting activity |
| US20040002451A1 (en) | 2002-06-20 | 2004-01-01 | Bruce Kerwin | Compositions of pegylated soluble tumor necrosis factor receptors and methods of preparing |
| RU2329255C2 (en) * | 2002-12-02 | 2008-07-20 | Актелион Фармасьютиклз Лтд | Pyrimidinesulphamides and their use as antagonists of endothelial receptors |
| UY28213A1 (en) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | NEW CYANOPIRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS. |
| DE602004011340T2 (en) | 2003-05-20 | 2008-11-06 | Bayer Healthcare Llc | DIARYL-UREA SUBSTANCES WITH CHINESE-INHIBITING EFFECT |
| EP1663978B1 (en) | 2003-07-23 | 2007-11-28 | Bayer Pharmaceuticals Corporation | Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions |
| GB0327839D0 (en) | 2003-12-01 | 2003-12-31 | Novartis Ag | Organic compounds |
| AU2005224014B9 (en) | 2004-03-17 | 2009-08-27 | Novartis Ag | Use of organic compounds |
| TW200628467A (en) | 2004-11-11 | 2006-08-16 | Actelion Pharmaceuticals Ltd | Novel sulfamides |
| US7402730B1 (en) | 2005-02-03 | 2008-07-22 | Lexicon Pharmaceuticals, Inc. | Knockout animals manifesting hyperlipidemia |
| GT200600381A (en) | 2005-08-25 | 2007-03-28 | ORGANIC COMPOUNDS | |
| KR101149274B1 (en) | 2006-07-20 | 2012-05-29 | 노파르티스 아게 | Amino-piperidine derivatives as cetp inhibitors |
| AR062501A1 (en) | 2006-08-29 | 2008-11-12 | Actelion Pharmaceuticals Ltd | THERAPEUTIC COMPOSITIONS |
| ZA200904022B (en) | 2006-12-08 | 2010-08-25 | Lexicon Pharmaceuticals Inc | Monoclonal antibodies against ANGPTL3 |
| WO2008103345A2 (en) | 2007-02-19 | 2008-08-28 | Marine Polymer Technologies, Inc. | Hemostatic compositions and therapeutic regimens |
| MX2010001837A (en) | 2007-08-17 | 2010-03-10 | Actelion Pharmaceuticals Ltd | DERIVATIVES OF 4-PYRIMIDINASULFAMIDA. |
| FR2921062A1 (en) | 2007-09-17 | 2009-03-20 | Commissariat Energie Atomique | COMPOUNDS USEFUL AS LIGANDS AND IN PARTICULAR AS ORGANIC CHROMOPHORES FOR COMPLEXING LANTHANIDES AND THEIR APPLICATIONS |
| AR069165A1 (en) | 2007-11-05 | 2010-01-06 | Novartis Ag | DERIVATIVES OF 4-BENCILAMINO-1-CARBOXACILPIPERIDINA AS USEFUL CETP INHIBITORS FOR HYPERLIPIDEMIA TREATMENT |
| PT2229356E (en) | 2007-12-03 | 2012-01-20 | Novartis Ag | 1,2-disubstituted-4-benzylamino-pyrrolidine derivatives as cetp inhibitors useful for the treatment of diseases such as hyperli pidemia or arteriosclerosis |
| AU2010247391A1 (en) | 2009-05-15 | 2011-12-01 | Novartis Ag | Benzoxazolone derivatives as aldosterone synthase inhibitors |
| SI2429995T1 (en) | 2009-05-15 | 2014-05-30 | Novartis Ag | Aryl pyridine as aldosterone synthase inhibitors |
| MX2011012627A (en) | 2009-05-28 | 2011-12-14 | Novartis Ag | Substituted aminobutyric derivatives as neprilysin inhibitors. |
| NZ596304A (en) | 2009-05-28 | 2014-01-31 | Novartis Ag | Substituted aminopropionic derivatives as neprilysin inhibitors |
| US8519134B2 (en) | 2009-11-17 | 2013-08-27 | Novartis Ag | Aryl-pyridine derivatives as aldosterone synthase inhibitors |
| JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors |
| EP2507234B1 (en) | 2009-11-30 | 2014-03-12 | Novartis AG | Imidazole derivatives as aldosterone synthase inhibitors |
| US8858964B2 (en) | 2010-04-15 | 2014-10-14 | Marine Polymer Technologies, Inc. | Anti-bacterial applications of poly-N-acetylglucosamine nanofibers |
| US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
| US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
| SG189982A1 (en) | 2010-11-24 | 2013-06-28 | Lexicon Pharmaceuticals Inc | Antibodies to notum pectinacetylesterase |
| US20140127310A1 (en) | 2011-04-15 | 2014-05-08 | Marine Polymer Technologies, Inc. | Treatment of disease with poly-n-acetylglucosamine nanofibers |
| UY35144A (en) | 2012-11-20 | 2014-06-30 | Novartis Ag | APELINE SYNTHETIC LINEAR MIMETICS FOR THE CARDIAC INSUFFICIENCY TREATMENT |
| US9383357B2 (en) | 2012-12-07 | 2016-07-05 | Northwestern University | Biomarker for replicative senescence |
| AP2015008621A0 (en) | 2013-02-14 | 2015-07-31 | Novartis Ag | Substituted bisphenyl butanoic nep 'neutral endopeptidase' inhibitors |
| CN105705167A (en) | 2013-07-25 | 2016-06-22 | 诺华股份有限公司 | Bioconjugates of synthetic APELIN polypeptides |
| CN105612172A (en) | 2013-07-25 | 2016-05-25 | 诺华股份有限公司 | Cyclic polypeptides for the treatment of heart failure |
| PE20171328A1 (en) | 2015-01-23 | 2017-09-12 | Novartis Ag | CONJUGATES OF FATTY ACIDS AND SYNTHETIC APELLIN WITH LONGER HALF-LIFE |
| UY38072A (en) | 2018-02-07 | 2019-10-01 | Novartis Ag | COMPOSITIONS DERIVED FROM BUTANOIC ESTER SUBSTITUTED WITH BISPHENYL AS INHIBITORS OF NEP, COMPOSITIONS AND COMBINATIONS OF THE SAME |
| TWI835843B (en) | 2018-10-03 | 2024-03-21 | 瑞士商亨斯邁紡織染化（瑞士）有限公司 | New pyridine- and pyrimidine-substituted triazine uv absorbers |
| US20230373967A1 (en) | 2020-11-05 | 2023-11-23 | Idorsia Pharmaceuticals Ltd | A stable crystalline hydrate of clazosentan disodium salt |
| EP4448511A1 (en) | 2021-12-17 | 2024-10-23 | Idorsia Pharmaceuticals Ltd | Clazosentan disodium salt, its preparation and pharmaceutical compositions comprising the same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW270116B (en) * | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
| RU2086544C1 (en) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Benzenesulfonamide derivatives of pyrimidine or their salts, pharmaceutical composition for treatment of diseases associated with endothelin activity |
| TW287160B (en) * | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
| TW394761B (en) * | 1993-06-28 | 2000-06-21 | Hoffmann La Roche | Novel Sulfonylamino Pyrimidines |
| IL111959A (en) * | 1993-12-17 | 2000-07-16 | Tanabe Seiyaku Co | N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them |
-
1995
- 1995-11-11 TW TW084111957A patent/TW313568B/zh not_active IP Right Cessation
- 1995-11-29 SA SA95160421A patent/SA95160421B1/en unknown
- 1995-12-08 CZ CZ19971874A patent/CZ287916B6/en not_active IP Right Cessation
- 1995-12-08 DE DE69531457T patent/DE69531457T2/en not_active Expired - Lifetime
- 1995-12-08 HU HU9702407A patent/HU228619B1/en unknown
- 1995-12-08 BR BR9510104A patent/BR9510104A/en not_active IP Right Cessation
- 1995-12-08 NZ NZ297797A patent/NZ297797A/en not_active IP Right Cessation
- 1995-12-08 EP EP95941706A patent/EP0799209B1/en not_active Expired - Lifetime
- 1995-12-08 CA CA002208018A patent/CA2208018C/en not_active Expired - Lifetime
- 1995-12-08 KR KR1019970704135A patent/KR100445085B1/en not_active Expired - Lifetime
- 1995-12-08 ES ES95941706T patent/ES2203649T3/en not_active Expired - Lifetime
- 1995-12-08 AU AU43041/96A patent/AU701767B2/en not_active Expired
- 1995-12-08 PT PT95941706T patent/PT799209E/en unknown
- 1995-12-08 AT AT95941706T patent/ATE246681T1/en active
- 1995-12-08 CN CN95196948A patent/CN1098254C/en not_active Expired - Lifetime
- 1995-12-08 DK DK95941706T patent/DK0799209T3/en active
- 1995-12-08 JP JP8519469A patent/JP2989014B2/en not_active Expired - Lifetime
- 1995-12-08 WO PCT/EP1995/004843 patent/WO1996019459A1/en active IP Right Grant
- 1995-12-08 US US08/860,107 patent/US6004965A/en not_active Expired - Lifetime
- 1995-12-14 IL IL11638595A patent/IL116385A/en not_active IP Right Cessation
- 1995-12-15 MA MA24095A patent/MA23744A1/en unknown
- 1995-12-18 MY MYPI95003923A patent/MY131126A/en unknown
-
1997
- 1997-06-04 NO NO19972538A patent/NO316645B1/en not_active IP Right Cessation
- 1997-06-18 FI FI972628A patent/FI120397B/en not_active IP Right Cessation
-
1998
- 1998-02-09 HK HK98100968A patent/HK1001973A1/en not_active IP Right Cessation
-
2004
- 2004-12-14 CY CY0400089A patent/CY2495B1/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL116385A (en) | Sulphonamides their manufacture and pharmaceutical compositions containing them | |
| IL111077A (en) | Pyridine derivatives processes for the preparation thereof and pharmaceutical compositions containing them | |
| TR27835A (en) | Substituted azadioxacycloalkenes. | |
| AU687911B2 (en) | Novel benzoyl guanidines, their production and their use in medicaments | |
| KR960701051A (en) | IMIDAZOPYRIDINES AND THEIR USE IN TREATING CASTROINTESTINAL DISEASES | |
| BG103399A (en) | New heterocycle-substituted benzamides and their application for the treatment of diseases | |
| AU2672995A (en) | {a}-annelated pyrrole derivatives and pharmaceutical uses thereof | |
| ZA959451B (en) | 2,2-Dichloroalkanecarboxylic acids process of their production and pharmaceutical agents containing these | |
| IL116231A (en) | Dipeptide p-amidinobenzylamides with n-terminal sulfonyl or aminosulfonyl radicals as thrombin inhibitors | |
| HUT76271A (en) | Substituted aminoalkylaminopyridines, process for producing them and their use | |
| IL117734A0 (en) | Beta-carbolines and pharmaceutical compositions containing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |