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IL111127A - Short-acting calcium antagonist dihydropyridines process for their preparation and pharmaceutical compositions containing them - Google Patents

Short-acting calcium antagonist dihydropyridines process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL111127A
IL111127A IL11112794A IL11112794A IL111127A IL 111127 A IL111127 A IL 111127A IL 11112794 A IL11112794 A IL 11112794A IL 11112794 A IL11112794 A IL 11112794A IL 111127 A IL111127 A IL 111127A
Authority
IL
Israel
Prior art keywords
hydrogen
pct
preparation
dihydropyridines
short
Prior art date
Application number
IL11112794A
Other languages
English (en)
Other versions
IL111127A0 (en
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of IL111127A0 publication Critical patent/IL111127A0/xx
Publication of IL111127A publication Critical patent/IL111127A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
IL11112794A 1993-11-05 1994-10-03 Short-acting calcium antagonist dihydropyridines process for their preparation and pharmaceutical compositions containing them IL111127A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9303657A SE9303657D0 (sv) 1993-11-05 1993-11-05 Short-acting dihydropyridines

Publications (2)

Publication Number Publication Date
IL111127A0 IL111127A0 (en) 1994-12-29
IL111127A true IL111127A (en) 2000-11-21

Family

ID=20391655

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11112794A IL111127A (en) 1993-11-05 1994-10-03 Short-acting calcium antagonist dihydropyridines process for their preparation and pharmaceutical compositions containing them

Country Status (36)

Country Link
US (1) US5856346A (xx)
EP (1) EP0726894B1 (xx)
JP (1) JP3712209B2 (xx)
KR (1) KR100331663B1 (xx)
CN (1) CN1049428C (xx)
AT (1) ATE194330T1 (xx)
AU (1) AU685532B2 (xx)
BR (1) BR9407946A (xx)
CA (1) CA2174969C (xx)
CZ (1) CZ285691B6 (xx)
DE (1) DE69425152T2 (xx)
DK (1) DK0726894T3 (xx)
EE (1) EE03230B1 (xx)
EG (1) EG20539A (xx)
ES (1) ES2150544T3 (xx)
FI (1) FI110429B (xx)
FR (1) FR12C0053I2 (xx)
GR (1) GR3034469T3 (xx)
HK (1) HK1013292A1 (xx)
HU (1) HU215591B (xx)
IL (1) IL111127A (xx)
IS (1) IS1674B (xx)
LU (1) LU92209I2 (xx)
MY (1) MY111770A (xx)
NO (1) NO305656B1 (xx)
NZ (1) NZ275915A (xx)
PL (1) PL185099B1 (xx)
PT (1) PT726894E (xx)
RU (1) RU2139278C1 (xx)
SA (1) SA94150250B1 (xx)
SE (1) SE9303657D0 (xx)
SK (1) SK281467B6 (xx)
TW (1) TW279859B (xx)
UA (1) UA45959C2 (xx)
WO (1) WO1995012578A1 (xx)
ZA (1) ZA947570B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9804002D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New manufacturing process
KR100976291B1 (ko) * 2001-12-21 2010-08-16 알콘, 인코퍼레이티드 안과용 조성물중의 살생물제에 대한 담체로서 나노입자의용도
FR2922439B1 (fr) * 2007-10-18 2010-12-10 Hill Rom Ind Sa Procede de gonflage alterne d'un dispositif de support a cellules gonflables et dispositif pour sa mise en oeuvre
AU2009276560B2 (en) * 2008-08-01 2015-04-16 Chiesi Farmaceutici S.P.A. Pharmaceutical compositions and methods for producing low impurity concentrations of the same
KR101644286B1 (ko) * 2009-09-30 2016-08-10 마이크로도스 테라퓨특스, 인코포레이티드 레이노 증후군의 치료를 위한 방법들 및 조성물들
CN101780036B (zh) * 2010-03-30 2011-11-16 武汉武药科技有限公司 丁酸氯维地平脂微球注射液及其制备方法
CA2701087A1 (en) * 2010-04-12 2011-10-12 Alphora Research Inc. Preparation of clevidipine butyrate ring the same
EP2386544B1 (en) 2010-05-07 2016-02-10 Laboratorios Lesvi, S.L. Preparation of dihydropyridines
US8455655B2 (en) 2010-05-07 2013-06-04 Laboratorios Lesvi, S.L. Preparation of dihydropyridines
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
CN103237446B (zh) 2010-10-12 2014-11-05 医药公司 含有抗微生物剂的氯维地平乳剂制剂
CA2832066C (en) 2011-04-01 2023-04-18 The Medicines Company Short-acting dihydropyridines (clevidipine) for use in reducing stroke damage
AU2012303683B2 (en) 2011-08-26 2016-09-08 Wockhardt Limited Methods for treating cardiovascular disorders
CN103420899B (zh) * 2012-05-25 2016-01-27 四川科伦药物研究有限公司 一种丁酸氯维地平的纯化方法
CN110840890A (zh) 2012-10-26 2020-02-28 凯西制药公司 用于在心力衰竭中控制血压和减轻呼吸困难的方法
CN103086956B (zh) * 2013-01-17 2015-11-04 北京嘉林药业股份有限公司 一种丁酸氯维地平中间体的纯化方法
CN103073485B (zh) * 2013-01-17 2015-09-02 北京嘉林药业股份有限公司 一种丁酸氯维地平的制备方法
US11737989B2 (en) 2014-05-19 2023-08-29 Chiesi Farmaceutici S.P.A. Clevidipine nanoparticles and pharmaceutical compositions thereof
CN105367487A (zh) * 2014-08-23 2016-03-02 南京海纳医药科技有限公司 一种丁酸氯维地平重要中间体新的合成方法
CN104370802A (zh) * 2014-09-24 2015-02-25 北京蓝丹医药科技有限公司 氯维地平衍生物及其制备方法
JP7045191B2 (ja) 2015-05-20 2022-03-31 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 駆虫性デプシペプチド化合物
KR102427124B1 (ko) 2015-12-28 2022-07-28 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 뎁시펩티드 화합물
BR112019009977A2 (pt) 2016-11-16 2019-08-27 Boehringer Ingelheim Animal Health Usa Inc compostos depsipeptídicos anti-helmínticos
RU2755349C1 (ru) * 2021-02-16 2021-09-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US4154839A (en) * 1975-11-05 1979-05-15 Bayer Aktiengesellschaft 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
KR940003492B1 (ko) * 1988-10-27 1994-04-23 주식회사 유한양행 1,4-디하이드로피리딘유도체 및 그의 제조방법
US5134139A (en) * 1989-08-31 1992-07-28 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and preparation thereof
JPH0641075A (ja) * 1990-09-01 1994-02-15 Kazuo Achinami 新規な１，４−ジヒドロピリジン化合物及びその製造方法

Also Published As

Publication number Publication date
HU9601187D0 (en) 1996-07-29
DK0726894T3 (da) 2000-10-23
EP0726894B1 (en) 2000-07-05
NZ275915A (en) 1997-04-24
NO305656B1 (no) 1999-07-05
EP0726894A1 (en) 1996-08-21
KR100331663B1 (ko) 2002-09-26
JP3712209B2 (ja) 2005-11-02
UA45959C2 (uk) 2002-05-15
FR12C0053I1 (xx) 2012-02-11
NO961776D0 (no) 1996-05-02
FI961914A0 (fi) 1996-05-06
AU8119694A (en) 1995-05-23
ES2150544T3 (es) 2000-12-01
GR3034469T3 (en) 2000-12-29
JPH09504542A (ja) 1997-05-06
SK281467B6 (sk) 2001-04-09
SA94150250B1 (ar) 2006-03-01
SK55996A3 (en) 1996-12-04
MY111770A (en) 2000-12-30
CN1137269A (zh) 1996-12-04
FI110429B (fi) 2003-01-31
HU215591B (hu) 1999-01-28
HUT75316A (en) 1997-05-28
CZ285691B6 (cs) 1999-10-13
PT726894E (pt) 2000-10-31
NO961776L (no) 1996-05-02
TW279859B (xx) 1996-07-01
EE03230B1 (et) 1999-10-15
US5856346A (en) 1999-01-05
IS1674B (is) 1997-12-31
EG20539A (en) 1999-07-31
BR9407946A (pt) 1996-11-26
CN1049428C (zh) 2000-02-16
FI961914A (fi) 1996-05-06
PL314128A1 (en) 1996-08-19
SE9303657D0 (sv) 1993-11-05
CZ127396A3 (en) 1996-09-11
IS4218A (is) 1995-05-06
AU685532B2 (en) 1998-01-22
RU2139278C1 (ru) 1999-10-10
ZA947570B (en) 1995-05-29
LU92209I2 (fr) 2013-08-23
PL185099B1 (pl) 2003-02-28
DE69425152D1 (de) 2000-08-10
IL111127A0 (en) 1994-12-29
ATE194330T1 (de) 2000-07-15
CA2174969C (en) 2005-05-17
HK1013292A1 (en) 1999-08-20
DE69425152T2 (de) 2001-03-22
CA2174969A1 (en) 1995-05-11
FR12C0053I2 (fr) 2013-08-16
WO1995012578A1 (en) 1995-05-11

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