[go: up one dir, main page]

IL110509A - Pyrimido Compounds [D-5,4] Pyrimidine 2,4,8-Trimot preparation preparations and pharmaceutical preparations containing them - Google Patents

Pyrimido Compounds [D-5,4] Pyrimidine 2,4,8-Trimot preparation preparations and pharmaceutical preparations containing them

Info

Publication number
IL110509A
IL110509A IL110509A IL11050994A IL110509A IL 110509 A IL110509 A IL 110509A IL 110509 A IL110509 A IL 110509A IL 11050994 A IL11050994 A IL 11050994A IL 110509 A IL110509 A IL 110509A
Authority
IL
Israel
Prior art keywords
piperidino
pyrimido
pyrimidine
morpholino
methyl
Prior art date
Application number
IL110509A
Other languages
English (en)
Hebrew (he)
Other versions
IL110509A0 (en
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of IL110509A0 publication Critical patent/IL110509A0/xx
Publication of IL110509A publication Critical patent/IL110509A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL110509A 1993-08-02 1994-07-29 Pyrimido Compounds [D-5,4] Pyrimidine 2,4,8-Trimot preparation preparations and pharmaceutical preparations containing them IL110509A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4325900A DE4325900A1 (de) 1993-08-02 1993-08-02 Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Publications (2)

Publication Number Publication Date
IL110509A0 IL110509A0 (en) 1994-10-21
IL110509A true IL110509A (en) 1998-01-04

Family

ID=6494272

Family Applications (1)

Application Number Title Priority Date Filing Date
IL110509A IL110509A (en) 1993-08-02 1994-07-29 Pyrimido Compounds [D-5,4] Pyrimidine 2,4,8-Trimot preparation preparations and pharmaceutical preparations containing them

Country Status (22)

Country Link
US (1) US5618814A (zh)
EP (1) EP0645390A1 (zh)
JP (1) JPH0789963A (zh)
KR (1) KR950005828A (zh)
CN (1) CN1041091C (zh)
AU (1) AU683888B2 (zh)
BG (1) BG98931A (zh)
CA (1) CA2129179A1 (zh)
CZ (1) CZ184594A3 (zh)
DE (1) DE4325900A1 (zh)
EE (1) EE9400255A (zh)
FI (1) FI943574A (zh)
HU (1) HUT70957A (zh)
IL (1) IL110509A (zh)
NO (1) NO301479B1 (zh)
NZ (1) NZ264133A (zh)
PL (1) PL304512A1 (zh)
RO (1) RO113557B1 (zh)
RU (1) RU94028278A (zh)
SK (1) SK91594A3 (zh)
TW (1) TW251286B (zh)
ZA (1) ZA945689B (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW414798B (en) * 1994-09-07 2000-12-11 Thomae Gmbh Dr K Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
DE19608653A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US6331543B1 (en) * 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
USRE37234E1 (en) * 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
JP5129957B2 (ja) * 2003-07-03 2013-01-30 ミリアド ジェネティクス， インコーポレイテッド カスパーゼの活性化因子およびアポトーシスの誘発因子としての４−アリールアミノ−キナゾリン
DE102004002557A1 (de) * 2004-01-17 2005-08-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CN115650827B (zh) * 2022-10-27 2024-03-15 戊言医药科技（上海）有限公司 用于一类蒽环类毒素衍生物的制备方法、中间体化合物及合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0023559B1 (de) * 1979-07-03 1984-09-19 Dr. Karl Thomae GmbH 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidine, ihre Herstellung und diese Verbindungen enthaltenden Arzneimittel
DE2931573A1 (de) * 1979-08-03 1981-02-26 Thomae Gmbh Dr K Mittel zur bekaempfung des wachstums von krebszellen und dessen herstellung
DE3049207A1 (de) * 1980-12-27 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel
DE3423092A1 (de) * 1984-06-22 1986-01-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3833392A1 (de) * 1988-10-01 1990-04-05 Thomae Gmbh Dr K Verwendung von pyrimido(5,4-d)pyrimidinen zur verhinderung der primaeren und sekundaeren resistenz bei der chemotherapie und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
FI943574A0 (fi) 1994-08-01
IL110509A0 (en) 1994-10-21
FI943574A (fi) 1995-02-03
EE9400255A (et) 1996-02-15
SK91594A3 (en) 1995-04-12
NZ264133A (en) 1996-05-28
TW251286B (zh) 1995-07-11
PL304512A1 (en) 1995-02-06
CN1041091C (zh) 1998-12-09
CA2129179A1 (en) 1995-02-03
RU94028278A (ru) 1996-08-27
HU9402253D0 (en) 1994-09-28
CN1106405A (zh) 1995-08-09
ZA945689B (en) 1996-02-01
DE4325900A1 (de) 1995-02-09
EP0645390A1 (de) 1995-03-29
AU683888B2 (en) 1997-11-27
AU6881394A (en) 1995-02-09
NO942853L (no) 1995-02-03
BG98931A (en) 1995-09-29
NO301479B1 (no) 1997-11-03
CZ184594A3 (en) 1995-02-15
US5618814A (en) 1997-04-08
NO942853D0 (zh) 1994-08-01
KR950005828A (ko) 1995-03-20
JPH0789963A (ja) 1995-04-04
HUT70957A (en) 1995-11-28
RO113557B1 (ro) 1998-08-28

Similar Documents

Publication Publication Date Title
JP4571969B2 (ja) キナーゼインヒビターとしてのピラゾロトリアジン
JP4845379B2 (ja) サイクリン依存性キナーゼインヒビターとしてのイミダゾピリジン
JP4790265B2 (ja) サイクリン依存性キナーゼインヒビターとしての新規ピラゾロピリミジン
AU2013343550B2 (en) Substituted tricyclic benzimidazoles as kinase inhibitors
US5977102A (en) Pyrimido [5, 4-d] pyrimidines, pharmaceuticals containing these compounds, their use and processes for their preparation
KR20190099209A (ko) 8,9-디하이드로이미다졸[1,2-a]피리미도[5,4-e]피리미딘-5(6H)-케톤계 화합물
JP2006507253A (ja) サイクリン依存性キナーゼインヒビターとしてのイミダゾピラジン
US20090275593A1 (en) 3 Substituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors
US5618814A (en) Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds
JP6457523B2 (ja) 医薬組成物のためのスルホキシイミン置換キナゾリン
TW553945B (en) Triazolopurine derivatives, medicinal composition containing the derivatives, adenosine A3 receptor compatibilizing agent, and asthmatic remedy
EP1742937B1 (en) Pyrrolopyrimidine derivatives for treating proliferative diseases
EP3098222B1 (en) Fused acridine derivative and pharmaceutical composition, preparation method and use thereof
HU203347B (en) Process for producing new condensed diazepines and pharmaceutical compositions comprising same
KR20250011138A (ko) Ptpn2 저해제
DE19502179A1 (de) Trisubstituierte Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
RH Patent void