IL106840A - Process for basic anatomization of pentopornosyl nucleosides - Google Patents

Process for basic anatomization of pentopornosyl nucleosides

Info

Publication number: IL106840A
Authority: IL; Israel
Prior art keywords: hydroxide; lower alkyl; fluoro; hydroxy; group
Prior art date: 1992-09-01

Application number

IL10684093A

Other languages

English (en)

Hebrew (he)

Other versions

IL106840A0 (en

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-01

Filing date

1993-08-30

Publication date

1998-09-24

1993-08-30 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1993-12-08 Publication of IL106840A0 publication Critical patent/IL106840A0/xx

1998-09-24 Publication of IL106840A publication Critical patent/IL106840A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL10684093A 1992-09-01 1993-08-30 Process for basic anatomization of pentopornosyl nucleosides IL106840A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US93879192A	1992-09-01	1992-09-01

Publications (2)

Publication Number	Publication Date
IL106840A0 IL106840A0 (en)	1993-12-08
IL106840A true IL106840A (en)	1998-09-24

Family

ID=25471966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10684093A IL106840A (en)	1992-09-01	1993-08-30	Process for basic anatomization of pentopornosyl nucleosides

Country Status (15)

Country	Link
US (1)	US5420266A (pt)
EP (1)	EP0587364B1 (pt)
JP (1)	JP3462893B2 (pt)
KR (1)	KR100252451B1 (pt)
AT (1)	ATE138929T1 (pt)
BR (1)	BR9303658A (pt)
CA (1)	CA2105112C (pt)
DE (1)	DE69302977T2 (pt)
DK (1)	DK0587364T3 (pt)
ES (1)	ES2090880T3 (pt)
GR (1)	GR3020426T3 (pt)
HU (1)	HU214980B (pt)
IL (1)	IL106840A (pt)
MX (1)	MX9305301A (pt)
TW (1)	TW356472B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5627160A (en) *	1993-05-25	1997-05-06	Yale University	L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
TW374087B (en) *	1993-05-25	1999-11-11	Univ Yale	L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents
US5637688A (en)	1994-12-13	1997-06-10	Eli Lilly And Company	Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
US5869461A (en) *	1995-03-16	1999-02-09	Yale University	Reducing toxicity of L-nucleosides with D-nucleosides
CA2171518A1 (en) *	1995-03-24	1996-09-25	Douglas Patton Kjell	Process for the preparation of 2,2'-anhydro- and 2' -keto-1-(3', 5'-di-o-protected-.beta.-d-arabinofuranosyl) nucleosides
US5633367A (en) *	1995-03-24	1997-05-27	Eli Lilly And Company	Process for the preparation of a 2-substituted 3,3-difluorofuran
US6013790A (en) *	1996-09-25	2000-01-11	Board Of Regents University Of Nebraska-Lincoln	Heavily fluorinated sugar analogs
US6248878B1 (en) *	1996-12-24	2001-06-19	Ribozyme Pharmaceuticals, Inc.	Nucleoside analogs
MY164523A (en)	2000-05-23	2017-12-29	Univ Degli Studi Cagliari	Methods and compositions for treating hepatitis c virus
KR20080021797A (ko)	2000-05-26	2008-03-07	이데닉스(케이만)리미티드	플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
KR100467016B1 (ko) *	2002-05-30	2005-01-24	삼성전자주식회사	반도체기판의 세정방법
US7662798B2 (en)	2002-06-28	2010-02-16	Idenix Pharmaceuticals, Inc.	2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7608600B2 (en)	2002-06-28	2009-10-27	Idenix Pharmaceuticals, Inc.	Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7824851B2 (en)	2002-11-15	2010-11-02	Idenix Pharmaceuticals, Inc.	2′-branched nucleosides and Flaviviridae mutation
PT2604620T (pt) *	2003-05-30	2016-08-18	Gilead Pharmasset Llc	Analogos de nucleósido fluorados modificados
CN101023094B (zh) *	2004-07-21	2011-05-18	法莫赛特股份有限公司	烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
EP1809301B1 (en)	2004-09-14	2019-11-06	Gilead Pharmasset LLC	2-fluoro-2-alkyl-substituted d-ribonolactone intermediates
ES2341663T3 (es) *	2005-03-04	2010-06-24	Fresenius Kabi Oncology Limited	Intermedio y procedimiento para preparar 2'-desoxi-2',2'-difluoro-d-ribofuranosil nucleosidos enriquecidos en el anomero beta.
US7781576B2 (en)	2005-12-23	2010-08-24	Idenix Pharmaceuticals, Inc.	Process for preparing a synthetic intermediate for preparation of branched nucleosides
US7964580B2 (en)	2007-03-30	2011-06-21	Pharmasset, Inc.	Nucleoside phosphoramidate prodrugs
US8173621B2 (en) *	2008-06-11	2012-05-08	Gilead Pharmasset Llc	Nucleoside cyclicphosphates
AR074897A1 (es) *	2008-12-23	2011-02-23	Pharmasset Inc	Fosforamidatos de nucleosidos
SG194404A1 (en)	2008-12-23	2013-11-29	Gilead Pharmasset Llc	Synthesis of purine nucleosides
AU2009329917B2 (en) *	2008-12-23	2016-03-31	Gilead Pharmasset Llc	Nucleoside analogs
US8618076B2 (en)	2009-05-20	2013-12-31	Gilead Pharmasset Llc	Nucleoside phosphoramidates
TWI576352B (zh)	2009-05-20	2017-04-01	基利法瑪席特有限責任公司	核苷磷醯胺
PT2609923T (pt)	2010-03-31	2017-08-30	Gilead Pharmasset Llc	Processo para a cristalização de 2-(((s)- (perfluorofenoxi)(fenoxi)fosforil)amino)propanoato de (s)-isopropilo
US8563530B2 (en)	2010-03-31	2013-10-22	Gilead Pharmassel LLC	Purine nucleoside phosphoramidate
EP2646453A1 (en)	2010-11-30	2013-10-09	Gilead Pharmasset LLC	Compounds
US8889159B2 (en)	2011-11-29	2014-11-18	Gilead Pharmasset Llc	Compositions and methods for treating hepatitis C virus
CN102603838B (zh) *	2012-02-14	2015-02-18	江苏八巨药业有限公司	一种制备吉西他滨盐酸盐的方法
PT3038601T (pt)	2013-08-27	2020-06-30	Gilead Pharmasset Llc	Formulação combinada de dois compostos antivirais
WO2020001475A1 (en)	2018-06-29	2020-01-02	Shanghai Changchengyiyaokeji Company Limited	Phosphorus-containing prodrugs of gemcitabine

1993
- 1993-08-30 HU HU9302452A patent/HU214980B/hu not_active IP Right Cessation
- 1993-08-30 TW TW082107028A patent/TW356472B/zh active
- 1993-08-30 KR KR1019930017031A patent/KR100252451B1/ko not_active IP Right Cessation
- 1993-08-30 CA CA002105112A patent/CA2105112C/en not_active Expired - Lifetime
- 1993-08-30 IL IL10684093A patent/IL106840A/en not_active IP Right Cessation
- 1993-08-31 ES ES93306886T patent/ES2090880T3/es not_active Expired - Lifetime
- 1993-08-31 DE DE69302977T patent/DE69302977T2/de not_active Expired - Lifetime
- 1993-08-31 EP EP93306886A patent/EP0587364B1/en not_active Expired - Lifetime
- 1993-08-31 DK DK93306886.8T patent/DK0587364T3/da active
- 1993-08-31 JP JP21565393A patent/JP3462893B2/ja not_active Expired - Fee Related
- 1993-08-31 MX MX9305301A patent/MX9305301A/es unknown
- 1993-08-31 BR BR9303658A patent/BR9303658A/pt not_active Application Discontinuation
- 1993-08-31 AT AT93306886T patent/ATE138929T1/de not_active IP Right Cessation
1994
- 1994-01-03 US US08/176,981 patent/US5420266A/en not_active Expired - Lifetime
1996
- 1996-07-02 GR GR960401799T patent/GR3020426T3/el unknown

Also Published As

Publication number	Publication date
CA2105112A1 (en)	1994-03-02
ATE138929T1 (de)	1996-06-15
DE69302977D1 (de)	1996-07-11
JP3462893B2 (ja)	2003-11-05
ES2090880T3 (es)	1996-10-16
KR940007053A (ko)	1994-04-26
US5420266A (en)	1995-05-30
DE69302977T2 (de)	1996-10-31
EP0587364A1 (en)	1994-03-16
EP0587364B1 (en)	1996-06-05
KR100252451B1 (ko)	2000-04-15
JPH06157571A (ja)	1994-06-03
GR3020426T3 (en)	1996-10-31
CA2105112C (en)	2005-08-02
DK0587364T3 (da)	1996-07-01
IL106840A0 (en)	1993-12-08
TW356472B (en)	1999-04-21
HUT65137A (en)	1994-04-28
HU9302452D0 (en)	1993-11-29
BR9303658A (pt)	1994-03-22
MX9305301A (es)	1994-06-30
HU214980B (hu)	1998-08-28

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Legal Events

Date	Code	Title
1999-01-26	FF	Patent granted
1999-07-14	KB	Patent renewed
1999-12-31	KB	Patent renewed
2001-06-14	RH	Patent void
2004-05-12	RH1	Patent not in force