BR9303658A - Processo para aumentar a quantidade de nucleosideo de beta-anomero - Google Patents

Processo para aumentar a quantidade de nucleosideo de beta-anomero

Info

Publication number: BR9303658A
Authority: BR; Brazil
Prior art keywords: nucleoside; beta; anomero; increase; anomer
Prior art date: 1992-09-01

Application number

BR9303658A

Other languages

English (en)

Inventor

Thomas Charles Britton

Michael Edward Le Tourneau

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-01

Filing date

1993-08-31

Publication date

1994-03-22

1993-08-31 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1994-03-22 Publication of BR9303658A publication Critical patent/BR9303658A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BR9303658A 1992-09-01 1993-08-31 Processo para aumentar a quantidade de nucleosideo de beta-anomero BR9303658A (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US93879192A	1992-09-01	1992-09-01

Publications (1)

Publication Number	Publication Date
BR9303658A true BR9303658A (pt)	1994-03-22

Family

ID=25471966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9303658A BR9303658A (pt)	1992-09-01	1993-08-31	Processo para aumentar a quantidade de nucleosideo de beta-anomero

Country Status (15)

Country	Link
US (1)	US5420266A (pt)
EP (1)	EP0587364B1 (pt)
JP (1)	JP3462893B2 (pt)
KR (1)	KR100252451B1 (pt)
AT (1)	ATE138929T1 (pt)
BR (1)	BR9303658A (pt)
CA (1)	CA2105112C (pt)
DE (1)	DE69302977T2 (pt)
DK (1)	DK0587364T3 (pt)
ES (1)	ES2090880T3 (pt)
GR (1)	GR3020426T3 (pt)
HU (1)	HU214980B (pt)
IL (1)	IL106840A (pt)
MX (1)	MX9305301A (pt)
TW (1)	TW356472B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5627160A (en) *	1993-05-25	1997-05-06	Yale University	L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
TW374087B (en) *	1993-05-25	1999-11-11	Univ Yale	L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents
US5637688A (en)	1994-12-13	1997-06-10	Eli Lilly And Company	Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
US5869461A (en) *	1995-03-16	1999-02-09	Yale University	Reducing toxicity of L-nucleosides with D-nucleosides
CA2171518A1 (en) *	1995-03-24	1996-09-25	Douglas Patton Kjell	Process for the preparation of 2,2'-anhydro- and 2' -keto-1-(3', 5'-di-o-protected-.beta.-d-arabinofuranosyl) nucleosides
US5633367A (en) *	1995-03-24	1997-05-27	Eli Lilly And Company	Process for the preparation of a 2-substituted 3,3-difluorofuran
US6013790A (en) *	1996-09-25	2000-01-11	Board Of Regents University Of Nebraska-Lincoln	Heavily fluorinated sugar analogs
US6248878B1 (en) *	1996-12-24	2001-06-19	Ribozyme Pharmaceuticals, Inc.	Nucleoside analogs
MY164523A (en)	2000-05-23	2017-12-29	Univ Degli Studi Cagliari	Methods and compositions for treating hepatitis c virus
KR20080021797A (ko)	2000-05-26	2008-03-07	이데닉스(케이만)리미티드	플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
KR100467016B1 (ko) *	2002-05-30	2005-01-24	삼성전자주식회사	반도체기판의 세정방법
US7662798B2 (en)	2002-06-28	2010-02-16	Idenix Pharmaceuticals, Inc.	2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7608600B2 (en)	2002-06-28	2009-10-27	Idenix Pharmaceuticals, Inc.	Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7824851B2 (en)	2002-11-15	2010-11-02	Idenix Pharmaceuticals, Inc.	2′-branched nucleosides and Flaviviridae mutation
PT2604620T (pt) *	2003-05-30	2016-08-18	Gilead Pharmasset Llc	Analogos de nucleósido fluorados modificados
CN101023094B (zh) *	2004-07-21	2011-05-18	法莫赛特股份有限公司	烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
EP1809301B1 (en)	2004-09-14	2019-11-06	Gilead Pharmasset LLC	2-fluoro-2-alkyl-substituted d-ribonolactone intermediates
ES2341663T3 (es) *	2005-03-04	2010-06-24	Fresenius Kabi Oncology Limited	Intermedio y procedimiento para preparar 2'-desoxi-2',2'-difluoro-d-ribofuranosil nucleosidos enriquecidos en el anomero beta.
US7781576B2 (en)	2005-12-23	2010-08-24	Idenix Pharmaceuticals, Inc.	Process for preparing a synthetic intermediate for preparation of branched nucleosides
US7964580B2 (en)	2007-03-30	2011-06-21	Pharmasset, Inc.	Nucleoside phosphoramidate prodrugs
US8173621B2 (en) *	2008-06-11	2012-05-08	Gilead Pharmasset Llc	Nucleoside cyclicphosphates
AR074897A1 (es) *	2008-12-23	2011-02-23	Pharmasset Inc	Fosforamidatos de nucleosidos
SG194404A1 (en)	2008-12-23	2013-11-29	Gilead Pharmasset Llc	Synthesis of purine nucleosides
AU2009329917B2 (en) *	2008-12-23	2016-03-31	Gilead Pharmasset Llc	Nucleoside analogs
US8618076B2 (en)	2009-05-20	2013-12-31	Gilead Pharmasset Llc	Nucleoside phosphoramidates
TWI576352B (zh)	2009-05-20	2017-04-01	基利法瑪席特有限責任公司	核苷磷醯胺
PT2609923T (pt)	2010-03-31	2017-08-30	Gilead Pharmasset Llc	Processo para a cristalização de 2-(((s)- (perfluorofenoxi)(fenoxi)fosforil)amino)propanoato de (s)-isopropilo
US8563530B2 (en)	2010-03-31	2013-10-22	Gilead Pharmassel LLC	Purine nucleoside phosphoramidate
EP2646453A1 (en)	2010-11-30	2013-10-09	Gilead Pharmasset LLC	Compounds
US8889159B2 (en)	2011-11-29	2014-11-18	Gilead Pharmasset Llc	Compositions and methods for treating hepatitis C virus
CN102603838B (zh) *	2012-02-14	2015-02-18	江苏八巨药业有限公司	一种制备吉西他滨盐酸盐的方法
PT3038601T (pt)	2013-08-27	2020-06-30	Gilead Pharmasset Llc	Formulação combinada de dois compostos antivirais
WO2020001475A1 (en)	2018-06-29	2020-01-02	Shanghai Changchengyiyaokeji Company Limited	Phosphorus-containing prodrugs of gemcitabine

1993
- 1993-08-30 HU HU9302452A patent/HU214980B/hu not_active IP Right Cessation
- 1993-08-30 TW TW082107028A patent/TW356472B/zh active
- 1993-08-30 KR KR1019930017031A patent/KR100252451B1/ko not_active IP Right Cessation
- 1993-08-30 CA CA002105112A patent/CA2105112C/en not_active Expired - Lifetime
- 1993-08-30 IL IL10684093A patent/IL106840A/en not_active IP Right Cessation
- 1993-08-31 ES ES93306886T patent/ES2090880T3/es not_active Expired - Lifetime
- 1993-08-31 DE DE69302977T patent/DE69302977T2/de not_active Expired - Lifetime
- 1993-08-31 EP EP93306886A patent/EP0587364B1/en not_active Expired - Lifetime
- 1993-08-31 DK DK93306886.8T patent/DK0587364T3/da active
- 1993-08-31 JP JP21565393A patent/JP3462893B2/ja not_active Expired - Fee Related
- 1993-08-31 MX MX9305301A patent/MX9305301A/es unknown
- 1993-08-31 BR BR9303658A patent/BR9303658A/pt not_active Application Discontinuation
- 1993-08-31 AT AT93306886T patent/ATE138929T1/de not_active IP Right Cessation
1994
- 1994-01-03 US US08/176,981 patent/US5420266A/en not_active Expired - Lifetime
1996
- 1996-07-02 GR GR960401799T patent/GR3020426T3/el unknown

Also Published As

Publication number	Publication date
CA2105112A1 (en)	1994-03-02
ATE138929T1 (de)	1996-06-15
DE69302977D1 (de)	1996-07-11
JP3462893B2 (ja)	2003-11-05
ES2090880T3 (es)	1996-10-16
KR940007053A (ko)	1994-04-26
US5420266A (en)	1995-05-30
DE69302977T2 (de)	1996-10-31
EP0587364A1 (en)	1994-03-16
EP0587364B1 (en)	1996-06-05
KR100252451B1 (ko)	2000-04-15
JPH06157571A (ja)	1994-06-03
GR3020426T3 (en)	1996-10-31
CA2105112C (en)	2005-08-02
DK0587364T3 (da)	1996-07-01
IL106840A0 (en)	1993-12-08
TW356472B (en)	1999-04-21
HUT65137A (en)	1994-04-28
HU9302452D0 (en)	1993-11-29
MX9305301A (es)	1994-06-30
HU214980B (hu)	1998-08-28
IL106840A (en)	1998-09-24

Publication	Publication Date	Title
BR9303658A (pt)	1994-03-22	Processo para aumentar a quantidade de nucleosideo de beta-anomero
BR9302429A (pt)	1994-01-11	Processo para a preparacao de um sulfonato de riboturanosila enriquecido do anomero alfa
BR9302434A (pt)	1994-02-16	Processo para preparar um nucleosidio enriquecido com beta-anomero
BR9302428A (pt)	1994-01-11	Processo estereosseletivo a baixa temperatura para preparar um derivado enriquecido de riboturanosila alfa-anomero e o derivado obitdo
NO932286L (no)	1993-12-23	Stereoselektiv anion-glykosyleringsprosess
ATE174926T1 (de)	1999-01-15	Hydrophobe nukleinsäure-sonde
CY2091B1 (en)	2002-04-05	Process for separating 2-deoxy-2, 2-difluoro-d-ribofuranosyl alkylsulfonate anomers
DE3671896D1 (de)	1990-07-19	Herstellung von cytosin-nukleosiden.
JPS565497A (en)	1981-01-20	Novel manufacture of 5**deoxyy55fluorouridine
EP0328959A3 (de)	1990-03-07	Verfahren zur Reinigung von langkettigen Alkylglucosiden
ES2094623T3 (es)	1997-01-16	Procedimiento estereoselectivo para la preparacion de 2-desoxi-2,2-difluoro-d-ribofuranosil-3,5-hidroxi protegido-1-alquil y aril-sulfonatos intermedios enriquecidos en el anomero beta.
FR2610861B2 (fr)	1989-09-01	Dispositif pour le percage de panneaux de bois en vue de leur assemblage par chevilles
ES2127249T3 (es)	1999-04-16	Procedimiento para preparar 2-desoxi-2,2-difluoro-d-ribofuranosil-arilsulfonatos enriquecidos en el anomero beta.
BR8803909A (pt)	1989-02-28	Processo de producao de alcool sensivelmente anidro incluindo pelo menos 2 atomos de carbono por destilacao e extracao de uma solucao aquosa desse alcool e utilizacao
NZ238521A (en)	1992-12-23	Process for the conversion of avermectin glycone to avermectin mono- and disaccharides by fermentation with streptomyces avermitilis ma6078
KR910004645A (ko)	1991-03-29	신규 안트라사이클린 글리코사이드 유도체
ES2052878T3 (es)	1994-07-16	Nuevos derivados de azucares, metodo para su produccion y aplicacion.
RU93046506A (ru)	1996-12-27	Способ получения нуклеозидов

Legal Events

Date	Code	Title
1996-08-13	EE	Request for examination
1999-02-02	EG	Technical examination (opinion): publication of technical examination (opinion)
1999-07-27	FC	Decision: refusal
1999-11-30	CKFC	Appeal: appeal against refusal