IL105827A - 10-substituted 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepines their preparation and pharmaceutical compositions containing them - Google Patents

10-substituted 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepines their preparation and pharmaceutical compositions containing them

Info

Publication number: IL105827A
Authority: IL; Israel
Prior art keywords: methyl; benzodiazepines; thieno; piperazinyl; substituted
Prior art date: 1992-05-29

Application number

IL10582793A

Other languages

English (en)

Other versions

IL105827A0 (en

Original Assignee

Lilly Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-05-29

Filing date

1993-05-28

Publication date

1997-02-18

1992-05-29 Priority claimed from GB929211379A external-priority patent/GB9211379D0/en

1993-04-30 Priority claimed from GB939309025A external-priority patent/GB9309025D0/en

1993-05-28 Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd

1993-09-22 Publication of IL105827A0 publication Critical patent/IL105827A0/xx

1997-02-18 Publication of IL105827A publication Critical patent/IL105827A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL10582793A 1992-05-29 1993-05-28 10-substituted 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepines their preparation and pharmaceutical compositions containing them IL105827A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929211379A GB9211379D0 (en)	1992-05-29	1992-05-29	Pharmaceutical compounds
GB939309025A GB9309025D0 (en)	1993-04-30	1993-04-30	Pharmaceutical compounds

Publications (2)

Publication Number	Publication Date
IL105827A0 IL105827A0 (en)	1993-09-22
IL105827A true IL105827A (en)	1997-02-18

Family

ID=26300951

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10582793A IL105827A (en)	1992-05-29	1993-05-28	10-substituted 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepines their preparation and pharmaceutical compositions containing them

Country Status (21)

Country	Link
EP (1)	EP0582368B1 (fi)
JP (1)	JP3219541B2 (fi)
CN (1)	CN1043994C (fi)
AT (1)	ATE198891T1 (fi)
AU (1)	AU668159B2 (fi)
CA (1)	CA2097016A1 (fi)
CZ (1)	CZ282783B6 (fi)
DE (1)	DE69329887T2 (fi)
DK (1)	DK0582368T3 (fi)
ES (1)	ES2153373T3 (fi)
FI (1)	FI101538B (fi)
GR (1)	GR3035587T3 (fi)
HU (1)	HU218278B (fi)
IL (1)	IL105827A (fi)
MX (1)	MX9303124A (fi)
MY (1)	MY109943A (fi)
NO (1)	NO305125B1 (fi)
NZ (1)	NZ247703A (fi)
PT (1)	PT582368E (fi)
RU (1)	RU2125574C1 (fi)
TW (1)	TW268005B (fi)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5457101A (en) *	1994-06-03	1995-10-10	Eli Lilly And Company	Thieno[1,5]benzoidiazepine use
US5574028A (en) *	1994-10-31	1996-11-12	Eli Lilly And Company	Method for treating anxiety
CR5278A (es) *	1995-03-24	1996-07-04	Lilly Co Eli	Formulacion oral de 2-metil-tieno-benzodiacepina
EG24221A (en) *	1995-03-24	2008-11-10	Lilly Co Eli	Process for preparing olanzapine
EG23659A (en) *	1995-03-24	2007-03-26	Lilly Co Eli	Process and crystal forms of methyl-thieno-benzodiazepine
US5891461A (en) *	1995-09-14	1999-04-06	Cygnus, Inc.	Transdermal administration of olanzapine
US6258807B1 (en) *	1996-03-25	2001-07-10	Eli Lilly And Company	Method for treating pain
JP2001508759A (ja) *	1996-03-25	2001-07-03	イーライ・リリー・アンド・カンパニー	片頭痛の処置法
UA48219C2 (uk) *	1996-03-25	2002-08-15	Елі Ліллі Енд Компані	Композиція для вгамування болю (варіанти) та спосіб вгамування болю
ZA978515B (en) *	1996-09-23	1999-03-23	Lilly Co Eli	Intermediates and process for preparing olanzapine
BR9711541A (pt) *	1996-09-23	1999-08-24	Lilly Co Eli	Dihidrato d de olanzapina
WO1998013027A1 (en) *	1996-09-24	1998-04-02	Eli Lilly And Company	Coated particle formulation
US9494607B2 (en)	2012-08-21	2016-11-15	Janssen Pharmaceutica Nv	Antibodies to aripiprazole and use thereof
CA2882557C (en)	2012-08-21	2020-10-27	Ortho-Clinical Diagnostics, Inc.	Haptens of quetiapine for use in immunoassays
US9751953B2 (en)	2012-08-21	2017-09-05	Janssen Pharmaceutica Nv	Antibodies to risperidone haptens and use thereof
US9611332B2 (en)	2012-08-21	2017-04-04	Janssen Pharmaceutica Nv	Antibodies to aripiprazole haptens and use thereof
JP6171014B2 (ja) *	2012-08-21	2017-07-26	ヤンセンファーマシューティカエヌ．ベー．	オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン
AU2013305904B2 (en)	2012-08-21	2017-08-17	Saladax Biomedical Inc.	Antibodies to quetiapine haptens and use thereof
CN104736566A (zh)	2012-08-21	2015-06-24	奥索临床诊断有限公司	帕潘立酮半抗原的抗体及其用途
ES2904838T3 (es)	2012-08-21	2022-04-06	Janssen Pharmaceutica Nv	Haptenos de risperidona y paliperidona
PL2888234T3 (pl)	2012-08-21	2018-07-31	Janssen Pharmaceutica Nv	Hapteny arypiprazolu i ich zastosowanie w testach immunologicznych
EP2888277A4 (en)	2012-08-21	2016-05-18	Ortho Clinical Diagnostics Inc	ANTIBODIES AGAINST PALIPERIDONE AND USE THEREOF
CA2882555C (en)	2012-08-21	2018-11-06	Janssen Pharmaceutica Nv	Haptens of paliperidone
WO2014031648A2 (en)	2012-08-21	2014-02-27	Ortho-Clinical Diagnostics, Inc	Antibodies to risperidone and use thereof
PT2888590T (pt)	2012-08-21	2020-09-11	Janssen Pharmaceutica Nv	Anticorpos para olanzapina e utilização destes
US9410972B2 (en)	2012-08-21	2016-08-09	Janssen Pharmaceutica Nv	Antibodies to quetiapine and use thereof
ES2733963T3 (es)	2012-08-21	2019-12-03	Janssen Pharmaceutica Nv	Anticuerpos contra haptenos de olanzapina y uso de los mismos
EP3390455A1 (en)	2015-12-17	2018-10-24	Janssen Pharmaceutica NV	Antibodies to quetiapine and use thereof
JP6949025B2 (ja)	2015-12-17	2021-10-13	ヤンセンファーマシューティカエヌ．ベー．	リスペリドンに対する抗体及びその使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU629879A3 (ru) *	1974-11-26	1978-10-25	Лилли Индастриз Лимитед, (Фирма)	Способ получени тиено(1,5) бензодиазепинов или их солей
DK416476A (da) *	1975-09-24	1977-03-25	Sandoz Ag	Fremgangsmade til fremstilling af diazepinderivater
GB9009229D0 (en) *	1990-04-25	1990-06-20	Lilly Industries Ltd	Pharmaceutical compounds

1993
- 1993-05-26 NO NO931917A patent/NO305125B1/no not_active IP Right Cessation
- 1993-05-26 ES ES93304102T patent/ES2153373T3/es not_active Expired - Lifetime
- 1993-05-26 TW TW082104161A patent/TW268005B/zh active
- 1993-05-26 EP EP93304102A patent/EP0582368B1/en not_active Expired - Lifetime
- 1993-05-26 PT PT93304102T patent/PT582368E/pt unknown
- 1993-05-26 NZ NZ247703A patent/NZ247703A/en unknown
- 1993-05-26 AT AT93304102T patent/ATE198891T1/de not_active IP Right Cessation
- 1993-05-26 DE DE69329887T patent/DE69329887T2/de not_active Expired - Fee Related
- 1993-05-26 DK DK93304102T patent/DK0582368T3/da active
- 1993-05-26 CA CA002097016A patent/CA2097016A1/en not_active Abandoned
- 1993-05-26 AU AU39807/93A patent/AU668159B2/en not_active Ceased
- 1993-05-27 MX MX9303124A patent/MX9303124A/es not_active IP Right Cessation
- 1993-05-28 MY MYPI93001036A patent/MY109943A/en unknown
- 1993-05-28 IL IL10582793A patent/IL105827A/xx not_active IP Right Cessation
- 1993-05-28 CZ CZ931024A patent/CZ282783B6/cs not_active IP Right Cessation
- 1993-05-28 FI FI932445A patent/FI101538B/fi active
- 1993-05-28 CN CN93108212A patent/CN1043994C/zh not_active Expired - Fee Related
- 1993-05-28 HU HU9301579A patent/HU218278B/hu not_active IP Right Cessation
- 1993-05-28 JP JP12642993A patent/JP3219541B2/ja not_active Expired - Fee Related
- 1993-05-28 RU RU93005057A patent/RU2125574C1/ru active
2001
- 2001-03-15 GR GR20010400431T patent/GR3035587T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69329887D1 (de)	2001-03-01
NO305125B1 (no)	1999-04-06
MY109943A (en)	1997-10-31
JP3219541B2 (ja)	2001-10-15
DK0582368T3 (da)	2001-02-05
EP0582368B1 (en)	2001-01-24
IL105827A0 (en)	1993-09-22
CZ102493A3 (en)	1993-12-15
FI932445A0 (fi)	1993-05-28
CN1085903A (zh)	1994-04-27
FI101538B1 (fi)	1998-07-15
NO931917L (no)	1993-11-30
FI932445L (fi)	1993-11-30
GR3035587T3 (en)	2001-06-29
HUT66180A (en)	1994-09-28
NO931917D0 (no)	1993-05-26
HU9301579D0 (en)	1993-09-28
RU2125574C1 (ru)	1999-01-27
ES2153373T3 (es)	2001-03-01
AU668159B2 (en)	1996-04-26
AU3980793A (en)	1993-12-02
MX9303124A (es)	1993-11-01
JPH0687862A (ja)	1994-03-29
HU218278B (en)	2000-07-28
FI101538B (fi)	1998-07-15
ATE198891T1 (de)	2001-02-15
CN1043994C (zh)	1999-07-07
DE69329887T2 (de)	2001-05-23
PT582368E (pt)	2001-05-31
CZ282783B6 (cs)	1997-10-15
EP0582368A1 (en)	1994-02-09
NZ247703A (en)	1995-07-26
CA2097016A1 (en)	1993-11-30
TW268005B (fi)	1996-01-11

Publication	Publication Date	Title
IL105827A (en)	1997-02-18	10-substituted 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno [2,3-b][1,5] benzodiazepines their preparation and pharmaceutical compositions containing them
HUT67691A (en)	1995-04-28	7-(substituted)-8-(substituted)-9-[(substituted-glycyl)amido]6-demethyl-6-deoxytetracyclines, pharmaceutical compositions containing them and process to prepare them
ZA867716B (en)	1987-05-27	Novel pharmacological compounds
IL100572A (en)	1997-01-10	Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them
HUP9802824A2 (hu)	1999-06-28	Egy 2-metil-tieno-benzodiazepin-származék kristályformái és eljárás azok előállítására
IL132763A0 (en)	2001-03-19	Novel compounds
GR3019765T3 (en)	1996-07-31	Use of a dihydrothienopyridine-derivative for inhibiting the release of cerebral glutamate
IL114785A0 (en)	1995-11-27	Pyrrolocarbazoles their preparation and pharmaceutical compositions containing them
HUT64026A (en)	1993-11-29	Process for producing 4-alkyl-3-amino-2-chloropyridines
IL97999A0 (en)	1992-06-21	Pyrido(2,3-f)(1,4)thiazepines and pyrido(3,2-b)(1,5)-benzothiazepines,their preparation and pharmaceutical compositions containing them
AU630575B2 (en)	1992-10-29	Benzodiazepine derivatives
IL107614A0 (en)	1994-02-27	Vitamin d3 analogs their preparation and pharmaceutical compositions containing them
ZA864444B (en)	1987-02-25	Pyrrolidone derivatives
ES2094913T3 (es)	1997-02-01	Metodo para la preparacion de 3-amino-2-cloro-4-alquilpiridinas.
UA41981C2 (uk)	2001-10-15	Біотинові сполуки, спосіб їх отримання, фармацевтична композиція та спосіб її отримання
TW275629B (fi)	1996-05-11
IL113650A0 (en)	1995-08-31	8-amino-10- (azabicycloalkyl)-pyrido [1,2,3-d, e][1,3,4] benzoxadiazine derivatives their preparartion and pharmaceutical compositions containing them
GB8823040D0 (en)	1988-11-09	Organic compounds & their use as pharmaceuticals
KR937000511A (ko)	1993-03-15	신규한 화합물

Legal Events

Date	Code	Title
1997-08-14	FF	Patent granted
1998-01-04	KB	Patent renewed
1999-06-20	HC	Change of name of proprietor(s)
1999-12-22	KB	Patent renewed
2004-02-08	RH1	Patent not in force