IL104105A - 19-nor steroids having a thiocarbon chain in position 11-beta, their preparation and pharmaceutical compositions containing them - Google Patents
19-nor steroids having a thiocarbon chain in position 11-beta, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL104105A IL104105A IL104105A IL10410592A IL104105A IL 104105 A IL104105 A IL 104105A IL 104105 A IL104105 A IL 104105A IL 10410592 A IL10410592 A IL 10410592A IL 104105 A IL104105 A IL 104105A
- Authority
- IL
- Israel
- Prior art keywords
- carbon atoms
- alkyl
- optionally substituted
- aryl
- radical
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 12
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- -1 alkyl radical Chemical class 0.000 abstract 4
- 150000003254 radicals Chemical class 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- KCNKJCHARANTIP-SNAWJCMRSA-N allyl-{4-[3-(4-bromo-phenyl)-benzofuran-6-yloxy]-but-2-enyl}-methyl-amine Chemical compound C=1OC2=CC(OC/C=C/CN(CC=C)C)=CC=C2C=1C1=CC=C(Br)C=C1 KCNKJCHARANTIP-SNAWJCMRSA-N 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 125000000732 arylene group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 abstract 1
- 230000002254 contraceptive effect Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 125000005638 hydrazono group Chemical group 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9115856A FR2685332A1 (fr) | 1991-12-20 | 1991-12-20 | Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL104105A0 IL104105A0 (en) | 1993-05-13 |
| IL104105A true IL104105A (en) | 1997-07-13 |
Family
ID=9420274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL104105A IL104105A (en) | 1991-12-20 | 1992-12-15 | 19-nor steroids having a thiocarbon chain in position 11-beta, their preparation and pharmaceutical compositions containing them |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6281204B1 (xx) |
| EP (1) | EP0623140B1 (xx) |
| JP (1) | JP3445271B2 (xx) |
| KR (1) | KR100278465B1 (xx) |
| CN (1) | CN1036718C (xx) |
| AT (1) | ATE165365T1 (xx) |
| AU (1) | AU666916B2 (xx) |
| CA (1) | CA2124339C (xx) |
| DE (1) | DE69225243T2 (xx) |
| DK (1) | DK0623140T3 (xx) |
| ES (1) | ES2115754T3 (xx) |
| FI (1) | FI114866B (xx) |
| FR (1) | FR2685332A1 (xx) |
| HU (1) | HU221482B (xx) |
| IL (1) | IL104105A (xx) |
| MX (1) | MX9207421A (xx) |
| NZ (1) | NZ246624A (xx) |
| RU (1) | RU2111213C1 (xx) |
| WO (1) | WO1993013123A1 (xx) |
| ZA (1) | ZA929859B (xx) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2685332A1 (fr) * | 1991-12-20 | 1993-06-25 | Roussel Uclaf | Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments. |
| FR2706454B1 (fr) * | 1993-06-17 | 1995-09-15 | Roussel Uclaf | Nouveaux 19-Nor stéroïdes, procédé et intermédiaires de préparation, application comme médicaments et compositions pharmaceutiques les contenant. |
| DE19510862A1 (de) * | 1995-03-16 | 1996-09-19 | Schering Ag | Verwendung von Antiestrogenen zur männlichen Fertilitätskontrolle |
| DE19526146A1 (de) * | 1995-07-07 | 1997-01-09 | Schering Ag | Triphenylethylene, Verfahren zu deren Herstellung, diese Triphenylethylene enthaltene pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
| DE19724187A1 (de) * | 1997-06-02 | 1998-12-03 | Schering Ag | 11beta-Arylsubstituierte 14,17-Ethanoestratriene, Verfahren zur Herstellung dieser Verbindungen, sowie ihre Verwendung zur Herstellung von Arzneimitteln |
| EP0909749B1 (de) * | 1997-10-14 | 2002-08-28 | Bayer Ag | Verfahren zur Herstellung von Pentafluorpentanol |
| US6548491B2 (en) | 1997-12-24 | 2003-04-15 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
| US6503896B1 (en) | 1997-12-24 | 2003-01-07 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
| US6054446A (en) * | 1997-12-24 | 2000-04-25 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
| DE19826213A1 (de) * | 1998-06-09 | 1999-12-16 | Schering Ag | Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| FR2780060B1 (fr) * | 1998-06-23 | 2000-08-04 | Hoechst Marion Roussel Inc | Nouveaux 19-nor steroides 17-halogenes, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant |
| EP1131336B1 (en) * | 1998-11-20 | 2002-08-28 | Akzo Nobel N.V. | Estrogenic estra-1,3,5(10)-trienes with differential effects on the alpha and beta estrogen receptors, having a linear hydrocarbon chain of from 5-9 carbon atoms in position 11 |
| DE19929715A1 (de) | 1999-06-24 | 2000-12-28 | Schering Ag | 11ß-langkettig-substituierte Estratriene, Verfahren zur Herstellung , pharmazeutische Präparate, die diese 11ß-langkettig-substituierten Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
| WO2001040805A1 (en) * | 1999-11-30 | 2001-06-07 | Akzo Nobel N.V. | Steroid compounds for steroid receptor binding assays |
| WO2005090379A1 (en) * | 2004-03-17 | 2005-09-29 | The Central Science Laboratory, 'csl' | Compounds and sensor for detecion of polycyclic aromatic hydrocarbons |
| EP1623713A1 (en) * | 2004-07-09 | 2006-02-08 | Proskelia SAS | Cominations of pure anti-estrogen with aromatase inhibitors |
| EP1630167A1 (en) * | 2004-07-09 | 2006-03-01 | Proskelia SAS | Polymorphs of 19-Nor steroid derivatives |
| CN100420681C (zh) * | 2005-04-29 | 2008-09-24 | 上海奥锐特国际贸易有限公司 | 多烯紫杉醇三水物的制备方法 |
| DE102008061722A1 (de) | 2008-12-12 | 2010-06-17 | Saltigo Gmbh | Verfahren zur Herstellung von Perfluoralkyl- oder Perfluoralkoxyalkanolen |
| LT3099306T (lt) | 2014-01-29 | 2019-03-12 | Umecrine Cognition Ab | Steroidinis junginys, skirtas panaudoti kepenų encefalopatijos gydymui |
| AR103384A1 (es) | 2015-01-12 | 2017-05-03 | Umecrine Cognition Ab | 3a-ETINILO, 3b-HIDROXI, 5a-PREGNAN-20-OXIMA COMO MODULADOR DE GABA |
| US10278977B2 (en) | 2016-06-06 | 2019-05-07 | Umecrine Cognition Ab | Methods for treating hypersomnolence |
| CN110117217B (zh) * | 2018-12-19 | 2021-09-28 | 浙江普洛家园药业有限公司 | 1-溴代甲基-2,3,5,6-四氟-4-(三氟甲基)苯的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2528434B1 (fr) * | 1982-06-11 | 1985-07-19 | Roussel Uclaf | Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament |
| FR2643638B1 (fr) * | 1989-02-24 | 1991-06-14 | Roussel Uclaf | Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant |
| ES2112268T3 (es) * | 1990-08-14 | 1998-04-01 | Hoechst Marion Roussel Inc | Nuevos 19-nor-esteroides que tienen en posicion 11beta una cadena carbonada que comprende una funcion amida, su preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen. |
| FR2685332A1 (fr) * | 1991-12-20 | 1993-06-25 | Roussel Uclaf | Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments. |
-
1991
- 1991-12-20 FR FR9115856A patent/FR2685332A1/fr active Granted
-
1992
- 1992-12-15 IL IL104105A patent/IL104105A/xx not_active IP Right Cessation
- 1992-12-17 NZ NZ246624A patent/NZ246624A/en unknown
- 1992-12-17 US US08/244,735 patent/US6281204B1/en not_active Expired - Fee Related
- 1992-12-17 CA CA002124339A patent/CA2124339C/fr not_active Expired - Fee Related
- 1992-12-17 AU AU33570/93A patent/AU666916B2/en not_active Ceased
- 1992-12-17 KR KR1019940702134A patent/KR100278465B1/ko not_active IP Right Cessation
- 1992-12-17 WO PCT/FR1992/001193 patent/WO1993013123A1/fr active IP Right Grant
- 1992-12-17 JP JP51147893A patent/JP3445271B2/ja not_active Expired - Fee Related
- 1992-12-17 EP EP93902339A patent/EP0623140B1/fr not_active Expired - Lifetime
- 1992-12-17 DE DE69225243T patent/DE69225243T2/de not_active Expired - Fee Related
- 1992-12-17 DK DK93902339T patent/DK0623140T3/da active
- 1992-12-17 HU HU9402134A patent/HU221482B/hu not_active IP Right Cessation
- 1992-12-17 AT AT93902339T patent/ATE165365T1/de not_active IP Right Cessation
- 1992-12-17 ES ES93902339T patent/ES2115754T3/es not_active Expired - Lifetime
- 1992-12-17 RU RU94031162/04A patent/RU2111213C1/ru not_active IP Right Cessation
- 1992-12-18 MX MX9207421A patent/MX9207421A/es not_active IP Right Cessation
- 1992-12-18 ZA ZA929859A patent/ZA929859B/xx unknown
- 1992-12-19 CN CN92115248A patent/CN1036718C/zh not_active Expired - Fee Related
-
1994
- 1994-06-17 FI FI942944A patent/FI114866B/fi not_active IP Right Cessation
-
2001
- 2001-06-26 US US09/891,433 patent/US6596885B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1075722A (zh) | 1993-09-01 |
| KR100278465B1 (ko) | 2001-02-01 |
| AU666916B2 (en) | 1996-02-29 |
| DE69225243D1 (de) | 1998-05-28 |
| DE69225243T2 (de) | 1998-10-29 |
| CN1036718C (zh) | 1997-12-17 |
| ES2115754T3 (es) | 1998-07-01 |
| IL104105A0 (en) | 1993-05-13 |
| EP0623140B1 (fr) | 1998-04-22 |
| AU3357093A (en) | 1993-07-28 |
| DK0623140T3 (da) | 1999-02-15 |
| JPH07502281A (ja) | 1995-03-09 |
| US6596885B2 (en) | 2003-07-22 |
| CA2124339C (fr) | 2005-02-15 |
| RU2111213C1 (ru) | 1998-05-20 |
| JP3445271B2 (ja) | 2003-09-08 |
| CA2124339A1 (fr) | 1993-07-08 |
| US20020072624A1 (en) | 2002-06-13 |
| HU9402134D0 (en) | 1994-09-28 |
| FI114866B (fi) | 2005-01-14 |
| ATE165365T1 (de) | 1998-05-15 |
| RU94031162A (ru) | 1996-04-20 |
| EP0623140A1 (fr) | 1994-11-09 |
| HUT68068A (en) | 1995-05-29 |
| HU221482B (en) | 2002-10-28 |
| FI942944A0 (fi) | 1994-06-17 |
| NZ246624A (en) | 1995-12-21 |
| WO1993013123A1 (fr) | 1993-07-08 |
| MX9207421A (es) | 1993-07-01 |
| FR2685332A1 (fr) | 1993-06-25 |
| FI942944L (fi) | 1994-06-17 |
| FR2685332B1 (xx) | 1995-06-02 |
| US6281204B1 (en) | 2001-08-28 |
| ZA929859B (en) | 1993-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| HCE | Change of name and address of proprietor(s) | ||
| HCA | Change of name of proprietor(s) after amalgamation | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |