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IL102520A0 - 8-vinyl-and 8-ethinyl-quinolone-carboxylic acids,their preparation and pharmaceutical compositions containing them - Google Patents

8-vinyl-and 8-ethinyl-quinolone-carboxylic acids,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL102520A0
IL102520A0 IL102520A IL10252092A IL102520A0 IL 102520 A0 IL102520 A0 IL 102520A0 IL 102520 A IL102520 A IL 102520A IL 10252092 A IL10252092 A IL 10252092A IL 102520 A0 IL102520 A0 IL 102520A0
Authority
IL
Israel
Prior art keywords
vinyl
preparation
ethinyl
quinolone
pharmaceutical compositions
Prior art date
Application number
IL102520A
Other versions
IL102520A (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL102520A0 publication Critical patent/IL102520A0/en
Publication of IL102520A publication Critical patent/IL102520A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paints Or Removers (AREA)

Abstract

The invention relates to novel 8-vinyl- and 8-ethynyl- quinolonecarboxylic acids, a process for their preparation and antibacterial agents and feed additives containing them.
IL102520A 1991-07-19 1992-07-16 8-vinyl-, 8-propenyl and 8-ethinyl-quinolone- carboxylic acids, their preparation, intermediates therefor and pharmaceutical compositions containing them IL102520A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4123918A DE4123918A1 (en) 1991-07-19 1991-07-19 8-VINYL AND 8-ETHINYL-CHINOLON CARBONIC ACIDS

Publications (2)

Publication Number Publication Date
IL102520A0 true IL102520A0 (en) 1993-01-14
IL102520A IL102520A (en) 1997-07-13

Family

ID=6436512

Family Applications (1)

Application Number Title Priority Date Filing Date
IL102520A IL102520A (en) 1991-07-19 1992-07-16 8-vinyl-, 8-propenyl and 8-ethinyl-quinolone- carboxylic acids, their preparation, intermediates therefor and pharmaceutical compositions containing them

Country Status (22)

Country Link
EP (1) EP0523512B1 (en)
JP (1) JP3174405B2 (en)
KR (1) KR100240608B1 (en)
AT (1) ATE147733T1 (en)
AU (1) AU658901B2 (en)
CA (1) CA2073993A1 (en)
CZ (1) CZ282037B6 (en)
DE (2) DE4123918A1 (en)
DK (1) DK0523512T3 (en)
ES (1) ES2097835T3 (en)
FI (1) FI103043B (en)
GR (1) GR3022305T3 (en)
HU (1) HU219910B (en)
IE (1) IE80557B1 (en)
IL (1) IL102520A (en)
MX (1) MX9204110A (en)
NO (1) NO302886B1 (en)
PL (1) PL171910B1 (en)
RU (1) RU2077533C1 (en)
SK (1) SK279221B6 (en)
TW (1) TW201309B (en)
ZA (1) ZA925351B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121214A1 (en) * 1991-06-27 1993-01-14 Bayer Ag 7-AZAISOINDOLINYL CHINOLONE AND NAPHTHYRIDONE CARBONIC ACID DERIVATIVES
DE4230804A1 (en) * 1992-09-15 1994-03-17 Bayer Ag 7-isoindolinyl quinolone and naphthyridone derivatives
DE4303657A1 (en) * 1993-02-09 1994-08-11 Bayer Ag New quinolone and naphthyridonecarboxylic acid derivatives
KR950018003A (en) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 Novel quinolone derivatives and methods for their preparation
DE4418510A1 (en) * 1994-05-27 1995-11-30 Bayer Ag 1,9-bridged thiazolol [3,4-a] quinoline derivatives
DE4425659A1 (en) * 1994-07-20 1996-01-25 Bayer Ag New N1-diverse 6-fluoro-8-difluoromethoxy substituted quinolonecarboxylic acids
DE4427530A1 (en) * 1994-08-04 1996-02-08 Bayer Ag New 7-tri:cyclic amino-quinolone or naphthyridone derivs
JP3484703B2 (en) 1996-04-19 2004-01-06 湧永製薬株式会社 Novel pyridonecarboxylic acid derivative or salt thereof and resistance agent containing the substance as active ingredient
WO1998024781A1 (en) * 1996-12-04 1998-06-11 Daiichi Pharmaceutical Co., Ltd. Substituted aminomethylpyrrolidine derivatives
CA2303389C (en) 1997-09-15 2007-07-17 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
EP1666477B1 (en) 2003-09-10 2013-07-03 Kyorin Pharmaceutical Co., Ltd. 7-(4-substituted 3- cyclopropylaminomethyl-1- pyrrolidinyl) q uinolonecarboxylic acid derivative
US7563805B2 (en) * 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
WO2007037303A1 (en) * 2005-09-28 2007-04-05 Daiichi Sankyo Company, Limited Process for preparation of tetrasubstituted 5-azaspiro[2.4]- heptane derivatives and optically active intermediates thereof
PL2001862T3 (en) 2006-03-28 2011-09-30 Warner Chilcott Co Llc Malate salts, and polymorphs of (3s,5s)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
JP2009531418A (en) 2006-03-28 2009-09-03 ザ プロクター アンド ギャンブル カンパニー Coupling method for the preparation of quinolone intermediates
EP2149571A4 (en) 2007-05-24 2010-09-01 Kyorin Seiyaku Kk MUTILINE DERIVATIVE HAVING CARBOXYLIC ACID STRUCTURE HETEROCYCLIC AROMATIC CORE SUBSTITUTED AT POSITION 14
PL3790874T3 (en) * 2018-05-09 2023-06-19 Bayer Animal Health Gmbh Anthelmintic quinoline derivatives
RU2757741C1 (en) * 2021-03-01 2021-10-21 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) Ciprofloxacin derivative with antibacterial activity against antibiotic-resistant strains of microorganisms

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123536A (en) * 1977-12-14 1978-10-31 Warner-Lambert Company Dialkyl ({[3-(alkoxycarbonyl)-1,4-dihydro-4-oxo-8-quinolinyl]amino}methylene)propanedioates
DE3705621C2 (en) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclic substituted quinolonecarboxylic acid derivatives
JPS62215572A (en) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd Quinolone carboxylic acid derivative
US5047538A (en) * 1990-04-12 1991-09-10 Warner-Lambert Company Quinolinecarboxylic acid antibacterial agents

Also Published As

Publication number Publication date
HUT61741A (en) 1993-03-01
PL295331A1 (en) 1993-07-12
HU219910B (en) 2001-09-28
JPH05262738A (en) 1993-10-12
MX9204110A (en) 1993-08-01
AU658901B2 (en) 1995-05-04
SK219192A3 (en) 1998-08-05
RU2077533C1 (en) 1997-04-20
DK0523512T3 (en) 1997-06-30
JP3174405B2 (en) 2001-06-11
IE922348A1 (en) 1993-01-27
FI923268A0 (en) 1992-07-16
DE4123918A1 (en) 1993-01-21
HU9202349D0 (en) 1992-10-28
IL102520A (en) 1997-07-13
ES2097835T3 (en) 1997-04-16
GR3022305T3 (en) 1997-04-30
CZ282037B6 (en) 1997-04-16
TW201309B (en) 1993-03-01
PL171910B1 (en) 1997-06-30
AU1966392A (en) 1993-01-21
CA2073993A1 (en) 1993-01-20
CZ219192A3 (en) 1993-02-17
ZA925351B (en) 1993-04-28
FI923268L (en) 1993-01-20
EP0523512B1 (en) 1997-01-15
DE59207880D1 (en) 1997-02-27
FI103043B1 (en) 1999-04-15
ATE147733T1 (en) 1997-02-15
SK279221B6 (en) 1998-08-05
KR100240608B1 (en) 2000-03-02
NO302886B1 (en) 1998-05-04
KR930002320A (en) 1993-02-22
FI103043B (en) 1999-04-15
IE80557B1 (en) 1998-09-23
EP0523512A1 (en) 1993-01-20
NO922639D0 (en) 1992-07-03
NO922639L (en) 1993-01-20

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees