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IE912025A1 - Substituted benzimidazoles, process for their preparation¹and their pharmaceutical use - Google Patents

Substituted benzimidazoles, process for their preparation¹and their pharmaceutical use

Info

Publication number
IE912025A1
IE912025A1 IE202591A IE202591A IE912025A1 IE 912025 A1 IE912025 A1 IE 912025A1 IE 202591 A IE202591 A IE 202591A IE 202591 A IE202591 A IE 202591A IE 912025 A1 IE912025 A1 IE 912025A1
Authority
IE
Ireland
Prior art keywords
methyl
compound according
compound
benzimidazole
carbon atoms
Prior art date
Application number
IE202591A
Other languages
English (en)
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of IE912025A1 publication Critical patent/IE912025A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
IE202591A 1990-06-20 1991-06-14 Substituted benzimidazoles, process for their preparation¹and their pharmaceutical use IE912025A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9002206A SE9002206D0 (sv) 1990-06-20 1990-06-20 New compounds

Publications (1)

Publication Number Publication Date
IE912025A1 true IE912025A1 (en) 1992-01-01

Family

ID=20379831

Family Applications (1)

Application Number Title Priority Date Filing Date
IE202591A IE912025A1 (en) 1990-06-20 1991-06-14 Substituted benzimidazoles, process for their preparation¹and their pharmaceutical use

Country Status (27)

Country Link
EP (1) EP0535081A1 (pt)
JP (1) JPH05507713A (pt)
CN (1) CN1058212A (pt)
AP (1) AP215A (pt)
AU (1) AU649453B2 (pt)
BG (1) BG97200A (pt)
CA (1) CA2083714A1 (pt)
CZ (1) CZ279772B6 (pt)
FI (1) FI925766A (pt)
HU (1) HUT62881A (pt)
IE (1) IE912025A1 (pt)
IL (1) IL98470A0 (pt)
IS (1) IS3721A7 (pt)
LT (2) LT3952B (pt)
LV (1) LV10953A (pt)
MA (1) MA22199A1 (pt)
NO (1) NO924775D0 (pt)
NZ (1) NZ238546A (pt)
OA (1) OA09682A (pt)
PT (1) PT98035A (pt)
RO (1) RO110493B1 (pt)
SE (1) SE9002206D0 (pt)
TN (1) TNSN91049A1 (pt)
TW (1) TW216418B (pt)
WO (1) WO1991019711A1 (pt)
YU (1) YU104191A (pt)
ZA (2) ZA914297B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
SE9103776D0 (sv) * 1991-12-19 1991-12-19 Astra Ab New compounds
IS4232A (is) * 1993-12-06 1995-06-07 Astra Aktiebolag Súbstitúerað bensimidasól, aðferðir við framleiðslu þess og lyfjafræðileg notkun
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
ES2232459T3 (es) 2000-02-24 2005-06-01 Kopran Research Laboratories Limited Derivados de benzimidazol antiulcerosos estables frente a los acidos de administracion oral.
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
US7906145B2 (en) 2002-04-09 2011-03-15 Flamel Technologies Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s)
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
EP2184058B1 (en) 2003-09-26 2012-02-08 ALZA Corporation Drug coating providing high drug loading and methods for providing the same
TW200606163A (en) 2004-04-22 2006-02-16 Eisai Co Ltd Imidazopyridine compound
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US20070015782A1 (en) * 2005-04-15 2007-01-18 Eisai Co., Ltd. Benzimidazole compound
US9040564B2 (en) 2005-04-28 2015-05-26 Eisai R&D Management Co., Ltd. Stabilized composition
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
WO2007122686A1 (ja) * 2006-04-14 2007-11-01 Eisai R & D Management Co., Ltd. ベンズイミダゾール化合物
ES2511792T3 (es) 2006-07-25 2014-10-23 Vecta Ltd. Composiciones y métodos para la inhibición de la secreción de ácido gástrico usando derivados de pequeños ácidos dicarboxílicos en combinación con IBP
JP5492417B2 (ja) * 2006-10-13 2014-05-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 胃酸分泌抑制作用を有するベンズイミダゾール化合物
US9220698B2 (en) 2008-09-09 2015-12-29 Pozen Inc. Method for delivering a pharmaceutical composition to patient in need thereof
WO2010151216A1 (en) 2009-06-25 2010-12-29 Astrazeneca Ab Method for treating a patient at risk for developing an nsaid-associated ulcer
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
US20120294937A1 (en) 2009-12-29 2012-11-22 Novartis Ag New pharmaceutical dosage form for the treatment of gastric acid-related disorders
EP2601947A1 (en) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Fixed-dose combination for treatment of helicobacter pylori associated diseases
WO2013101897A2 (en) 2011-12-28 2013-07-04 Pozen Inc. Improved compositions and methods for delivery of omeprazole plus acetylsalicylic acid
IL307576B1 (en) 2016-09-14 2025-02-01 Yufeng Jane Tseng History of new modified benzimidazoles as D-amino acid oxidase (DAAO) inhibitors

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418966B (sv) 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (pt) 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
SE8300736D0 (sv) 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
SE8301182D0 (sv) 1983-03-04 1983-03-04 Haessle Ab Novel compounds
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
US4738975A (en) 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
NZ234564A (en) 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
HU886738D0 (en) * 1987-10-30 1990-02-28 Haessle Ab Process for the preparation of pharmaceutical compositions against osteoporosis containing 2-pyridinyl-methyl-(sulfinyl or thio)-benzimidazoles
EP0390842A1 (de) * 1987-12-11 1990-10-10 Byk Gulden Lomberg Chemische Fabrik GmbH Neue benzimidazolderivate
EP0415990A1 (de) * 1988-05-25 1991-03-13 Byk Gulden Lomberg Chemische Fabrik GmbH Neue fluoralkoxyverbindungen

Also Published As

Publication number Publication date
WO1991019711A1 (en) 1991-12-26
OA09682A (en) 1993-05-15
JPH05507713A (ja) 1993-11-04
HU9204033D0 (en) 1993-03-29
BG97200A (bg) 1993-12-24
IS3721A7 (is) 1991-12-21
EP0535081A1 (en) 1993-04-07
AU8009791A (en) 1992-01-07
CZ279772B6 (cs) 1995-06-14
FI925766A0 (fi) 1992-12-18
TNSN91049A1 (fr) 1992-10-25
CA2083714A1 (en) 1991-12-21
MA22199A1 (fr) 1992-04-01
IL98470A0 (en) 1992-07-15
TW216418B (pt) 1993-11-21
HUT62881A (en) 1993-06-28
FI925766A (fi) 1992-12-18
LV10953A (lv) 1995-12-20
NO924775L (no) 1992-12-10
LTIP1713A (en) 1995-08-25
RO110493B1 (ro) 1996-01-30
LTIP1712A (en) 1995-08-25
ZA914297B (en) 1992-03-25
ZA914296B (en) 1992-03-25
AP215A (en) 1992-09-02
AP9100285A0 (en) 1991-07-31
AU649453B2 (en) 1994-05-26
LT3977B (en) 1996-06-25
PT98035A (pt) 1992-03-31
CS189491A3 (en) 1992-04-15
NZ238546A (en) 1994-03-25
LT3952B (en) 1996-05-27
NO924775D0 (no) 1992-12-10
CN1058212A (zh) 1992-01-29
YU104191A (sh) 1994-01-20
SE9002206D0 (sv) 1990-06-20

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