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IE842524L - Cephalosporins and analogous carboxyalkenoic acid¹derivatives - Google Patents

Cephalosporins and analogous carboxyalkenoic acid¹derivatives

Info

Publication number
IE842524L
IE842524L IE842524A IE252484A IE842524L IE 842524 L IE842524 L IE 842524L IE 842524 A IE842524 A IE 842524A IE 252484 A IE252484 A IE 252484A IE 842524 L IE842524 L IE 842524L
Authority
IE
Ireland
Prior art keywords
hydrogen
cephalosporins
carboxyalkenoic
analogous
same
Prior art date
Application number
IE842524A
Other versions
IE57744B1 (en
Original Assignee
Sitionogi & Lo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP58186601A external-priority patent/JPS6078987A/en
Priority claimed from JP59018563A external-priority patent/JPS60163884A/en
Priority claimed from JP59100890A external-priority patent/JPH0780892B2/en
Application filed by Sitionogi & Lo Ltd filed Critical Sitionogi & Lo Ltd
Publication of IE842524L publication Critical patent/IE842524L/en
Publication of IE57744B1 publication Critical patent/IE57744B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Steroid Compounds (AREA)

Abstract

An antibacterial 7beta-(carboxyalkenoyl)amino-3-cephem-4-carboxylic acid represented by the following formula: <IMAGE> (wherein R is aryl or a heterocyclic group; R1 is hydrogen or halogen; R2 is a single bond, alkylene, or thiaalkylene; R3 is a hydrogen atom or carboxy modifying group; R4 is hydrogen or methoxy; R5 is hydrogen or a 3-substituent of cephalosporins; R6 is a hydrogen atom or carboxy modifying group; and X is oxygen, sulfur, or sulfinyl) a pharmaceutical composition containing the same, and a method for treating a bacterial infection with the same. [US4634697A]
IE2524/84A 1983-10-04 1984-10-03 Carboxybutenamidocephalosporins IE57744B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP58186601A JPS6078987A (en) 1983-10-04 1983-10-04 Acrylamidocephalosporins
JP59018563A JPS60163884A (en) 1984-02-03 1984-02-03 Carboxyalkenamidocephalosporin
JP59100890A JPH0780892B2 (en) 1984-05-18 1984-05-18 Carboxy alkenamide cefalosporin

Publications (2)

Publication Number Publication Date
IE842524L true IE842524L (en) 1985-04-04
IE57744B1 IE57744B1 (en) 1993-03-24

Family

ID=27282263

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2524/84A IE57744B1 (en) 1983-10-04 1984-10-03 Carboxybutenamidocephalosporins

Country Status (22)

Country Link
US (3) US4634697A (en)
EP (1) EP0136721B1 (en)
KR (2) KR880002376B1 (en)
AR (1) AR242392A1 (en)
AT (1) ATE99311T1 (en)
AU (2) AU575854B2 (en)
CA (2) CA1238910A (en)
DE (2) DE3486259T2 (en)
DK (1) DK171043B1 (en)
ES (3) ES8604602A1 (en)
FI (1) FI82057C (en)
GB (3) GB2154580B (en)
GR (1) GR80544B (en)
HU (1) HU193298B (en)
IE (1) IE57744B1 (en)
IL (3) IL84653A (en)
MX (1) MX174328B (en)
NL (1) NL940013I2 (en)
NO (2) NO173238C (en)
NZ (2) NZ209634A (en)
PH (2) PH20223A (en)
PT (1) PT79287A (en)

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JPS6124580A (en) * 1984-07-12 1986-02-03 Shionogi & Co Ltd Aminothiazolylglutaric acid derivative
JPS6153272A (en) * 1984-08-24 1986-03-17 Shionogi & Co Ltd Preparation of glutaconic acid derivative
AU580855B2 (en) * 1985-03-29 1989-02-02 Shionogi & Co., Ltd. Alkeneamidocephalosporin esters
ZA863170B (en) 1985-04-30 1987-12-30 Lilly Co Eli 7-substituted bicyclic pyrazolidinones
US4731362A (en) * 1985-08-05 1988-03-15 Shionogi & Co., Ltd. Alkylcarbamoyloxymethylcephem compounds
DE3745094B4 (en) * 1986-07-02 2004-12-30 Shionogi & Co., Ltd. New stable hydrate of 7-butenoyl:amino- cephalosporin derivs. - esp. formulated in soft gelatin capsules sealed with gelatin layer
NZ220764A (en) * 1986-07-02 1989-09-27 Shionogi & Co Crystalline form of 7beta((z)-2-(2-aminothiazol-4-yl)-4- carboxybut-2-enoylamino)-3-cephem-4-carboxylic acid and pharmaceutical compositions
AT396652B (en) * 1986-07-02 1993-11-25 Shionogi & Co Process for the preparation of hard gelatin capsule compositions
US5017380A (en) * 1986-07-02 1991-05-21 Shionogi & Co., Ltd. Gelatin hard capsule containing crystalline hydrate of oral cephalosporin
US5147871A (en) * 1986-07-03 1992-09-15 Hoffmann La-Roche, Inc. Anti-bacterial cephalosporin compounds
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US5336768A (en) * 1988-05-24 1994-08-09 Hoffmann-La Roche Inc. Antibacterial cephalosporin compounds
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WO2005009364A2 (en) * 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
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Also Published As

Publication number Publication date
GB2198727B (en) 1988-11-16
AU601842B2 (en) 1990-09-20
KR850002989A (en) 1985-05-28
KR880002684B1 (en) 1988-12-20
GB8726623D0 (en) 1987-12-16
DK474584A (en) 1985-04-05
IL84653A (en) 1990-08-31
ES547301A0 (en) 1986-03-16
FI843871L (en) 1985-04-05
DE136721T1 (en) 1985-08-29
PT79287A (en) 1984-11-01
NZ218741A (en) 1988-07-28
CA1272713C (en) 1990-08-14
GB2190914A (en) 1987-12-02
ES536502A0 (en) 1986-02-01
KR880002376B1 (en) 1988-11-03
NO176567B (en) 1995-01-16
NO843956L (en) 1985-04-09
NZ209634A (en) 1988-07-28
GR80544B (en) 1985-02-05
NL940013I2 (en) 1999-06-01
IL84653A0 (en) 1988-04-29
HUT36129A (en) 1985-08-28
EP0136721A2 (en) 1985-04-10
US4748170A (en) 1988-05-31
NO853806L (en) 1985-04-09
ES8605278A1 (en) 1986-03-16
PH21766A (en) 1988-02-18
NO176567C (en) 1995-04-26
GB2154580A (en) 1985-09-11
NO173238B (en) 1993-08-09
MX174328B (en) 1994-05-09
AU1619488A (en) 1988-08-11
GB2190914B (en) 1988-08-17
FI82057B (en) 1990-09-28
PH20223A (en) 1986-10-23
US4634697A (en) 1987-01-06
NL940013I1 (en) 1994-08-16
IL73159A (en) 1990-08-31
CA1238910A (en) 1988-07-05
DK171043B1 (en) 1996-04-29
DE3486259D1 (en) 1994-02-10
ES547300A0 (en) 1986-11-16
AU575854B2 (en) 1988-08-11
CA1272713A (en) 1990-08-14
DK474584D0 (en) 1984-10-03
HU193298B (en) 1987-09-28
FI82057C (en) 1991-01-10
FI843871A0 (en) 1984-10-02
AR242392A1 (en) 1993-03-31
DE3486259T2 (en) 1994-07-21
EP0136721A3 (en) 1986-01-22
GB8700123D0 (en) 1987-02-11
IE57744B1 (en) 1993-03-24
GB2198727A (en) 1988-06-22
EP0136721B1 (en) 1993-12-29
US4912224A (en) 1990-03-27
NO173238C (en) 1993-11-17
ES8604602A1 (en) 1986-02-01
GB2154580B (en) 1988-08-17
IL73159A0 (en) 1985-01-31
ES8700222A1 (en) 1986-11-16
GB8424923D0 (en) 1984-11-07
AU3330084A (en) 1985-05-09
ATE99311T1 (en) 1994-01-15

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