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IE39869L - 2- (1'-piperazinyl)- quinoxaline compounds - Google Patents

2- (1'-piperazinyl)- quinoxaline compounds

Info

Publication number
IE39869L
IE39869L IE741397A IE139774A IE39869L IE 39869 L IE39869 L IE 39869L IE 741397 A IE741397 A IE 741397A IE 139774 A IE139774 A IE 139774A IE 39869 L IE39869 L IE 39869L
Authority
IE
Ireland
Prior art keywords
alkyl
hydrogen
alkanoyl
carbamoyl
alkoxycarbonyl
Prior art date
Application number
IE741397A
Other versions
IE39869B1 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IE39869L publication Critical patent/IE39869L/en
Publication of IE39869B1 publication Critical patent/IE39869B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
    • C07D241/52—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1440722 2 - (1<SP>1</SP> - Piperazinyl) - quinoxaline compounds MERCK & CO Inc 8 July 1974 [13 July 1973 29 April 1974] 30176/74 Heading C2C Novel 2 - (1<SP>1</SP> - piperazinyl) - quinoxaline compounds of the formula in which the dotted line indicates that the compounds are saturated or ethylenically unsaturated at the 3,4-position; R<SP>1</SP> is oxygen; each of n and m is 0 or 1; R<SP>4</SP> is oxygen, hydrogen, alkyl, or aminoalkyl and R<SP>3</SP> is hydrogen, alkyl, alkoxycarbonyl, alkanoyl, aryl, substituted aryl, alkylthio, arylthio, alkoxy, amino, keto, alkylamino, dialkylamino, hydroxy, halo, carboxy, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl or alkylimino; or R<SP>4</SP> and R<SP>3</SP> are joined to form, together with the adjacent nitrogen and carbon atoms of the quinoxaline nucleus, a 5-to-7-membered ring; each of R<SP>5</SP>, R<SP>6</SP>, R<SP>7</SP> and R<SP>8</SP> is hydrogen, allyl, haloalkyl, haloalkylthio, arylalkyl, cycloalkyl, aroyl, alkyl, nitro, alkanoyl, aryl, substituted aryl, alkylthio, alkylsulphonyl, haloalkylsulphonyl, alkylsulphinyl, haloalkylsulphinyl, arylthio, alkoxy, haloalkoxy, amino, alkylamino, dialkylamino, hydroxy, halo, carboxy, alkoxycarbonyl, carbamoyl, N-alkyl-carbamoyl, cyano, N,N-dialkylcarbamoyl or dialkylsulphamoyl ; R<SP>4</SP> is hydrogen, allyl, substituted allyl, haloalkyl, arylalkyl, cycloalkyl, alkanoyl, aroyl, alkylidenaminoxycarbonyl, alkoxycarbonalkylenedithiocarbonyl, alkyldithiocarbonyl, #-cyanoethyl, alkoxycarbonyl, aryloxycarbonyl, or aralkyloxycarbonyl; and each of R<SP>2</SP>', R<SP>3</SP>', R<SP>5</SP>' and R<SP>6</SP>' is keto or two of the following univalent atoms or groups: hydrogen, alkyl, alkanoyl, aryl, substituted aryl, carboxy, alkoxycarbonyl, carbamoyl, N - alkylcarbamoyl or N,N- dialkylcarbamoyl, or R<SP>2</SP>' and R<SP>3</SP>' and/or R<SP>6</SP>' and R<SP>8</SP>' are joined to form a cycloaliphatic substituent sharing the 2',3'-carbon atoms and/or 5',6'-carbon atoms, as the case may be, of the piperazine ring or a non-toxic, pharmaceutically acceptable acid-addition salt thereof, are prepared by reacting a quinoxaline of the formula with a piperazine of the formula wherein Y is a replaceable group. The novel compounds are useful as antidepressant agents in the control of appetite, sleep and pain. [GB1440722A]
IE1397/74A 1973-07-13 1974-07-02 2-(1'-piperazinyl)-quinoxaline compounds having pharmaceutical activity IE39869B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37902273A 1973-07-13 1973-07-13
US46538174A 1974-04-29 1974-04-29

Publications (2)

Publication Number Publication Date
IE39869L true IE39869L (en) 1975-01-13
IE39869B1 IE39869B1 (en) 1979-01-17

Family

ID=27008442

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1397/74A IE39869B1 (en) 1973-07-13 1974-07-02 2-(1'-piperazinyl)-quinoxaline compounds having pharmaceutical activity

Country Status (18)

Country Link
JP (1) JPS5037791A (en)
AU (1) AU7073174A (en)
BG (1) BG21606A3 (en)
CH (1) CH605919A5 (en)
DD (1) DD112127A5 (en)
DE (1) DE2433397A1 (en)
DK (1) DK342674A (en)
ES (1) ES428107A1 (en)
FI (1) FI193974A (en)
FR (1) FR2236499B1 (en)
GB (1) GB1440722A (en)
IE (1) IE39869B1 (en)
IL (1) IL45158A0 (en)
LU (1) LU70510A1 (en)
NL (1) NL7408705A (en)
NO (1) NO742351L (en)
RO (1) RO63539A (en)
SE (1) SE417316B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4082845A (en) 1977-04-25 1978-04-04 Merck & Co., Inc. 3-(1-Piperazinyl)-pyrido[2,3-b]pyrazines
US4107309A (en) * 1977-05-23 1978-08-15 American Cyanamid Company Substituted imidazo[1,2-d]-as-triazines
US4091101A (en) * 1977-06-15 1978-05-23 Merck & Co., Inc. 6-(1-Piperazinyl)quinoxaline
EP0094498A3 (en) * 1982-05-06 1985-04-03 American Cyanamid Company Antiatherosclerotic 1-piperazine derivatives
ES2042395B1 (en) * 1992-02-27 1994-06-16 Promotora Catalana De Inversio PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF 2-CIANO-3-PIPERACINILQUINOXALINAS.
FR2731221B1 (en) * 1995-03-01 1997-05-30 Pf Medicament NOVEL DERIVATIVES OF ETHYL-1 DIHYDRO-1, 2 OXO-2 METHYLAMINO-3 QUINOXALINE, THEIR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
US6040448A (en) 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
WO1999021850A1 (en) * 1997-10-24 1999-05-06 Neurogen Corporation 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl)piperazines being dopamine d4 receptor subtype ligands
WO2000012500A2 (en) * 1998-09-02 2000-03-09 Neurogen Corporation 2-aryl-4-(1-[4-heteroaryl]piperazin-1-yl) methylimidazoles: dopamine d4 receptor subtype ligands
US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
KR100722090B1 (en) * 1999-05-21 2007-05-25 바이오비트럼 에이비 New Compounds, Uses thereof, and Methods for Making the Sames
SE9901884D0 (en) * 1999-05-21 1999-05-21 Pharmacia & Upjohn Ab Novel compounds their use and preparation
JP4707261B2 (en) * 2001-05-15 2011-06-22 日本エンバイロケミカルズ株式会社 Quinoxaline compound and industrial bactericidal composition
IL165220A0 (en) 2002-06-19 2005-12-18 Biovitrum Ab Novel compounds, their use and preparation
SE0202287D0 (en) * 2002-07-19 2002-07-19 Biovitrum Ab New compounds
KR20050025628A (en) * 2002-07-19 2005-03-14 바이오비트럼 에이비 Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders
AU2004221812B2 (en) 2003-03-19 2010-02-18 Exelixis Inc. Tie-2 modulators and methods of use
CN1886389B (en) * 2003-09-30 2010-07-21 詹森药业有限公司 Quinoxaline compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL260335A (en) * 1960-01-22
CH450434A (en) * 1961-12-14 1968-01-31 Ciba Geigy Process for the preparation of diazines
BE788451A (en) * 1971-09-08 1973-03-06 Bayer Ag NEW 2-AMINO-QUINOXALINES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS INSECTICIDES, ACARICIDES AND FUNGICIDES
GB1457005A (en) * 1972-11-20 1976-12-01 Pfizer 2-substituted-3-aminoquinoxalines

Also Published As

Publication number Publication date
DD112127A5 (en) 1975-03-20
RO63539A (en) 1978-07-15
SE417316B (en) 1981-03-09
LU70510A1 (en) 1975-03-27
BG21606A3 (en) 1976-07-20
JPS5037791A (en) 1975-04-08
NO742351L (en) 1975-02-10
CH605919A5 (en) 1978-10-13
AU7073174A (en) 1976-01-08
FR2236499A1 (en) 1975-02-07
IE39869B1 (en) 1979-01-17
ES428107A1 (en) 1976-11-16
NL7408705A (en) 1975-01-15
FI193974A (en) 1975-01-14
FR2236499B1 (en) 1977-04-15
DE2433397A1 (en) 1975-02-06
SE7408486L (en) 1975-01-14
IL45158A0 (en) 1974-11-29
GB1440722A (en) 1976-06-23
DK342674A (en) 1975-03-03

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