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ID25469A - Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannya - Google Patents

Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannya

Info

Publication number
ID25469A
ID25469A IDW20001303A ID20001303A ID25469A ID 25469 A ID25469 A ID 25469A ID W20001303 A IDW20001303 A ID W20001303A ID 20001303 A ID20001303 A ID 20001303A ID 25469 A ID25469 A ID 25469A
Authority
ID
Indonesia
Prior art keywords
sefalosporine
christalography
amorf
stories
making
Prior art date
Application number
IDW20001303A
Other languages
English (en)
Inventor
Masahiro Onodera
Masamichi Sukegawa
Kiyoshi Yasui
Tatsuo Watanabe
Toyomi Sato
Yasushi Muria
Katsuharu Iinuma
Original Assignee
Meiji Seika Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha filed Critical Meiji Seika Kaisha
Publication of ID25469A publication Critical patent/ID25469A/id

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IDW20001303A 1998-01-07 1999-01-07 Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannya ID25469A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP192098 1998-01-07

Publications (1)

Publication Number Publication Date
ID25469A true ID25469A (id) 2000-10-05

Family

ID=11515039

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20001303A ID25469A (id) 1998-01-07 1999-01-07 Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannya

Country Status (22)

Country Link
US (2) US6342493B1 (id)
EP (1) EP1051978B1 (id)
JP (1) JP3413406B2 (id)
KR (1) KR100435315B1 (id)
CN (1) CN1151845C (id)
AU (1) AU736555B2 (id)
BR (1) BRPI9907084B8 (id)
CA (1) CA2316841C (id)
CZ (1) CZ302082B6 (id)
EA (1) EA002881B1 (id)
ES (1) ES2393972T3 (id)
HU (1) HU230295B1 (id)
ID (1) ID25469A (id)
IL (2) IL137004A0 (id)
NZ (1) NZ505871A (id)
PL (1) PL194097B1 (id)
PT (1) PT1051978E (id)
SK (1) SK286631B6 (id)
TR (1) TR200001903T2 (id)
TW (1) TW587946B (id)
UA (1) UA70311C2 (id)
WO (1) WO1999034832A1 (id)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200001903T2 (tr) * 1998-01-07 2000-11-21 Meiji Seika Kaisha, Ltd. Kristalografik açıdan kararlı, şekilsiz sefalosporin bileşimleri ve bunların üretilmesine ilişkin işlem.
HK1049656A1 (zh) 1999-10-08 2003-05-23 Smithkline Beecham Corporation Fab i抑制剂
US7049310B2 (en) 2001-04-06 2006-05-23 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US7527808B2 (en) 2001-04-26 2009-05-05 Meiji Seika Kaisha, Ltd. Amorphous cefditoren pivoxil composition and process for producing the same
PT1555024E (pt) 2002-10-02 2010-11-18 Meiji Seika Kaisha Composição medicinal antibacteriana com absorção oral melhorada
US7790709B2 (en) 2002-12-06 2010-09-07 Affinium Pharmaceuticals, Inc. Heterocyclic compounds, methods of making them and their use in therapy
DE602004016831D1 (de) * 2003-03-17 2008-11-13 Affinium Pharm Inc Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend
WO2004113451A1 (ja) * 2003-06-20 2004-12-29 Meiji Seika Kaisha, Ltd. 難溶性物質と水溶性高分子との共沈物およびその製造方法
ATE539738T1 (de) 2003-10-08 2012-01-15 Meiji Seika Pharma Co Ltd Nichtkristalline antibakterielle zusammensetzung mit cefditoren-pivoxil
JP2007510709A (ja) * 2003-11-07 2007-04-26 ランバクシー ラボラトリーズ リミテッド 高純度3−(2−置換ビニル)セファロスポリンの製法
JP2005162696A (ja) * 2003-12-04 2005-06-23 Nichiko Pharmaceutical Co Ltd 溶出性に優れたセフジトレンピボキシル製剤
WO2005082330A2 (en) * 2004-02-19 2005-09-09 Ranbaxy Laboratories Limited Co-precipitated amorphous cefditoren pivoxil and dosage forms comprising the same
CA2568914C (en) 2004-06-04 2013-09-24 Affinium Pharmaceuticals, Inc. Therapeutic agents, and methods of making and using the same
US20080069879A1 (en) * 2006-05-02 2008-03-20 Ravishekhar Bhiwgade Stable solid dosage form containing amorphous cefditoren pivoxil and process for preparation thereof
EP2687533B1 (en) 2006-07-20 2017-07-19 Debiopharm International SA Acrylamide derivatives as FAB I inhibitors
WO2008057058A1 (en) * 2006-11-10 2008-05-15 Nobel Ilac Sanayii Ve Ticaret As Oral pharmaceutical compositions
WO2008098374A1 (en) 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
CN101560216B (zh) * 2009-05-27 2011-06-15 上海交通大学 头孢妥仑酯的制备方法
WO2012010938A2 (en) * 2010-07-23 2012-01-26 Lupin Limited Pharmaceutical compositions of cefditoren pivoxil
SI2623497T1 (sl) 2010-09-30 2016-04-29 Toyama Chemical Co., Ltd. Megluminska sol 6-fluoro-3-hidroksi-2-pirazinkarboksamida
ES2554630T3 (es) 2010-09-30 2015-12-22 Toyama Chemical Co., Ltd. Sal sódica de 6-fluoro-3-hidroxi-2-pirazinocarboxamida
HRP20190980T1 (hr) 2012-06-19 2019-08-23 Debiopharm International Sa Derivati predlijeka (e)-n-metil-n((3-metilbenzofuran-2 il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)akrilamida
US9951009B2 (en) * 2013-08-29 2018-04-24 Cadila Healthcare Limited Polymorphic form of pyrrole derivative and intermediate thereof
WO2016114727A1 (en) 2015-01-16 2016-07-21 Öğün Yusuf Toktamiş Cefditoren pivoxil compositions with improved stability and production methods thereof
EP3419628B1 (en) 2016-02-26 2020-10-14 Debiopharm International SA Medicament for treatment of diabetic foot infections
CN109053768A (zh) * 2018-08-07 2018-12-21 中国医药集团总公司四川抗菌素工业研究所 一种无定型头孢妥仑酯的制备方法
HUE062061T2 (hu) 2019-02-14 2023-09-28 Debiopharm Int Sa Afabicin készítmény, eljárás annak elõállítására
PH12021553086A1 (en) 2019-06-14 2023-08-14 Debiopharm Int Sa Medicament and use thereof for treating bacterial infections involving biofilm
CN110251467A (zh) * 2019-06-26 2019-09-20 北京济美堂医药研究有限公司 一种无定形态头孢妥仑匹酯组合物的制备方法
CN112190539B (zh) * 2020-11-10 2021-11-02 深圳立健药业有限公司 一种头孢妥仑匹酯组合物及其应用
CN120732800B (zh) * 2025-08-19 2025-12-02 湖南恒昌医药集团股份有限公司 头孢托仑匹酯缓释片及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0678234B2 (ja) * 1988-04-19 1994-10-05 明治製菓株式会社 経口投与用抗菌組成物
JPH05306227A (ja) * 1992-04-27 1993-11-19 Lion Corp 徐放性口腔内疾患治療剤
JP2576927B2 (ja) * 1992-05-15 1997-01-29 ファイザー製薬株式会社 細粒核
JPH06316517A (ja) * 1993-02-22 1994-11-15 Grelan Pharmaceut Co Ltd 放出制御製剤
JPH0717866A (ja) * 1993-06-16 1995-01-20 Meiji Seika Kaisha Ltd 医薬組成物
WO1996019239A1 (en) 1994-12-21 1996-06-27 Yamanouchi Pharmaceutical Co., Ltd. Solid composition with improved solubility and absorbability
AR004014A1 (es) * 1995-10-13 1998-09-30 Meiji Seika Kaisha Una composicion antibacteriana de cefditoren pivoxilo para administracion oral y metodo para obtener dicha composicion
ATE255883T1 (de) 1996-05-20 2003-12-15 Janssen Pharmaceutica Nv Fungizide mittel mit verbesserter bioverfügbarkeit
PL189548B1 (pl) * 1996-09-20 2005-08-31 Meiji Seika Kaisha Krystaliczny cefditoren piwoksylu i sposób jego wytwarzania
TR200001903T2 (tr) * 1998-01-07 2000-11-21 Meiji Seika Kaisha, Ltd. Kristalografik açıdan kararlı, şekilsiz sefalosporin bileşimleri ve bunların üretilmesine ilişkin işlem.

Also Published As

Publication number Publication date
WO1999034832A1 (en) 1999-07-15
SK286631B6 (sk) 2009-02-05
AU736555B2 (en) 2001-08-02
CA2316841C (en) 2007-11-20
HUP0101272A3 (en) 2002-07-29
BR9907084A (pt) 2000-10-17
ES2393972T3 (es) 2013-01-03
KR20010033961A (ko) 2001-04-25
KR100435315B1 (ko) 2004-06-10
AU1784599A (en) 1999-07-26
EP1051978B1 (en) 2012-08-22
EP1051978A1 (en) 2000-11-15
UA70311C2 (uk) 2004-10-15
NZ505871A (en) 2002-10-25
TR200001903T2 (tr) 2000-11-21
EP1051978A4 (en) 2007-05-02
PT1051978E (pt) 2012-11-20
CN1290177A (zh) 2001-04-04
CZ20002542A3 (cs) 2000-12-13
CZ302082B6 (cs) 2010-09-29
BRPI9907084B8 (pt) 2021-05-25
EA200000742A1 (ru) 2001-02-26
EA002881B1 (ru) 2002-10-31
IL137004A0 (en) 2001-06-14
PL341589A1 (en) 2001-04-23
IL137004A (en) 2008-11-03
ES2393972T8 (es) 2013-02-25
SK10262000A3 (sk) 2001-01-18
US6342493B1 (en) 2002-01-29
HUP0101272A2 (hu) 2001-12-28
WO1999034832A8 (en) 1999-10-28
CN1151845C (zh) 2004-06-02
BRPI9907084B1 (pt) 2017-04-25
US20020037322A1 (en) 2002-03-28
HU230295B1 (hu) 2015-12-28
US6486149B2 (en) 2002-11-26
CA2316841A1 (en) 1999-07-15
TW587946B (en) 2004-05-21
PL194097B1 (pl) 2007-04-30
JP3413406B2 (ja) 2003-06-03
HK1035148A1 (en) 2001-11-16

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