HUT72896A - Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia - Google Patents
Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia Download PDFInfo
- Publication number
- HUT72896A HUT72896A HU9502832A HU9502832A HUT72896A HU T72896 A HUT72896 A HU T72896A HU 9502832 A HU9502832 A HU 9502832A HU 9502832 A HU9502832 A HU 9502832A HU T72896 A HUT72896 A HU T72896A
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- formula
- group
- hydrogen
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3844893A | 1993-03-29 | 1993-03-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HU9502832D0 HU9502832D0 (en) | 1995-11-28 |
| HUT72896A true HUT72896A (en) | 1996-06-28 |
Family
ID=21900014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9502832A HUT72896A (en) | 1993-03-29 | 1994-03-28 | Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0691987A1 (fi) |
| JP (1) | JPH08508498A (fi) |
| AU (1) | AU6415894A (fi) |
| CA (1) | CA2159070A1 (fi) |
| FI (1) | FI954556A (fi) |
| HU (1) | HUT72896A (fi) |
| NO (1) | NO953832L (fi) |
| NZ (1) | NZ263456A (fi) |
| PL (1) | PL310896A1 (fi) |
| WO (1) | WO1994022910A1 (fi) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2159072A1 (en) * | 1993-03-29 | 1994-10-13 | Lin-Hua Zhang | Novel processes and intermediate compounds for the preparation of platelet glycoprotein iib/iiia inhibitors |
| US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
| CA2272317C (en) * | 1996-11-27 | 2001-01-30 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Pharmaceutical composition comprising a compound having anti-xa activity and a platelet aggregation antagonist compound |
| US6010911A (en) * | 1997-04-30 | 2000-01-04 | Medtronic, Inc. | Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique |
| US6537520B1 (en) | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
| GB0623607D0 (en) | 2006-11-27 | 2007-01-03 | Haemostatix Ltd | Tissue adhesive |
| JP5649825B2 (ja) | 2007-01-31 | 2015-01-07 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 安定化させたｐ５３ペプチドおよびその使用法 |
| CA2682174C (en) | 2007-03-28 | 2021-04-06 | President And Fellows Of Harvard College | Stitched polypeptides |
| US11673914B2 (en) | 2009-11-10 | 2023-06-13 | Allegro Pharmaceuticals, LLC | Peptide therapies for reduction of macular thickening |
| BR112012011731A2 (pt) * | 2009-11-10 | 2020-08-25 | Allegro Pharmaceuticals, Inc. | composições e métodos para inibir a adesão celular ou direcionamento dos agentes de diagnóstico ou terapêuticos para os sítios de ligação rgd |
| PL2603600T3 (pl) | 2010-08-13 | 2019-06-28 | Aileron Therapeutics, Inc. | Makrocykle peptidomometyczne |
| JP6106159B2 (ja) | 2011-05-09 | 2017-03-29 | アレグロ ファーマシューティカルズ インコーポレイテッドＡｌｌｅｇｒｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | Ｒ−ｇ−システイン酸ペプチドを含む医薬組成物 |
| AR088392A1 (es) | 2011-10-18 | 2014-05-28 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos |
| CN104144695A (zh) | 2012-02-15 | 2014-11-12 | 爱勒让治疗公司 | 三唑交联的和硫醚交联的拟肽大环化合物 |
| RU2017145921A (ru) | 2012-02-15 | 2019-02-21 | Эйлерон Терапьютикс, Инк. | Пептидомиметические макроциклы |
| KR20150082307A (ko) | 2012-11-01 | 2015-07-15 | 에일러론 테라퓨틱스 인코포레이티드 | 이치환 아미노산 및 이의 제조 및 사용 방법 |
| SG11201702175YA (en) | 2014-09-24 | 2017-04-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof |
| SG10201902594QA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| KR20170129879A (ko) | 2015-03-20 | 2017-11-27 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 용도 |
| CN108368161A (zh) | 2015-09-10 | 2018-08-03 | 艾瑞朗医疗公司 | 作为mcl-1调节剂的拟肽大环化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2636066B1 (fr) * | 1988-09-02 | 1991-10-25 | Centre Nat Rech Scient | Derives de cyclopeptides, utilisables comme inhibiteurs selectifs vis-a-vis de proteases a serine active |
| US5384309A (en) * | 1989-07-17 | 1995-01-24 | Genentech, Inc. | Cyclized peptides and their use as platelet aggregation inhibitors |
| AU6470590A (en) * | 1989-10-23 | 1991-04-26 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
| IL103252A (en) * | 1991-09-30 | 1997-03-18 | Du Pont Merck Pharma | CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
-
1994
- 1994-03-28 PL PL94310896A patent/PL310896A1/xx unknown
- 1994-03-28 CA CA002159070A patent/CA2159070A1/en not_active Abandoned
- 1994-03-28 EP EP94911703A patent/EP0691987A1/en not_active Withdrawn
- 1994-03-28 NZ NZ263456A patent/NZ263456A/en not_active IP Right Cessation
- 1994-03-28 WO PCT/US1994/003223 patent/WO1994022910A1/en not_active Application Discontinuation
- 1994-03-28 HU HU9502832A patent/HUT72896A/hu unknown
- 1994-03-28 AU AU64158/94A patent/AU6415894A/en not_active Abandoned
- 1994-03-28 JP JP6522195A patent/JPH08508498A/ja not_active Ceased
-
1995
- 1995-09-26 FI FI954556A patent/FI954556A/fi unknown
- 1995-09-28 NO NO953832A patent/NO953832L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI954556A0 (fi) | 1995-09-26 |
| FI954556A (fi) | 1995-09-26 |
| NZ263456A (en) | 1996-11-26 |
| EP0691987A1 (en) | 1996-01-17 |
| NO953832L (no) | 1995-11-28 |
| AU6415894A (en) | 1994-10-24 |
| WO1994022910A1 (en) | 1994-10-13 |
| JPH08508498A (ja) | 1996-09-10 |
| PL310896A1 (en) | 1996-01-08 |
| NO953832D0 (no) | 1995-09-28 |
| HU9502832D0 (en) | 1995-11-28 |
| CA2159070A1 (en) | 1994-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUT72896A (en) | Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia | |
| KR102481876B1 (ko) | 니트릴-함유 항바이러스 화합물 | |
| JP3042887B2 (ja) | 血栓塞栓症疾患を診断するための像形成剤としての放射線標識された血小板ＧＰ▲ＩＩ▼ｂ／▲ＩＩＩ▼ａ受容体アンタゴニスト | |
| US9879046B2 (en) | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions | |
| JP3281370B2 (ja) | 血小板凝集阻害剤 | |
| EP0625164B1 (en) | CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa | |
| RU2157379C2 (ru) | Циклопептиды, способ их получения, содержащая их фармацевтическая композиция, способ ее получения | |
| KR19990022198A (ko) | 신규한 이속사졸린 및 이속사졸 피브리노겐 수용체 길항제 | |
| US5635477A (en) | Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA | |
| US20140045768A1 (en) | Tight Junction Protein Modulators and Uses Thereof | |
| JPH08503217A (ja) | 血小板糖タンパク質▲ＩＩ▼ｂ／▲ＩＩＩ▼ａの阻害剤として有用な複素環式環により結合された環状化合物 | |
| JP2003503426A (ja) | ＦＶＩＩａアンタゴニスト | |
| US6056958A (en) | Method of treatment of arterial and venous thromboembolic disorders | |
| KR20220010535A (ko) | 면역조정제 | |
| CZ20014484A3 (cs) | Inhibitory integrinu alfa v beta 6 | |
| RU2096415C1 (ru) | Циклические пептиды или их фармацевтически приемлемые соли, фармацевтическая композиция | |
| WO1995023811A1 (en) | Novel carbocyclic compounds which inhibit platelet aggregation by interaction with the gpiib/iiia receptor complex | |
| WO2024010810A2 (en) | Fc conjugates including an inhibitor of cd73 and uses thereof | |
| WO2004106370A1 (en) | M11l derived peptides and therapeutic use thereof | |
| CZ286170B6 (cs) | Cyklopeptidy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DFC4 | Cancellation of temporary prot. due to refusal |