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HUP9904155A2 - Eljárás [(1-butil-4-piperidil)-metil]-amin előállítására - Google Patents

Eljárás [(1-butil-4-piperidil)-metil]-amin előállítására

Info

Publication number
HUP9904155A2
HUP9904155A2 HU9904155A HUP9904155A HUP9904155A2 HU P9904155 A2 HUP9904155 A2 HU P9904155A2 HU 9904155 A HU9904155 A HU 9904155A HU P9904155 A HUP9904155 A HU P9904155A HU P9904155 A2 HUP9904155 A2 HU P9904155A2
Authority
HU
Hungary
Prior art keywords
butyl
iznonipekotinamide
piperidyl
amine
methyl
Prior art date
Application number
HU9904155A
Other languages
English (en)
Inventor
Michael Fedouloff
David William Guest
Gillian Elizabeth Smith
Original Assignee
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.
Publication of HUP9904155A2 publication Critical patent/HUP9904155A2/hu
Publication of HUP9904155A3 publication Critical patent/HUP9904155A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Optical Couplings Of Light Guides (AREA)

Abstract

A találmány tárgya eljárás[(1-bűtil-4-piperidil)-metil]-aminelőállítására, amelynek sőrán i) izőnipekőtinsavamidőt 1-bróm-bűtánnal reagáltalva előállítják az izőnipekőtinsavamid N-bűtil-származékát, majd ii) lítiűm-alűmíniűm-hidriddel redűkciót végeznek,ahől az eljárásra az jellemző, hőgy az i) és a ii) lépést tőlűőlőldószerben hajtják végre. Az[(1-bűtil-4-piperidil-metil]-amin egyirritábilis bélszindróma kezelésére szőlgáló gyógyszerkészítményhatóanyagának szintézisére alkalmazható intermedier. ŕ
HU9904155A 1996-09-11 1997-09-09 Preparation of 1-butyl-4-piperidinylmethylamine HUP9904155A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9618967.5A GB9618967D0 (en) 1996-09-11 1996-09-11 Pharmaceuticals

Publications (2)

Publication Number Publication Date
HUP9904155A2 true HUP9904155A2 (hu) 2000-05-28
HUP9904155A3 HUP9904155A3 (en) 2001-01-29

Family

ID=10799764

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904155A HUP9904155A3 (en) 1996-09-11 1997-09-09 Preparation of 1-butyl-4-piperidinylmethylamine

Country Status (30)

Country Link
US (1) US6331631B1 (hu)
EP (1) EP0927163B1 (hu)
JP (2) JP3748570B2 (hu)
KR (1) KR100525703B1 (hu)
CN (1) CN1102927C (hu)
AR (1) AR008174A1 (hu)
AT (1) ATE358121T1 (hu)
AU (1) AU725210B2 (hu)
BR (1) BR9712014A (hu)
CA (1) CA2266468C (hu)
CO (1) CO4930263A1 (hu)
CY (1) CY2590B2 (hu)
CZ (1) CZ290932B6 (hu)
DE (1) DE69737529T2 (hu)
DK (1) DK0927163T3 (hu)
ES (1) ES2285732T3 (hu)
GB (1) GB9618967D0 (hu)
HK (1) HK1020963A1 (hu)
HU (1) HUP9904155A3 (hu)
IL (1) IL128785A0 (hu)
NO (1) NO312587B1 (hu)
NZ (1) NZ334272A (hu)
PL (1) PL191373B1 (hu)
PT (1) PT927163E (hu)
SA (1) SA97180387B1 (hu)
SI (1) SI0927163T1 (hu)
TR (1) TR199900493T2 (hu)
TW (1) TW432048B (hu)
WO (1) WO1998011067A1 (hu)
ZA (1) ZA978087B (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9618967D0 (en) * 1996-09-11 1996-10-23 Smithkline Beecham Plc Pharmaceuticals
US20020091271A1 (en) 1998-07-16 2002-07-11 Smithkline Beecham Plc Process for the preparation of an indole derivative
GB0211230D0 (en) * 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
CN104557672B (zh) * 2015-01-26 2016-09-21 湖南华腾制药有限公司 一种1位取代哌啶衍生物的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5821904B2 (ja) * 1975-04-04 1983-05-04 住友化学工業株式会社 シンキナメタノ−アントラセンユウドウタイノセイゾウホウホウ
ZA899436B (en) * 1988-12-12 1990-08-29 Ciba Geigy Piperidine derivatives
AT394715B (de) * 1990-08-14 1992-06-10 Chemie Linz Gmbh Verfahren zur n-alkylierung von harnstoffen
SK30294A3 (en) * 1991-09-12 1994-12-07 Smithkline Beecham Plc Antagonists of 5-ht4 receptors
MA22647A1 (fr) * 1991-09-14 1993-04-01 Smithkline Beecham Plc Procede de preparation d'un ester ou d'un amide d'un nouveau produit .
ATE180785T1 (de) * 1992-03-12 1999-06-15 Smithkline Beecham Plc Kondensierte indol-derivate als 5-ht4-rezeptor- antagonisten
GB9209687D0 (en) * 1992-05-06 1992-06-17 Smithkline Beecham Plc Novel process
EP0664794A1 (en) * 1992-10-16 1995-08-02 Smithkline Beecham Plc N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists
DE4427836A1 (de) * 1994-08-05 1996-02-08 Hoechst Ag Verbindungen aus der Reihe der Phosphane, Verfahren zu ihrer Herstellung sowie ihre Verwendung
CA2222532A1 (en) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amine
GB9618967D0 (en) * 1996-09-11 1996-10-23 Smithkline Beecham Plc Pharmaceuticals

Also Published As

Publication number Publication date
CY2590B2 (en) 2009-11-04
CZ80999A3 (cs) 1999-11-17
PL332088A1 (en) 1999-08-30
NO991148D0 (no) 1999-03-10
TW432048B (en) 2001-05-01
TR199900493T2 (xx) 1999-06-21
WO1998011067A1 (en) 1998-03-19
JP3748570B2 (ja) 2006-02-22
CA2266468C (en) 2005-10-25
US6331631B1 (en) 2001-12-18
SA97180387B1 (ar) 2006-11-04
ZA978087B (en) 1999-03-09
DE69737529T2 (de) 2008-01-31
JP2001500148A (ja) 2001-01-09
PL191373B1 (pl) 2006-05-31
AU4776497A (en) 1998-04-02
NZ334272A (en) 2000-08-25
HK1020963A1 (en) 2000-05-26
KR20000038041A (ko) 2000-07-05
CA2266468A1 (en) 1998-03-19
DK0927163T3 (da) 2007-08-06
GB9618967D0 (en) 1996-10-23
NO991148L (no) 1999-03-10
EP0927163A1 (en) 1999-07-07
DE69737529D1 (de) 2007-05-10
BR9712014A (pt) 1999-08-24
JP2005220126A (ja) 2005-08-18
IL128785A0 (en) 2000-01-31
AU725210B2 (en) 2000-10-05
AR008174A1 (es) 1999-12-09
EP0927163B1 (en) 2007-03-28
CZ290932B6 (cs) 2002-11-13
KR100525703B1 (ko) 2005-11-03
NO312587B1 (no) 2002-06-03
SI0927163T1 (sl) 2007-08-31
PT927163E (pt) 2007-07-06
CN1230179A (zh) 1999-09-29
CO4930263A1 (es) 2000-06-27
CN1102927C (zh) 2003-03-12
HUP9904155A3 (en) 2001-01-29
ATE358121T1 (de) 2007-04-15
ES2285732T3 (es) 2007-11-16

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees