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ATE246496T1 - Spheroide, verfahren zu ihrer herstellung und diese enthaltende arzneiformen - Google Patents

Spheroide, verfahren zu ihrer herstellung und diese enthaltende arzneiformen

Info

Publication number
ATE246496T1
ATE246496T1 AT98954683T AT98954683T ATE246496T1 AT E246496 T1 ATE246496 T1 AT E246496T1 AT 98954683 T AT98954683 T AT 98954683T AT 98954683 T AT98954683 T AT 98954683T AT E246496 T1 ATE246496 T1 AT E246496T1
Authority
AT
Austria
Prior art keywords
spheroids
production
forms containing
containing same
medicinal forms
Prior art date
Application number
AT98954683T
Other languages
English (en)
Inventor
Patrice Debregeas
Gerard Leduc
Pascal Oury
Pascal Suplie
Original Assignee
Ethypharm Lab Prod Ethiques
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm Lab Prod Ethiques filed Critical Ethypharm Lab Prod Ethiques
Application granted granted Critical
Publication of ATE246496T1 publication Critical patent/ATE246496T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
AT98954683T 1997-11-21 1998-11-19 Spheroide, verfahren zu ihrer herstellung und diese enthaltende arzneiformen ATE246496T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9714631A FR2771291B1 (fr) 1997-11-21 1997-11-21 Spheroides, procede de preparation et compositions pharmaceutiques
PCT/IB1998/001911 WO1999026608A1 (fr) 1997-11-21 1998-11-19 Spheroides, procede de preparation et compositions pharmaceutiques

Publications (1)

Publication Number Publication Date
ATE246496T1 true ATE246496T1 (de) 2003-08-15

Family

ID=9513635

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98954683T ATE246496T1 (de) 1997-11-21 1998-11-19 Spheroide, verfahren zu ihrer herstellung und diese enthaltende arzneiformen

Country Status (29)

Country Link
US (1) US6077544A (de)
EP (1) EP1032374B1 (de)
JP (1) JP2001523706A (de)
KR (1) KR100502938B1 (de)
CN (1) CN1223341C (de)
AT (1) ATE246496T1 (de)
AU (1) AU744580B2 (de)
BG (1) BG65117B1 (de)
BR (1) BR9814672A (de)
CA (1) CA2310147C (de)
CZ (1) CZ299110B6 (de)
DE (1) DE69817010T2 (de)
DK (1) DK1032374T3 (de)
EA (1) EA003324B1 (de)
ES (1) ES2203989T3 (de)
FR (1) FR2771291B1 (de)
HR (1) HRP20000323B1 (de)
HU (1) HU230053B1 (de)
IL (2) IL136215A0 (de)
MX (1) MXPA00004959A (de)
NO (1) NO329728B1 (de)
NZ (1) NZ504662A (de)
PL (1) PL193878B1 (de)
PT (1) PT1032374E (de)
SK (1) SK284493B6 (de)
TR (1) TR200002130T2 (de)
WO (1) WO1999026608A1 (de)
YU (1) YU31000A (de)
ZA (1) ZA9810631B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790668B1 (fr) * 1999-03-12 2002-07-26 D B F Granules contenant une substance vegetale et leur procede de preparation
ES2234581T3 (es) 1999-04-06 2005-07-01 Ethypharm Suspension farmaceutica bebible de ibuprofeno.
FR2794646B1 (fr) 1999-06-09 2001-09-21 Ethypharm Lab Prod Ethiques Microgranules de sulfate de morphine, procede de preparation et composition les contenant
EP1414956B1 (de) 2001-06-22 2007-10-24 Genencor International, Inc. Granulat mit hoher schlagfestigkeit
AR034813A1 (es) † 2001-07-20 2004-03-17 Novartis Ag Composiciones farmaceuticas y uso de las mismas
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
FR2830447B1 (fr) * 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
FR2837100B1 (fr) * 2002-03-18 2004-07-23 Flamel Tech Sa Comprimes a bases de microcapsules a liberation modifiee
US7906145B2 (en) 2002-04-09 2011-03-15 Flamel Technologies Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s)
CN100577164C (zh) * 2002-04-09 2010-01-06 弗拉梅技术公司 可改进释放阿莫西林的微囊含水混悬液形式的口服药物制剂
FR2838647B1 (fr) * 2002-04-23 2006-02-17 Particules enrobees a liberation prolongee, leur procede de preparation et comprimes les contenant
US20040013737A1 (en) * 2002-07-19 2004-01-22 Philippe Becourt Taste masked oral composition of telithromycin
FR2845289B1 (fr) * 2002-10-04 2004-12-03 Ethypharm Sa Spheroides, procede de preparation et compositions pharmaceutiques.
US9107804B2 (en) 2002-12-10 2015-08-18 Nortec Development Associates, Inc. Method of preparing biologically active formulations
NZ523946A (en) * 2003-01-31 2004-06-25 Carl Ernest Alexander Portable hygiene compositions comprising a semi-solid gel and active ingredients in bead form for use in personal oral, dental or skin care
ES2221804B1 (es) * 2003-06-18 2006-04-01 Lipofoods, S.L. Microcapsulas para la administracion de ingredientes activos.
MXPA06003942A (es) * 2003-10-10 2006-07-05 Ethypharm Sa Microgranulos de liberacion sostenida que contienen extracto de gingko biloba, y procedimiento para la fabricacion de los mismos.
FR2861990B1 (fr) 2003-11-10 2006-02-10 Nouveaux Produits Pharma Comprimes faiblement doses a reseau de polymeres
JP2007532623A (ja) * 2004-04-12 2007-11-15 ファイザー・プロダクツ・インク 破裂型多重粒子中の味マスキング薬物
US20070224269A1 (en) * 2004-06-10 2007-09-27 Rubino Orapin P Controlled Release Pharmaceutical Formulation
FR2883179B1 (fr) * 2005-03-18 2009-04-17 Ethypharm Sa Comprime enrobe
US20100233257A1 (en) * 2006-06-09 2010-09-16 Ethypharm Low dose sublingual tablets of opioid analgesics and preparation process
US20070286900A1 (en) * 2006-06-09 2007-12-13 Catherine Herry Low dose tablets of opioid analgesics and preparation process
US11116728B2 (en) 2006-11-30 2021-09-14 Bend Research, Inc. Multiparticulates of spray-coated drug and polymer on a meltable core
WO2008065504A1 (en) * 2006-11-30 2008-06-05 Pfizer Products Inc. Multiparticulates of spray-coated drug and polymer on a meltable core
EP2468263A1 (de) 2010-12-23 2012-06-27 Laboratorios Del. Dr. Esteve, S.A. Komprimierte feste Darreichungsformen
CN114772256B (zh) 2018-05-11 2024-05-17 斯多里机械有限责任公司 快速更换式真空星轮组件和缩颈机
US11534817B2 (en) 2018-05-11 2022-12-27 Stolle Machinery Company, Llc Infeed assembly full inspection assembly
CN112118921B (zh) 2018-05-11 2023-04-18 斯多里机械有限责任公司 旋转歧管
US11097333B2 (en) 2018-05-11 2021-08-24 Stolle Machinery Company, Llc Process shaft tooling assembly
US11370015B2 (en) 2018-05-11 2022-06-28 Stolle Machinery Company, Llc Drive assembly
EP3790821B1 (de) 2018-05-11 2025-04-02 Stolle Machinery Company, LLC Schnellwechselfunktionen einer zuführanordnung
WO2019217667A1 (en) 2018-05-11 2019-11-14 Stolle Machinery Company, Llc Quick change tooling assembly
US11420242B2 (en) 2019-08-16 2022-08-23 Stolle Machinery Company, Llc Reformer assembly

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684516A (en) * 1983-08-01 1987-08-04 Alra Laboratories, Inc. Sustained release tablets and method of making same
NZ230763A (en) * 1988-09-27 1991-10-25 Takeda Chemical Industries Ltd Production of granules having a core by spraying the cores with a dispersion of hydroxypropylcellulose, optionally incorporating an active ingredient
EP0418596A3 (en) * 1989-09-21 1991-10-23 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
JP2572673B2 (ja) * 1990-07-25 1997-01-16 エスエス製薬株式会社 徐放性錠剤
FR2679451B1 (fr) * 1991-07-22 1994-09-09 Prographarm Laboratoires Comprime multiparticulaire a delitement rapide.
GB9117361D0 (en) * 1991-08-12 1991-09-25 Euro Celtique Sa Oral dosage form
FR2692146B1 (fr) * 1992-06-16 1995-06-02 Ethypharm Sa Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention.
CZ284822B6 (cs) * 1993-06-14 1999-03-17 Janssen Pharmaceutica N. V. Tableta a způsob její výroby
SE9402422D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New beads for controlled release and a pharmaceutical preparation containing the same
SE9600070D0 (sv) * 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
FR2771292B1 (fr) * 1997-11-21 2000-02-18 Ethypharm Lab Prod Ethiques Spheroides contenant de la tiagabine, procede de preparation et compositions pharmaceutiques

Also Published As

Publication number Publication date
PL340659A1 (en) 2001-02-12
EP1032374A1 (de) 2000-09-06
HU230053B1 (hu) 2015-06-29
EA200000548A1 (ru) 2000-12-25
ZA9810631B (en) 1999-05-24
SK284493B6 (sk) 2005-05-05
IL136215A (en) 2006-12-31
ES2203989T3 (es) 2004-04-16
NO20002605D0 (no) 2000-05-19
PL193878B1 (pl) 2007-03-30
FR2771291A1 (fr) 1999-05-28
DK1032374T3 (da) 2003-11-24
JP2001523706A (ja) 2001-11-27
NO20002605L (no) 2000-07-05
AU744580B2 (en) 2002-02-28
AU1170499A (en) 1999-06-15
CN1282239A (zh) 2001-01-31
BG65117B1 (bg) 2007-03-30
HRP20000323B1 (en) 2006-07-31
HRP20000323A2 (en) 2001-06-30
SK7562000A3 (en) 2001-06-11
DE69817010T2 (de) 2004-05-27
KR20010032329A (ko) 2001-04-16
EA003324B1 (ru) 2003-04-24
CN1223341C (zh) 2005-10-19
CZ299110B6 (cs) 2008-04-23
BG104511A (en) 2001-04-30
TR200002130T2 (tr) 2000-12-21
FR2771291B1 (fr) 2000-02-25
WO1999026608A1 (fr) 1999-06-03
BR9814672A (pt) 2000-10-03
US6077544A (en) 2000-06-20
HUP0100562A2 (hu) 2002-05-29
NO329728B1 (no) 2010-12-06
HUP0100562A3 (en) 2002-08-28
CZ20001849A3 (cs) 2000-10-11
MXPA00004959A (es) 2002-10-17
CA2310147C (fr) 2010-05-25
YU31000A (sh) 2002-11-15
DE69817010D1 (de) 2003-09-11
CA2310147A1 (fr) 1999-06-03
PT1032374E (pt) 2003-12-31
KR100502938B1 (ko) 2005-07-25
IL136215A0 (en) 2001-05-20
EP1032374B1 (de) 2003-08-06
NZ504662A (en) 2002-09-27

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