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HUP9904035A2 - Módosított kristály formájú R(-)-N-(4,4-di(3-metil-tien-2-il)-but-3-enil)-nipekotinsav-hidroklorid - Google Patents

Módosított kristály formájú R(-)-N-(4,4-di(3-metil-tien-2-il)-but-3-enil)-nipekotinsav-hidroklorid

Info

Publication number
HUP9904035A2
HUP9904035A2 HU9904035A HUP9904035A HUP9904035A2 HU P9904035 A2 HUP9904035 A2 HU P9904035A2 HU 9904035 A HU9904035 A HU 9904035A HU P9904035 A HUP9904035 A HU P9904035A HU P9904035 A2 HUP9904035 A2 HU P9904035A2
Authority
HU
Hungary
Prior art keywords
enyl
acid hydrochloride
methylthien
crystalline form
nipecotic acid
Prior art date
Application number
HU9904035A
Other languages
English (en)
Inventor
Preben Ahrndt
Kimberly Ann Allen
Michael H. Chain
Vincent H. Chang
Henning Borge Petersen
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of HUP9904035A2 publication Critical patent/HUP9904035A2/hu
Publication of HUP9904035A3 publication Critical patent/HUP9904035A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány tárgya vízmentes kristály főrmájú R(-)-N-(4,4-di(3-metil-tien-2-il)-bűt-3-enil)-nipekőtinsav-hidrőklőrid (generikűs néventriagabin). A találmány szerinti vegyület GABA-felvétellel kapcsőlatősmegbetegedések és epilepszia kezelésére használhatók. ŕ
HU9904035A 1996-06-14 1997-06-03 Modified crystalline form of the r-(-)-n-(4,4-di(3-methylthien-2-yl)but-3-enyl)-nipecotic acid hydrochloride HUP9904035A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK66196 1996-06-14

Publications (2)

Publication Number Publication Date
HUP9904035A2 true HUP9904035A2 (hu) 2000-05-28
HUP9904035A3 HUP9904035A3 (en) 2000-07-28

Family

ID=8096101

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904035A HUP9904035A3 (en) 1996-06-14 1997-06-03 Modified crystalline form of the r-(-)-n-(4,4-di(3-methylthien-2-yl)but-3-enyl)-nipecotic acid hydrochloride

Country Status (20)

Country Link
EP (1) EP0906309B1 (hu)
JP (1) JP2000511909A (hu)
CN (1) CN1636565A (hu)
AR (1) AR008236A1 (hu)
AT (1) ATE223405T1 (hu)
AU (1) AU723267B2 (hu)
BR (1) BR9709725A (hu)
CZ (1) CZ295578B6 (hu)
DE (1) DE69715196T2 (hu)
DK (1) DK0906309T3 (hu)
ES (1) ES2181002T3 (hu)
HU (1) HUP9904035A3 (hu)
IL (1) IL127469A (hu)
NO (1) NO316889B1 (hu)
PL (1) PL190858B1 (hu)
PT (1) PT906309E (hu)
RU (1) RU2177478C2 (hu)
UA (1) UA52661C2 (hu)
WO (1) WO1997047619A1 (hu)
ZA (1) ZA975266B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5914333A (en) * 1996-07-31 1999-06-22 Novo Nordisk A/S Treatment of psychotic disorders
DE69803670T2 (de) * 1997-08-01 2002-11-21 Elan Corp. Plc, Dublin Tiagabinhaltige arzneizubereitungen mit gesteuerter wirkstoffverabreichung
IE970588A1 (en) 1997-08-01 2000-08-23 Elan Corp Plc Controlled release pharmaceutical compositions containing tiagabine
CN1314684C (zh) * 2003-12-24 2007-05-09 中国科学院上海有机化学研究所 噻加宾及其消旋体和s－构型的合成方法及其无定形粉末的制法
GB0402118D0 (en) * 2004-01-30 2004-03-03 Merck Sharp & Dohme Polymorphic forms of a GABAA agonist
WO2005092886A1 (en) * 2004-03-29 2005-10-06 Ranbaxy Laboratories Limited Process for the preparation of amorphous form of tiagabine
US20080064727A1 (en) * 2006-08-18 2008-03-13 Cephalon, Inc. Crystalline forms of tiagabine hydrochloride

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK288385D0 (da) * 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
DK58291D0 (da) * 1991-04-02 1991-04-02 Novo Nordisk As Krystalinsk stof og dets fremstilling
US5750140A (en) * 1994-05-20 1998-05-12 Novo Nordisk A/S Transdermal delivery of tiagabine

Also Published As

Publication number Publication date
DE69715196T2 (de) 2003-05-15
CN1636565A (zh) 2005-07-13
NO985809L (no) 1998-12-11
HUP9904035A3 (en) 2000-07-28
DE69715196D1 (de) 2002-10-10
AU723267B2 (en) 2000-08-24
EP0906309A1 (en) 1999-04-07
PL190858B1 (pl) 2006-02-28
JP2000511909A (ja) 2000-09-12
AU3165397A (en) 1998-01-07
AR008236A1 (es) 1999-12-29
PT906309E (pt) 2002-12-31
WO1997047619A1 (en) 1997-12-18
BR9709725A (pt) 1999-08-10
UA52661C2 (uk) 2003-01-15
ZA975266B (en) 1998-02-04
IL127469A0 (en) 1999-10-28
ATE223405T1 (de) 2002-09-15
NO985809D0 (no) 1998-12-11
DK0906309T3 (da) 2002-12-16
EP0906309B1 (en) 2002-09-04
CZ295578B6 (cs) 2005-08-17
PL330424A1 (en) 1999-05-10
IL127469A (en) 2001-01-11
NO316889B1 (no) 2004-06-14
ES2181002T3 (es) 2003-02-16
CZ401998A3 (cs) 1999-06-16
RU2177478C2 (ru) 2001-12-27

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees