[go: up one dir, main page]

HUP9903741A2 - Asztmaellenes, allergiaellenes, immunvisszaszorító és/vagy immunmoduláló hatású N-helyettesített indol-3-glioxilamidok - Google Patents

Asztmaellenes, allergiaellenes, immunvisszaszorító és/vagy immunmoduláló hatású N-helyettesített indol-3-glioxilamidok

Info

Publication number
HUP9903741A2
HUP9903741A2 HU9903741A HUP9903741A HUP9903741A2 HU P9903741 A2 HUP9903741 A2 HU P9903741A2 HU 9903741 A HU9903741 A HU 9903741A HU P9903741 A HUP9903741 A HU P9903741A HU P9903741 A2 HUP9903741 A2 HU P9903741A2
Authority
HU
Hungary
Prior art keywords
antiallergic
immunosuppressive
glyoxylamid
antiasthmatic
immunomodulating effect
Prior art date
Application number
HU9903741A
Other languages
English (en)
Inventor
Kay Brune
Peter Emig
Bernhard Kutscher
Guillaume Lebaut
Cécilia Menciu
Stefan Szelenyi
Original Assignee
Asta Medica Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Aktiengesellschaft filed Critical Asta Medica Aktiengesellschaft
Publication of HUP9903741A2 publication Critical patent/HUP9903741A2/hu
Publication of HUP9903741A3 publication Critical patent/HUP9903741A3/hu
Publication of HU227797B1 publication Critical patent/HU227797B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

A találmány (I) általánős képletű N-helyettesített indől-3-gliőxőlamidőkra, ezek előállítására és gyógyszerészeti alkalmazásűkravőnatkőzik. A vegyületek hisztamingátló, allergiaellenes ésimműngátló/imműnmődűláló hatással rendelkeznek. (I) ŕ
HU9903741A 1996-09-06 1997-08-16 N-substituted indol-3-glyoxylamid with antiasthmatic, antiallergic and immunosuppressive/immunomodulating effect HU227797B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19636150A DE19636150A1 (de) 1996-09-06 1996-09-06 N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
PCT/EP1997/004474 WO1998009946A1 (de) 1996-09-06 1997-08-16 N-substituierte indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender wirkung

Publications (3)

Publication Number Publication Date
HUP9903741A2 true HUP9903741A2 (hu) 2000-04-28
HUP9903741A3 HUP9903741A3 (en) 2001-01-29
HU227797B1 HU227797B1 (en) 2012-03-28

Family

ID=7804772

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903741A HU227797B1 (en) 1996-09-06 1997-08-16 N-substituted indol-3-glyoxylamid with antiasthmatic, antiallergic and immunosuppressive/immunomodulating effect

Country Status (26)

Country Link
US (4) US6008231A (hu)
EP (1) EP0931063B3 (hu)
JP (1) JP3296437B2 (hu)
KR (1) KR100516321B1 (hu)
CN (3) CN100376554C (hu)
AR (1) AR008630A1 (hu)
AT (1) ATE342889T1 (hu)
AU (1) AU726521B2 (hu)
BR (1) BR9712808B1 (hu)
CA (1) CA2215013C (hu)
CZ (1) CZ302301B6 (hu)
DE (2) DE19636150A1 (hu)
DK (1) DK0931063T5 (hu)
ES (1) ES2276433T7 (hu)
HU (1) HU227797B1 (hu)
IL (1) IL127798A (hu)
NO (2) NO314725B3 (hu)
NZ (1) NZ334476A (hu)
PT (1) PT931063E (hu)
RU (1) RU2237661C2 (hu)
SK (1) SK285618B6 (hu)
TR (1) TR199900469T2 (hu)
TW (1) TW550256B (hu)
UA (1) UA60312C2 (hu)
WO (1) WO1998009946A1 (hu)
ZA (1) ZA977475B (hu)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
AP2000001929A0 (en) * 1998-03-31 2000-09-30 Inst For Pharm Discovery Inc Substituted indolealkanoic acids.
DE19946301A1 (de) 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
CZ302588B6 (cs) * 1998-04-02 2011-07-27 Ziopharm Oncology, Inc. Použití N-substituovaného indol-3-glyoxylamidu pro výrobu léciva
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DE19818964A1 (de) * 1998-04-28 1999-11-04 Dresden Arzneimittel Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
DE19917504A1 (de) * 1999-04-17 2000-10-19 Dresden Arzneimittel Verwendung von Hydroxyindolen, die Inhibitoren der Phosphodiesterase 4 sind, zur Therapie chronisch obstruktiver Lungenerkrankungen
PT1076657E (pt) * 1998-04-28 2004-11-30 Elbion Ag Novos hidroxi-indoles, sua utilizacao como inibidores da fosfodiesterase 4 e processo para a sua producao
ATE320800T1 (de) 1999-08-21 2006-04-15 Altana Pharma Ag Synergistische kombination von roflumilast und salmeterol
TWI269654B (en) * 1999-09-28 2007-01-01 Baxter Healthcare Sa N-substituted indole-3-glyoxylamide compounds having anti-tumor action
DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
DE10022925A1 (de) * 2000-05-11 2001-11-15 Basf Ag Substituierte Indole als PARP-Inhibitoren
DE10037310A1 (de) 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
AU2002323474B2 (en) * 2001-09-13 2006-10-05 Synta Pharmaceuticals Corp 3-glyoxlylamideindoles for treating cancer
RU2337906C2 (ru) * 2001-12-03 2008-11-10 Уайт Ингибиторы цитозольной фосфолипазы а2
US6903104B2 (en) * 2001-12-06 2005-06-07 National Health Research Institutes Indol-3-YL-2-oxoacetamide compounds and methods of use thereof
CA2493755A1 (en) * 2002-07-26 2004-02-05 The Institutes For Pharmaceutical Discovery, Llc Substituted indolealkanoic acids derivative and formulations containing same for use in treatment of diabetic complications
HRP20050201A2 (en) * 2002-08-01 2005-04-30 Elbion Ag Method for producing highly pure hydroxy indolyl glyoxylic acid amideslyoxylic acid amides
DE10253426B4 (de) * 2002-11-15 2005-09-22 Elbion Ag Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
WO2004087211A2 (en) 2003-04-01 2004-10-14 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
DE10318610A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 7-Azaindole und deren Verwendung als Therapeutika
DE10318611A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE10318609A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
DE10334040A1 (de) * 2003-07-25 2005-03-10 Zentaris Gmbh Neue N-substituierte Indolyl-3-glyoxylsäureamide, deren Verwendung als Arzneimittel und Verfahren zu deren Herstellung
MXPA06002853A (es) 2003-09-11 2006-06-14 Kemia Inc Inhibidores citoquina.
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
DE102004031538A1 (de) * 2004-06-29 2006-02-09 Baxter International Inc., Deerfield Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit
AU2005304952B2 (en) * 2004-11-08 2013-04-04 Baxter Healthcare S.A. Nanoparticulate compositions of tubulin inhibitors
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100432A1 (en) * 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US9040558B2 (en) 2004-12-31 2015-05-26 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
JP2006247963A (ja) * 2005-03-09 2006-09-21 Oji Paper Co Ltd インクジェット記録用シート
JP5385605B2 (ja) * 2005-03-11 2014-01-08 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｐ結合カセットトランスポーターのモジュレーター
US7392768B2 (en) 2005-04-29 2008-07-01 Tendix Development, Llc Radial impulse engine, pump, and compressor systems, and associated methods of operation
US20060280787A1 (en) * 2005-06-14 2006-12-14 Baxter International Inc. Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof
US7598380B2 (en) * 2005-08-03 2009-10-06 Bristol-Myers Squibb Company Method of preparation of azaindole derivatives
ITMI20051999A1 (it) * 2005-10-21 2007-04-22 Eratech S R L Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita'
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
PL2359826T3 (pl) 2006-07-05 2014-04-30 Astrazeneca Ab Połączenie inhibitora reduktazy HMG-CoA rosuwastatyny z inhibitorem fosfodiesterazy 4, takim jak roflumilast, N-tlenek roflumilastu, do leczenia chorób zapalnych płuc
EP2610244A1 (en) 2006-08-07 2013-07-03 Ironwood Pharmaceuticals, Inc. Indole compounds
JP2010509237A (ja) * 2006-11-02 2010-03-25 アレテ セラピューティクス， インコーポレイテッド 可溶性エポキシドヒドロラーゼ阻害剤
JP2010511041A (ja) * 2006-11-28 2010-04-08 ジオファーム オンコロジー， インコーポレイテッド インジブリンを含むインドリル−３−グリオキシル酸誘導体の癌を処置するための単独またはさらなる薬剤との組み合わせでの使用
EP3563842A1 (en) 2009-04-29 2019-11-06 Amarin Pharmaceuticals Ireland Limited Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
EP2744803A2 (en) 2011-08-18 2014-06-25 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (cetp) inhibitors
US9000007B2 (en) 2011-09-27 2015-04-07 Dr. Reddy's Laboratories Ltd. 5-benzylaminomethyl-6-aminopyrazolo [3, 4 -B] pyridine derivatives as cholesteryl ester-transfer protein (CETP) inhibitors useful for the treatment of atherosclerosis
EP3165224A1 (en) 2015-11-09 2017-05-10 Albert-Ludwigs-Universität Freiburg Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
CN109000634B (zh) * 2018-06-04 2022-06-03 上海智蕙林医疗科技有限公司 一种导航对象行进路线的提醒方法和系统

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB797258A (en) * 1955-04-11 1958-06-25 Upjohn Co 3-substituted indoles
GB944443A (hu) * 1959-09-25 1900-01-01
GB1028812A (en) * 1962-08-28 1966-05-11 Ici Ltd Indole derivatives
GB1089071A (en) * 1964-02-28 1967-11-01 Merck & Co Inc Indole derivatives
US3686213A (en) * 1970-08-28 1972-08-22 American Cyanamid Co Substituted aminoethyl indoles
SU457698A1 (ru) * 1972-10-20 1975-01-25 Всесоюзный научно-исследовательский химико-фармацевтический институт им. Серго Орджоникидзе Способ получени производных индолил-2-уксусной кислоты
FR2689888B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
IL113210A (en) * 1994-04-01 2001-01-28 Lilly Co Eli 1H-indole-3- glyoxylamide spla2 inhibitors and pharmaceutical compositions containing them
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
DE19946301A1 (de) * 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
US7205299B2 (en) * 2003-06-05 2007-04-17 Zentaris Gmbh Indole derivatives having an apoptosis-inducing effect

Also Published As

Publication number Publication date
IL127798A0 (en) 1999-10-28
CN100488948C (zh) 2009-05-20
CN100376554C (zh) 2008-03-26
HK1123280A1 (en) 2009-06-12
WO1998009946A1 (de) 1998-03-12
CN1227542A (zh) 1999-09-01
BR9712808B1 (pt) 2009-05-05
JP2000505098A (ja) 2000-04-25
EP0931063B1 (de) 2006-10-18
NO991071L (no) 1999-03-04
EP0931063B3 (de) 2009-04-08
NO314725B3 (no) 2009-03-09
NO314725B1 (no) 2003-05-12
CA2215013C (en) 2002-03-05
KR20000068495A (ko) 2000-11-25
TW550256B (en) 2003-09-01
CZ302301B6 (cs) 2011-02-09
US6008231A (en) 1999-12-28
JP3296437B2 (ja) 2002-07-02
CN101219985B (zh) 2011-04-27
HK1064379A1 (zh) 2005-01-28
HUP9903741A3 (en) 2001-01-29
US20020161025A1 (en) 2002-10-31
RU2237661C2 (ru) 2004-10-10
SK285618B6 (sk) 2007-05-03
NZ334476A (en) 2000-05-26
CN101219985A (zh) 2008-07-16
AU726521C (en) 1998-03-26
BR9712808A (pt) 1999-11-23
IL127798A (en) 2003-07-31
ES2276433T7 (es) 2009-11-05
SK27199A3 (en) 1999-08-06
DE59712752D1 (de) 2006-11-30
US6344467B1 (en) 2002-02-05
ES2276433T3 (es) 2007-06-16
PT931063E (pt) 2007-02-28
HK1021641A1 (zh) 2000-06-23
US20030207892A1 (en) 2003-11-06
DK0931063T3 (da) 2007-02-19
ZA977475B (en) 1998-02-19
NO20030481L (no) 1999-03-04
AU726521B2 (en) 2000-11-09
HU227797B1 (en) 2012-03-28
NO991071D0 (no) 1999-03-04
AU4015897A (en) 1998-03-26
DK0931063T5 (da) 2010-01-11
US6919344B2 (en) 2005-07-19
KR100516321B1 (ko) 2005-09-23
NO20030481D0 (no) 2003-01-30
AR008630A1 (es) 2000-02-09
ATE342889T1 (de) 2006-11-15
CN1496980A (zh) 2004-05-19
UA60312C2 (uk) 2003-10-15
CA2215013A1 (en) 1998-03-06
EP0931063A1 (de) 1999-07-28
DE19636150A1 (de) 1998-03-12
TR199900469T2 (xx) 1999-05-21
CZ61699A3 (cs) 1999-06-16

Similar Documents

Publication Publication Date Title
HUP9903741A2 (hu) Asztmaellenes, allergiaellenes, immunvisszaszorító és/vagy immunmoduláló hatású N-helyettesített indol-3-glioxilamidok
WO2001072728A3 (en) Novel piperazine derivatives
PT1193270E (pt) Pirrolobenzodiazepinas
CY2488B1 (en) New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for trea.
MY134129A (en) Polymorphs of an epothilone analog
ES2191208T3 (es) Oxiimino-pregnano-carbolactonas.
CA2216796A1 (en) Quinazoline derivatives
AP9801169A0 (en) N-hydroxy-B-sulfonyl propionamide derivatives.
EP0680328A1 (en) KETOCONAZOLE COMPOSITIONS FOR LOCAL USE.
FR2735127B1 (fr) Nouvelles piperazines heteroaromatiques utiles comme medicaments.
MX9605206A (es) 1alfa,26-dihidroxi-d-homo-vitamina d3.
FI980862A0 (fi) Kiraalisia metyylifenyylioksatsolidinoneja
HUP9901616A3 (en) Novel benzofuranone derivatives, process for their production and pharmaceutical compositions of the same
MY133112A (en) 3-amino-3-arylpropan-1-ol derivatives, and their preparation and use
WO2002032901A3 (en) Bridged piperazine derivatives
BR0114380A (pt) Derivados-1-aminobutan-3-ol-substituìdos
MY133169A (en) Substituted heterocyclic benzocycloalkenes and the use thereof as substances having an analgesic effect
GEP20032924B (en) Novel Furan Diarylmethylidene Derivatives, Method for Their Preparation and Pharmaceutical Composition
EP0816366A4 (en) IMIDAZOTHIAZOLE COMPOUNDS
NO961168L (no) Nye uretanholdige aminosteroid forbindelser
TR199701298T1 (xx) Tetralinler.
AP2002002595A0 (en) Heterocyclic amide derivatives.
PT1246790E (pt) Bases de mannich de 1- e 2-naftol substituido
AU6832498A (en) Substituted benzyl oximino compounds
HUT77174A (hu) Heterociklusos csoporttal szubsztituált 3-(indol-3-il)-akrilsav-származékok, mint NMDA antagonisták, és a vegyületeket tartalmazó gyógyszerkészítmények

Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: ZIOPHARM ONCOLOGY, INC., US

Free format text: FORMER OWNER(S): ASTA MEDICA AKTIENGESELLSCHAFT, DE

HC9A Change of name, address

Owner name: ZIOPHARM ONCOLOGY, INC., US

Free format text: FORMER OWNER(S): ASTA MEDICA AKTIENGESELLSCHAFT, DE; ZIOPHARM ONCOLOGY, INC., US

MM4A Lapse of definitive patent protection due to non-payment of fees