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HUP9903478A2 - Új eljárás klavulánsav sójának előállítására - Google Patents

Új eljárás klavulánsav sójának előállítására

Info

Publication number
HUP9903478A2
HUP9903478A2 HU9903478A HUP9903478A HUP9903478A2 HU P9903478 A2 HUP9903478 A2 HU P9903478A2 HU 9903478 A HU9903478 A HU 9903478A HU P9903478 A HUP9903478 A HU P9903478A HU P9903478 A2 HUP9903478 A2 HU P9903478A2
Authority
HU
Hungary
Prior art keywords
clavulanic acid
salt
production
new process
subject
Prior art date
Application number
HU9903478A
Other languages
English (en)
Inventor
Helmut Wagner
Original Assignee
Biochemie Gesellschaft Mbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie Gesellschaft Mbh. filed Critical Biochemie Gesellschaft Mbh.
Publication of HUP9903478A2 publication Critical patent/HUP9903478A2/hu
Publication of HUP9903478A3 publication Critical patent/HUP9903478A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D503/02—Preparation
    • C07D503/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D503/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

A találmány tárgya eljárás az (I) képletű klavűlánsav alkáifémsójánakelőállítására, melyre jellemző, hőgy a klavűlánsav gyógyászatiszempőntból alkalmazható sóvá való átalakítását őldószerként n-bűtanőlban vagy izőbűtanőlban (2-metil-1-prőpanől) végzik. A találmánytővábbi tárgyát képezi a klavűlánsav n-bűtanőlt vagy izőbűtanőlttartalmazó káliűmsója. ŕ
HU9903478A 1995-11-15 1996-11-14 New process for the production of a salt of clavulanic acid HUP9903478A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0186795A AT403375B (de) 1995-11-15 1995-11-15 Verfahren zur fällung von alkalisalzen der clavulansäure
PCT/EP1996/005015 WO1997018216A1 (en) 1995-11-15 1996-11-14 Production of a salt of clavulanic acid

Publications (2)

Publication Number Publication Date
HUP9903478A2 true HUP9903478A2 (hu) 2000-03-28
HUP9903478A3 HUP9903478A3 (en) 2000-05-29

Family

ID=3522721

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903478A HUP9903478A3 (en) 1995-11-15 1996-11-14 New process for the production of a salt of clavulanic acid

Country Status (25)

Country Link
US (1) US6133441A (hu)
EP (1) EP0874855B1 (hu)
JP (1) JP4319252B2 (hu)
KR (1) KR100537732B1 (hu)
CN (1) CN1090636C (hu)
AT (2) AT403375B (hu)
AU (1) AU714017B2 (hu)
BR (1) BR9611572A (hu)
CA (1) CA2237763C (hu)
CZ (1) CZ296567B6 (hu)
DE (1) DE69631608T2 (hu)
ES (1) ES2216073T3 (hu)
HK (1) HK1016971A1 (hu)
HU (1) HUP9903478A3 (hu)
IL (1) IL124353A (hu)
MX (1) MX9803887A (hu)
NO (1) NO982107D0 (hu)
NZ (1) NZ322485A (hu)
PL (1) PL188634B1 (hu)
RU (1) RU2179171C2 (hu)
SI (1) SI0874855T1 (hu)
SK (1) SK285138B6 (hu)
TR (1) TR199800860T2 (hu)
TW (1) TW427991B (hu)
WO (1) WO1997018216A1 (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
CN1267437C (zh) * 2000-10-20 2006-08-02 桑多斯股份公司 微粒形式的克拉维酸或其盐
WO2009049086A1 (en) 2007-10-09 2009-04-16 Larry Sutton Broad spectrum beta-lactamase inhibitors
US20100261700A1 (en) * 2009-04-09 2010-10-14 Larry Sutton Beta-lactamase inhibitors
WO2014165126A2 (en) 2013-03-12 2014-10-09 Sopharmia, Inc. Derivatized 3-styryl-cephalosporins
CN109535184B (zh) * 2017-09-21 2020-11-20 联邦制药(内蒙古)有限公司 一种克拉维酸叔辛胺制备克拉维酸钾的方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
US4144242A (en) * 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
GB2003863B (en) * 1977-09-01 1982-03-31 Beecham Group Ltd Chemical process
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration
AU600655B2 (en) * 1984-10-27 1990-08-23 Beecham Group Plc Preparation of clavulanic acid and its salts and esters
GB8618888D0 (en) * 1986-08-01 1986-09-10 Davy Mckee Ltd Process
US5679789A (en) * 1987-01-29 1997-10-21 Beecham Group, P.L.C. Pharmaceutical compositions comprising potassium clavulanate and methods of using them
PT86631B (pt) * 1987-01-29 1992-01-31 Beecham Group Plc Processo para a preparacao de uma nova forma cristalina de clavulanato de potassio
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
US5210296A (en) * 1990-11-19 1993-05-11 E. I. Du Pont De Nemours And Company Recovery of lactate esters and lactic acid from fermentation broth
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
SI9200139A (en) * 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9401969D0 (en) * 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB2298201B (en) * 1995-02-25 1997-05-28 Spurcourt Ltd Clavulanic acid salts
CN1175952A (zh) * 1995-02-25 1998-03-11 斯勃苛尔脱有限公司 克拉维酸盐及其制备方法
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko) * 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
SI9500265A1 (en) * 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
ZA975198B (en) * 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
JP2001503763A (ja) * 1996-11-11 2001-03-21 ギスト ブロカデス ベスローテン フェンノートシャップ クラバラン酸の塩及びエステルの調製法

Also Published As

Publication number Publication date
EP0874855B1 (en) 2004-02-18
DE69631608T2 (de) 2004-12-23
US6133441A (en) 2000-10-17
HK1016971A1 (en) 1999-11-12
CA2237763C (en) 2008-05-06
NO982107L (no) 1998-05-08
PL326696A1 (en) 1998-10-26
SK64098A3 (en) 1998-10-07
RU2179171C2 (ru) 2002-02-10
IL124353A (en) 2005-06-19
CZ296567B6 (cs) 2006-04-12
NO982107D0 (no) 1998-05-08
NZ322485A (en) 2000-01-28
ES2216073T3 (es) 2004-10-16
TW427991B (en) 2001-04-01
KR100537732B1 (ko) 2006-04-14
CA2237763A1 (en) 1997-05-22
CN1090636C (zh) 2002-09-11
EP0874855A1 (en) 1998-11-04
AU714017B2 (en) 1999-12-16
AU7625096A (en) 1997-06-05
PL188634B1 (pl) 2005-03-31
AT403375B (de) 1998-01-26
IL124353A0 (en) 1998-12-06
CZ149198A3 (cs) 1998-08-12
JP4319252B2 (ja) 2009-08-26
WO1997018216A1 (en) 1997-05-22
DE69631608D1 (de) 2004-03-25
ATA186795A (de) 1997-06-15
TR199800860T2 (xx) 2000-07-21
MX9803887A (es) 1998-09-30
CN1204337A (zh) 1999-01-06
BR9611572A (pt) 1999-03-30
KR19990067480A (ko) 1999-08-25
JP2000500149A (ja) 2000-01-11
SK285138B6 (sk) 2006-07-07
HUP9903478A3 (en) 2000-05-29
SI0874855T1 (en) 2004-06-30
ATE259817T1 (de) 2004-03-15

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