HUP9902437A2 - Gamma-Hidroxi-vajsavamid-származékok, eljárás előállításukra és ilyen vegyületeket tartalmazó, gyógyszerfüggőség kezelésére alkalmas gyógyszerkészítmények - Google Patents
Gamma-Hidroxi-vajsavamid-származékok, eljárás előállításukra és ilyen vegyületeket tartalmazó, gyógyszerfüggőség kezelésére alkalmas gyógyszerkészítményekInfo
- Publication number
- HUP9902437A2 HUP9902437A2 HU9902437A HUP9902437A HUP9902437A2 HU P9902437 A2 HUP9902437 A2 HU P9902437A2 HU 9902437 A HU9902437 A HU 9902437A HU P9902437 A HUP9902437 A HU P9902437A HU P9902437 A2 HUP9902437 A2 HU P9902437A2
- Authority
- HU
- Hungary
- Prior art keywords
- hydroxybutyric acid
- alkyl
- acid amides
- gamma
- contg
- Prior art date
Links
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 title 2
- 239000003814 drug Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A találmány tárgya az (I) általánős képletű g-hidrőxi-vajsavamid-származékők alkalmazása kábítószerfüggőség, példáűl herőin-, mőrfin-és pszichőaktív kábítószerfüggőség, tővábbá alkőhőlizműs kezelésérealkalmas gyógyszerkészítmény előállítására. Az (I) általánős képletben R1 jelentése egy vagy több 5 és 7 közötti számú gyűrűatőmőt tartalmazókarbőciklűsős vagy heterőciklűsős arőmás gyűrűt, vagy ezek keverékéttartalmazó mőnő- vagy pőliciklűsős arőmás csőpőrt, ahől a gyűrűk adőttesetben egy vagy több 1-8 szénatőmős alkil-, 1-8 szénatőmős alkőxi-,aminő-, 1-8 szénatőmős mőnő- vagy dialkil-aminő-csőpőrttal vagyhalőgénatőmmal vannak helyettesítve, ahől az 1-8 szénatőmős alkil- ésaz 1-8 szénatőmős alkőxicsőpőrt egy vagy több kettős vagy hármaskötést tartalmazhat vagy egy vagy több halőgénatőmőt tartalmazócsőpőrttal lehet helyettesítve; R2 jelentése egyenes vagy elágazó láncú alkilcsőpőrt, egy vagy többkettős, vagy hármas kötést tartalmazó vagy egy, vagy több arőmáscsőpőrttal helyettesített alkilcsőpőrt; Q jelentése hidrőgénatőm vagy 1-6 szénatőmős egyenes vagy elágazóláncú alkilcsőpőrt; n értéke 1 és 4 közötti egész szám; T1 és T2 jelentése egymástól függetlenül hidrőgénatőm vagy 1-6szénatőmős egyenes vagy elágazó láncú alkilcsőpőrt. A fentivegyületekkel csökkenthető a krónikűs alkőhőlisták alkőhőltartalmúitalők főgyasztása iránti vágya, és kezelhető az alkőhől- absztinenciaszindróma. A találmány kiterjed a fenti vegyületek előállítására,tővábbá az ezeket tartalmazó készítményekre is. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI001732A IT1283782B1 (it) | 1996-08-09 | 1996-08-09 | Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo |
| PCT/EP1997/004309 WO1998006690A1 (en) | 1996-08-09 | 1997-08-07 | USE OF η-HYDROXYBUTYRIC ACID AMIDES IN THE TREATMENT OF DRUG ADDICTION AND IN PARTICULAR OF ALCOHOLISM |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP9902437A2 true HUP9902437A2 (hu) | 1999-12-28 |
| HUP9902437A3 HUP9902437A3 (en) | 2001-07-30 |
| HU228595B1 HU228595B1 (en) | 2013-04-29 |
Family
ID=11374795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9902437A HU228595B1 (en) | 1996-08-09 | 1997-08-07 | Gamma-hydroxybutyric acid amides, process to prepare them, use gamma-hydroxybutyric acid amides, and pharmaceuticals contg. them for the treatmant of drug abusing |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6436998B1 (hu) |
| EP (1) | EP0932597B1 (hu) |
| JP (1) | JP4259615B2 (hu) |
| AT (1) | ATE215065T1 (hu) |
| AU (1) | AU4379097A (hu) |
| CA (1) | CA2263328C (hu) |
| DE (1) | DE69711411T2 (hu) |
| DK (1) | DK0932597T3 (hu) |
| ES (1) | ES2174287T3 (hu) |
| HU (1) | HU228595B1 (hu) |
| IT (1) | IT1283782B1 (hu) |
| PT (1) | PT932597E (hu) |
| WO (1) | WO1998006690A1 (hu) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7491747B2 (en) | 2001-07-30 | 2009-02-17 | Merck Patent Gmbh | Butyric acid derivatives |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1140061T3 (da) | 1998-12-23 | 2003-08-25 | Orphan Medical Inc | Mikrobiologisk sunde og stabile opløsninger af gamma-hydroxybutyratsalt til behandling af narcolepsi |
| AU2003295393A1 (en) * | 2002-11-01 | 2004-06-07 | Baylor Research Institute | Ghb treatment methods |
| US7838556B2 (en) * | 2006-02-21 | 2010-11-23 | University Of Maryland, Baltimore | Ethers of 3-hydroxyphenylacetic acid as selective gamma-hydroxybutyric acid receptor ligands |
| EP2062875A1 (en) | 2007-11-13 | 2009-05-27 | LABORATORIO FARMACEUTICO C.T. S.r.l. | New polymorphic forms of n-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide |
| US8771735B2 (en) * | 2008-11-04 | 2014-07-08 | Jazz Pharmaceuticals, Inc. | Immediate release dosage forms of sodium oxybate |
| US8778398B2 (en) * | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
| CA2794171C (en) | 2010-03-24 | 2018-07-03 | Jazz Pharmaceuticals, Inc. | Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances |
| US8591922B1 (en) | 2012-12-14 | 2013-11-26 | Jazz Pharmacuticals, Inc. | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| ITMI20132041A1 (it) * | 2013-12-06 | 2015-06-07 | Ct Lab Farm Srl | Derivati dell'acido gamma-idrossibutirrico, loro preparazione e loro uso medico. |
| US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
| ITUB20152860A1 (it) * | 2015-08-04 | 2017-02-04 | Laboratorio Farm C T S R L | Selezionata amide dell?acido ?-idrossibutirrico e suoi usi nel trattamento dell?abuso da alcool |
| ITUA20164040A1 (it) * | 2016-06-01 | 2017-12-01 | Laboratorio Farm C T S R L | Procedimento per la preparazione di polimorfo a |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| WO2020106735A1 (en) | 2018-11-19 | 2020-05-28 | Jazz Pharmaceuticals Ireland Limited | Alcohol-resistant drug formulations |
| BR112021013766A2 (pt) | 2019-03-01 | 2021-09-21 | Flamel Ireland Limited | Composições de gama-hidroxibutirato com farmacocinética melhorada no estado alimentado |
| TW202139986A (zh) | 2020-02-21 | 2021-11-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 治療原發性嗜睡症之方法 |
| WO2023126076A1 (en) | 2022-01-03 | 2023-07-06 | Laboratorio Farmaceutico C.T. S.R.L. | Medical use of an amide of y-hydroxybutyric acid in the treatment of fragile x syndrome |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3940258A (en) * | 1971-11-26 | 1976-02-24 | Gaf Corporation | Method for controlling aquatic weeds with N-phenylalkyl-γ-hydroxybutyramide |
| JPS6016432B2 (ja) * | 1977-07-26 | 1985-04-25 | グレラン製薬株式会社 | 複素環式化合物類およびその製造法 |
| ES2103287T3 (es) * | 1987-02-23 | 1997-09-16 | Ono Pharmaceutical Co | Nuevos derivados de tiazolidina. |
| IT1217783B (it) | 1988-06-03 | 1990-03-30 | Farmaceutico Ct S R L Lab | Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative |
| IT1248588B (it) * | 1991-06-28 | 1995-01-19 | Gaetano Crepaldi | Composizioni farmaceutiche per la terapia dell'astinenza, del " craving", della dipendenza da sostanze stupefacenti, da sostanze psicoattive, da nicotina e dei disturbi alimentari. |
| JPH10501238A (ja) * | 1994-06-01 | 1998-02-03 | アリス ファーマシューティカル コーポレイション | 肥満細胞媒介症状を治療するための組成物及び方法 |
| AU712467B2 (en) * | 1995-09-18 | 1999-11-04 | Sankyo Company Limited | New urea derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use |
| EP1029851B1 (en) * | 1997-10-14 | 2005-04-20 | Mitsubishi Pharma Corporation | Piperazine compounds and medicinal use thereof |
-
1996
- 1996-08-09 IT IT96MI001732A patent/IT1283782B1/it active IP Right Grant
-
1997
- 1997-08-07 PT PT97941921T patent/PT932597E/pt unknown
- 1997-08-07 US US09/242,048 patent/US6436998B1/en not_active Expired - Lifetime
- 1997-08-07 AU AU43790/97A patent/AU4379097A/en not_active Abandoned
- 1997-08-07 ES ES97941921T patent/ES2174287T3/es not_active Expired - Lifetime
- 1997-08-07 AT AT97941921T patent/ATE215065T1/de active
- 1997-08-07 DK DK97941921T patent/DK0932597T3/da active
- 1997-08-07 WO PCT/EP1997/004309 patent/WO1998006690A1/en active IP Right Grant
- 1997-08-07 EP EP97941921A patent/EP0932597B1/en not_active Expired - Lifetime
- 1997-08-07 JP JP50937298A patent/JP4259615B2/ja not_active Expired - Lifetime
- 1997-08-07 HU HU9902437A patent/HU228595B1/hu unknown
- 1997-08-07 CA CA002263328A patent/CA2263328C/en not_active Expired - Lifetime
- 1997-08-07 DE DE69711411T patent/DE69711411T2/de not_active Expired - Lifetime
-
2001
- 2001-12-11 US US10/013,971 patent/US6770784B2/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7491747B2 (en) | 2001-07-30 | 2009-02-17 | Merck Patent Gmbh | Butyric acid derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| US6770784B2 (en) | 2004-08-03 |
| PT932597E (pt) | 2002-09-30 |
| HUP9902437A3 (en) | 2001-07-30 |
| AU4379097A (en) | 1998-03-06 |
| JP2000516225A (ja) | 2000-12-05 |
| US20020165224A1 (en) | 2002-11-07 |
| DK0932597T3 (da) | 2002-06-24 |
| DE69711411T2 (de) | 2002-11-07 |
| EP0932597A1 (en) | 1999-08-04 |
| US6436998B1 (en) | 2002-08-20 |
| ES2174287T3 (es) | 2002-11-01 |
| DE69711411D1 (de) | 2002-05-02 |
| ATE215065T1 (de) | 2002-04-15 |
| JP4259615B2 (ja) | 2009-04-30 |
| CA2263328C (en) | 2006-07-25 |
| ITMI961732A1 (it) | 1998-02-09 |
| ITMI961732A0 (hu) | 1996-08-09 |
| WO1998006690A1 (en) | 1998-02-19 |
| EP0932597B1 (en) | 2002-03-27 |
| CA2263328A1 (en) | 1998-02-19 |
| HU228595B1 (en) | 2013-04-29 |
| IT1283782B1 (it) | 1998-04-30 |
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