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HUP9902040A2 - Új eljárás 4-fenil-1,2,3,6-tetrahidro-piridin-származékok előállítására és az alkalmazott köztitermékek - Google Patents

Új eljárás 4-fenil-1,2,3,6-tetrahidro-piridin-származékok előállítására és az alkalmazott köztitermékek

Info

Publication number
HUP9902040A2
HUP9902040A2 HU9902040A HUP9902040A HUP9902040A2 HU P9902040 A2 HUP9902040 A2 HU P9902040A2 HU 9902040 A HU9902040 A HU 9902040A HU P9902040 A HUP9902040 A HU P9902040A HU P9902040 A2 HUP9902040 A2 HU P9902040A2
Authority
HU
Hungary
Prior art keywords
formula
tetrahydro
phenyl
producing
alkyl group
Prior art date
Application number
HU9902040A
Other languages
English (en)
Inventor
Francis Brion
Christian Richard
Original Assignee
Hoechst Marion Roussel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel filed Critical Hoechst Marion Roussel
Publication of HU9902040D0 publication Critical patent/HU9902040D0/hu
Publication of HUP9902040A2 publication Critical patent/HUP9902040A2/hu
Publication of HU225621B1 publication Critical patent/HU225621B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya új eljárás az ismert (I) általános képletűvegyületek - a képletben R1 jelentése hidrogénatom vagy alkilcsoport,R2 és R4, jelentése alkilcsoport, és R3 jelentése alkilcsoport -előállítására. Az eljárás abban áll, hogy valamely (II) általánosképletű vegyületet - a képletben R1 , R2, R3 és R4, jelentése akorábban megadott - egy elektrofil halogénezőszerrel, majd egyhalogénhidroxilezőszerrel, ezután egy bázissal, majd egydiasztereoszelektív redukálószerrel és végül egy redukálószerrelkezelnek az (I) általános képletű vegyületek előállítása céljából. Ó
HU9902040A 1998-06-18 1999-06-17 Process for producing 4-phenyl-1,2,3,6-tetrahydro-pyridine derivatives and the intermediates employed HU225621B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9807677A FR2780056B1 (fr) 1998-06-18 1998-06-18 Nouveau procede de preparation de derives de la 4-phenyl-1-2 3,6-tetrahydropyridine et les produits imtermediaires mis en oeuvre

Publications (3)

Publication Number Publication Date
HU9902040D0 HU9902040D0 (en) 1999-08-30
HUP9902040A2 true HUP9902040A2 (hu) 2001-11-28
HU225621B1 HU225621B1 (en) 2007-05-02

Family

ID=9527532

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9902040A HU225621B1 (en) 1998-06-18 1999-06-17 Process for producing 4-phenyl-1,2,3,6-tetrahydro-pyridine derivatives and the intermediates employed

Country Status (11)

Country Link
US (1) US6136981A (hu)
EP (1) EP0965588B1 (hu)
JP (1) JP4538114B2 (hu)
AT (1) ATE261432T1 (hu)
CA (1) CA2275192C (hu)
DE (1) DE69915413T2 (hu)
DK (1) DK0965588T3 (hu)
ES (1) ES2213991T3 (hu)
FR (1) FR2780056B1 (hu)
HU (1) HU225621B1 (hu)
PT (1) PT965588E (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5981747B2 (ja) * 2012-03-28 2016-08-31 東ソー・ファインケム株式会社 アザディールス−アルダー反応用触媒、それを用いたテトラヒドロピリジン化合物の製造方法
AU2016252609B2 (en) 2015-04-20 2022-06-30 Sumitomo Pharma Oncology, Inc. Predicting response to alvocidib by mitochondrial profiling
PL3298021T3 (pl) 2015-05-18 2019-11-29 Tolero Pharmaceuticals Inc Proleki alvocidibu o zwiększonej biodostępności
AU2016301315C1 (en) 2015-08-03 2022-07-07 Sumitomo Pharma Oncology, Inc. Combination therapies for treatment of cancer
US11279694B2 (en) 2016-11-18 2022-03-22 Sumitomo Dainippon Pharma Oncology, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
KR20190099260A (ko) 2016-12-19 2019-08-26 톨레로 파마수티컬스, 인크. 프로파일링 펩티드 및 감도 프로파일링을 위한 방법
WO2019055579A1 (en) 2017-09-12 2019-03-21 Tolero Pharmaceuticals, Inc. TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR
CA3119807A1 (en) 2018-12-04 2020-06-11 Sumitomo Dainippon Pharma Oncology, Inc. Cdk9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
WO2020191326A1 (en) 2019-03-20 2020-09-24 Sumitomo Dainippon Pharma Oncology, Inc. Treatment of acute myeloid leukemia (aml) with venetoclax failure

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2338043A1 (fr) * 1976-01-13 1977-08-12 Delmar Chem Derives de 4-arylpiperidine et procedes de production
US4132710A (en) * 1976-12-20 1979-01-02 Ayerst, Mckenna And Harrison, Ltd. [2]Benzopyrano[3,4-c]pyridines and process therefor
US5849733A (en) * 1996-05-10 1998-12-15 Bristol-Myers Squibb Co. 2-thio or 2-oxo flavopiridol analogs
US6268499B1 (en) * 1998-08-10 2001-07-31 Hoffman-La Roche Inc. Process and intermediates for preparation of substituted piperidine-epoxides

Also Published As

Publication number Publication date
ES2213991T3 (es) 2004-09-01
PT965588E (pt) 2004-07-30
DE69915413T2 (de) 2004-08-19
DE69915413D1 (de) 2004-04-15
FR2780056A1 (fr) 1999-12-24
ATE261432T1 (de) 2004-03-15
DK0965588T3 (da) 2004-06-21
EP0965588B1 (fr) 2004-03-10
JP4538114B2 (ja) 2010-09-08
CA2275192A1 (fr) 1999-12-18
US6136981A (en) 2000-10-24
CA2275192C (fr) 2008-12-30
EP0965588A1 (fr) 1999-12-22
HU225621B1 (en) 2007-05-02
HU9902040D0 (en) 1999-08-30
FR2780056B1 (fr) 2000-08-04
JP2000026418A (ja) 2000-01-25

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