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HUP0202383A2 - Eljárás 2-(2-aril-morfolin-il)-etanol-származékok előállítása és közbenső termékek - Google Patents

Eljárás 2-(2-aril-morfolin-il)-etanol-származékok előállítása és közbenső termékek

Info

Publication number
HUP0202383A2
HUP0202383A2 HU0202383A HUP0202383A HUP0202383A2 HU P0202383 A2 HUP0202383 A2 HU P0202383A2 HU 0202383 A HU0202383 A HU 0202383A HU P0202383 A HUP0202383 A HU P0202383A HU P0202383 A2 HUP0202383 A2 HU P0202383A2
Authority
HU
Hungary
Prior art keywords
arylmorpholin
intermediates
preparing
ethanol derivatives
ethanol
Prior art date
Application number
HU0202383A
Other languages
English (en)
Inventor
Alain Aulombard
Franqoise Bernon
Sabrina Bonnefoy
Alain Burgos
Claude Cabos
Eric Lucas
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of HUP0202383A2 publication Critical patent/HUP0202383A2/hu
Publication of HUP0202383A3 publication Critical patent/HUP0202383A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483—Monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány (I) általános képletű, helyettesített 2-(2-ailmorfolin-2-il)etanol-származékok enantiomertiszta formában való előállításáraalkalmas új eljárásokra és ezen eljárásokban alkalmazott új közbensőtermékekre vonatkozik, a képletben X jelentése halogénatom. Ó
HU0202383A 1999-07-09 2000-07-07 Method for preparing 2-(2-arylmorpholin-2-yl)ethanol derivatives and intermediates HUP0202383A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9909061A FR2796069B3 (fr) 1999-07-09 1999-07-09 Nouveaux procedes de preparation de derives de 2-(2- arylmorpholin-2-yl)ethanol substitues, enantiomeriquement purs, et composes intermediaires utiles dans ces procedes

Publications (2)

Publication Number Publication Date
HUP0202383A2 true HUP0202383A2 (hu) 2002-11-28
HUP0202383A3 HUP0202383A3 (en) 2004-12-28

Family

ID=9548041

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202383A HUP0202383A3 (en) 1999-07-09 2000-07-07 Method for preparing 2-(2-arylmorpholin-2-yl)ethanol derivatives and intermediates

Country Status (19)

Country Link
US (3) US7038044B1 (hu)
EP (1) EP1200417B1 (hu)
JP (1) JP3891840B2 (hu)
CN (2) CN1266115C (hu)
AT (1) ATE252566T1 (hu)
AU (1) AU6295600A (hu)
BR (1) BR0012324A (hu)
CA (1) CA2378002C (hu)
CZ (1) CZ300744B6 (hu)
DE (1) DE60006125T2 (hu)
ES (1) ES2208381T3 (hu)
FR (1) FR2796069B3 (hu)
HR (1) HRP20020021B1 (hu)
HU (1) HUP0202383A3 (hu)
MX (1) MXPA02000307A (hu)
PL (1) PL203213B1 (hu)
SI (1) SI1200417T1 (hu)
SK (1) SK286671B6 (hu)
WO (1) WO2001004105A1 (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796069B3 (fr) * 1999-07-09 2001-08-24 Sanofi Synthelabo Nouveaux procedes de preparation de derives de 2-(2- arylmorpholin-2-yl)ethanol substitues, enantiomeriquement purs, et composes intermediaires utiles dans ces procedes
JP2008273841A (ja) * 2005-07-14 2008-11-13 Zeria Pharmaceut Co Ltd エチレンジアミン誘導体及びその製造法
CA2992219A1 (en) * 2010-04-12 2011-10-20 Supernus Pharmaceuticals Inc. Methods for producing viloxazine salts and novel polymorphs thereof
CN115448816B (zh) * 2022-09-16 2024-04-12 中国石油大学(华东) 一种β-氟代烯基醇的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH396942A (de) * 1959-03-21 1965-08-15 Thomae Gmbh Dr K Verfahren zur Herstellung basisch substituierter Carbinole
BE790604A (fr) * 1971-10-28 1973-04-26 Sandoz Sa Nouveaux aminoalcanols, leur preparation et leur application comme medicaments
GB9108629D0 (en) * 1991-04-23 1991-06-12 Wellcome Found Heterocyclic pharmaceutical compounds,preparation and use
US5780466A (en) 1995-01-30 1998-07-14 Sanofi Substituted heterocyclic compounds method of preparing them and pharmaceutical compositions in which they are present
FR2729954B1 (fr) * 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
US5616777A (en) * 1995-04-19 1997-04-01 Schering Corporation Chiral hydrazine derivatives
US5760466A (en) * 1995-04-20 1998-06-02 Kyocera Corporation Semiconductor device having improved heat resistance
HU224225B1 (hu) * 1995-12-01 2005-06-28 Sankyo Co. Ltd. Tachikinin receptor antagonista hatású heterociklusos vegyületek, ezek előállítási eljárása és alkalmazásuk gyógyszerkészítmények előállítására
TR200001622T2 (tr) 1997-12-04 2001-07-23 Sankyo Company Limited Asilatlı Hetero-Alisiklik Türevleri
PT1140788E (pt) * 1998-12-29 2004-07-30 Upjohn Co Metodo de preparacao de eteres arilicos
FR2796069B3 (fr) * 1999-07-09 2001-08-24 Sanofi Synthelabo Nouveaux procedes de preparation de derives de 2-(2- arylmorpholin-2-yl)ethanol substitues, enantiomeriquement purs, et composes intermediaires utiles dans ces procedes

Also Published As

Publication number Publication date
FR2796069A1 (fr) 2001-01-12
CZ300744B6 (cs) 2009-07-29
JP3891840B2 (ja) 2007-03-14
FR2796069B3 (fr) 2001-08-24
AU6295600A (en) 2001-01-30
CA2378002C (en) 2007-03-27
CN1266115C (zh) 2006-07-26
CN1367781A (zh) 2002-09-04
SI1200417T1 (en) 2004-04-30
PL356064A1 (en) 2004-06-14
ES2208381T3 (es) 2004-06-16
CA2378002A1 (en) 2001-01-18
US7038044B1 (en) 2006-05-02
HUP0202383A3 (en) 2004-12-28
DE60006125D1 (de) 2003-11-27
SK182002A3 (en) 2002-06-04
WO2001004105A1 (fr) 2001-01-18
US7223860B2 (en) 2007-05-29
DE60006125T2 (de) 2004-07-08
ATE252566T1 (de) 2003-11-15
BR0012324A (pt) 2002-03-19
EP1200417B1 (fr) 2003-10-22
SK286671B6 (sk) 2009-03-05
HRP20020021B1 (en) 2004-10-31
HRP20020021A2 (en) 2003-08-31
PL203213B1 (pl) 2009-09-30
US20070167623A1 (en) 2007-07-19
CN1534015A (zh) 2004-10-06
CZ200259A3 (cs) 2002-04-17
JP2003504362A (ja) 2003-02-04
US7378521B2 (en) 2008-05-27
MXPA02000307A (es) 2002-07-30
EP1200417A1 (fr) 2002-05-02
US20060149058A1 (en) 2006-07-06
CN1183121C (zh) 2005-01-05

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