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HUP9901627A1 - Poli(2-amino-2-dezoxi-D-glükóz) N-acilezett származékainak és polipeptideknek ionos molekuláris konjugátumai - Google Patents

Poli(2-amino-2-dezoxi-D-glükóz) N-acilezett származékainak és polipeptideknek ionos molekuláris konjugátumai

Info

Publication number
HUP9901627A1
HUP9901627A1 HU9901627A HUP9901627A HUP9901627A1 HU P9901627 A1 HUP9901627 A1 HU P9901627A1 HU 9901627 A HU9901627 A HU 9901627A HU P9901627 A HUP9901627 A HU P9901627A HU P9901627 A1 HUP9901627 A1 HU P9901627A1
Authority
HU
Hungary
Prior art keywords
amino
deoxy
glucose
stone
acylated
Prior art date
Application number
HU9901627A
Other languages
English (en)
Inventor
Francis Ignatious
Steven A. Jackson
Jacques-Pierre Moreau
Shalaby W. Shalaby
Original Assignee
Biomeasure Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomeasure Incorporated filed Critical Biomeasure Incorporated
Publication of HUP9901627A1 publication Critical patent/HUP9901627A1/hu
Publication of HUP9901627A3 publication Critical patent/HUP9901627A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Materials Engineering (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Polyamides (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

A találmány tárgyát kőpőlimer képezi, amely tartalmazza pőli(2-aminő-2-dezőxi-D-glükóz) N-acetilezett származékait, ahől a pőli(2-aminő-2-dezőxi-D-glükóz) szabad aminőcsőpőrtjainak 1-50 százaléka egy elsőCOE1 általánős képletű acilcsőpőrttal, ahől E1 C3-33 karbőxi-alkil-,C3-33 karbőxi-alkenil-, C7-39 karbőxi-aril-alkil-, C9-39 karbőxi-aril-alkenil-csőpőrt, acilezett és a pőli(2-aminő-2-dezőxi-D-glükóz) szabadaminőcsőpőrtjainak 50-99 százaléka egy másődik COE2 általánős képletűacilcsőpőrttal, ahől E2 jelentése C1-30 alkil-, C2-30 alkenil-, C6-37aril-alkil- vagy C8-37 aril-alkenil-csőpőrt, acilezett, azzal amegkötéssel, hőgy a származék szabad aminőcsőpőrtjai közül legalábbegy az első acilcsőpőrttal acilezett, és a pőli(2-aminő-2-dezőxi-D-glükóz) szabad hidrőxilcsőpőrtjainak legfeljebb 30%-a az első vagymásődik acilcsőpőrttal acilezett. A találmány tárgya tővábbá eljárás akőpőlimer, valamint a kőpőlimert és pőlipeptidet tartalmazó készítményelőállítására, ahől a készítmény pőlipeptid-kőpőlimer iőnős kőnjűgátűmfőrmájában van jelen. ŕ
HU9901627A 1995-06-06 1996-05-24 Ionic molecular conjugates of n-acylated derivatives of poly(2-amino-2-deoxy-d-glucose) and polypeptides HUP9901627A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/468,947 US5665702A (en) 1995-06-06 1995-06-06 Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides

Publications (2)

Publication Number Publication Date
HUP9901627A1 true HUP9901627A1 (hu) 1999-09-28
HUP9901627A3 HUP9901627A3 (en) 1999-11-29

Family

ID=23861854

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901627A HUP9901627A3 (en) 1995-06-06 1996-05-24 Ionic molecular conjugates of n-acylated derivatives of poly(2-amino-2-deoxy-d-glucose) and polypeptides

Country Status (21)

Country Link
US (2) US5665702A (hu)
EP (1) EP0830137B1 (hu)
JP (1) JPH11508289A (hu)
KR (1) KR19990022399A (hu)
CN (1) CN1192152A (hu)
AT (1) ATE245031T1 (hu)
AU (1) AU717188B2 (hu)
BR (1) BR9609031A (hu)
CA (1) CA2222995C (hu)
CZ (1) CZ391697A3 (hu)
DE (1) DE69629114T2 (hu)
DK (1) DK0830137T3 (hu)
ES (1) ES2201188T3 (hu)
HU (1) HUP9901627A3 (hu)
NZ (1) NZ308909A (hu)
PL (1) PL323735A1 (hu)
PT (1) PT830137E (hu)
RU (1) RU2172323C2 (hu)
SI (1) SI9620090A (hu)
SK (1) SK168397A3 (hu)
WO (1) WO1996039160A1 (hu)

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US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6479457B2 (en) * 1995-06-06 2002-11-12 Kinerton Limited Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
HUP0101250A3 (en) * 1998-01-29 2006-06-28 Poly Med Inc Anderson Absorbable microparticles
AR014069A1 (es) 1998-01-29 2001-01-31 Kinerton Ltd Procedimiento para preparar microparticula o microparticulas unidas encapsuladas
CN101108878B (zh) 1998-12-07 2012-08-29 研究及应用科学协会股份有限公司 胰高血糖素样肽-1的类似物
JP4532618B2 (ja) * 1999-02-25 2010-08-25 株式会社グライコメディクス 新規糖鎖プライマー
ATE552859T1 (de) 2000-09-13 2012-04-15 Praecis Pharm Inc Pharmazeutische formulierungen zur kontinuierlichen abgabe von peptiden
US7122622B2 (en) * 2002-04-16 2006-10-17 Biosynthema Inc. Peptide compounds having improved binding affinity to somatostatin receptors
US7244445B2 (en) 2002-07-29 2007-07-17 Poly Med, Inc Conformable, absorbable, solid composite preforms and their use for bone tissue engineering
MXPA05003659A (es) * 2002-10-31 2005-09-20 Pfizer Prod Inc Conjugados liquidos de compuestos farmaceuticos solidos.
ATE512674T1 (de) 2003-01-06 2011-07-15 Angiochem Inc Angiopep-1, verwandte verbindungen, und deren verwnedungen
JP2007536214A (ja) 2003-12-16 2007-12-13 ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス Ｇｌｐ−１類似体
EP2548568B1 (en) 2005-07-08 2018-01-10 Ipsen Pharma Melanocortin receptor ligands
ES2744225T3 (es) 2005-07-15 2020-02-24 Angiochem Inc Uso de polipéptidos de aprotinina como portadores en conjugados farmacéuticos
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
EP2650006A1 (en) 2007-09-07 2013-10-16 Ipsen Pharma S.A.S. Analogues of exendin-4 and exendin-3
ES2690556T3 (es) 2007-11-05 2018-11-21 Ipsen Pharma S.A.S. Uso de melanocortinas para tratar la sensibilidad a la insulina
WO2009123713A1 (en) * 2008-04-01 2009-10-08 Cornell University Organo-soluble chitosan salts and chitosan-derived biomaterials prepared thereof
AU2009265121A1 (en) 2008-07-04 2010-01-07 Traslational Cancer Drugs Pharma, S.L. Methods for the treatment and diagnosis of cancer
WO2010016935A2 (en) 2008-08-07 2010-02-11 Ipsen Pharma S.A.S. Truncated analogues of glucose-dependent insulinotropic polypeptide
AU2009280017B2 (en) 2008-08-07 2013-01-10 Ipsen Pharma S.A.S. Analogues of glucose-dependent insulinotropic polypeptide
EP2769986A3 (en) 2008-08-07 2014-11-26 Ipsen Pharma S.A.S. Analogues of glucose-dependent insulinotropic polypeptide (GIP) modified at N-terminal
MX2011004019A (es) 2008-10-15 2011-06-24 Angiochem Inc Conjugados de etoposido y doxorubicina para entrega de farmacos.
EP2346906A4 (en) 2008-10-15 2013-04-24 Angiochem Inc CONJUGATES FROM GLP-1 AGONISTS AND THEIR USE
US9914754B2 (en) 2008-12-05 2018-03-13 Angiochem Inc. Conjugates of neurotensin or neurotensin analogs and uses thereof
AU2009327267A1 (en) 2008-12-17 2011-07-14 Angiochem, Inc. Membrane type-1 matrix metalloprotein inhibitors and uses thereof
JP2012517459A (ja) 2009-02-12 2012-08-02 プロイェクト、デ、ビオメディシナ、シーマ、ソシエダッド、リミターダ 代謝障害治療のためのカルジオトロフィン１の使用
US9161988B2 (en) 2009-07-02 2015-10-20 Angiochem Inc. Multimeric peptide conjugates and uses thereof
CN102510757B (zh) 2009-07-22 2015-03-18 益普生制药股份有限公司 在第59位置处具有氨基酸替换的胰岛素样生长因子-1(igf-1)类似物
KR102038677B1 (ko) * 2011-06-14 2019-10-30 입센 파마 에스.에이.에스 활성 성분으로 멜라노코르틴 수용체 리간드를 함유하는 지속-방출형 조성물
US9962401B2 (en) * 2011-09-27 2018-05-08 Purdue Research Foundation Chitosan derivatives for inactivation of endotoxins and surface protection of nanoparticles
ES2826827T3 (es) 2015-06-15 2021-05-19 Angiochem Inc Métodos para el tratamiento de carcinomatosis leptomeníngea

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US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
JPS63258579A (ja) * 1987-04-15 1988-10-26 Fuji Boseki Kk 生理活性物質固定化用担体の製造法
US5271945A (en) * 1988-07-05 1993-12-21 Takeda Chemical Industries, Ltd. Sustained release microcapsule for water soluble drug
DK0544000T3 (da) * 1990-08-17 1997-11-03 Drug Delivery System Inst Ltd N-acetylcarboxymethylchitosanderivater og fremgangsmåde til fremstilling deraf.
US5298488A (en) * 1990-10-26 1994-03-29 Fuji Photo Film Co., Ltd. CM-chitin derivatives and use thereof
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
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Also Published As

Publication number Publication date
EP0830137B1 (en) 2003-07-16
PL323735A1 (en) 1998-04-14
EP0830137A1 (en) 1998-03-25
RU2172323C2 (ru) 2001-08-20
CA2222995C (en) 2005-05-10
SI9620090A (sl) 1998-08-31
EP0830137A4 (en) 2002-06-26
PT830137E (pt) 2003-10-31
WO1996039160A1 (en) 1996-12-12
DK0830137T3 (da) 2003-11-03
JPH11508289A (ja) 1999-07-21
BR9609031A (pt) 1999-12-14
DE69629114D1 (de) 2003-08-21
CN1192152A (zh) 1998-09-02
ES2201188T3 (es) 2004-03-16
CZ391697A3 (cs) 1998-05-13
NZ308909A (en) 1999-06-29
HUP9901627A3 (en) 1999-11-29
CA2222995A1 (en) 1996-12-12
US5665702A (en) 1997-09-09
AU5878996A (en) 1996-12-24
KR19990022399A (ko) 1999-03-25
US5821221A (en) 1998-10-13
ATE245031T1 (de) 2003-08-15
SK168397A3 (en) 1998-04-08
AU717188B2 (en) 2000-03-23
DE69629114T2 (de) 2004-04-22

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