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HUP9802005A2 - Nátrium/hidrogén-csere inhibitorok alkalmazása különböző anyagok által a szívre gyakorolt nem kívánt hatások csökkentésére alkalmas gyógyszerkészítmények előállítására - Google Patents

Nátrium/hidrogén-csere inhibitorok alkalmazása különböző anyagok által a szívre gyakorolt nem kívánt hatások csökkentésére alkalmas gyógyszerkészítmények előállítására

Info

Publication number
HUP9802005A2
HUP9802005A2 HU9802005A HUP9802005A HUP9802005A2 HU P9802005 A2 HUP9802005 A2 HU P9802005A2 HU 9802005 A HU9802005 A HU 9802005A HU P9802005 A HUP9802005 A HU P9802005A HU P9802005 A2 HUP9802005 A2 HU P9802005A2
Authority
HU
Hungary
Prior art keywords
sodium
inhibitors
hydrogen
substances
reducing
Prior art date
Application number
HU9802005A
Other languages
English (en)
Inventor
Holger Heitsch
Hans Jochen Lang
Wolfgang Linz
Hartmut Rütten
Bernward Schölkens
Original Assignee
Hoechst Marion Roussel Deutschland Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Deutschland Gmbh. filed Critical Hoechst Marion Roussel Deutschland Gmbh.
Publication of HU9802005D0 publication Critical patent/HU9802005D0/hu
Publication of HUP9802005A2 publication Critical patent/HUP9802005A2/hu
Publication of HUP9802005A3 publication Critical patent/HUP9802005A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

A találmány tárgya nátriűm/hidrőgén-csere inhibitőrők alkalmazása ahűmán vagy állatgyógyászatban akűt vagy krónikűs módőn adagőlt anyagőkáltal a szívre gyakőrőlt nem kívánt hatásők csökkentésére alkalmasgyógyszerkészítmények előállítására. A találmány értelmében nátriűm/hidrőgén-csere inhibitőrként előnyösenalkalmazhatók különböző benzőilgűanidinszármazékők. ŕ
HU9802005A 1997-09-04 1998-09-03 Use of sodium-hydrogen-exchange-inhibitors for producing pharmaceutical compositions for reducing the cardiotoxic effect of some substances HUP9802005A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19738604A DE19738604A1 (de) 1997-09-04 1997-09-04 Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verminderung der Giftigkeit cardiotoxischer Stoffe

Publications (3)

Publication Number Publication Date
HU9802005D0 HU9802005D0 (en) 1998-11-30
HUP9802005A2 true HUP9802005A2 (hu) 1999-04-28
HUP9802005A3 HUP9802005A3 (en) 2005-06-28

Family

ID=7841131

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802005A HUP9802005A3 (en) 1997-09-04 1998-09-03 Use of sodium-hydrogen-exchange-inhibitors for producing pharmaceutical compositions for reducing the cardiotoxic effect of some substances

Country Status (23)

Country Link
US (1) US6462024B1 (hu)
EP (1) EP0916337A3 (hu)
JP (1) JP4555409B2 (hu)
KR (1) KR19990029520A (hu)
CN (1) CN1195508C (hu)
AR (1) AR015718A1 (hu)
AU (1) AU753899B2 (hu)
BR (1) BR9803319A (hu)
CA (1) CA2246633A1 (hu)
CZ (1) CZ280898A3 (hu)
DE (1) DE19738604A1 (hu)
HK (1) HK1018212A1 (hu)
HR (1) HRP980488A2 (hu)
HU (1) HUP9802005A3 (hu)
IL (1) IL126068A0 (hu)
NO (1) NO984071L (hu)
NZ (1) NZ331682A (hu)
PL (1) PL328366A1 (hu)
RU (1) RU2252754C2 (hu)
SK (1) SK121198A3 (hu)
TR (1) TR199801728A2 (hu)
TW (1) TW592693B (hu)
ZA (1) ZA988066B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7375138B2 (en) * 2002-05-18 2008-05-20 Sanofi-Aventis Deutschland Gmbh Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them
FR2840302B1 (fr) * 2002-06-03 2004-07-16 Aventis Pharma Sa Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant
US6878748B2 (en) 2002-06-13 2005-04-12 Aventis Pharma Deutschland Gmbh Fluorinated cycloalkyl-derivatized benzoylguanidines, process for their preparation, their uses as medicament, and medicament containing them
EP1620394B1 (de) * 2003-05-06 2008-08-13 MERCK PATENT GmbH Verfahren zur kristallisation von guanidinium-salzen
CN112107568B (zh) * 2019-06-19 2022-03-25 北京龙嘉博创医药科技有限公司 二芳基酰胺类化合物及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
DE4127026A1 (de) * 1991-08-16 1993-02-18 Boehringer Ingelheim Kg Neue pyrazinderivate, ihre herstellung und verwendung
CZ284456B6 (cs) * 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
EP0589336B1 (de) * 1992-09-22 1997-01-08 Hoechst Aktiengesellschaft Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika
TW250479B (hu) * 1992-12-15 1995-07-01 Hoechst Ag
DE4337609A1 (de) * 1993-11-04 1995-05-11 Boehringer Ingelheim Kg Neue Pyrazincarboxamidderivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE4422685A1 (de) * 1994-06-29 1996-01-04 Hoechst Ag Ortho-amino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4428480A1 (de) * 1994-08-11 1996-03-07 Hoechst Ag Substituierte Benzoesäureester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Synthese von Inhibitoren des zellulären Na·+·/H·+·-Austauschs
DE4430861A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Heterocyclyl-benzoylguanidine
DE4441880A1 (de) * 1994-11-24 1996-05-30 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19734693A1 (de) * 1997-08-11 1998-01-22 Hoechst Marion Roussel De Gmbh Verwendung von Cariporide als Inhibitor des zellulären NA+/H+-Exchangers (NHE) zur Herstellung eines Medikaments zur Behandlung von cardialen und nichtcardialen Krankheiten

Also Published As

Publication number Publication date
HRP980488A2 (en) 1999-06-30
NO984071D0 (no) 1998-09-04
ZA988066B (en) 1999-03-11
PL328366A1 (en) 1999-03-15
CN1195508C (zh) 2005-04-06
AU8307398A (en) 1999-03-18
CN1209995A (zh) 1999-03-10
CA2246633A1 (en) 1999-03-04
TR199801728A2 (xx) 1999-04-21
DE19738604A1 (de) 1999-03-11
JP4555409B2 (ja) 2010-09-29
NZ331682A (en) 2001-08-31
EP0916337A2 (de) 1999-05-19
HUP9802005A3 (en) 2005-06-28
EP0916337A3 (de) 2004-03-17
KR19990029520A (ko) 1999-04-26
HU9802005D0 (en) 1998-11-30
RU2252754C2 (ru) 2005-05-27
JPH11180896A (ja) 1999-07-06
US6462024B1 (en) 2002-10-08
TW592693B (en) 2004-06-21
NO984071L (no) 1999-03-05
CZ280898A3 (cs) 1999-03-17
AU753899B2 (en) 2002-10-31
BR9803319A (pt) 2000-03-21
SK121198A3 (en) 1999-03-12
IL126068A0 (en) 1999-05-09
AR015718A1 (es) 2001-05-16
HK1018212A1 (en) 1999-12-17

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Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished