HUP9801334A2 - A 18-as típusú humán papillomavírust kódoló DNS - Google Patents
A 18-as típusú humán papillomavírust kódoló DNSInfo
- Publication number
- HUP9801334A2 HUP9801334A2 HU9801334A HUP9801334A HUP9801334A2 HU P9801334 A2 HUP9801334 A2 HU P9801334A2 HU 9801334 A HU9801334 A HU 9801334A HU P9801334 A HUP9801334 A HU P9801334A HU P9801334 A2 HUP9801334 A2 HU P9801334A2
- Authority
- HU
- Hungary
- Prior art keywords
- dna
- proteins
- hpv18
- encoded
- virus
- Prior art date
Links
- 241000341657 Human papillomavirus type 18 Species 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 7
- 108090000623 proteins and genes Proteins 0.000 abstract 7
- 239000012634 fragment Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 241001631646 Papillomaviridae Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000003172 anti-dna Effects 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 230000008105 immune reaction Effects 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/905—Stable introduction of foreign DNA into chromosome using homologous recombination in yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány tárgyát a 18-as típűsú hűmán papillőmavírűs (HPV18)prőteinjeit és azők származékait kódőló DNS-mőlekűlák képezik. Atalálmány tárgyát képezik tővábbá a találmány szerinti DNS-mőlekűlákexpresszáltatására alkalmas expressziós vektőrők, rekőmbinánspapillőmavírűs-prőteinek, vírűsszerű részecskék, a találmány szerintiDNS által kódőlt peptidek és prőteinek, a találmány szerinti DNSelleni antitestek, illetve a DNS által kódőlt prőteinek elleniantitestek, a találmány szerinti DNS-t vagy a DNS által kódőltprőteineket tartalmazó vakcinák, a találmány szerinti DNS-t vagy a DNSáltal kódőlt prőteineket tartalmazó imműnőlógiai készítmények, tővábbáeljárásők a 18-as típűsú hűmán papillőmavírűs prőteinjeinekexpresszáltatására, vírűsszerű részecskék előállítására ésimműnreakciók indűkálására. A találmány szerinti tisztítőtt HPV18-DNSvagy annak fragmensei felhasználhatók a HPV18 hőmőlógjainak vagyfragmenseinek egyéb főrrásőkból történő izőlálására és tisztítására.Ezen túlmenően, a találmány szerinti készítmények és eljárásőkalkalmasak HPV18-fertőzéssel összefüggő betegségek és állapőtőkkezelésére és megelőzésére. ŕ
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/408,669 US5840306A (en) | 1995-03-22 | 1995-03-22 | DNA encoding human papillomavirus type 18 |
| US08/409,122 US5820870A (en) | 1995-03-22 | 1995-03-22 | Recombinant human papillomavirus type 18 vaccine |
| PCT/US1996/003649 WO1996029413A2 (en) | 1995-03-22 | 1996-03-18 | Dna encoding human papilloma virus type 18 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP9801334A2 true HUP9801334A2 (hu) | 1998-08-28 |
| HUP9801334A3 HUP9801334A3 (en) | 1999-04-28 |
| HU223761B1 HU223761B1 (hu) | 2005-01-28 |
Family
ID=27020342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9801334A HU223761B1 (hu) | 1995-03-22 | 1996-03-18 | A 18-as típusú humán papillomavírust kódoló DNS |
Country Status (22)
| Country | Link |
|---|---|
| EP (2) | EP0817851B9 (hu) |
| JP (1) | JPH11502704A (hu) |
| KR (1) | KR100430698B1 (hu) |
| CN (1) | CN1100876C (hu) |
| AT (1) | ATE259879T1 (hu) |
| AU (1) | AU714533B2 (hu) |
| CA (1) | CA2215834C (hu) |
| CZ (1) | CZ291242B6 (hu) |
| DE (4) | DE122007000030I1 (hu) |
| DK (1) | DK0817851T5 (hu) |
| EA (1) | EA001092B1 (hu) |
| ES (1) | ES2213772T3 (hu) |
| FR (1) | FR07C0023I2 (hu) |
| HU (1) | HU223761B1 (hu) |
| IL (1) | IL117459A (hu) |
| NL (3) | NL300273I1 (hu) |
| NO (1) | NO322254B1 (hu) |
| NZ (1) | NZ305188A (hu) |
| PL (1) | PL184022B1 (hu) |
| PT (1) | PT817851E (hu) |
| SK (1) | SK284281B6 (hu) |
| WO (1) | WO1996029413A2 (hu) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9621091D0 (en) | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| ZA982950B (en) | 1997-04-08 | 1998-10-19 | Merck & Co Inc | Stabilized human papillomavirus formulations |
| KR20010006169A (ko) * | 1997-04-08 | 2001-01-26 | 폴락 돈나 엘. | 안정화된 사람 파필로마바이러스 제형물 |
| KR20010072470A (ko) * | 1998-08-14 | 2001-07-31 | 폴락 돈나 엘. | 사람 유두종바이러스 바이러스-유사 입자의 정제방법 |
| AUPP765398A0 (en) * | 1998-12-11 | 1999-01-14 | University Of Queensland, The | Treatment of papillomavirus infections |
| ES2313881T3 (es) | 1999-02-05 | 2009-03-16 | MERCK & CO., INC. | Formulaciones de vacunas frente al papilomavirus humano. |
| FR2795074A1 (fr) * | 1999-05-21 | 2000-12-22 | Inst Nat Sante Rech Med | Polypeptides transporteurs d'acides amines, et en particulier du glutamate, et procedes de criblage de composes inhibiteurs ou activateurs de l'activite de transport |
| ATE546529T1 (de) * | 2003-03-24 | 2012-03-15 | Merck Sharp & Dohme | Optimierte expression von hpv 31 l1 in hefe |
| MY140664A (en) * | 2003-09-29 | 2010-01-15 | Merck Sharp & Dohme | Optimized expression of hpv 45 l1 in yeast |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| WO2008134935A1 (fr) * | 2007-04-29 | 2008-11-13 | Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. | Protéines 18 l1 de type papillomavirus humain tronqué |
| WO2008134934A1 (en) | 2007-04-29 | 2008-11-13 | Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. | A truncated l1 protein of human papillomavirus 16 |
| CN101440373B (zh) * | 2007-11-23 | 2012-09-05 | 上海泽润生物科技有限公司 | 一种截短型的18型人乳头状瘤病毒主要衣壳蛋白l1基因 |
| PE20120563A1 (es) * | 2009-06-25 | 2012-05-17 | Glaxosmithkline Biolog Sa | Construcciones novedosas de proteina del virus de papiloma humano (hpv) y su uso en la prevencion de la enfermedad por el hpv |
| US8871466B2 (en) * | 2011-06-15 | 2014-10-28 | Chung-Ang University Industry-Academic Cooperation Foundation | Method for enhancing the production yield of human papillomavirus L1 protein |
| EP2827891A1 (en) | 2012-03-18 | 2015-01-28 | GlaxoSmithKline Biologicals S.A. | Method of vaccination against human papillomavirus |
| CN108276491B (zh) * | 2018-02-05 | 2021-01-12 | 南京薇熙生物医药科技有限公司 | 一种可特异性识别hpv18 l1蛋白的单克隆抗体及其应用 |
| JP2022540951A (ja) | 2019-07-19 | 2022-09-20 | 神州細胞工程有限公司 | キメラパピローマウイルスｌ１タンパク質 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3625257A1 (de) * | 1986-07-23 | 1988-02-04 | Behringwerke Ag | Expressionsprodukte der menschlichen papillomviren typ 16 und 18, fuer diese proteine spezifische antikoerper und diese antikoerper bzw. entsprechende dna enthaltende diagnostika |
| DE4015044A1 (de) * | 1990-05-10 | 1991-11-14 | Behringwerke Ag | Seroreaktive epitope auf proteinen des menschlichen papillomavirus (hpv) 18 |
| ATE356142T1 (de) * | 1991-07-19 | 2007-03-15 | Univ Queensland | Impfstoff gegen humanes papillomavirus (typ 18) |
| DE122007000094I1 (de) * | 1992-06-25 | 2008-03-27 | Papillomavirus vakzine | |
| US5437951A (en) * | 1992-09-03 | 1995-08-01 | The United States Of America As Represented By The Department Of Health And Human Services | Self-assembling recombinant papillomavirus capsid proteins |
| AU688759C (en) * | 1993-03-09 | 2006-12-21 | University Of Rochester | Production of human papillomavirus capsid protein and virus-like particles |
-
1996
- 1996-03-13 IL IL11745996A patent/IL117459A/xx active Protection Beyond IP Right Term
- 1996-03-18 CN CN96194121A patent/CN1100876C/zh not_active Expired - Lifetime
- 1996-03-18 AU AU53141/96A patent/AU714533B2/en not_active Expired
- 1996-03-18 EP EP96909743A patent/EP0817851B9/en not_active Expired - Lifetime
- 1996-03-18 KR KR1019970706580A patent/KR100430698B1/ko not_active Expired - Lifetime
- 1996-03-18 DE DE200712000030 patent/DE122007000030I1/de active Pending
- 1996-03-18 AT AT96909743T patent/ATE259879T1/de active
- 1996-03-18 DE DE200712000031 patent/DE122007000031I1/de active Pending
- 1996-03-18 DE DE1996631586 patent/DE122007000025I1/de active Pending
- 1996-03-18 WO PCT/US1996/003649 patent/WO1996029413A2/en active IP Right Grant
- 1996-03-18 NZ NZ305188A patent/NZ305188A/xx not_active IP Right Cessation
- 1996-03-18 DK DK96909743T patent/DK0817851T5/da active
- 1996-03-18 PL PL96322333A patent/PL184022B1/pl unknown
- 1996-03-18 EP EP04075256A patent/EP1422294A1/en not_active Withdrawn
- 1996-03-18 CZ CZ19972936A patent/CZ291242B6/cs not_active IP Right Cessation
- 1996-03-18 PT PT96909743T patent/PT817851E/pt unknown
- 1996-03-18 ES ES96909743T patent/ES2213772T3/es not_active Expired - Lifetime
- 1996-03-18 CA CA002215834A patent/CA2215834C/en not_active Expired - Lifetime
- 1996-03-18 EA EA199700256A patent/EA001092B1/ru not_active IP Right Cessation
- 1996-03-18 SK SK1278-97A patent/SK284281B6/sk not_active IP Right Cessation
- 1996-03-18 JP JP8528535A patent/JPH11502704A/ja active Pending
- 1996-03-18 DE DE69631586T patent/DE69631586T9/de active Active
- 1996-03-18 HU HU9801334A patent/HU223761B1/hu active IP Right Grant
-
1997
- 1997-09-19 NO NO19974322A patent/NO322254B1/no not_active IP Right Cessation
-
2007
- 2007-03-14 NL NL300273C patent/NL300273I1/nl unknown
- 2007-03-14 NL NL300272C patent/NL300272I1/nl unknown
- 2007-03-14 NL NL300271C patent/NL300271I1/nl unknown
- 2007-03-20 FR FR07C0023C patent/FR07C0023I2/fr active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HFG4 | Patent granted, date of granting |
Effective date: 20041122 |
|
| GB9A | Succession in title |
Owner name: MERCK SHARP & DOHME CORP., US Free format text: FORMER OWNER(S): MERCK & CO., INC., US |
|
| GB9A | Succession in title |
Owner name: MERCK SHARP & DOHME CORP., US Free format text: FORMER OWNER(S): MERCK & CO., INC., US; MERCK SHARP & DOHME CORP., US |