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HUP9800091A2 - Enzimatikusan aktív rekombináns karboxipeptidáz-B előállítása - Google Patents

Enzimatikusan aktív rekombináns karboxipeptidáz-B előállítása

Info

Publication number
HUP9800091A2
HUP9800091A2 HU9800091A HUP9800091A HUP9800091A2 HU P9800091 A2 HUP9800091 A2 HU P9800091A2 HU 9800091 A HU9800091 A HU 9800091A HU P9800091 A HUP9800091 A HU P9800091A HU P9800091 A2 HUP9800091 A2 HU P9800091A2
Authority
HU
Hungary
Prior art keywords
production
carboxypeptidase
enzymatically active
active recombinant
recombinant carboxypeptidase
Prior art date
Application number
HU9800091A
Other languages
English (en)
Inventor
Netta Fulga
Marian Gorecki
Jacob Hartman
Simona Mendelovitch
Original Assignee
Biotechnology General Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotechnology General Corporation filed Critical Biotechnology General Corporation
Publication of HUP9800091A2 publication Critical patent/HUP9800091A2/hu
Publication of HUP9800091A3 publication Critical patent/HUP9800091A3/hu
Publication of HU225673B1 publication Critical patent/HU225673B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány tárgyát képezi egy eljárás enzimatikűsan aktív rekőmbinánskarbőxipeptidáz-B (CPB) előállítására. Szintén a találmány tárgyátképezi a találmány szerinti eljárással előállítőtt emlős-karbőxipeptidáz-B.A találmány szerinti eljárás alkalmas emlőseredetű anyagőktól mentes,enzimatikűsan aktív emlős-karbőxipeptidáz-B előállítására, amelynekspecifikűs aktivitása lényegesen nagyőbb a kereskedelmi főrgalőmbanbeszerezhető sertés-karbőxipeptidáz-B aktivitásánál.ŕ
HU9800091A 1995-01-25 1996-01-25 Production of enzymatically active recombinant carboxypeptidase b HU225673B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37823395A 1995-01-25 1995-01-25
PCT/US1996/000995 WO1996023064A1 (en) 1995-01-25 1996-01-25 Production of enzymatically active recombinant carboxypeptidase b

Publications (3)

Publication Number Publication Date
HUP9800091A2 true HUP9800091A2 (hu) 1998-05-28
HUP9800091A3 HUP9800091A3 (en) 2004-03-29
HU225673B1 HU225673B1 (en) 2007-06-28

Family

ID=23492292

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9800091A HU225673B1 (en) 1995-01-25 1996-01-25 Production of enzymatically active recombinant carboxypeptidase b

Country Status (22)

Country Link
US (1) US5948668A (hu)
EP (1) EP0871718B1 (hu)
JP (1) JP4250716B2 (hu)
KR (1) KR100566136B1 (hu)
CN (1) CN1144874C (hu)
AT (1) ATE358717T1 (hu)
AU (1) AU698889B2 (hu)
BR (1) BR9606795A (hu)
CA (1) CA2210242C (hu)
CZ (1) CZ292541B6 (hu)
DE (1) DE69637011T2 (hu)
DK (1) DK0871718T3 (hu)
ES (1) ES2284167T3 (hu)
HK (1) HK1014986A1 (hu)
HU (1) HU225673B1 (hu)
IL (1) IL116696A (hu)
MX (1) MX9705279A (hu)
NZ (1) NZ302874A (hu)
PL (1) PL183228B1 (hu)
PT (1) PT871718E (hu)
WO (1) WO1996023064A1 (hu)
ZA (1) ZA96515B (hu)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL123271A0 (en) 1995-08-16 1998-09-24 Zeneca Ltd Chemical compounds
EP1588716B1 (en) 1998-08-06 2011-02-16 Mountain View Pharmaceuticals, Inc. Peg-urate oxidase conjugates and use thereof
US20040117863A1 (en) * 1998-09-18 2004-06-17 Edge Michael D. Transgenically produced fusion proteins
DE19915938A1 (de) * 1999-04-09 2000-10-19 Aventis Pharma Gmbh Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
WO2001019846A1 (en) * 1999-09-17 2001-03-22 Genzyme Transgenics Corporation Transgenically produced fusion proteins
CA2385883A1 (en) 1999-09-29 2001-04-05 Lexicon Genetics Incorporated Human carboxypeptidases and polynucleotides encoding the same
EP1632575B1 (en) * 1999-09-29 2009-01-28 Lexicon Pharmaceuticals, Inc. Human carboxypeptidases and polynucleotides encoding the same
WO2001051624A2 (en) * 2000-01-12 2001-07-19 Eli Lilly And Company Carboxypeptidase b free of animal products and contaminating enyzme activity
JP4411192B2 (ja) * 2003-12-05 2010-02-10 エフ．ホフマン−ラ ロシュ アーゲー 組換えで発現されるカルボキシペプチダーゼｂおよびその精製
EP1538203B1 (en) * 2003-12-05 2010-01-20 Roche Diagnostics GmbH Recombinantly expressed carboxypeptidase B and purification thereof
EP1794294B1 (de) * 2004-09-27 2011-07-20 Sanofi-Aventis Deutschland GmbH Rekombinante carboxypeptidase b
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
TW200716751A (en) 2005-04-11 2007-05-01 Savient Pharmaceuticals Inc A variant form of urate oxidase and use thereof
US20080159976A1 (en) * 2005-04-11 2008-07-03 Jacob Hartman Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
LT3321359T (lt) 2005-04-11 2021-05-10 Horizon Pharma Rheumatology Llc Urato oksidazės variantinės formos ir jų panaudojimas
US20090081122A1 (en) * 2005-05-23 2009-03-26 Universite De Geneve Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant
KR101288027B1 (ko) 2006-04-12 2013-07-22 새비언트 파마수티컬즈 인크. 양이온 계면활성제를 이용한 단백질 정제 방법
CN101058805B (zh) * 2007-03-21 2011-09-07 北京贯虹科技有限公司 突变羧肽酶原b及突变羧肽酶b的生产方法
US8993714B2 (en) * 2007-10-26 2015-03-31 Imiplex Llc Streptavidin macromolecular adaptor and complexes thereof
US9102526B2 (en) 2008-08-12 2015-08-11 Imiplex Llc Node polypeptides for nanostructure assembly
WO2010132363A1 (en) 2009-05-11 2010-11-18 Imiplex Llc Method of protein nanostructure fabrication
US9377454B2 (en) 2009-06-25 2016-06-28 Crealta Pharmaceuticals Llc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
CN101967467B (zh) * 2009-07-28 2012-11-14 上海雅心生物技术有限公司 一种高稳定性的重组羧肽酶b的生产及应用
US12121566B2 (en) 2019-01-30 2024-10-22 Horizon Therapeutics Usa, Inc. Methods for treating gout
US11918624B2 (en) * 2020-06-10 2024-03-05 Kelsius Laboratories LLC Therapeutic composition for use in the treatment of COVID-19 and other cytokine storm associated disorders
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE724843A (hu) * 1967-12-04 1969-06-03
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
HU190129B (en) * 1983-07-11 1986-08-28 Reanal Finomvegyszergyar,Hu Process for the isolation of carboxypeptidase b enzyme from mammal pancreas
US5206161A (en) * 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
FR2692907B1 (fr) * 1992-06-25 1995-06-30 Rhone Poulenc Rorer Sa Levures kluyveromyces modifiees, preparation et utilisation.
JP3472587B2 (ja) * 1992-08-28 2003-12-02 アベンティス ファーマ株式会社 骨関連カルボキシペプチダーゼ様タンパク質およびその製造法
JPH09505998A (ja) * 1993-11-16 1997-06-17 イーライ・リリー・アンド・カンパニー ブタ膵臓カルボキシペプチダーゼｂをコードするｄｎａ配列

Also Published As

Publication number Publication date
MX9705279A (es) 1998-06-30
CA2210242A1 (en) 1996-08-01
IL116696A0 (en) 1996-05-14
PL183228B1 (pl) 2002-06-28
JP4250716B2 (ja) 2009-04-08
US5948668A (en) 1999-09-07
HU225673B1 (en) 2007-06-28
IL116696A (en) 1999-08-17
KR19980701652A (ko) 1998-06-25
ES2284167T3 (es) 2007-11-01
PL321499A1 (en) 1997-12-08
KR100566136B1 (ko) 2006-11-10
DK0871718T3 (da) 2007-07-02
DE69637011T2 (de) 2007-12-13
WO1996023064A1 (en) 1996-08-01
CA2210242C (en) 2010-04-27
HK1014986A1 (en) 1999-10-08
DE69637011D1 (de) 2007-05-16
CN1144874C (zh) 2004-04-07
AU698889B2 (en) 1998-11-12
ATE358717T1 (de) 2007-04-15
ZA96515B (en) 1996-08-15
EP0871718A4 (en) 2000-06-07
EP0871718B1 (en) 2007-04-04
BR9606795A (pt) 1997-12-30
JPH11503002A (ja) 1999-03-23
CZ225897A3 (cs) 1998-10-14
PT871718E (pt) 2007-06-26
CN1177377A (zh) 1998-03-25
HUP9800091A3 (en) 2004-03-29
EP0871718A1 (en) 1998-10-21
NZ302874A (en) 1998-11-25
AU4903496A (en) 1996-08-14
CZ292541B6 (cs) 2003-10-15

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: FERRING INTERNATIONAL CENTER S.A., CH

Free format text: FORMER OWNER(S): BIOTECHNOLOGY GENERAL CORPORATION, US; SAVIENT PHARMACEUTICALS, INC., US