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HUP1600376A2 - A production method and a new crystalline from of an intermediate of synthesis of ticagrelor - Google Patents

A production method and a new crystalline from of an intermediate of synthesis of ticagrelor

Info

Publication number
HUP1600376A2
HUP1600376A2 HU1600376A HUP1600376A HUP1600376A2 HU P1600376 A2 HUP1600376 A2 HU P1600376A2 HU 1600376 A HU1600376 A HU 1600376A HU P1600376 A HUP1600376 A HU P1600376A HU P1600376 A2 HUP1600376 A2 HU P1600376A2
Authority
HU
Hungary
Prior art keywords
ticagrelor
synthesis
production method
new crystalline
crystalline
Prior art date
Application number
HU1600376A
Other languages
Hungarian (hu)
Inventor
Michal Voslar
Ivo Strelec
Ondrej Dammer
Rostislav Vyslouzil
Ivan Stehli�Ek
Jaroslav Riha
Tomas Hes
Iva Obadalova
Original Assignee
Zentiva As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva As filed Critical Zentiva As
Publication of HUP1600376A2 publication Critical patent/HUP1600376A2/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU1600376A 2013-11-08 2014-11-07 A production method and a new crystalline from of an intermediate of synthesis of ticagrelor HUP1600376A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ2013-866A CZ2013866A3 (en) 2013-11-08 2013-11-08 Novel crystalline form of ticagrelor synthesis intermediate and process for preparing thereof
PCT/CZ2014/000131 WO2015067230A1 (en) 2013-11-08 2014-11-07 A production method and a new crystalline form of an intermediate of synthesis of ticagrelor

Publications (1)

Publication Number Publication Date
HUP1600376A2 true HUP1600376A2 (en) 2016-08-29

Family

ID=52117822

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1600376A HUP1600376A2 (en) 2013-11-08 2014-11-07 A production method and a new crystalline from of an intermediate of synthesis of ticagrelor

Country Status (4)

Country Link
CN (1) CN105940003A (en)
CZ (1) CZ2013866A3 (en)
HU (1) HUP1600376A2 (en)
WO (1) WO2015067230A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106946885A (en) * 2016-01-07 2017-07-14 南京济群医药科技股份有限公司 A kind of preparation method of ticagrelor monocrystalline

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB0013407D0 (en) 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
GB0013488D0 (en) 2000-06-02 2000-07-26 Astrazeneca Ab Chemical compound
TWI482772B (en) 2006-08-21 2015-05-01 Astrazeneca Ab Compositions, suitable for oral administration, comprising a triazolo(4,5-d)pyrimidin derivate
WO2008024044A1 (en) 2006-08-21 2008-02-28 Astrazeneca Ab Compositions, suitable for oral administration, comprising a triazolo [4, 5] pyrimidin derivate
CN102770434A (en) 2009-12-03 2012-11-07 阿斯利康(瑞典)有限公司 Co - crystals of a triazolo [4,5 - d] pyrimidine platelet aggregation inhibitor
EP2633857B1 (en) 2009-12-23 2015-08-12 ratiopharm GmbH Solid pharmaceutical dosage form of ticagrelor and acetylsalicylic acid
US9056838B2 (en) * 2011-04-06 2015-06-16 Teva Pharmaceutical Industries Ltd. Intermediates and processes for preparing Ticagrelor
IN2014KN01491A (en) * 2011-12-23 2015-10-23 Lek Pharmaceuticals
IN2012MU03723A (en) * 2012-12-31 2015-07-10 Megafine Pharma P Ltd
CZ307217B6 (en) * 2013-03-14 2018-04-04 Zentiva, K.S. An improved manufacturing process and new intermediates for synthesis of ticagrelor
CN104098553B (en) * 2013-04-10 2017-11-28 江苏恒瑞医药股份有限公司 The preparation method of intermediate of ticagrelor and preparation method thereof and ticagrelor

Also Published As

Publication number Publication date
CZ2013866A3 (en) 2015-05-20
CN105940003A (en) 2016-09-14
WO2015067230A1 (en) 2015-05-14

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees