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IN2012MU03723A - - Google Patents

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Publication number
IN2012MU03723A
IN2012MU03723A IN3723MU2012A IN2012MU03723A IN 2012MU03723 A IN2012MU03723 A IN 2012MU03723A IN 3723MU2012 A IN3723MU2012 A IN 3723MU2012A IN 2012MU03723 A IN2012MU03723 A IN 2012MU03723A
Authority
IN
India
Prior art keywords
ticagrelor
intermediates
preparation
substantially eliminates
potential impurities
Prior art date
Application number
Inventor
Vijayavitthal Thippannachar Mathad
Navnath Chintaman Niphade
Gorakshanath Balasaheb Shinde
Santosh Ambadas Padaki
Pravin Keshav Mahale
Original Assignee
Megafine Pharma P Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Megafine Pharma P Ltd filed Critical Megafine Pharma P Ltd
Priority to IN3723MU2012 priority Critical patent/IN2012MU03723A/en
Priority to PCT/IN2013/000812 priority patent/WO2014102830A1/en
Publication of IN2012MU03723A publication Critical patent/IN2012MU03723A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Ceramic Products (AREA)

Abstract

An improved process for the preparation of Ticagrelor and its intermediates thereof; wherein the said process substantially eliminates the potential impurities.
IN3723MU2012 2012-12-31 2013-12-30 IN2012MU03723A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IN3723MU2012 IN2012MU03723A (en) 2012-12-31 2013-12-30
PCT/IN2013/000812 WO2014102830A1 (en) 2012-12-31 2013-12-30 A process for preparation of ticagrelor and intermediates thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN3723MU2012 IN2012MU03723A (en) 2012-12-31 2013-12-30

Publications (1)

Publication Number Publication Date
IN2012MU03723A true IN2012MU03723A (en) 2015-07-10

Family

ID=50097795

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3723MU2012 IN2012MU03723A (en) 2012-12-31 2013-12-30

Country Status (2)

Country Link
IN (1) IN2012MU03723A (en)
WO (1) WO2014102830A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
CZ2013866A3 (en) * 2013-11-08 2015-05-20 Zentiva, K.S. Novel crystalline form of ticagrelor synthesis intermediate and process for preparing thereof
WO2016030704A1 (en) * 2014-08-30 2016-03-03 Cipla Limited Solid form of intermediate of ticagrelor
CN105481861B (en) * 2014-09-19 2018-04-17 北京普禄德医药科技有限公司 A kind of platelet aggregation inhibitor and its preparation method and application
CN105503876B (en) * 2014-09-24 2017-09-05 海门慧聚药业有限公司 The preparation method of ticagrelor
CN105859720A (en) * 2015-01-20 2016-08-17 上海方楠生物科技有限公司 Method for preparing ticagrelor solution
WO2016128996A2 (en) * 2015-02-14 2016-08-18 Strides Shasun Limited An improved process for preparation of ticagrelor and intermediates thereof
CN105153167B (en) * 2015-09-06 2017-09-19 惠州信立泰药业有限公司 A kind of ticagrelor crystallization and the pharmaceutical composition containing the crystallization
CN105669681A (en) * 2016-04-11 2016-06-15 成都华宇制药有限公司 Synthesis method for ticagrelor
CN106543191B (en) * 2016-10-28 2019-03-01 天津红日药业股份有限公司 A kind of ticagrelor preparation process
CN108892670B (en) * 2018-07-12 2019-12-20 江西国药有限责任公司 Preparation method of high-purity ticagrelor
CN110437237A (en) * 2019-09-06 2019-11-12 上海汇伦生命科技有限公司 A kind of preparation method of the single crystallization of 1,2- diol compound
CN110684019B (en) * 2019-10-29 2020-08-18 株洲千金药业股份有限公司 Preparation method of ticagrelor intermediate oxide impurity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9702773D0 (en) 1997-07-22 1997-07-22 Astra Pharma Prod Novel compounds
TWI229674B (en) * 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB0013488D0 (en) 2000-06-02 2000-07-26 Astrazeneca Ab Chemical compound
AU2009292269B2 (en) * 2008-09-09 2012-11-01 Astrazeneca Ab A process for preparing [1S- [1-alpha, 2-alpha, 3-beta (1S*, 2R*) 5-beta] ] -3- [7- [2- (3, 4-dif luorophenyl) -cyclopropylamino] - 5- (propylthio) -3H-1, 2, 3-triazolo [4, 5-d] pyrimidin-3-yl] -5- (2- hydroxyethoxy) cyclopentane-1, 2-diol and to its intermediates
EP2459564B1 (en) * 2009-07-27 2016-09-07 Auspex Pharmaceuticals, Inc. Cyclopropyl modulators of p2y12 receptor

Also Published As

Publication number Publication date
WO2014102830A1 (en) 2014-07-03

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