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HUP0303310A2 - Csökkentett immunogenitású módosított ciliáris neurotrofikus faktor (CNTF) - Google Patents

Csökkentett immunogenitású módosított ciliáris neurotrofikus faktor (CNTF)

Info

Publication number
HUP0303310A2
HUP0303310A2 HU0303310A HUP0303310A HUP0303310A2 HU P0303310 A2 HUP0303310 A2 HU P0303310A2 HU 0303310 A HU0303310 A HU 0303310A HU P0303310 A HUP0303310 A HU P0303310A HU P0303310 A2 HUP0303310 A2 HU P0303310A2
Authority
HU
Hungary
Prior art keywords
neurotrophic factor
cntf
ciliary neurotrophic
administered
reduced immunogenicity
Prior art date
Application number
HU0303310A
Other languages
English (en)
Inventor
Francis J. Carr
Graham Carter
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of HUP0303310A2 publication Critical patent/HUP0303310A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány tárgyát különösen embereknek beadandó, és különösenterápiás alkalmazású polipeptidek képezik. A polipeptidek módosítottpolipeptidek, amelyekben a módosítás a polipeptid csökkentett hajlamáteredményezi immunválasz kiváltására emberi személynek történő beadásesetén. A találmány tárgya különösen humán ciliáris neurotrofikusfaktor módosítása, olyan CNTF fehérjéket eredményezve, amelyeklényegében nem immunogének, vagy kevésbé immunogének, mint bármilyenmódosítatlan társuk, amikor in vivo beadják azokat. Ó
HU0303310A 2001-03-02 2002-02-27 Csökkentett immunogenitású módosított ciliáris neurotrofikus faktor (CNTF) HUP0303310A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01105089 2001-03-02
PCT/EP2002/002084 WO2002070698A2 (en) 2001-03-02 2002-02-27 Modified ciliary neurotrophic factor (cntf) with reduced immunogenicity

Publications (1)

Publication Number Publication Date
HUP0303310A2 true HUP0303310A2 (hu) 2003-12-29

Family

ID=8176647

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303310A HUP0303310A2 (hu) 2001-03-02 2002-02-27 Csökkentett immunogenitású módosított ciliáris neurotrofikus faktor (CNTF)

Country Status (13)

Country Link
US (1) US20040087503A1 (hu)
EP (1) EP1379655A2 (hu)
JP (1) JP2004529629A (hu)
KR (1) KR20030081480A (hu)
CN (1) CN1494593A (hu)
BR (1) BR0207705A (hu)
CA (1) CA2439682A1 (hu)
HU (1) HUP0303310A2 (hu)
MX (1) MXPA03007839A (hu)
PL (1) PL362704A1 (hu)
RU (1) RU2003129069A (hu)
WO (1) WO2002070698A2 (hu)
ZA (1) ZA200307678B (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050064555A1 (en) * 2003-07-09 2005-03-24 Xencor, Inc. Ciliary neurotrophic factor variants
WO2005033137A1 (en) * 2003-09-30 2005-04-14 Regeneron Pharmaceuticals, Inc. Modified ciliary neurotrophic factor polypeptides with reduced antigenicity
US8592374B2 (en) 2007-03-16 2013-11-26 Research Foundation For Mental Hygiene, Inc. Neurotrophic peptides
EP2009103A1 (en) * 2007-03-16 2008-12-31 Ebewe Pharma Ges.m.b.H. Nfg. KG Neurotrophic peptides
EP2167528B1 (en) * 2007-06-21 2018-01-10 Angelica Therapeutics, INC. Modified toxins
US8470314B2 (en) * 2008-02-29 2013-06-25 Angelica Therapeutics, Inc. Modified toxins
DE102011104822A1 (de) 2011-06-18 2012-12-20 Christian-Albrechts-Universität Zu Kiel Ciliary-Neutrophic-Factor-Varianten
EP2968450A4 (en) 2013-03-15 2016-10-26 Angelica Therapeutics Inc MODIFIED TOXINS
US11139049B2 (en) * 2014-11-14 2021-10-05 D.E. Shaw Research, Llc Suppressing interaction between bonded particles
CN118141922A (zh) * 2016-12-06 2024-06-07 小利兰·斯坦福大学理事会 睫状神经营养因子受体配体结合剂及其使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593857A (en) * 1991-08-23 1997-01-14 Scios Inc. Production of homogeneous truncated CNTF
AU2925392A (en) * 1991-11-11 1993-06-15 Fidia S.P.A. Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor
US5939534A (en) * 1993-12-29 1999-08-17 Sumitomo Pharmaceuticals Company, Limited Factors mutated in the D1 cap region
IT1288388B1 (it) * 1996-11-19 1998-09-22 Angeletti P Ist Richerche Bio Uso di sostanze che attivano il recettore del cntf ( fattore neurotrofico ciliare) per la preparazione di farmaci per la terapia
BR0013204A (pt) * 1999-08-13 2004-02-17 Regeneron Pharma Uso do fator neurotrófico ciliar modificado ax-15, métodos para tratar a diabetes, para reduzir a resistência à insulina, para aumentar a sensibilidade à insulina, para abaixar os nìveis de ácido graxo livre de soro, para tratar uma doença ou distúrbio do sistema endócrino, e para prevenir a ocorrência de diabetes gestacional ou diabetes mellitus não dependente de insulina, em um mamìfero, e, composição

Also Published As

Publication number Publication date
CN1494593A (zh) 2004-05-05
BR0207705A (pt) 2004-03-23
US20040087503A1 (en) 2004-05-06
WO2002070698A2 (en) 2002-09-12
MXPA03007839A (es) 2003-12-08
PL362704A1 (en) 2004-11-02
KR20030081480A (ko) 2003-10-17
RU2003129069A (ru) 2005-04-20
WO2002070698A3 (en) 2003-11-20
EP1379655A2 (en) 2004-01-14
CA2439682A1 (en) 2002-09-12
JP2004529629A (ja) 2004-09-30
ZA200307678B (en) 2004-08-31

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees