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HUP0302968A2 - (Aminoalkilbenzoil)benzofuránok vagy -benzotiofének, eljárás a vegyületek előállítására és a vegyületeket tartalmazó készítmények - Google Patents

(Aminoalkilbenzoil)benzofuránok vagy -benzotiofének, eljárás a vegyületek előállítására és a vegyületeket tartalmazó készítmények

Info

Publication number
HUP0302968A2
HUP0302968A2 HU0302968A HUP0302968A HUP0302968A2 HU P0302968 A2 HUP0302968 A2 HU P0302968A2 HU 0302968 A HU0302968 A HU 0302968A HU P0302968 A HUP0302968 A HU P0302968A HU P0302968 A2 HUP0302968 A2 HU P0302968A2
Authority
HU
Hungary
Prior art keywords
group
atom
optionally substituted
general formula
alkyl
Prior art date
Application number
HU0302968A
Other languages
English (en)
Inventor
Jean-Louis Assens
Claude Bernhart
Frédérique Cabanel-Haudricourt
Patrick Gautier
Dino Nisato
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of HUP0302968A2 publication Critical patent/HUP0302968A2/hu
Publication of HUP0302968A3 publication Critical patent/HUP0302968A3/hu
Publication of HU229456B1 publication Critical patent/HU229456B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány (1) általános képletű benzofurán- vagy benzotiofén-származékokra, a képletben A jelentése adott esetben helyettesítettvagy oxigénatommal megszakított alkiléncsoport, T jelentésehidrogénatom vagy alkilcsoport, R30 és R31 jelentése együtt aszénatommal, amelyhez kapcsolódnak, karbonilcsoport vagy egy -O-R29-O-(m) általános képletű csoport, amelyben R29 jelentése 1-4 szénatomosalkiléncsoport, R jelentése ciano-, hidroximetil-, formil- vagytetrazolil-, észter-, adott esetben helyettesített karboxil-, amid-,keton-, oximcsoport, R1 jelentése hidrogénatom; alkil-, 3-6 szénatomoscikloalkil-, benzil- vagy adott esetben helyettesített fenil-,karboxialkil vagy hidroxialkilcsoport, R2 és R3 jelentésehidrogénatom, adott esetben helyettesített alkilcsoport, cikloalkil-vagy alkoxialkilcsoport, vagy R2 és R3 együtt alkiléncsoportot, vagy anitrogénatommal, amelyhez kapcsolódnak egy adott esetbenhelyettesített piperazincsoportot alkot, W, W' és Z jelentése olyan,hogy - amikor W és W' azonos, és CH csoportot jelent, Z jelentése -O-vagy -S-, - amikor W jelentése CH csoport és W' jelentése C-R13általános képletű csoport, Z jelentése -CH=C(R14)- általános képletűcsoport, R13 és R14 jelentése hidrogénatom, halogénatom, alkil- vagyalkoxicsoport, X jelentése -O- vagy -S-, a vegyületek előállítására ésa vegyületeket tartalmazó gyógyászati készítményekre vonatkozik. Ó
HU0302968A 2000-08-23 2001-08-21 Aminoalkylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same HU229456B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0010834A FR2813306B1 (fr) 2000-08-23 2000-08-23 Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
PCT/FR2001/002640 WO2002016339A1 (fr) 2000-08-23 2001-08-21 Aminoalkylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant

Publications (3)

Publication Number Publication Date
HUP0302968A2 true HUP0302968A2 (hu) 2003-12-29
HUP0302968A3 HUP0302968A3 (en) 2005-02-28
HU229456B1 HU229456B1 (en) 2013-12-30

Family

ID=8853674

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302968A HU229456B1 (en) 2000-08-23 2001-08-21 Aminoalkylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same

Country Status (36)

Country Link
US (1) US6949583B2 (hu)
EP (1) EP1315709B1 (hu)
JP (2) JP5081363B2 (hu)
KR (1) KR100911280B1 (hu)
CN (1) CN1246315C (hu)
AR (1) AR032892A1 (hu)
AT (1) ATE469138T1 (hu)
AU (2) AU8414901A (hu)
BG (1) BG66240B1 (hu)
BR (1) BR0113425B1 (hu)
CA (1) CA2415847C (hu)
CY (1) CY1110738T1 (hu)
CZ (1) CZ304003B6 (hu)
DE (1) DE60142240D1 (hu)
DK (1) DK1315709T3 (hu)
EA (1) EA006237B1 (hu)
ES (1) ES2346291T3 (hu)
FR (1) FR2813306B1 (hu)
HK (1) HK1053113A1 (hu)
HU (1) HU229456B1 (hu)
IL (2) IL153632A0 (hu)
IS (1) IS2821B (hu)
MA (1) MA26943A1 (hu)
ME (2) ME00106B (hu)
MX (1) MXPA03001463A (hu)
NO (1) NO328138B1 (hu)
NZ (1) NZ523446A (hu)
OA (1) OA12359A (hu)
PL (1) PL219848B1 (hu)
PT (1) PT1315709E (hu)
RS (1) RS51603B (hu)
SI (1) SI1315709T1 (hu)
SK (1) SK288126B6 (hu)
TW (1) TWI290920B (hu)
WO (1) WO2002016339A1 (hu)
ZA (1) ZA200300744B (hu)

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* Cited by examiner, † Cited by third party
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US7401072B2 (en) * 2003-06-10 2008-07-15 Google Inc. Named URL entry
CA2606861C (en) * 2005-05-05 2012-08-07 Sanofi-Aventis U.S. Llc Stable nanoparticle formulations
FR2893616B1 (fr) * 2005-11-23 2008-01-04 Sanofi Aventis Sa Nouveaux derives d'indolizine, leur procede de preparation et les compositions therapeutiques les comprenant
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及系统
EP2308488A1 (en) 2009-10-09 2011-04-13 Sanofi-Aventis Use of celivarone for the preparation of a medicament for use in the prevention of implantable cardioverter defibrillator interventions or death
US20110207811A1 (en) * 2010-02-19 2011-08-25 Sanofi-Aventis Use of celivarone for reducing occurrences of cardiovascular hospitalization
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
AU2011202542A1 (en) 2010-07-14 2012-02-02 Indian Institute Of Science Benzothiophene carboxamide compounds, composition and applications thereof
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
FR2967067A1 (fr) 2010-11-10 2012-05-11 Sanofi Aventis Composition pharmaceutique et forme galenique a base de dronedarone et son procede de preparation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
CN102757444B (zh) * 2011-04-29 2016-02-10 南京信诺泰医药有限公司 具有一氧化氮供体性质的苯并呋喃类化合物
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
WO2013121234A1 (en) 2012-02-14 2013-08-22 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
WO2013124745A1 (en) 2012-02-22 2013-08-29 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
US9238636B2 (en) 2012-05-31 2016-01-19 Sanofi Process for preparation of dronedarone by Grignard reaction
CN105315245B (zh) * 2014-06-16 2018-10-12 华润赛科药业有限责任公司 苯并呋喃类衍生物、其制备方法和应用

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GB1345872A (en) * 1970-09-03 1974-02-06 Wyeth John & Brother Ltd Amino-and acylamino-pyridine and hydropyridine derivatives
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AT391316B (de) * 1988-09-15 1990-09-25 Ebewe Arzneimittel Neue thienyloxy-alkylamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
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CA2217373A1 (en) * 1996-10-10 1998-04-10 Michael John Martin Benzo¬b|thiophene compounds, intermediates, formulations, and methods

Also Published As

Publication number Publication date
IL153632A0 (en) 2003-07-06
RS51603B (sr) 2011-08-31
DK1315709T3 (da) 2010-09-20
MXPA03001463A (es) 2004-05-04
AU2001284149B2 (en) 2006-09-21
MEP23008A (en) 2010-06-10
ME00106B (me) 2010-10-10
HUP0302968A3 (en) 2005-02-28
CN1471521A (zh) 2004-01-28
PT1315709E (pt) 2010-07-29
NZ523446A (en) 2004-12-24
TWI290920B (en) 2007-12-11
SK2162003A3 (en) 2003-08-05
CZ304003B6 (cs) 2013-08-14
BG66240B1 (bg) 2012-08-31
SK288126B6 (sk) 2013-10-02
JP5081363B2 (ja) 2012-11-28
IS2821B (is) 2013-02-15
JP2012097100A (ja) 2012-05-24
EA200300062A1 (ru) 2003-08-28
ES2346291T3 (es) 2010-10-14
JP5603849B2 (ja) 2014-10-08
EA006237B1 (ru) 2005-10-27
NO20030800D0 (no) 2003-02-20
EP1315709B1 (fr) 2010-05-26
FR2813306B1 (fr) 2005-10-21
ZA200300744B (en) 2004-02-05
PL362119A1 (en) 2004-10-18
OA12359A (fr) 2006-05-16
KR100911280B1 (ko) 2009-08-11
BR0113425B1 (pt) 2014-02-25
CZ2003521A3 (cs) 2003-05-14
ATE469138T1 (de) 2010-06-15
CY1110738T1 (el) 2015-06-10
HU229456B1 (en) 2013-12-30
YU12903A (sh) 2006-05-25
IL153632A (en) 2007-07-24
AR032892A1 (es) 2003-12-03
CA2415847A1 (fr) 2002-02-28
WO2002016339A1 (fr) 2002-02-28
HK1053113A1 (en) 2003-10-10
BG107527A (bg) 2003-10-31
NO20030800L (no) 2003-04-23
CA2415847C (fr) 2011-09-27
DE60142240D1 (de) 2010-07-08
US6949583B2 (en) 2005-09-27
CN1246315C (zh) 2006-03-22
JP2004506727A (ja) 2004-03-04
KR20030023767A (ko) 2003-03-19
FR2813306A1 (fr) 2002-03-01
MA26943A1 (fr) 2004-12-20
IS6677A (is) 2003-01-13
EP1315709A1 (fr) 2003-06-04
NO328138B1 (no) 2009-12-14
US20030225100A1 (en) 2003-12-04
SI1315709T1 (sl) 2010-09-30
AU8414901A (en) 2002-03-04
PL219848B1 (pl) 2015-07-31
BR0113425A (pt) 2003-07-15

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