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HUP0202648A2 - Imidazolilszármazékok, ezeket tartalmazó gyógyászati készítmények és alkalmazásuk - Google Patents

Imidazolilszármazékok, ezeket tartalmazó gyógyászati készítmények és alkalmazásuk

Info

Publication number
HUP0202648A2
HUP0202648A2 HU0202648A HUP0202648A HUP0202648A2 HU P0202648 A2 HUP0202648 A2 HU P0202648A2 HU 0202648 A HU0202648 A HU 0202648A HU P0202648 A HUP0202648 A HU P0202648A HU P0202648 A2 HUP0202648 A2 HU P0202648A2
Authority
HU
Hungary
Prior art keywords
alkyl
group
compounds
pharmaceutical compositions
compositions containing
Prior art date
Application number
HU0202648A
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English (en)
Inventor
Marie-Odile Galcera
Thomas D. Gordon
Christophe Philippe Moinet
Barry Morgan
Lydie Francine Poitout
Christophe Alain Thurieau
Original Assignee
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. filed Critical Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S.
Publication of HUP0202648A2 publication Critical patent/HUP0202648A2/hu
Publication of HUP0202648A3 publication Critical patent/HUP0202648A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

A találmány (I) általános képletű vegyületekre, azok racém ésdiasztereomer elegyeire és optikai izomerjeire, továbbá azokgyógyászatilag elfogadható sóira és elővegyületeire vonatkozik - aképletben a szubsztituensek főbb jelentései: - - - - - jelentése adottesetben jelen levő kötés; R1 jelentése H, -(CH2)m-C(O)-(CH2)m-Z1, -(CH2)m-Z1 vagy -(CH2)m-O-Z1 általános képletű csoport; Z1 jelentéseadott esetben szubsztituált 1-12 szénatomos alkilcsoport, fenilcsoportvagy naftilcsoport; R2 jelentése hidrogénatom vagy 1-6 szénatomosalkilcsoport; R3 jelentése -(CH2)m-E-(CH2)m-Z2 általános képletű csoport, ahol Ejelentése O, S vagy egy kötés; Z2 jelentése H, 1-12 szénatomosalkilcsoport vagy aminocsoport; R4 jelentése H vagy -(CH2)m-A1általános képletű csoport, ahol A1 jelentése X2 általános képletűcsoport, ahol X2 jelentése adott esetben szubsztituált 1-12 szénatomosalkilcsoport; R5 jelentése 1-12 szénatomos alkilcsoport; és R6jelentése H vagy 1-6 szénatomos alkilcsoport; és m értéke 0-6. Atalálmány szerinti vegyületek szomatosztatin-receptorok agonistáikéntvagy antagonistáiként használhatók fel. A találmány kiterjed avegyületeket tartalmazó gyógyászati készítményekre is. Ó
HU0202648A 1998-06-12 1999-06-08 Imidazolyl derivatives, pharmaceutical compositions containing them and their use HUP0202648A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8908798P 1998-06-12 1998-06-12
US9643198A 1998-06-12 1998-06-12
PCT/US1999/012760 WO1999064401A2 (en) 1998-06-12 1999-06-08 Imidazolyl derivatives and their use as somatostatin receptor ligands

Publications (2)

Publication Number Publication Date
HUP0202648A2 true HUP0202648A2 (hu) 2002-12-28
HUP0202648A3 HUP0202648A3 (en) 2003-02-28

Family

ID=26780237

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202648A HUP0202648A3 (en) 1998-06-12 1999-06-08 Imidazolyl derivatives, pharmaceutical compositions containing them and their use

Country Status (21)

Country Link
US (3) US6852725B1 (hu)
EP (1) EP1086086B1 (hu)
JP (1) JP2003523921A (hu)
CN (1) CN1319094A (hu)
AR (1) AR018671A1 (hu)
AT (1) ATE279396T1 (hu)
AU (1) AU746963B2 (hu)
CA (1) CA2334945A1 (hu)
CZ (1) CZ20004568A3 (hu)
DE (1) DE69921124T2 (hu)
DK (1) DK1086086T3 (hu)
ES (1) ES2229718T3 (hu)
HK (1) HK1031873A1 (hu)
HU (1) HUP0202648A3 (hu)
IL (1) IL139835A (hu)
NO (2) NO20006267L (hu)
PL (1) PL347139A1 (hu)
PT (1) PT1086086E (hu)
RU (1) RU2263111C2 (hu)
TW (1) TWI245758B (hu)
WO (1) WO1999064401A2 (hu)

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AU746963B2 (en) * 1998-06-12 2002-05-09 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Imidazolyl derivatives
US6525203B1 (en) 1999-03-12 2003-02-25 Bristol-Myers Squibb Company Heterocyclic aromatic compounds useful as growth hormone secretagogues
US6518292B1 (en) 1999-03-12 2003-02-11 Bristol-Myers Squibb Co. Heterocyclic aromatic compounds usefuls as growth hormone secretagogues
EP1172359A4 (en) * 1999-04-07 2002-09-11 Santen Pharmaceutical Co Ltd N-SUBSTITUTED-N'-SUBSTITUTED UREA DERIVATIVE, AND ITS USE AS AN INHIBITOR OF TNF PRODUCTION- $ g (a)
FR2796945B1 (fr) * 1999-07-30 2002-06-28 Sod Conseils Rech Applic Nouveaux derives d'hydantoines, de thiohydantoines, de pyrimidinediones et de thioxopyrimidinones, leurs procedes de preparation et leur application a titre de medicaments
US6696418B1 (en) 1999-09-01 2004-02-24 Pfizer Inc. Somatostatin antagonists and agonists that act at the SST subtype 2 receptor
TWI283577B (en) * 1999-10-11 2007-07-11 Sod Conseils Rech Applic Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof
FR2812546B1 (fr) * 2000-08-01 2008-11-21 Sod Conseils Rech Applic Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments
JP2003513082A (ja) 1999-11-04 2003-04-08 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド バソプレッシン拮抗物質としての非ペプチド置換されたベンゾチアゼピン類
US6495589B2 (en) 2000-04-28 2002-12-17 Pfizer Inc. Somatostatin antagonists and agonists that act at the SST subtype 2 receptor
US6372795B1 (en) * 2000-06-30 2002-04-16 Unilever Home And Personal Care Usa, A Division Of Conopco, Inc. Cosmetic compositions containing substituted amide derivatives
KR20030020960A (ko) * 2000-08-01 2003-03-10 소시에떼 더 콘세이유 더 레세르세 에 다플리까띠옹 시엔띠피끄, 에스.아.에스. 이미다졸일 유도체
US6653478B2 (en) 2000-10-27 2003-11-25 Ortho-Mcneil Pharmaceutical, Inc. Substituted benzimidazol-2-ones as vasopressin receptor antagonists and neuropeptide Y modulators
US6720330B2 (en) 2000-11-17 2004-04-13 Pfizer Inc. Somatostatin antagonists and agonists that act at the SST subtype 2 receptor
CA2450446A1 (en) * 2001-06-25 2003-01-03 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R Pharmaceutical compositions which inhibit proliferation of pituitary adenomas and method of use thereof
US20050154039A1 (en) * 2001-11-28 2005-07-14 Marie-Odile Glacera Contour 5-Sulphanyl-4h-1,2,4-triazole derivatives and their use as medicine
FR2832710B1 (fr) * 2001-11-28 2004-09-03 Sod Conseils Rech Applic Derives de 5-sulfanyl-4h-1,2,4-triazoles et leur utilisation en tant que medicaments
CA2480039A1 (en) * 2002-03-22 2003-10-02 Toray Industries, Inc. Spiro derivatives and adhesion molecule inhibitors comprising the same as active ingredient
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