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HUP0104022A2 - Béta-szekretáz típusú aktivitással rendelkező polipeptidek - Google Patents

Béta-szekretáz típusú aktivitással rendelkező polipeptidek

Info

Publication number
HUP0104022A2
HUP0104022A2 HU0104022A HUP0104022A HUP0104022A2 HU P0104022 A2 HUP0104022 A2 HU P0104022A2 HU 0104022 A HU0104022 A HU 0104022A HU P0104022 A HUP0104022 A HU P0104022A HU P0104022 A2 HUP0104022 A2 HU P0104022A2
Authority
HU
Hungary
Prior art keywords
polypeptides
beta
type activity
secretase
secretase type
Prior art date
Application number
HU0104022A
Other languages
English (en)
Inventor
Philippe Bertrand
Paul Cohen
Mohamed Moutaouakil
Noeli Munoz-Gimenez
Mohamed Rholam
Original Assignee
Aventis Pharma S.A.
Universite Pierre Et Marie Curie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9807068A external-priority patent/FR2779444A1/fr
Application filed by Aventis Pharma S.A., Universite Pierre Et Marie Curie filed Critical Aventis Pharma S.A.
Publication of HUP0104022A2 publication Critical patent/HUP0104022A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A találmány tárgyát új polipeptidek és ezek gyógyászati alkalmazásaképezi. Pontosabban, a találmány tárgyát új b-szekretáz típusúaktivitással rendelkező peptidek képezik, amelyekre az jellemző, hogyképesek specifikus módon hasítani a b-amiloidpeptid természetesprekurzorát (APP). Ó
HU0104022A 1998-06-05 1999-06-04 Béta-szekretáz típusú aktivitással rendelkező polipeptidek HUP0104022A2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9807068A FR2779444A1 (fr) 1998-06-05 1998-06-05 Polypeptides possedant une activite de type beta-secretase et capables de cliver le precurseur naturel du peptide beta-amyloide (app)
US12259999P 1999-03-03 1999-03-03
PCT/FR1999/001326 WO1999064587A1 (fr) 1998-06-05 1999-06-04 Polypeptides possedant une activite de type beta-secretase

Publications (1)

Publication Number Publication Date
HUP0104022A2 true HUP0104022A2 (hu) 2002-03-28

Family

ID=26234362

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0104022A HUP0104022A2 (hu) 1998-06-05 1999-06-04 Béta-szekretáz típusú aktivitással rendelkező polipeptidek

Country Status (7)

Country Link
EP (1) EP1084240A1 (hu)
KR (1) KR20010052499A (hu)
AU (1) AU4045599A (hu)
CA (1) CA2330242A1 (hu)
HU (1) HUP0104022A2 (hu)
IL (1) IL139739A0 (hu)
WO (1) WO1999064587A1 (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1115874B1 (en) 1998-09-24 2009-01-07 Pharmacia & Upjohn Company LLC Alzheimer's disease secretase
US6844148B1 (en) 1998-09-24 2005-01-18 Pharmacia & Upjohn Company Alzheimer's disease secretase, APP substrates therefor, and uses therefor
US6699671B1 (en) 1998-09-24 2004-03-02 Pharmacia & Upjohn Company Alzheimer's disease secretase, APP substrates therefor, and uses therefor
US7456007B1 (en) 1998-12-31 2008-11-25 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
US7115410B1 (en) 1999-02-10 2006-10-03 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
CN1390232A (zh) 1999-02-10 2003-01-08 艾兰制药公司 人β分泌酶、抑制剂、其组合物和用途
AU3770800A (en) 1999-03-26 2000-10-16 Amgen, Inc. Beta secretase genes and polypeptides
WO2001000663A2 (en) 1999-06-28 2001-01-04 Oklahoma Medical Research Foundation Catalytically active recombinant memapsin and methods of use thereof
US7514408B1 (en) 1999-12-02 2009-04-07 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
AU2001277950A1 (en) * 2000-07-19 2002-01-30 Pharmacia And Upjohn Company Llc Substrates and assays for beta-secretase activity
US7138262B1 (en) * 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
US7196163B2 (en) 2001-05-22 2007-03-27 Merk & Co., Inc. Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity
WO2003039454A2 (en) 2001-10-23 2003-05-15 Oklahoma Medical Research Foundation Beta-secretase inhibitors and methods of use
EP2361613B1 (en) 2006-02-07 2020-08-12 Shire Human Genetic Therapies, Inc. Stabilized compositions of proteins having a free thiol moiety
PL3354277T3 (pl) 2009-07-28 2021-12-13 Takeda Pharmaceutical Company Limited Kompozycje i sposoby leczenia choroby gauchera
EP2595651B1 (en) 2010-07-19 2017-03-29 Shire Human Genetic Therapies, Inc. Mannose receptor c type 1 (mrc1) codon optimized cell line and uses thereof
CN104245938B (zh) 2011-06-10 2018-06-01 淡马锡生命科学研究院有限公司 用于柄锈菌亚门和黑粉菌亚门的基因操作和表达系统
CN104519905A (zh) 2012-03-02 2015-04-15 夏尔人类遗传性治疗公司 用于治疗iii型戈谢病的组合物和方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0732399A3 (en) * 1990-03-05 1997-03-12 Cephalon Inc Chymotrypsin-like proteases and their inhibitors
JPH06503948A (ja) * 1990-08-17 1994-05-12 ボストン・ユニヴァーシティー アミロイドβ―蛋白質のプレカーサーの異常分解をひき起こすプロテアーゼ
US5292652A (en) * 1990-10-05 1994-03-08 Athena Neurosciences, Inc. Amyloidin protease and uses thereof
AU679675B2 (en) * 1992-05-11 1997-07-10 Bayer Corporation Methods for detecting beta amyloid precursor protein processing enzymes
IL105793A0 (en) * 1992-05-28 1993-09-22 Lilly Co Eli Protease and related dna compounds
AU6383396A (en) * 1995-06-07 1996-12-30 Athena Neurosciences, Inc. Beta-secretase, antibodies to beta-secretase, and assays for detecting beta-secretase inhibition

Also Published As

Publication number Publication date
WO1999064587A8 (fr) 2001-08-02
CA2330242A1 (fr) 1999-12-16
AU4045599A (en) 1999-12-30
IL139739A0 (en) 2002-02-10
EP1084240A1 (fr) 2001-03-21
WO1999064587A1 (fr) 1999-12-16
KR20010052499A (ko) 2001-06-25

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