[go: up one dir, main page]

HUP0102290A2 - Hidroxámsav-származékok alkalmazása antibakteriális hatású gyógyszerkészítmények előállítására - Google Patents

Hidroxámsav-származékok alkalmazása antibakteriális hatású gyógyszerkészítmények előállítására

Info

Publication number
HUP0102290A2
HUP0102290A2 HU0102290A HUP0102290A HUP0102290A2 HU P0102290 A2 HUP0102290 A2 HU P0102290A2 HU 0102290 A HU0102290 A HU 0102290A HU P0102290 A HUP0102290 A HU P0102290A HU P0102290 A2 HUP0102290 A2 HU P0102290A2
Authority
HU
Hungary
Prior art keywords
group
alkyl
carbon atoms
acid derivatives
hydroxamic acid
Prior art date
Application number
HU0102290A
Other languages
English (en)
Inventor
Raymond Paul Beckett
John Martin Clements
Michael George Hunter
Zoe Marie Spavold
Mark Whittaker
Original Assignee
British Biotech Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Biotech Pharmaceuticals Ltd. filed Critical British Biotech Pharmaceuticals Ltd.
Publication of HUP0102290A2 publication Critical patent/HUP0102290A2/hu
Publication of HUP0102290A3 publication Critical patent/HUP0102290A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

A találmány tárgyát az (I) általános képletű hidroxámsavszármazékokantibakteriális hatóanyagokként történő alkalmazása képezi, ahol aképletben R1 jelentése hidrogénatom, vagy 1-6 szénatomos alkilcsoport,egy vagy több halogénatommal helyettesített 1-6 szénatomosalkilcsoport; R2 jelentése R10-(X)n-(ALK)m- általános képletű csoport,ahol R10 jelentése hidrogénatom vagy 1-6 szénatomos alkilcsoport, 2-6szénatomos alkenilcsoport, 2-6 szénatomos alkinilcsoport,cikloalkilcsoport, arilcsoport vagy heterociklusos csoport, amelyekbármelyike lehet helyettesítetlen vagy 1-6 szénatomos alkilcsoporttal,1-6 szénatomos alkoxicsoporttal, hidroxicsoporttal,merkaptocsoporttal, 1-6 szénatomos alkiltio csoporttal,aminocsoporttal, halocsoporttal (ideértve a flour, klór, bróm és jódatomokat), trifluormetilcsoporttal, cianocsoporttal, nitrocsoporttal,-COOH csoporttal, -CONH2 csoporttal, -COORA csoporttal, -NHCORAcsoporttal, -CONHRA csoporttal, - NHRA csoporttal, -NRARB csoporttalvagy -CONRARB csoporttal helyettesítettek, ahol az RA és RB jelentéseegymástól függetlenül 1-6 szénatomos alkilcsoport és az ALK egyenesvagy elágazó szénláncú két vegyértékű 1-6 szénatomos alkiléncsoport,2-6 szénatomos alkeniléncsoport vagy 2-6 szénatomos alkiniléncsoport,valamint egy vagy több nem szomszédos -NH-, -O- vagy -S- kötésekkelmegszakított lehet; X jelentése -NH-, -O- vagy -S- és m és n értékeegymástól függetlenül 0 vagy 1; valamint A jelentése a leírásbandefiniált csoport. Ó
HU0102290A 1998-05-16 1999-05-14 Use of hydroxamic acid derivatives for producing pharmaceutical compositions having antibacterial activity HUP0102290A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9810464.9A GB9810464D0 (en) 1998-05-16 1998-05-16 Hydroxamic acid derivatives
PCT/GB1999/001541 WO1999059568A1 (en) 1998-05-16 1999-05-14 Hydroxamic acid derivatives as antibacterials

Publications (2)

Publication Number Publication Date
HUP0102290A2 true HUP0102290A2 (hu) 2001-11-28
HUP0102290A3 HUP0102290A3 (en) 2001-12-28

Family

ID=10832125

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0102290A HUP0102290A3 (en) 1998-05-16 1999-05-14 Use of hydroxamic acid derivatives for producing pharmaceutical compositions having antibacterial activity

Country Status (23)

Country Link
US (3) US6441042B1 (hu)
EP (2) EP1754477A3 (hu)
JP (1) JP2002515427A (hu)
KR (1) KR100634089B1 (hu)
CN (1) CN1300210A (hu)
AT (1) ATE347356T1 (hu)
AU (1) AU754063B2 (hu)
BR (1) BR9910488A (hu)
CA (1) CA2332713C (hu)
CY (1) CY1106452T1 (hu)
DE (1) DE69934309T2 (hu)
DK (1) DK1079819T3 (hu)
ES (1) ES2278444T3 (hu)
GB (2) GB9810464D0 (hu)
HU (1) HUP0102290A3 (hu)
IL (2) IL139059A0 (hu)
NO (1) NO20005782L (hu)
NZ (1) NZ507560A (hu)
PL (1) PL344438A1 (hu)
PT (1) PT1079819E (hu)
TR (1) TR200003376T2 (hu)
WO (1) WO1999059568A1 (hu)
ZA (1) ZA200006131B (hu)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ505675A (en) * 1998-02-07 2002-11-26 British Biotech Pharm N-alkylamide substituted hydroxamic acid derivatives are used as antibacterial agents
GB9810464D0 (en) * 1998-05-16 1998-07-15 British Biotech Pharm Hydroxamic acid derivatives
ES2242411T3 (es) * 1999-08-10 2005-11-01 Vernalis (Oxford) Ltd Agentes antibacterianos.
FR2801591B1 (fr) * 1999-11-30 2002-03-01 Aventis Pharma Sa Derives macrocycliques de l'acide hydroxamique, leur preparation et les compositions qui les contiennent
AU2180201A (en) * 1999-11-30 2001-06-12 Aventis Pharma S.A. Hydroxamic acid macrocyclic derivatives, preparation method and compositions containing same
WO2001044178A1 (en) * 1999-12-17 2001-06-21 Versicor, Inc. Novel urea compounds, compositions and methods of use and preparation
GB9929979D0 (en) * 1999-12-17 2000-02-09 Darwin Discovery Ltd Hydroxamic acid derivatives
WO2002028829A2 (en) * 2000-09-25 2002-04-11 Questcor Pharmaceuticals, Inc. Peptide deformylase inhibitors
US7173053B2 (en) 2000-11-23 2007-02-06 British Biotech Pharmaceuticals Limited N-formyl hydroxylamine derivatives as inhibitors of bacterial polypeptide formylase for treating microbial infections
CA2441822A1 (en) * 2001-03-19 2002-09-26 Sloan Kettering Institute For Cancer Research Asymmetric synthesis of (s, s, r)-(-)-actinonin and its analogs and uses therefor
JP2004527530A (ja) * 2001-04-05 2004-09-09 スミスクライン・ビーチャム・コーポレイション ペプチドデホルミラーゼ阻害物質
GB0128943D0 (en) * 2001-12-04 2002-01-23 Novo Pharmaceuticals De Ltd Bacterial enzyme inhibitors
JP4190862B2 (ja) * 2001-12-18 2008-12-03 シャープ株式会社 表示装置およびその駆動方法
GB0208579D0 (en) * 2002-04-13 2002-05-22 British Biotech Pharm Antibacterial agents
DE10320453A1 (de) * 2003-05-08 2004-11-25 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Bioisostere von Actinonin
EP3075401B1 (en) * 2007-11-29 2024-04-03 Inolex Investment Corporation Preservation for cosmetic, toiletry and pharmaceutical compositions
DE102011088962A1 (de) * 2011-12-19 2013-06-20 Beiersdorf Ag Wirkstoffkombinationen aus einer oder mehreren Carbonsäuren, insbesondereHydroxycarbonsäuren, und einer oder mehreren physiologisch unbedenklichen Hydroxamsäure sowie kosmetische oder dermatologische Zubereitungen, solcheWirkstoffkombinationen enthaltend
US10829440B2 (en) 2015-06-12 2020-11-10 Brown University Antibacterial compounds and methods of making and using same
RU2738413C1 (ru) * 2017-06-29 2020-12-14 Кимберли-Кларк Ворлдвайд, Инк. Противомикробная композиция, содержащая дигидроксамовую кислоту, и способы подавления микробного роста посредством ее применения
CN108672095A (zh) * 2018-05-04 2018-10-19 广东省资源综合利用研究所 γ-羟基烷基羟肟酸及其制备方法与应用
US11555010B2 (en) 2019-07-25 2023-01-17 Brown University Diamide antimicrobial agents

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1028921A (en) 1962-01-23 1966-05-11 Ranjeet Bhagwan Singh New antibiotic
US4303662A (en) * 1980-11-24 1981-12-01 E. R. Squibb & Sons, Inc. Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds
JPH0670019B2 (ja) 1989-07-21 1994-09-07 明治製菓株式会社 新抗生物質ｓｆ２１９７ｃ物質およびその製造法
GB8919251D0 (en) * 1989-08-24 1989-10-04 British Bio Technology Compounds
JPH03157372A (ja) 1989-11-13 1991-07-05 Yamanouchi Pharmaceut Co Ltd Ｙｌ―０１８６９ｐ物質及びその製造法
WO1992022523A2 (en) * 1991-06-14 1992-12-23 Research Corporation Technologies, Inc. Peptide derivatives of collagenase inhibitor
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
AU687436B2 (en) 1993-08-23 1998-02-26 Immunex Corporation Inhibitors of TNF-alpha secretion
JP3157372B2 (ja) 1993-11-29 2001-04-16 三洋電機株式会社 フィルタ
DE69516143T2 (de) * 1994-06-22 2000-10-19 British Biotech Pharmaceuticals Ltd., Cowley Metalloproteinase inhibitoren
US5532265A (en) * 1994-11-30 1996-07-02 The Board Of Trustees Of The Leland Stanford Junior University Treatment of central nervous system inflammatory disease with matrix metalloprotease inhibitors
GB9507799D0 (en) * 1995-04-18 1995-05-31 British Biotech Pharm Metalloproteinase inhibitors
US6281245B1 (en) * 1996-10-28 2001-08-28 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
WO1998024474A1 (en) 1996-12-06 1998-06-11 Fonden Til Fremme Af Eksperimentel Cancerforskning Inhibition of invasive remodelling
ZA9711121B (en) * 1996-12-13 1998-06-23 Handelman Joseph H Reduction of hair growth.
NZ505675A (en) * 1998-02-07 2002-11-26 British Biotech Pharm N-alkylamide substituted hydroxamic acid derivatives are used as antibacterial agents
GB9810464D0 (en) * 1998-05-16 1998-07-15 British Biotech Pharm Hydroxamic acid derivatives

Also Published As

Publication number Publication date
JP2002515427A (ja) 2002-05-28
DE69934309D1 (de) 2007-01-18
ATE347356T1 (de) 2006-12-15
US20020198241A1 (en) 2002-12-26
TR200003376T2 (tr) 2001-03-21
WO1999059568A1 (en) 1999-11-25
US7323563B2 (en) 2008-01-29
NO20005782D0 (no) 2000-11-15
ES2278444T3 (es) 2007-08-01
KR20010034861A (ko) 2001-04-25
US6441042B1 (en) 2002-08-27
PT1079819E (pt) 2007-03-30
EP1079819B1 (en) 2006-12-06
AU3942199A (en) 1999-12-06
BR9910488A (pt) 2001-01-09
PL344438A1 (en) 2001-11-05
EP1754477A2 (en) 2007-02-21
KR100634089B1 (ko) 2006-10-17
CA2332713C (en) 2008-04-01
GB2353708A (en) 2001-03-07
ZA200006131B (en) 2002-01-30
IL139059A (en) 2006-12-31
CY1106452T1 (el) 2011-10-12
EP1079819A1 (en) 2001-03-07
EP1754477A3 (en) 2007-03-14
CA2332713A1 (en) 1999-11-25
NZ507560A (en) 2003-06-30
NO20005782L (no) 2001-01-15
US20060211732A1 (en) 2006-09-21
DE69934309T2 (de) 2007-07-05
CN1300210A (zh) 2001-06-20
DK1079819T3 (da) 2007-04-10
HUP0102290A3 (en) 2001-12-28
AU754063B2 (en) 2002-10-31
GB0024789D0 (en) 2000-11-22
IL139059A0 (en) 2001-11-25
GB9810464D0 (en) 1998-07-15
US6992190B2 (en) 2006-01-31

Similar Documents

Publication Publication Date Title
HUP0102290A2 (hu) Hidroxámsav-származékok alkalmazása antibakteriális hatású gyógyszerkészítmények előállítására
HUP0401196A2 (hu) Csípőbélbeni epesav-transzportot gátló hatású benzotiazepin- és benzotiadiazepin-származékok, előállításuk és az ezeket tartalmazó gyógyászati készítmények hiperlipidémia kezelésére
TR200002311T2 (tr) Antibakteriyel ajanlar
ES2187473T3 (es) Triarylimidazoles.
DK0494819T3 (da) Hidtil ukendte phenylimidazolidiner, deres fremstilling, anvendelse som lægemidler samt farmaceutiske præparater med indhold heraf
NZ501346A (en) Valinyl aromatic beta amino acid dipeptide compounds having fungicidal activity and their agronomic use
HUP0302781A2 (hu) 4-Jód-fenil-amino-benzhidroxámsav-észter-származékok és ezeket tartalmazó gyógyászati készítmények
BR0312421A (pt) Uso de inibidores de cept e opcionalmente inibidores hmg coa redutase e/ou agentes anti-hipertensivos
HUP0103460A2 (hu) Vírusellenes hatású indolszármazékok és a vegyületeket tartalmazó gyógyszerkészítmények
DK1104760T3 (da) Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler
TR200201505T2 (tr) Terapötik maddeler olarak pirazolopirimidinler
NO20070532L (no) Substituerte 2-alkyl-kinazolinonderivater som PARP-inhibitorer
HUP0303347A2 (hu) (R)-2-aril-propionsav-omega-aminoalkilamidok mint polimorf magvú és egymagvú sejtek kemotaxisának inhibitorai, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
AU2002231122A1 (en) Methods of treating anxiety disorders
HUP0300195A2 (hu) Heterociklusos nátrium/proton-csere inhibitorok és ezeket tartalmazó gyógyszerkészítmények
YU401A (sh) Sredstva sa antidepresivnim dejstvom
HUP0001760A2 (hu) Aril-acil-piridazin-származékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és a vegyületek alkalmazása gyógyszerkészítmények előállítására
DK1104759T3 (da) Heteroarylphenylpyrazolforbindelser som antiinflammatoriske/analgetiske midler
HUP0202934A2 (hu) [(Aril-szulfonil)-amino]-szubsztituált hidroxámsav-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
NO995963D0 (no) Karboksamider anvendelige som 5-HTIF-agonister
HUP0004644A2 (hu) Neutrofil elasztáz inhibitor hatású pirrolo-pirrolon-származékok és ilyen vegyületeket hatóanyagként tartalmazó gyógyszerkészítmények
BR9807330A (pt) Agentes inibidores do progresso de pterìgio e recorrência pós-operatória do mesmo
DE69912639D1 (de) N-formyl hydroxylamin derivate als antibakterielle mittel
BR9406091A (pt) Composto derivado de ácido 3-hidróxi-antranílico processo para preparação do mesmo formulação farmacêutica processo para a fabricação de um medicamento e processo para a prevenção ou tratamento de neuro-degeneração
HUP0102773A2 (hu) Antikonvulzáns hatású tetrahidronaftiridinil-karboxamidok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees