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HUP0101808A2 - Eljárás izomertiszta, magas helyettesítési fokú azaciklikus vegyületek sztereokémiailag szabályozott előállítására - Google Patents

Eljárás izomertiszta, magas helyettesítési fokú azaciklikus vegyületek sztereokémiailag szabályozott előállítására

Info

Publication number
HUP0101808A2
HUP0101808A2 HU0101808A HUP0101808A HUP0101808A2 HU P0101808 A2 HUP0101808 A2 HU P0101808A2 HU 0101808 A HU0101808 A HU 0101808A HU P0101808 A HUP0101808 A HU P0101808A HU P0101808 A2 HUP0101808 A2 HU P0101808A2
Authority
HU
Hungary
Prior art keywords
controlled production
stereochemically controlled
azacyclic compounds
isomerically pure
highly substituted
Prior art date
Application number
HU0101808A
Other languages
English (en)
Inventor
Jochen Antel
Timo Heinrich
Bernd Junker
Ulf Preuschoff
Michael Reggelin
Original Assignee
Solvay Pharmaceuticals Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals Gmbh. filed Critical Solvay Pharmaceuticals Gmbh.
Publication of HUP0101808A2 publication Critical patent/HUP0101808A2/hu
Publication of HUP0101808A3 publication Critical patent/HUP0101808A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
    • C07D291/02—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms not condensed with other rings
    • C07D291/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • C07C381/10—Compounds containing sulfur atoms doubly-bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

A találmány (I) általános képletű azaciklikus vegyületek, (melyképletben a ciklikus alapváz 5-helyzetében levő R1R2CH-csoport és aciklikus alapváz 3-helyzetében levő hidroxilcsoport egymáshozviszonyítva mindenkor transzállású, és a ciklikus alapváz 4-helyzetében levő R4-helyettesítő és 3-helyzetében levő hidroxilcsoportegymáshoz viszonyítva mindenkor ciszállású; n értéke 0 vagy l; Yjelentése oxigénatom vagy -NH- sztereokémiailag szabályozottelőállítására, az eljárásnál felhasználható új közbenső termékekre ésúj azaciklénekre vonatkozik. Ó
HU0101808A 1998-05-13 1999-05-10 Method for stereochemically controlled production of isomerically pure highly substituted azacyclic compounds HUP0101808A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19821418 1998-05-13
PCT/DE1999/001417 WO1999058500A1 (de) 1998-05-13 1999-05-10 Verfahren zur stereochemisch kontrollierten herstellung isomerenreiner hochsubstituierter azacyclischer verbindungen

Publications (2)

Publication Number Publication Date
HUP0101808A2 true HUP0101808A2 (hu) 2001-09-28
HUP0101808A3 HUP0101808A3 (en) 2002-05-28

Family

ID=7867628

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101808A HUP0101808A3 (en) 1998-05-13 1999-05-10 Method for stereochemically controlled production of isomerically pure highly substituted azacyclic compounds

Country Status (29)

Country Link
US (1) US6900322B1 (hu)
EP (1) EP1076646B1 (hu)
JP (1) JP4503833B2 (hu)
KR (1) KR20010043475A (hu)
CN (1) CN1252052C (hu)
AR (1) AR016247A1 (hu)
AT (1) ATE272621T1 (hu)
AU (1) AU758192B2 (hu)
BR (1) BR9911770A (hu)
CA (1) CA2331758C (hu)
DE (2) DE59910141D1 (hu)
DK (1) DK1076646T3 (hu)
DZ (1) DZ2787A1 (hu)
ES (1) ES2228074T3 (hu)
HK (1) HK1036624A1 (hu)
HU (1) HUP0101808A3 (hu)
ID (1) ID26787A (hu)
IL (1) IL139519A0 (hu)
NO (1) NO317986B1 (hu)
NZ (1) NZ508043A (hu)
PL (1) PL197406B1 (hu)
PT (1) PT1076646E (hu)
RU (1) RU2225395C2 (hu)
SK (1) SK17122000A3 (hu)
TR (1) TR200003291T2 (hu)
TW (1) TWI220143B (hu)
UA (1) UA66859C2 (hu)
WO (1) WO1999058500A1 (hu)
ZA (1) ZA200006337B (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7119207B2 (en) 2000-04-10 2006-10-10 Pfizer Inc Benzoamide piperidine containing compounds and related compounds
NZ521346A (en) * 2000-04-10 2004-07-30 Pfizer Prod Inc Benzoamide piperidine containing compounds and related compounds
US7968734B2 (en) * 2004-07-01 2011-06-28 Stc.Unm Organocatalysts and methods of use in chemical synthesis
CN103096893B (zh) 2010-06-04 2016-05-04 阿尔巴尼分子研究公司 甘氨酸转运体-1抑制剂、其制备方法及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5102877A (en) * 1989-04-28 1992-04-07 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
TW214545B (hu) * 1992-02-17 1993-10-11 Ciba Geigy Ag
US5252747A (en) * 1992-09-11 1993-10-12 Abbott Laboratories Chiral quinolone intermediates

Also Published As

Publication number Publication date
ATE272621T1 (de) 2004-08-15
WO1999058500A1 (de) 1999-11-18
DE59910141D1 (de) 2004-09-09
SK17122000A3 (sk) 2001-04-09
NO20005666L (no) 2000-11-10
TWI220143B (en) 2004-08-11
BR9911770A (pt) 2001-02-06
TR200003291T2 (tr) 2001-03-21
DZ2787A1 (fr) 2003-12-01
CA2331758A1 (en) 1999-11-18
PT1076646E (pt) 2004-10-29
AR016247A1 (es) 2001-06-20
CA2331758C (en) 2009-01-20
KR20010043475A (ko) 2001-05-25
JP4503833B2 (ja) 2010-07-14
IL139519A0 (en) 2001-11-25
RU2225395C2 (ru) 2004-03-10
NZ508043A (en) 2003-05-30
EP1076646B1 (de) 2004-08-04
AU5025099A (en) 1999-11-29
EP1076646A1 (de) 2001-02-21
ZA200006337B (en) 2001-05-16
US6900322B1 (en) 2005-05-31
HUP0101808A3 (en) 2002-05-28
CN1252052C (zh) 2006-04-19
WO1999058500B1 (de) 1999-12-29
ID26787A (id) 2001-02-08
AU758192B2 (en) 2003-03-20
UA66859C2 (uk) 2004-06-15
JP2002514624A (ja) 2002-05-21
DE19921580A1 (de) 1999-11-25
CN1299345A (zh) 2001-06-13
DK1076646T3 (da) 2004-09-06
HK1036624A1 (en) 2002-01-11
ES2228074T3 (es) 2005-04-01
NO20005666D0 (no) 2000-11-10
PL344043A1 (en) 2001-09-24
PL197406B1 (pl) 2008-03-31
NO317986B1 (no) 2005-01-17

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