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HUP0003413A2 - Új kondenzált piridinszármazékok, eljárás előállításukra és az azokat tartalmazó gyógyászati készítmények - Google Patents

Új kondenzált piridinszármazékok, eljárás előállításukra és az azokat tartalmazó gyógyászati készítmények

Info

Publication number
HUP0003413A2
HUP0003413A2 HU0003413A HUP0003413A HUP0003413A2 HU P0003413 A2 HUP0003413 A2 HU P0003413A2 HU 0003413 A HU0003413 A HU 0003413A HU P0003413 A HUP0003413 A HU P0003413A HU P0003413 A2 HUP0003413 A2 HU P0003413A2
Authority
HU
Hungary
Prior art keywords
compounds
preparation
group
pyridine derivatives
pharmaceutical compositions
Prior art date
Application number
HU0003413A
Other languages
English (en)
Inventor
Anne Dekeyne
Aimée Dessinges
Mark Millan
Jean-Louis Peglion
Christophe Poitevin
Original Assignee
Adir Et Compagnie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir Et Compagnie filed Critical Adir Et Compagnie
Publication of HU0003413D0 publication Critical patent/HU0003413D0/hu
Publication of HUP0003413A2 publication Critical patent/HUP0003413A2/hu
Publication of HUP0003413A3 publication Critical patent/HUP0003413A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány új piridinszármazékokra, a vegyületek előállítására és avegyületeket tartalmazó gyógyászati készítményekre vonatkozik. Atalálmány tárgya (I) általános képletű vegyületek, ahol W adottesetben szubsztituált naftil- vagy Y csoport, ahol Y jelentése nértéke 1-6; Z jelentése vegyértékvonal, oxigén- vagy adott esetbenszubsztituált nitrogénatom; A jelentése CH csoport vagy nitrogénatom;M a fenilgyűrű szénatomjaival együtt, melyekhez kapcsolódik, tieno-,furo-, pirrolo- vagy oxo-pirrolo-csoportot képez; vagy izomerjei ésgyógyászatilag elfogadható savval vagy bázissal képezett addíciós sói.Az (I) általános képletű vegyületek gyógyszerek, amelyeket aszerotonin újrafelvétellel és/vagy az 5-HT1A receptorok szintjévelkapcsolatos betegségek gyógyítására lehet használni. Ó
HU0003413A 1999-08-27 2000-08-25 New fused pyridine derivatives, process for their preparation and pharmaceutical compositions containing them HUP0003413A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9910834A FR2797874B1 (fr) 1999-08-27 1999-08-27 Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
HU0003413D0 HU0003413D0 (en) 2000-08-25
HUP0003413A2 true HUP0003413A2 (hu) 2001-07-30
HUP0003413A3 HUP0003413A3 (en) 2003-11-28

Family

ID=9549376

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003413A HUP0003413A3 (en) 1999-08-27 2000-08-25 New fused pyridine derivatives, process for their preparation and pharmaceutical compositions containing them

Country Status (23)

Country Link
US (2) US6399616B1 (hu)
EP (1) EP1078928B1 (hu)
JP (1) JP3602780B2 (hu)
KR (1) KR100450317B1 (hu)
CN (1) CN1163495C (hu)
AT (1) ATE266664T1 (hu)
AU (1) AU765661B2 (hu)
BR (1) BR0003848A (hu)
CA (1) CA2317053A1 (hu)
DE (1) DE60010596T2 (hu)
DK (1) DK1078928T3 (hu)
EA (1) EA004102B1 (hu)
ES (1) ES2220359T3 (hu)
FR (1) FR2797874B1 (hu)
HK (1) HK1034250A1 (hu)
HU (1) HUP0003413A3 (hu)
MX (1) MXPA00008241A (hu)
NO (1) NO316651B1 (hu)
NZ (1) NZ506560A (hu)
PL (1) PL342178A1 (hu)
PT (1) PT1078928E (hu)
SI (1) SI1078928T1 (hu)
ZA (1) ZA200004411B (hu)

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FR2797874B1 (fr) * 1999-08-27 2002-03-29 Adir Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE10031391A1 (de) * 2000-07-03 2002-02-07 Knoll Ag Bicyclische Verbindungen und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie
AU2002242996A1 (en) * 2001-03-29 2002-10-15 Tanabe Seiyaku Co., Ltd. Spiroisoquinoline compounds, methods for their preparation and intermediates
DE10217006A1 (de) * 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
JP4897221B2 (ja) * 2002-12-20 2012-03-14 チバ ホールディング インコーポレーテッド アミン類の合成及びその合成のための中間体
JP4559749B2 (ja) * 2004-02-16 2010-10-13 あすか製薬株式会社 ピペラジニルピリジン誘導体
JP4596792B2 (ja) * 2004-02-24 2010-12-15 あすか製薬株式会社 ５−ｈｔ１ａ作動作用と５−ｈｔ３拮抗作用を併有する薬剤
JP4912145B2 (ja) 2004-02-26 2012-04-11 あすか製薬株式会社 ピリミジン誘導体
DE102004023506A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023501A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023508A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Säurederivate substituierter Cyclohexyl-1,4-diamine
WO2006008192A1 (en) * 2004-07-23 2006-01-26 Bayer Cropscience Sa N-[2-(4-pyridinyl)ethyl]benzamide derivatives as fungicides
US7635696B2 (en) 2004-11-26 2009-12-22 Janssen Pharmaceutica N.V. Isoxazoline-indole derivatives with an improved antipsychotic and anxiolytic activity
FR2909670B1 (fr) 2006-12-12 2010-07-30 Sanofi Aventis Derive fluore de quinoleine-2(1h)-one,son procede de preparation et son utilisation comme intermediaire de synthese
EP3027607B1 (en) 2013-07-29 2020-08-26 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
JP2016540013A (ja) * 2013-12-13 2016-12-22 武田薬品工業株式会社 Ｔｌｒ阻害剤としてのピロロ［３，２−ｃ］ピリジン誘導体
US9968604B2 (en) 2015-04-16 2018-05-15 Chiesi Farmaceutici S.P.A. Chromene derivatives as phoshoinositide 3-kinases inhibitors
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
CN106795160B (zh) * 2015-07-23 2019-04-19 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
AU2022237901A1 (en) * 2021-03-19 2023-09-28 Centre National De La Recherche Scientifique Applications of biased ligands of the serotonin 5-ht7 receptor for the treatment of pain, multiple sclerosis and the control of thermoregulation.

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Also Published As

Publication number Publication date
BR0003848A (pt) 2001-04-03
HUP0003413A3 (en) 2003-11-28
AU765661B2 (en) 2003-09-25
US6399616B1 (en) 2002-06-04
NO20004295L (no) 2001-02-28
FR2797874A1 (fr) 2001-03-02
MXPA00008241A (es) 2002-08-20
NO20004295D0 (no) 2000-08-28
US6486171B2 (en) 2002-11-26
ES2220359T3 (es) 2004-12-16
US20020161228A1 (en) 2002-10-31
SI1078928T1 (en) 2004-08-31
EA200000792A3 (ru) 2001-06-25
DE60010596T2 (de) 2005-05-19
AU5364200A (en) 2001-03-01
EA200000792A2 (ru) 2001-04-23
CA2317053A1 (fr) 2001-02-27
CN1286255A (zh) 2001-03-07
PL342178A1 (en) 2001-03-12
DE60010596D1 (de) 2004-06-17
JP2001097978A (ja) 2001-04-10
JP3602780B2 (ja) 2004-12-15
CN1163495C (zh) 2004-08-25
EA004102B1 (ru) 2003-12-25
EP1078928A1 (fr) 2001-02-28
HK1034250A1 (en) 2001-10-19
HU0003413D0 (en) 2000-08-25
ATE266664T1 (de) 2004-05-15
KR20010050228A (ko) 2001-06-15
NO316651B1 (no) 2004-03-22
DK1078928T3 (da) 2004-09-13
NZ506560A (en) 2001-06-29
FR2797874B1 (fr) 2002-03-29
KR100450317B1 (ko) 2004-09-30
EP1078928B1 (fr) 2004-05-12
ZA200004411B (en) 2001-02-28
PT1078928E (pt) 2004-09-30

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