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HUP0002869A2 - Benzotiofén-karboxamid-származékok, ezeket tartalmazó gyógyszerkészítmények, valamint intermedierek - Google Patents

Benzotiofén-karboxamid-származékok, ezeket tartalmazó gyógyszerkészítmények, valamint intermedierek

Info

Publication number
HUP0002869A2
HUP0002869A2 HU0002869A HUP0002869A HUP0002869A2 HU P0002869 A2 HUP0002869 A2 HU P0002869A2 HU 0002869 A HU0002869 A HU 0002869A HU P0002869 A HUP0002869 A HU P0002869A HU P0002869 A2 HUP0002869 A2 HU P0002869A2
Authority
HU
Hungary
Prior art keywords
group
general formula
formula
compounds
hydrogen atom
Prior art date
Application number
HU0002869A
Other languages
English (en)
Inventor
Akinori Arimura
Yoshiharu Hiramatsu
Tsunetoshi Honma
Original Assignee
Shionogi & Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co. Ltd. filed Critical Shionogi & Co. Ltd.
Publication of HUP0002869A2 publication Critical patent/HUP0002869A2/hu
Publication of HUP0002869A3 publication Critical patent/HUP0002869A3/hu
Publication of HU226458B1 publication Critical patent/HU226458B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgya (I) általános képletű vegyület - ahol a képletben Yjelentése valamely (A) vagy (B) képletű csoport, R jelentésehidrogénatom, alkilcsoport, alkoxicsoport, halogénatom,hidroxilcsoport, acil-oxi-csoport vagy kívánt esetben helyettesítettaril-szulfonil-oxi-csoport, X jelentése hidrogénatom vagy alkilcsoportés az a-láncon a kettős kötés E- vagy Z-konfigurációjú, azzal afeltétellel, hogy az (I) általános képletű vegyületek körébe tartozó(I') általános képletű vegyület, ahol a képletben R1a jelentésehidrogénatom, alkilcsoport vagy alkoxicsoport, X jelentése afentiekben megadott és az a-láncon a kettős kötés E- vagy Z-konfigurációjú, az oltalmi körből kizártak - és annak valamelygyógyászatilag elfogadható sói vagy hidrátjai. A találmány szerintivegyületek prosztaglandin (PGD2) antagonisták és nazális blokkkezelésére használható szerek, ezért a találmány tárgyát képezik afenti vegyületeket tartalmazó gyógyszerkészítmények is. A találmányhoztartoznak az (I) általános képletű vegyületek egyes intermedierjei is. Ó
HU0002869A 1996-12-13 1997-12-10 Benzothiophenecarboxamide derivatives, pharmaceutical compositions thereof and intermediates HU226458B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP33349596 1996-12-13
JP25400197 1997-09-19
PCT/JP1997/004527 WO1998025919A1 (en) 1996-12-13 1997-12-10 Benzothiophenecarboxamide derivatives and pgd2 antagonists comprising them

Publications (3)

Publication Number Publication Date
HUP0002869A2 true HUP0002869A2 (hu) 2001-06-28
HUP0002869A3 HUP0002869A3 (en) 2003-01-28
HU226458B1 HU226458B1 (en) 2008-12-29

Family

ID=26541496

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002869A HU226458B1 (en) 1996-12-13 1997-12-10 Benzothiophenecarboxamide derivatives, pharmaceutical compositions thereof and intermediates

Country Status (25)

Country Link
US (1) US6083974A (hu)
EP (1) EP0944614B1 (hu)
JP (1) JP3215441B2 (hu)
KR (1) KR100433568B1 (hu)
CN (2) CN1105112C (hu)
AR (1) AR008939A1 (hu)
AT (1) ATE223911T1 (hu)
AU (1) AU718958B2 (hu)
BR (1) BR9714016A (hu)
CA (1) CA2274591C (hu)
CZ (1) CZ297324B6 (hu)
DE (1) DE69715448T2 (hu)
DK (1) DK0944614T3 (hu)
ES (1) ES2181039T3 (hu)
HU (1) HU226458B1 (hu)
ID (1) ID22753A (hu)
IL (1) IL130660A (hu)
NO (1) NO992838L (hu)
NZ (1) NZ336143A (hu)
PL (1) PL191760B1 (hu)
PT (1) PT944614E (hu)
RU (1) RU2161617C1 (hu)
TR (1) TR199901280T2 (hu)
TW (1) TW438790B (hu)
WO (1) WO1998025919A1 (hu)

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Publication number Priority date Publication date Assignee Title
AU745129B2 (en) * 1998-03-31 2002-03-14 Shionogi & Co., Ltd. Process for producing 5-hydroxybenzo(b)thiophene-3- carboxylic acid derivatives
CN1138772C (zh) * 1998-03-31 2004-02-18 盐野义制药株式会社 苯并噻吩羧酸酰胺衍生物的制备方法
ATE295183T1 (de) * 1998-06-03 2005-05-15 Shionogi & Co Mittel zur linderung von juckreiz, enthaltend pgd2- antagonisten
EP1808427A3 (en) * 1999-07-02 2008-06-25 Shionogi & Co., Ltd. Novel processes for the preparation of bicyclic aminoalcohols
BR0109050A (pt) 2000-03-09 2004-04-27 Ono Pharmaceutical Co Derivados de indol, processo para prepapação e uso dos mesmos
AU2001250206A1 (en) * 2000-04-12 2001-10-30 Merck Frosst Canada Ltd Method and compositions for the treatment of allergic conditions using pgd2 receptor antagonists
US6410583B1 (en) * 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment
US7273883B2 (en) 2000-09-14 2007-09-25 Allergan, Inc. Prostaglandin EP4 antagonist
US7217725B2 (en) 2000-09-14 2007-05-15 Allergan, Inc. Prostaglandin D2 antagonist
AU2002213505A1 (en) 2000-10-17 2002-04-29 Shionogi & Co., Ltd Process for the preparation of pgd2 antagonist
EP1338594A4 (en) * 2000-11-01 2004-06-16 Shionogi & Co PGD2 RECEPTOR ANTAGONIST PHARMACEUTICAL COMPOSITIONS
AR038136A1 (es) 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
CN100378083C (zh) * 2002-03-19 2008-04-02 小野药品工业株式会社 羧酸化合物和含有所述化合物作为活性成分的药物制剂
AU2003252499B2 (en) * 2002-07-12 2007-11-08 Japan Science And Technology Agency Drugs for improving the prognosis of brain injury and a method of screening the same
EP1547598A1 (en) * 2002-09-30 2005-06-29 Shionogi & Co., Ltd. NOVEL USES OF PROSTAGLANDIN D sb 2 /sb , PROSTAGLANDIN D sb 2 /sb AGONIST AND PROSTAGLANDIN D sb 2 /sb ANTAGONIST
US7618979B2 (en) 2002-10-30 2009-11-17 Merck Frosst Canada Ltd. Pyridopyrrolizine and pyridoindolizine derivatives
DK1725553T3 (da) 2004-03-11 2008-08-18 Actelion Pharmaceuticals Ltd Tetrahydropyridoindolderivater
WO2006068162A1 (ja) * 2004-12-24 2006-06-29 Shionogi & Co., Ltd. 慢性閉塞性肺疾患の治療剤
TW200716093A (en) * 2005-04-28 2007-05-01 Shionogi & Co An antiasthmatic agent containing PGD2 receptor antagonist and leukotriene receptor antagonist
TWI410410B (zh) 2007-08-10 2013-10-01 Ono Pharmaceutical Co Phenylacetic acid compounds
PH12012501280A1 (en) 2009-12-23 2013-02-04 Ironwood Pharmaceuticals Inc Crth2 modulators
WO2011115804A1 (en) 2010-03-17 2011-09-22 Ironwood Pharmaceuticals, Inc. Sgc stimulators
EA026692B1 (ru) 2010-06-30 2017-05-31 Айронвуд Фармасьютикелз, Инк. Стимуляторы sgc
US20130216552A1 (en) 2010-07-12 2013-08-22 Ironwood Pharmaceuticals, Inc. Crth2 modulators
WO2012009134A1 (en) 2010-07-12 2012-01-19 Ironwood Pharmaceuticals, Inc. Crth2 modulators
EP2637659B1 (en) 2010-11-09 2016-05-18 Ironwood Pharmaceuticals, Inc. Sgc stimulators
EP2797915B1 (en) 2011-12-27 2016-07-13 Ironwood Pharmaceuticals, Inc. 2-benzyl-3-(oxazole/thiazole)-5-(pyrimidin-2-yl)-1(H)-pyrazole derivatives as stimulators of the soluble guanylate cyclase (sGC) for the treatment of e.g. hypertension or heart failure
US9309235B2 (en) 2012-09-18 2016-04-12 Ironwood Pharmaceuticals, Inc. SGC stimulators
EP2897953B8 (en) 2012-09-19 2019-06-26 Cyclerion Therapeutics, Inc. Sgc stimulators
EA033168B1 (ru) 2013-03-15 2019-09-30 Сайклерион Терапьютикс, Инк. СТИМУЛЯТОРЫ sGC
MX2016007522A (es) 2013-12-11 2017-12-15 Ironwood Pharmaceuticals Inc Estimuladores de guanilato ciclasa soluble (sgc).
WO2015106268A1 (en) 2014-01-13 2015-07-16 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS
AU2015317824A1 (en) 2014-09-17 2017-03-23 Cyclerion Therapeutics, Inc. Pyrazole derivatives as sGC stimulators
US20170298055A1 (en) 2014-09-17 2017-10-19 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
AU2015317823A1 (en) 2014-09-17 2017-03-23 Ironwood Pharmaceuticals, Inc. sGC stimulators
JP6770522B2 (ja) 2015-02-13 2020-10-14 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 全身性エリテマトーデスを予防し、及び／又は、治療するためのｐｔｇｄｒ−１及び／又はｐｔｇｄｒ−２アンタゴニスト
JP2019524710A (ja) 2016-07-07 2019-09-05 アイアンウッド ファーマシューティカルズ インコーポレイテッド Ｓｇｃ刺激剤の固体形態
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Also Published As

Publication number Publication date
CZ297324B6 (cs) 2006-11-15
CN1185226C (zh) 2005-01-19
CZ206599A3 (cs) 1999-11-17
ES2181039T3 (es) 2003-02-16
NO992838D0 (no) 1999-06-10
IL130660A0 (en) 2000-06-01
NZ336143A (en) 2002-05-31
PL191760B1 (pl) 2006-06-30
JP2000514824A (ja) 2000-11-07
HU226458B1 (en) 2008-12-29
KR100433568B1 (ko) 2004-05-31
CN1445225A (zh) 2003-10-01
US6083974A (en) 2000-07-04
PL334072A1 (en) 2000-01-31
ATE223911T1 (de) 2002-09-15
CA2274591A1 (en) 1998-06-18
EP0944614B1 (en) 2002-09-11
BR9714016A (pt) 2000-02-29
DE69715448D1 (de) 2002-10-17
ID22753A (id) 1999-12-09
PT944614E (pt) 2003-01-31
AU718958B2 (en) 2000-05-04
CN1105112C (zh) 2003-04-09
CN1240438A (zh) 2000-01-05
AU5409798A (en) 1998-07-03
IL130660A (en) 2002-03-10
HK1020045A1 (en) 2000-03-10
DK0944614T3 (da) 2003-01-13
HUP0002869A3 (en) 2003-01-28
EP0944614A1 (en) 1999-09-29
RU2161617C1 (ru) 2001-01-10
DE69715448T2 (de) 2003-08-07
TR199901280T2 (xx) 1999-10-21
JP3215441B2 (ja) 2001-10-09
CA2274591C (en) 2005-06-14
AR008939A1 (es) 2000-02-23
KR20000069402A (ko) 2000-11-25
NO992838L (no) 1999-07-20
WO1998025919A1 (en) 1998-06-18
TW438790B (en) 2001-06-07

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