HUP0002390A2 - Eljárás hibrid mag előállítására feltételes nősterilitás alkalmazásával - Google Patents
Eljárás hibrid mag előállítására feltételes nősterilitás alkalmazásávalInfo
- Publication number
- HUP0002390A2 HUP0002390A2 HU0002390A HUP0002390A HUP0002390A2 HU P0002390 A2 HUP0002390 A2 HU P0002390A2 HU 0002390 A HU0002390 A HU 0002390A HU P0002390 A HUP0002390 A HU P0002390A HU P0002390 A2 HUP0002390 A2 HU P0002390A2
- Authority
- HU
- Hungary
- Prior art keywords
- production
- hybrid seeds
- hybrid seed
- seed production
- hybrid
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 206010021928 Infertility female Diseases 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 230000001850 reproductive effect Effects 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000004720 fertilization Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000009877 rendering Methods 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8287—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for fertility modification, e.g. apomixis
- C12N15/8289—Male sterility
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8222—Developmentally regulated expression systems, tissue, organ specific, temporal or spatial regulation
- C12N15/823—Reproductive tissue-specific promoters
- C12N15/8233—Female-specific, e.g. pistil, ovule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8287—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for fertility modification, e.g. apomixis
- C12N15/829—Female sterility
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Botany (AREA)
- Pregnancy & Childbirth (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Physiology (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pretreatment Of Seeds And Plants (AREA)
- Compounds Of Unknown Constitution (AREA)
- Seeds, Soups, And Other Foods (AREA)
Abstract
A találmány hibrid magok előállítására vonatkozik növényekben.Pontosabban a találmány tárgya eljárás hibrid mag előállítására ahibrid egyik szülőjeként egy olyan kiméra génnel transzformált növénytalkalmazva, mely amikor a női reproduktív szerkezetekbenexpresszálódik, egy exogén módon alkalmazott protoxin-toxinátalakulást katalizáló fehérjét eredményez, és ezáltal a fertilizációthatástalanná teszi. A találmány magában foglalja feltételesen nősterilnövények alkalmazását feltételesen hímsteril növényekkel együtt ahibrid magok hatásosabb termelése céljából, a találmánybanalkalmazható kiméra géneket, a kiméra géneket tartalmazó transzgenikusnövényeket, és egy növény reproduktív szerkezeteiben az expressziórafelhasználható új promótereket. Ó
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3952797P | 1997-03-03 | 1997-03-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0002390A2 true HUP0002390A2 (hu) | 2000-11-28 |
HUP0002390A3 HUP0002390A3 (en) | 2002-08-28 |
Family
ID=21905956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0002390A HUP0002390A3 (en) | 1997-03-03 | 1998-02-27 | Method of hybrid seed production using conditional female sterility |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0972058B1 (hu) |
JP (1) | JP2001512988A (hu) |
KR (1) | KR100505908B1 (hu) |
CN (1) | CN1193098C (hu) |
AT (1) | ATE332385T1 (hu) |
AU (1) | AU725706B2 (hu) |
BR (1) | BR9808824A (hu) |
CA (1) | CA2281862C (hu) |
DE (1) | DE69835144T2 (hu) |
ES (1) | ES2263200T3 (hu) |
HU (1) | HUP0002390A3 (hu) |
IL (1) | IL131505A0 (hu) |
PL (1) | PL336800A1 (hu) |
RU (1) | RU2222599C2 (hu) |
TR (1) | TR199902113T2 (hu) |
UA (1) | UA73070C2 (hu) |
WO (1) | WO1998039462A1 (hu) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19639463A1 (de) * | 1996-09-26 | 1998-04-02 | Hoechst Schering Agrevo Gmbh | Verfahren zur Herstellung weiblich steriler Pflanzen |
US6815577B1 (en) | 1997-03-03 | 2004-11-09 | Syngenta Participations Ag | Method of hybrid seed production using conditional female sterility |
PT1054985E (pt) | 1998-02-20 | 2012-07-03 | Syngenta Ltd | Produção de semente híbrida |
US6515204B1 (en) * | 1999-10-05 | 2003-02-04 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food | Corn silk gene and regulatory region |
US6384304B1 (en) * | 1999-10-15 | 2002-05-07 | Plant Genetic Systems N.V. | Conditional sterility in wheat |
AU2001287853A1 (en) * | 2000-09-11 | 2002-03-26 | The Foundation For Research And Technology, Institute Of Molecular Biology And Biotechnology | Pest control system |
US20050081267A1 (en) * | 2001-03-12 | 2005-04-14 | Bayer Bioscience N.V. | Novel genes for conditional cell ablation |
AU2002315526A1 (en) | 2001-07-06 | 2003-01-21 | Monsanto Technology Llc | Methods for enhancing segregation of transgenes in plants and compositions thereof |
EP2278017B1 (en) * | 2002-02-26 | 2015-03-25 | Syngenta Limited | A method of selectively producing male or female sterile plants |
AU2003233489B2 (en) * | 2002-04-08 | 2008-10-02 | Pioneer Hi-Bred International, Inc. | Enhanced silk exsertion under stress |
DE10254165A1 (de) | 2002-11-20 | 2004-06-03 | Icon Genetics Ag | Verfahren zur Kontrolle eines zellulären Prozesses in einem multizellulären Organismus |
WO2005001101A1 (en) | 2003-06-03 | 2005-01-06 | University Of Georgia Research Foundation, Inc. | Conditional sterility in plants |
AU2004256264B2 (en) * | 2003-07-08 | 2010-03-11 | Syngenta Limited | A method of selectively producing male or female sterile plants |
US7491811B2 (en) | 2004-01-15 | 2009-02-17 | University Of Georgia Research Foundation, Inc. | Repressor-mediated tissue-specific gene expression in plants |
CA2594728C (en) * | 2005-01-13 | 2013-03-19 | Pioneer Hi-Bred International, Inc. | Maize cyclo1 gene and promoter |
MX2011010763A (es) * | 2009-04-17 | 2011-12-16 | Basf Plant Science Co Gmbh | Promotor de planta operable en endosperma y usos del mismo. |
CN101658129B (zh) * | 2009-09-18 | 2012-02-01 | 云南农业大学 | 雌性不育基因fst用于杂交水稻育种的方法 |
AU2010343047B2 (en) * | 2009-12-29 | 2015-06-11 | The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Male and female sterility lines used to make hybrids in genetically modified plants |
CN113429468B (zh) * | 2020-03-05 | 2023-04-18 | 山东农业大学 | 大麦雄性不育基因msg3002及其应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990008828A2 (en) * | 1989-02-02 | 1990-08-09 | Paladin Hybrids Inc. | Molecular methods of hybrid seed production |
DE3810286A1 (de) * | 1988-03-25 | 1989-10-12 | Max Planck Gesellschaft | Transgene pflanze mit modifizierter physiologie, morphologie und modifiziertem hormonmetabolismus, gewebekulturen dieser pflanze und verfahren zu ihrer herstellung |
EP0412006B1 (en) * | 1989-08-04 | 2000-11-29 | Aventis CropScience N.V. | Plants with modified flowers, seeds or embryos |
ATE496135T1 (de) * | 1989-08-10 | 2011-02-15 | Bayer Bioscience Nv | Pflanzen mit modifizierten blüten |
EP0825262A3 (en) * | 1989-12-29 | 1998-03-18 | Novartis AG | Tissue-specific toxin expression in plants |
AU8723791A (en) * | 1990-09-06 | 1992-03-30 | E.I. Du Pont De Nemours And Company | Compounds and constructs for producing male sterile plants |
US5254801A (en) * | 1990-12-03 | 1993-10-19 | Monsanto Company | Heterologous dominant conditional lethal gene which is a phosphonate monoester hydrolase and use thereof in plants |
DE4126414A1 (de) * | 1991-08-09 | 1993-02-11 | Hoechst Ag | Deacetylasegene zur erzeugung von phosphinothricin oder phosphinothricyl-alanyl-alanin, verfahren zu ihrer isolierung und ihre verwendung |
AU6819194A (en) * | 1993-05-03 | 1994-11-21 | Cornell Research Foundation Inc. | Isolated dna elements that direct pistil-specific and anther-specific gene expression and methods of using same |
DE19639463A1 (de) * | 1996-09-26 | 1998-04-02 | Hoechst Schering Agrevo Gmbh | Verfahren zur Herstellung weiblich steriler Pflanzen |
-
1998
- 1998-02-27 CA CA2281862A patent/CA2281862C/en not_active Expired - Lifetime
- 1998-02-27 AU AU63410/98A patent/AU725706B2/en not_active Expired
- 1998-02-27 RU RU99120671/13A patent/RU2222599C2/ru not_active IP Right Cessation
- 1998-02-27 DE DE69835144T patent/DE69835144T2/de not_active Expired - Lifetime
- 1998-02-27 IL IL13150598A patent/IL131505A0/xx unknown
- 1998-02-27 WO PCT/US1998/003838 patent/WO1998039462A1/en active IP Right Grant
- 1998-02-27 UA UA99094918A patent/UA73070C2/uk unknown
- 1998-02-27 CN CNB988030209A patent/CN1193098C/zh not_active Expired - Fee Related
- 1998-02-27 KR KR19997008020A patent/KR100505908B1/ko not_active IP Right Cessation
- 1998-02-27 TR TR1999/02113T patent/TR199902113T2/xx unknown
- 1998-02-27 EP EP98907657A patent/EP0972058B1/en not_active Expired - Lifetime
- 1998-02-27 JP JP53860398A patent/JP2001512988A/ja not_active Ceased
- 1998-02-27 BR BR9808824-6A patent/BR9808824A/pt not_active IP Right Cessation
- 1998-02-27 ES ES98907657T patent/ES2263200T3/es not_active Expired - Lifetime
- 1998-02-27 PL PL98336800A patent/PL336800A1/xx not_active IP Right Cessation
- 1998-02-27 AT AT98907657T patent/ATE332385T1/de not_active IP Right Cessation
- 1998-02-27 HU HU0002390A patent/HUP0002390A3/hu unknown
Also Published As
Publication number | Publication date |
---|---|
MX9908098A (es) | 2000-07-01 |
JP2001512988A (ja) | 2001-08-28 |
TR199902113T2 (xx) | 1999-12-21 |
EP0972058A1 (en) | 2000-01-19 |
UA73070C2 (en) | 2005-06-15 |
DE69835144T2 (de) | 2006-11-16 |
KR20000075938A (ko) | 2000-12-26 |
CN1193098C (zh) | 2005-03-16 |
BR9808824A (pt) | 2000-07-04 |
PL336800A1 (en) | 2000-07-17 |
RU2222599C2 (ru) | 2004-01-27 |
ATE332385T1 (de) | 2006-07-15 |
DE69835144D1 (de) | 2006-08-17 |
ES2263200T3 (es) | 2006-12-01 |
AU6341098A (en) | 1998-09-22 |
WO1998039462A1 (en) | 1998-09-11 |
CN1249782A (zh) | 2000-04-05 |
HUP0002390A3 (en) | 2002-08-28 |
CA2281862A1 (en) | 1998-09-11 |
KR100505908B1 (ko) | 2005-08-05 |
EP0972058B1 (en) | 2006-07-05 |
IL131505A0 (en) | 2001-01-28 |
CA2281862C (en) | 2014-09-30 |
AU725706B2 (en) | 2000-10-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0002390A2 (hu) | Eljárás hibrid mag előállítására feltételes nősterilitás alkalmazásával | |
MXPA02004884A (es) | Genes de tolerancia a patogenos. | |
DE69939744D1 (de) | Verfahren zur herstellung stresstoleranter pflanzen | |
HUP0002649A2 (hu) | Hímsterilitás létrehozása növényekben, avidin magas szintű expresszáltatásával | |
GB9127216D0 (en) | Plant cultivation system | |
ZA9711146B (en) | Novel genes coding for amino acid deacetylase with specificity for N-acetyl-L-phosphinotricin, their isolation and use. | |
HUP0002305A3 (en) | Chimeric genes and methods for increasing the lysine content of the seeds of plants | |
IL72643A (en) | Gene encoding an analog of human interleukin-ii which substantially retains the biological activity of natural human interleukin-ii,microorganism expression vector containing the gene,microorganisms transformed by the vector and the human interleukin-ii analog produced by the microorganisms | |
GR3034286T3 (en) | Geminivirus-based gene expression system | |
ATE266093T1 (de) | Zellkern-codiertes transkriptionssystem plastiden höherer pflanzen | |
IL124020A (en) | Plant optimized nucleotide sequence that encodes an insecticidal crystal protein | |
MX9800556A (es) | Secuencia aislada de adn para el uso como una region reguladora en un gen quimerico util para la transformacion de plantas. | |
ATE353952T1 (de) | Desaturasen und verfahren ihrer anwendung zur synthese von mehrfach ungesättigten fettsäuren | |
EP1071748A4 (en) | EXPRESSION OF ALFIN1 GENE AND METHODS OF PRODUCING TRANSGENIC PLANTS HAVING INCREASED ROOT GROWTH AND ENHANCED ACTIVATION OF SPECIFIC ROOT GENES | |
NZ336337A (en) | Antimicrobial proteins derived from Macadamia integrifolia, cotton and cocoa seeds useful in the treatment of microbial infection in plants and humans | |
AU1439295A (en) | Ungulate preblastocyst derived embryonic stem cells and use thereof to produce cloned transgenic and chimeric ungulates | |
CA2145833A1 (en) | Induction of embryogenesis and generation of doubled plant haploids using microtubule inhibitors | |
HUP0004938A2 (hu) | Drozomicint kódoló kiméra gén, valamint az ezt tartalmazó vektor és betegségekkel szemben ellenálló transzgenikus növények előállítása | |
HUP0202526A2 (hu) | Zsírsav-deszaturáz gén növényekből | |
NO955354D0 (no) | Fremstilling av trehalose i planter | |
WO2000000598A3 (en) | Plant dwarfing | |
MXPA02009612A (es) | Secuencia reguladora de la expresion especifica en antera de un gen y su empleo en la produccion de plantas androesteriles y semillas hibridas. | |
AU5539500A (en) | Promoter enabling transgene expression in the whole plant except in the seed | |
Vitousek | Plant and animal invasions: Can they alter ecosystem processes?. | |
IT1270660B (it) | Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi |